Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• nanoparticles consist of metal elements bonded with oxygen in intricate structures [3][4]. They exhibit exceptional physicochemical properties, which have led to their widespread utilization across various industries [5][6]. These nanomaterials are employed in, for example, electronics, cosmetics, and medicine

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• structure of a series of molecules to a biological/physicochemical property or activity, mostly through the use of statistical tools. Once a model has been constructed, it can be used to predict the property or biological effect of new structures quickly and at a very low cost in comparison to experimental

• used for NMs (e.g., “Au nanoparticles”) to refer to a family of materials combining different sizes and/or coating materials that can have different properties. Hence, ECHA defined a set of relevant physicochemical parameters to identify and register nanoforms, including six compulsory requirements

• of metal and oxygen atoms as descriptors in metal oxide models [15][16]. It is also common to find single-element descriptors based on the physicochemical properties of pure elements. The use of single-element descriptors is trivial in single-metal nanoforms, such as silver or gold nanoparticles [17

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• containing antibacterial and tissue-regenerating salts of zinc acetate or strontium nitrate in different concentrations, whose structures may be suitable for developing biomedical wound dressing systems in the future. Several experiments have been conducted to optimize the physicochemical, mechanical, and

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• , cost-effectiveness, and reliability. The use of modified electrodes has shown to improve significantly electrocatalytic activity and electrical conductivity of electrodes. Graphene, with sp2-hybridized carbon atoms in a single layer, has gained much attention because of its unique physicochemical

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• systems by architecting atoms, molecules, and nanomaterials as building blocks [1]. This interplay at the nanoscale renders a plethora of unique physicochemical properties to nanomaterials. These unique properties are due to the mean free path of an electron in a metal which is ≈10–100 nm at room

• ]. A very recent study reported photothermal effect of gold nanorods of shorter and longer lengths in gel and aqueous media [18]. In recent times, anisotropic nanoparticles due to their unique physicochemical properties have garnered attention among researchers and enabled them to manoeuvre into an

• diffraction (XRD), and FTIR, respectively, to establish physicochemical properties of the synthesized nanomaterials. Results Synthesis, optical spectroscopy, and zeta potential Anisotropic gold nanoparticles of makura shape were synthesized using seed-mediated approach as shown in Figure 1a. The Au seeds were

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• generation of inorganic particles is a physicochemical approach that claims to synthesize particles without surfactants or molecular additives. In contrast to other approaches of nanoparticle synthesis, LSPC only requires the neat (elemental) target materials while no other precursors or ligand exchange

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• databases Pubmed and SciFinder [63][64][65]. This dataset included 260 preclinical assays for 31 unique NPs. Therefore, the number of assays for each NP is about 8.39. Moreover, the data covered a huge range of properties of NPs such as morphology, physicochemical properties, coating agents, length, and

• reference or expected-value function f(vij)ref and the PT operators ΔDk(cj). Specifically, they are applied for accounting structural and assay information on NDDs and NPs. In addition, the PTOs ΔD(Ddk) and ΔD(Dnk) label structural and/or physicochemical characteristics of NDDs and NPs on the variables ΔD

• physicochemical properties for drugs in order to cross the BBB [89]. High lipophilicity can contribute to excessive distribution volumes, increased metabolic liability, and lower unbound drug concentration in the plasma and/or brain; it may also negatively affect pharmaceutical properties, in particular

Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• hydrothermal method was reported [7]. The effect of oleylamine concentration on the physicochemical properties of CF synthesized via a solvothermal process has been presented [8]. However, ferrites exhibit self-agglomeration due to their magnetic nature. Combining different functional materials to prepare

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• has shown significant treatment efficacy for central nervous system (CNS) disorders including depression, schizophrenia, Alzheimer’s disease, and post-traumatic stress disorder. The physicochemical properties of DCS, however, limit the options of formulation and medicinal applications of DCS, and

• ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [23]. The limitations of conventional medication delivery can be overcome by advanced drug delivery methodologies, such as transdermal drug delivery (TDD

• polymers can provide gastric protection against gastric-irritating compounds and/or stomach acidity, leading to improved drug release performance. We aimed to fabricate DCS nanocrystals and study their physicochemical and biological properties. The DCS already has great water solubility (Log P = −1.72), so

Controllable physicochemical properties of WO_x thin films grown under glancing angle

• Rupam Mandal,
• Aparajita Mandal,
• Alapan Dutta,
• Rengasamy Sivakumar,
• Sanjeev Kumar Srivastava and
• Tapobrata Som

Beilstein J. Nanotechnol. 2024, 15, 350–359, doi:10.3762/bjnano.15.31

• , Alagappa University, Karaikudi 630 003, India Department of Physics, Indian Institute of Technology Kharagpur, Kharagpur 721 302, India 10.3762/bjnano.15.31 Abstract In this work, various physicochemical properties are investigated in nanostructured WOx thin films prepared by radio-frequency magnetron

• -stoichiometric compositions and polymorphs, WOx usually behaves as an n-type semiconductor because an unintentional incorporation of a certain amount of reduced W cations is thermodynamically inevitable in these films [8]. It is, therefore, possible to tune the physicochemical properties, such as work function

• observations demonstrate a wide range of tunability and correlation among several physicochemical properties of glancing angle-deposited WOx films, which is due to serve as a guide for fabricating WOx-based optoelectronic devices, including carrier-selective contacts for photovoltaic cells. Experimental NS-WOx

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• present heterogeneous molecular nature, difficult to be precisely controlled, and cannot be fully characterized by physicochemical analysis; nanoparticles are not a mere excipient, but the entire complex is the active pharmaceutical ingredient [111]. The transition from small laboratory batch sizes to

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• the safety concerns regarding new NPs in this rapidly growing field. Therefore, computational-based approaches are effective methods in risk assessment. Among them, quantitative structure–property relationship (QSPR) models seem to be the most promising method [13]. However, the physicochemical and

• and toxicity endpoint. Physicochemical features encoding the information of MeOx NPs into PT descriptors were used to build prediction models for zeta potential and cytotoxicity (cell damage). The basic information of MeOx NPs was directly taken from the periodic table and some were calculated with

• have a regular pattern resulting in structural similarity and similar physicochemical, toxicokinetic, toxicodynamic, and ecotoxicological properties [36]. Therefore, after selecting the appropriate descriptors from the PLS model (model 2), we have applied the Quantitative Read-Across v4.0 tool

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• chemotherapy functionalities using a solvothermal method. The incorporation of PDA into the fabricated nanostructures imparts several advantages for cancer therapy and controlled drug release systems because of its robust structural and physicochemical properties. Additionally, aside from enhancing

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• engage in a complex interplay of dynamic physicochemical interactions, kinetics, and thermodynamic exchanges that can lead to undesirable outcomes [1][8][9][10]. In a more general context, the importance in understanding the mechanism of bionano interactions arises from the increasing awareness and

• concerns regarding the safety of nanoparticles (NPs) in relation to human and animal health. The toxicity of NPs is closely linked to their chemical aggressiveness and varies with their physicochemical properties, including surface area, charge, and reactivity. Understanding the intricate interplay between

• of the NP, which is influenced by its physicochemical composition, (ii) the interface between the solid NP and the surrounding liquid environment, where notable changes occur upon interaction, and (iii) the contact zone between the solid–liquid interface and biological substrates (Figure 2) [22]. In

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• nanoemulsion comprising 5% p-cymene stabilized with 1% Tween 80, with droplet sizes measuring approximately 150 nm, which maintained its stability for 60 days [31]. The zeta potential is used to predict the stability of dispersions, and its value depends on the physicochemical properties of active ingredients

• previously validated method. In silico molecular and physicochemical properties of the monoterpenes The ACD/Labs Percepta Platform, particularly the PhysChem Module, was employed to forecast molecular and physicochemical data. The ChemSpider tool facilitated the acquisition of these properties [56][57

• -Sol, (B) Myr-Sol, (C) Cym-NE, and (D) Myr-NE; DC: death control (100% methanol); SC: solvent control (ethanol 5%); TC: trauma control. Hydrodynamic diameter, PdI, and zeta potential of Cym-NEs.a Hydrodynamic diameter, PdI and zeta potential of Myr-NEs.a In silico molecular/physicochemical properties

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• temperature above LCST results in shrinkage of the hydrogel structure and formation of inhomogeneities. Such a hydrogel ceases to be transparent and loses most of its water [42]. Morphological and physicochemical characterisation Scanning electron microscopy was performed with an FE-SEM FEI Quanta FEG 250 at

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• high tolerance profile, and it has shown in vitro and in vivo leishmanicidal properties against different species of Leishmania spp. [11][14]. Despite its pharmacological potential, curcumin has some physicochemical and biopharmaceutical limitations that should be highlighted, such as: (i) low aqueous

• physicochemical properties of the systems, and by the release and targeting features of the loaded nanosystems, rather than by the drug properties themselves [58][59][60][61][62]. The intracellular amastigote form of Leishmania spp. allocates in macrophage phagolysosomes from infected individuals [63]. However

• limitations, improving their physicochemical and leishmanicidal properties [79][80]. In this context, curcumin-loaded SNEDDSs intended for the treatment of leishmaniasis were developed. Khan and collaborators developed curcumin-loaded self-emulsifying drug delivery systems (curc-SNEDDSs) for topical

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• , translation to the clinics or even market approval often fails. So far, the reason for this discrepancy is manifold. Physicochemical properties such as size, surface potential, and surface chemistry are in focus of research for many years. Other equally important parameters, influencing whether a successful

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• the aggregation pattern of nanomaterials, and extrinsic factors, including surrounding medium, medium viscosity, and concentration of the nanomaterial. Most often, nanomaterials with complex three-dimensional structures have better optical and physicochemical properties for the use in colorimetry

• ]. The photothermal properties can also be enhanced by optimizing the elemental composition of the nanomaterials [44]. Generally, nanocomposite materials are developed by incorporating two or more compounds in a single particle, resulting in enhanced physicochemical properties of the final composite

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• (P, As, Sb and Bi)) to multielementals (e.g., boron nitrate, metal dichalcogenides, MXenes, layered metal/covalent organic frameworks, or layered hydroxides/oxides) [9][10][11]. These systems exhibit an enormous variability in their physicochemical properties, which are defined by their layer-to

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• affected by their physicochemical properties, including hydrodynamic diameter, surface potential, shape, functional groups, and hydrophobicity. The protein corona reduces the targeted delivery of NPs by disturbing or inhibiting the binding of target molecules to their receptors. Mirshafiee et al. used a

• , and enhanced physicochemical features [89][90]. However, NPs can also be restricted by biological barriers; thus, to achieve site-specific delivery, the exterior of NPs is decorated with highly compatible ligands to enhance the receptor-mediated internalization of NPs [91]. The multifunctionalization

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• . These results show potential for the development of new nanomedicines against T. cruzi. Keywords: benznidazole; biopharmaceutical study; Chagas disease; nanoparticles; nanostructured lipid carriers; physicochemical characterization; Trypanosoma cruzi; Introduction Chagas disease is a neglected disease

• development of nanostructured lipid carriers (NLC) [20]. Here, we resort to NLC encapsulating BNZ, describing the preparation, physicochemical and biopharmaceutical characterization, and in vitro evaluation against T. cruzi intracellular and blood circulating forms. Interestingly, our formulation achieves a

• other researchers working in the field. Results and Discussion Formulation and physicochemical characterization of NLC-BNZ Nanoparticle formulations were prepared by the ultrasonication method and named as NLC-BNZ or NLC-VEHICLE, in that order, depending on whether they contained BNZ or not. Stable

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• . Subsequently, AgNPs@Lac/Alg was characterized using various analytical techniques and applied for the catalytic degradation of contaminants and in bacterial activity assays. Absorption spectra were analyzed to monitor changes in physicochemical properties at the maximum peak region of surface plasmon resonance

• in the absorbance value in the UV–vis spectra. Minor changes in λmax values were noted from the absorption data, indicating a slight influence of the silver-ion-to-nanocomposite ratio on the physicochemical properties of the synthesized AgNPs. Considering these findings, two ratios of silver ions to

• Lac/Alg, namely 0.3 (AgNPs@Lac/Alg-0.3) and 0.7 (AgNPs@Lac/Alg-0.7), were selected for further physicochemical characterizations. Physicochemical characterizations The stability and size of the nanocomposites in the colloidal solution were evaluated through zeta potential and DLS measurements at a

In situ magnesiothermic reduction synthesis of a Ge@C composite for high-performance lithium-ion batterie anodes

• Ha Tran Huu,
• Ngoc Phi Nguyen,
• Vuong Hoang Ngo,
• Huy Hoang Luc,
• Minh Kha Le,
• Minh Thu Nguyen,
• My Loan Phung Le,
• Hye Rim Kim,
• In Young Kim,
• Sung Jin Kim,
• Van Man Tran and
• Vien Vo

Beilstein J. Nanotechnol. 2023, 14, 751–761, doi:10.3762/bjnano.14.62

• between the components obtained via this route. Results and Discussion Physicochemical characterization The synthesis of Ge/C-iM750 (see Experimental section for sample denominations) was carried out through a one-pot in situ generation of Ge nanoparticles in the presence of a carbon matrix. In this

Nanomaterials for photocatalysis and applications in environmental remediation and renewable energy

• Viet Van Pham and
• Wee-Jun Ong

Beilstein J. Nanotechnol. 2023, 14, 722–724, doi:10.3762/bjnano.14.58

• , and related fields [4]. To reduce contaminants (e.g., air pollution (CO2, NOx, SO2), POPs) there are many routes (e.g., physicochemical approaches, biological fixation, advanced oxidation process, and photocatalysis [5][6][7][8]). Among the aforementioned methods, the photocatalysis route is