Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• imaging due to the nonconductive nature of the FP substrate. FESEM energy-dispersive X-ray spectroscopy (EDX) mapping investigations were conducted on Ag/Au alloy NPs deposited on a Si substrate by drop casting 10 µL to avoid confusion in the data caused by the Au coating. Transmission electron microscopy

Bolometric IR photoresponse based on a 3D micro-nano integrated CNT architecture

• Yasameen Al-Mafrachi,
• Sandeep Yadav,
• Sascha Preu,
• Jörg J. Schneider and
• Oktay Yilmazoglu

Beilstein J. Nanotechnol. 2024, 15, 1030–1040, doi:10.3762/bjnano.15.84

• integration techniques make it important for real-time broadband imaging systems. Keywords: 3D micro-nano architecture; blackbody absorption; CNT microbolometer; high responsivity; high spatial resolution; Introduction Non-cryogenic infrared (IR) microbolometers represent a cutting-edge technology with

Entry of nanoparticles into cells and tissues: status and challenges

• Kirsten Sandvig,
• Tore Geir Iversen and
• Tore Skotland

Beilstein J. Nanotechnol. 2024, 15, 1017–1029, doi:10.3762/bjnano.15.83

• intravenous (i.v.) injection is required to benefit from NPs as therapeutics or imaging agents in an optimal way. Many different types of NPs have been made; for an overview, see [1]. Doxorubicin encapsulated in liposomes (Doxil®/Caelyx®) was the first NP-based drug approved for cancer treatment by the US

• effect on cells. In the case of NP-based products used for radiotherapy or as imaging agents, it may be sufficient that they end up in the affected areas. Other NPs may, however, need to enter cells in order to deliver the drug to its intracellular target molecules. Also, the cellular location that the

• obtained during such studies [81]. As described above for in vitro studies, there are many similarities both regarding possibilities and challenges in how to perform such studies with NPs and EVs. Both types of particles can be labelled using partly similar strategies, and the same imaging modalities are

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• chemotherapeutic agent chlorambucil (CHL) and the imaging agent IR780. The approach in this study incorporates Pluronic F127-folate onto the PLGA nanoparticles, which enables targeted delivery to folate receptor-expressing cancer cells. The F127-folate@PLGA/CHL/IR780 nanoparticles were formulated using a

• and diagnosis, leveraging the advantages of PLGA, folate targeting, and the integration of therapeutic and imaging agents. Keywords: cancer; chlorambucil; drug carrier; IR780; PLGA nanoparticle; theragnostic; Introduction Poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA), a copolymer of poly(lactic acid

• folic acid to enhance the imaging contrast in magnetic resonance imaging (MRI) or to improve the therapeutic efficacy of nanoparticles [14]. Chlorambucil (CHL) is a nitrogen mustard alkylating drug used to treat several benign tumors and malignancies, including chronic lymphatic leukemia [15], Hodgkin’s

Water-assisted purification during electron beam-induced deposition of platinum and gold

• Cristiano Glessi,
• Fabian A. Polman and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 884–896, doi:10.3762/bjnano.15.73

• Cristiano Glessi Fabian A. Polman Cornelis W. Hagen Delft University of Technology, Fac. Applied Sciences, Dept. Imaging Physics, Lorentzweg 1, 2628CJ Delft, Netherlands 10.3762/bjnano.15.73 Abstract Direct fabrication of pure metallic nanostructures is one of the main aims of focused electron

• subsequently sonicated for 2 min in acetone and for 2 min in isopropyl alcohol. All depositions were performed with both GIS nozzles inserted. Deposition, imaging, and EDX analysis were performed in immersion mode at a working distance of 5 mm. Deposition conditions In general, the main parameters that control

• of 2g (1 µm line, 5 kV, 0.54 nA, 1 µs dwell, 4 nm pitch, 100000 passes) before FIB milling (top) and after milling (bottom). Imaging and milling were performed in a Thermo Fisher Scientific Helios dual-beam instrument. Electron beam-assisted purification of Au and Pt FEBID materials with oxidant gas

The effect of age on the attachment ability of stick insects (Phasmatodea)

• Marie Grote,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 867–883, doi:10.3762/bjnano.15.72

• . Freshly molted adult and subadult individuals were acquired from laboratory stock and used for imaging as well. Three individuals were chosen for each age group. Tarsi were cut off at the tarso-tibial joint and transferred into 1.5 mL solution of phosphate-buffered saline (PBS) and Triton TM-X100 (Sigma

• autofluorescence of the cuticle [50]. The samples were prepared the same way as for WFM imaging (see section 6). One tarsus per respective age group was examined (subadult, freshly molted adult, young, and old). The ZEN2008 software (Carl Zeiss AG, Oberkochen, Germany) was used to generate maximum intensity

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• ]. Additionally, focusing on the role of the NM as contrast agent in magnetic resonance imaging, the authors added the specific property of cellular internalization of iron, measured as the amount of iron inside the cells [25]. Zhang et al. [79] created a predictive model that uses regression trees to predict the

Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue

• Dalia Chávez-García,
• Mario Guzman,
• Viridiana Sanchez and
• Rubén D. Cadena-Nava

Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63

• of CQDs range from sensing and cell imaging to drug delivery, photocatalysis, and energy conversion [26][27][28][29]. In this study, biomass from watermelon shell and grape pomace waste is used as the carbon source. The hydrothermal method employing urea, nitric acid, and water is utilized. Samples

• properties for advanced photocatalytic applications. Furthermore, the assessment of luminescence activity unveiled the potential of CQDs for biomedical imaging, particularly with upconversion luminescence. This presents opportunities for targeted cell identification and drug delivery. This study underscores

Enhancing higher-order modal response in multifrequency atomic force microscopy with a coupled cantilever system

• Wendong Sun,
• Jianqiang Qian,
• Yingzi Li,
• Yanan Chen,
• Zhipeng Dou,
• Rui Lin,
• Peng Cheng,
• Xiaodong Gao,
• Quan Yuan and
• Yifan Hu

Beilstein J. Nanotechnol. 2024, 15, 694–703, doi:10.3762/bjnano.15.57

• , Chinese Academy of Sciences, Dalian 116023, P. R. China 10.3762/bjnano.15.57 Abstract Multifrequency atomic force microscopy (AFM) utilizes the multimode operation of cantilevers to achieve rapid high-resolution imaging and extract multiple properties. However, the higher-order modal response of

• ; Introduction Multifrequency atomic force microscopy (AFM) has become an important tool for nanoscale imaging and characterization [1][2]. This technique involves the excitation and detection of multiple frequencies to improve data acquisition speed, sensitivity, and resolution, as well as to enable material

• resonant mode tracking the sample topography and the higher-order resonant mode providing information about mechanical properties [5][6]. Bimodal AFM is relatively simple to operate and offers improved imaging quality. Hence, it is widely applicable in diverse fields such as physics, chemistry, and biology

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• hydrogels for enabling usage on nanophotonic, photothermal, and bio-imaging applications. Keywords: anisotropy; hydrogel; kappa-carrageenan; metal nanoparticles; nanoarchitectonics; nanomakura; photothermal properties; surfactants; Introduction Nanoarchitectonics is the fabrication of functional material

• competent authority of CSIR-IITR, Lucknow, India. The authors acknowledge Mr. Jai Shankar for TEM imaging, Dr. Aditya Kumar Kar for FTIR, and IIT Kanpur for XRD measurement. Nabojit Das and Akash Kumar are thankful to CSIR for providing fellowship. They are thankful to CSIR-IITR, Lucknow, and CSIR-CSIO

Exfoliation of titanium nitride using a non-thermal plasma process

• Priscila Jussiane Zambiazi,
• Dolores Ribeiro Ricci Lazar,
• Larissa Otubo,
• Rodrigo Fernando Brambilla de Souza,
• Almir Oliveira Neto and
• Cecilia Chaves Guedes-Silva

Beilstein J. Nanotechnol. 2024, 15, 631–637, doi:10.3762/bjnano.15.53

• exfoliation methods, offering promising prospects for applications in photoacoustic imaging and photothermal therapy of tumors because of their satisfactory absorption characteristics in the second near-infrared (NIR-II) region [5]. The non-thermal plasma (NTP) synthesis method enables the fabrication of 2D

Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• relatively large adhesive organs that bear no further surface microstructures [47][55][56] and because the droplet morphology of its tarsal secretion has been recently analysed [28][38][47][55][56]. Combining different imaging techniques, including scanning electron microscopy (SEM), confocal laser scanning

• with toluidine blue and exhibits a low degree of sclerotization in CLSM. Moreover, it presents a unique morphology, appearing fanned out, suggesting a more flexible structure (Figure 4B, Figure 4D). Based on these characteristics, this cuticle region is named flexible cuticle (fc). The µCT imaging of

• composition of the two tarsal attachment organs, euplantulae and arolium, were compared using different imaging techniques. The study revealed some similarities between them, corresponding to their roles in the attachment process [1]. In the interior of both organs, there is a hemolymph reservoir serving dual

Stiffness calibration of qPlus sensors at low temperature through thermal noise measurements

• Laurent Nony,
• Sylvain Clair,
• Daniel Uehli,
• Aitziber Herrero,
• Jean-Marc Themlin,
• Andrea Campos,
• Franck Para,
• Alessandro Pioda and
• Christian Loppacher

Beilstein J. Nanotechnol. 2024, 15, 580–602, doi:10.3762/bjnano.15.50

• University, CNRS, Centrale Marseille, FSCM (FR1739), CP2M, 13397 Marseille, France 10.3762/bjnano.15.50 Abstract Non-contact atomic force microscopy (nc-AFM) offers a unique experimental framework for topographical imaging of surfaces with atomic and/or sub-molecular resolution. The technique also permits

• used for imaging. At 15 kV, the resolution is 0.6 nm. Energy-dispersive X-ray spectroscopy (EDS) chemical analyses have been performed too, for which an EDAX Octane Silicon Dri Detector (129 eV energy resolution for manganese) coupled to the SEM was used at 15 kV. A large side view (cf. Figure 1a

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• Yanyan Wen Ningning Song Yueyou Peng Weiwei Wu Qixiong Lin Minjie Cui Rongrong Li Qiufeng Yu Sixue Wu Yongkang Liang Wei Tian Yanfeng Meng School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi

• , 030001, China Department of Radiology, Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi 030009, China The Ninth Clinical Medical School of Shanxi Medical University, Taiyuan, Shanxi 030009, China Department of Medical Imaging, Changzhi Medical College, Changzhi, Shanxi, 046000

• significantly suppressed HCC cell proliferation. Moreover, CUR-Fe@MnO2 NFs were effective T1/T2 contrast agents for molecular magnetic resonance imaging due to the release of Mn2+ and Fe3O4 NCs. Keywords: curcumin; hepatocellular carcinoma; magnetic resonance imaging (MRI); radiofrequency (RF) hyperthermia

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• incubation, the MTT solution was removed, the insoluble formazan crystals were dissolved in dimethyl sulfoxide (DMSO), and absorbance was measured at 570 nm in a Cytation™ 5 cell imaging multi-mode reader (Biotek Instruments, VT, USA). The cell viability was expressed as a percentage of the cells grown in

Sidewall angle tuning in focused electron beam-induced processing

• Sangeetha Hari,
• Willem F. van Dorp,
• Johannes J. L. Mulders,
• Piet H. F. Trompenaars,
• Pieter Kruit and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 447–456, doi:10.3762/bjnano.15.40

• Sangeetha Hari Willem F. van Dorp Johannes J. L. Mulders Piet H. F. Trompenaars Pieter Kruit Cornelis W. Hagen Department of Imaging Physics, Delft University of Technology, Lorentzweg 1, 2628CJ Delft, Netherlands Delmic B.V., Oostsingel 209, 2612 HL Delft, Netherlands Uniresearch B.V

• by etching with water and it is shown, using transmission electron microscopy imaging, that the sidewall angle can be tuned from outward to inward by controlling the etch position on the sidewall. A surprising under-etching due to the emission of secondary electrons from the deposit was observed

• sidewall. This suggests that etching can be carried out at any position on the sidewall if the right dose can be applied to make it vertical. From a practical point of view, it would be advantageous if this entire process, etching as well as imaging, could be implemented in situ in the SEM. The above

Unveiling the nature of atomic defects in graphene on a metal surface

• Karl Rothe,
• Nicolas Néel and
• Jörg Kröger

Beilstein J. Nanotechnol. 2024, 15, 416–425, doi:10.3762/bjnano.15.37

• an Ar+-induced Ir(111) surface defect [57]. In a next step, AFM imaging of the defects at different tip–surface distances was complemented by spatially resolved Δf(Δz) measurements (Figure 4). Figure 4a shows the evolution of the total vertical force recorded along the path across a type-1 defect

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• minimizing systemic side effects. For instance, studies by Cheng et al. revealed the successful application of gold NPs for delivering anti-inflammatory agents to atherosclerotic plaques and tomography imaging of atherosclerosis [172]. Recent research by Mao et al. and Wang et al. highlighted the efficacy of

• personalized and targeted treatments for sclerosis. Recently developed Fe3O4–CeO2 core–shell NPs have shown great potential as platforms for both the diagnosis and treatment of vascular disorders associated with ROS. This is attributed to their impressive magnetic resonance imaging (MRI) capabilities and

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• also includes cancer imaging and diagnosis such as the MRI imaging agent Resovist, carboxydextran-coated superparamagnetic iron oxide nanoparticles approved for liver contrast-enhanced MRI102 [87]. Another 10% are nanocrystals, such as Tricor (approved in 2004) or Triglide (approved in 2005), used to

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• discrepancies between the manufacturer’s measurements are observed for sample D, which has the largest primary particle size. The good agreement for the smaller samples, with all measurements coinciding within the 95% confidence interval, shows that all chosen imaging conditions are sufficient for the

Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS₂ thin films with domains much smaller than the laser spot size

• Felipe Wasem Klein,
• Jean-Roch Huntzinger,
• Vincent Astié,
• Damien Voiry,
• Romain Parret,
• Houssine Makhlouf,
• Sandrine Juillaguet,
• Jean-Manuel Decams,
• Sylvie Contreras,
• Périne Landois,
• Ahmed-Azmi Zahab,
• Jean-Louis Sauvajol and
• Matthieu Paillet

Beilstein J. Nanotechnol. 2024, 15, 279–296, doi:10.3762/bjnano.15.26

• Nmax being the largest number of layers present in the sample, the definition of the average number of layers can be written as and the total coverage (including bare substrate areas) is obviously 100%: AFM imaging (see Supporting Information File 1, Figure S4) reveals that for > 1.25, the surface is

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• ., cancer, diabetes, and atherosclerosis), magnetic resonance imaging (MRI), targeted drug delivery, photothermal therapy, gene therapy, and molecular and cellular monitoring [15][16]. Photothermal therapy (PTT), a treatment in which nanostructures are used, induces drug release or damages tumor cells with

• an infrared thermal imaging camera. Additionally, the photothermal stability of both PDA/Fe3O4 NPs and VNB/PDA/Fe3O4 NPs (at a concentration of 0.1 mg/mL and in a total volume of 1 mL) was assessed through a 5 min interaction with an 808 nm (1 W/cm2) NIR laser followed by a cooling process, for four

• interaction at the tumor site. The synthesized VNB/PDA/Fe3O4 NPs hold promise for effective photothermal therapy, magnetic targeting, MRI imaging, and chemotherapeutic capabilities in future studies. Conclusion In this study, we successfully synthesized VNB/PDA/Fe3O4 NPs with combined photothermal therapy and

Quantitative wear evaluation of tips based on sharp structures

• Ke Xu and
• Houwen Leng

Beilstein J. Nanotechnol. 2024, 15, 230–241, doi:10.3762/bjnano.15.22

• commonly known as the broadening effect of the probe tip. In mathematical morphology, the scanning image acquired during the AFM imaging process results from the interaction between sample and tip. The mathematical morphology (Equation 1) can describe the scanning image obtained from AFM. This formula

• using a tip to scan a sharp structure can achieve reverse imaging of the tip for both sharp and blunt tips. This inverse imaging of the tip through sharp structures allows for accurate and precise reconstruction of the morphological characteristics of the tips. Real data reconstruction results To

• , making it ideal for reverse imaging of the AFM probe tip to detect tip wear. AFM images were acquired using a Bruker Icon AFM system in tapping mode. The AFM probe used for AFM imaging was a Bruker FESPA-V2 probe. The cantilever was 225 µm long, 35 µm wide, and had a spring constant of 2.8 N/m. The

Ion beam processing of DNA origami nanostructures

• Leo Sala,
• Agnes Zerolová,
• Violaine Vizcaino,
• Alain Mery,
• Alicja Domaracka,
• Hermann Rothard,
• Philippe Boduch,
• Dominik Pinkas and
• Jaroslav Kocišek

Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20

• by ion beams, modeling ion implantation, lithography, and sputtering conditions. Structural changes in 2D DNA origami nanostructures deposited on Si are analyzed using AFM imaging. The observed effects on DNA origami include structure height decrease or increase upon fast heavy ion irradiation in

• analysis and imaging [32]. It is also worth mentioning that at high projectile charge states, the ions can be imagined as deep potential energy well, allowing for further surface interaction [33]; however, this will not be explored in the present study. The ability of ion beams to confine damage to the

• . Preparation of dry samples and AFM imaging Silicon wafers were cut into ∼7 × 7 mm2 chips and were then plasma-cleaned in air using a Roplass RPS40+ plasma cleaner, which generates a thin layer of plasma by diffuse coplanar surface barrier discharge [35]. The Si surface is exposed to the thin plasma layer for