Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

• Julia E. Poletaeva,
• Anastasiya V. Tupitsyna,
• Alina E. Grigor’eva,
• Ilya S. Dovydenko and
• Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

• protein corona is present on any nanoparticle (NP) entering biological fluids; however, the existence of a natural protein corona on natural NPs has not been experimentally confirmed. We used our previously developed photomodification method to fix the natural corona on “biological nanoparticles” (bio-NPs

• obtained direct images of a “natural” protein corona on natural bio-NPs of blood serum for the first time Keywords: chylomicrons; extracellular vesicles; lipoproteins; photomodification; protein corona; Introduction The existence of a protein corona on all nanoparticles (NPs) entering biological fluids

• (tears, urine, ascitic fluid, and nutrient media collected after culturing various cell lines) [17][18][19][20][21]. We consider the term “biological nanoparticles” (bio-NPs) proposed by Jens B. Simonsen and Rasmus Münter [22] to be adequate in defining the totality of all types of EVs and LPs present in

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation

• Abhishek Das,
• Mangababu Akkanaboina,
• Jagannath Rathod,
• R. Sai Prasad Goud,
• Kanaka Ravi Kumar,
• Raghu C. Reddy,
• Ratheesh Ravendran,
• Katia Vutova,
• S. V. S. Nageswara Rao and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1639–1653, doi:10.3762/bjnano.15.129

• /bjnano.15.129 Abstract This work presents a unique and straightforward method to synthesise hafnium oxide (HfO2) and hafnium carbide (HfC) nanoparticles (NPs) and to fabricate hafnium nanostructures (NSs) on a Hf surface. Ultrafast picosecond laser ablation of the Hf metal target was performed in three

• insight into their morphological and optical characteristics paving way for their applications in future. Keywords: hafnium; laser ablation in liquids; nanofibres; nanoparticles; nanostructures; Introduction Hafnium (Hf) is a tetravalent transition metal with compounds showing excellent thermal and

• expansion and shrinkage, releasing nanoparticles into the surrounding liquid. The formed nanoparticles stay in the liquid as colloidal suspensions or can agglomerate to form a precipitate [6][16][20][23][24][25][26][27]. LAL provides flexibility regarding the choice of the liquid medium surrounding the

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• strategy for personalized medicine. Keywords: cancer; drug delivery; human health; mimetics; nanotechnology; Introduction Human exposure to nanoparticles has naturally occurred for millennia, with a notable intensification following the industrial revolution [1]. The foundational concept of modern

• manipulation of matter on a nanoscale, typically ranging from 1 to 100 nm [2]. At this scale, nanoparticles can effectively interact with DNA and protein molecules [3][4]. Matter can exhibit distinct physical, chemical, and biological properties at the nanoscale compared to the macroscale, with significant

• differences in key characteristics. The National Nanotechnology Initiative (NNI) emphasizes that nanomaterials hold promising potential across various fields of knowledge [1][5]. Materials such as liposomes, nanoparticles, polymer–drug conjugates, inorganic noble metals, and quantum dots may improve

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• as food, agriculture, and medicine [20][114][115]. Diverse other substances and systems with antimicrobial activity (antibiotics, essential oils, phenolics, and metal nanoparticles) can be incorporated into the mucilage hydrogels, which after some additional modifications can be used for the

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• Biochemistry, Koryun St 2, Yerevan, Armenia Ghitu Institute of Electronic Engineering and Nanotechnologies of Technical University of Moldova, Chisinau, Moldova 10.3762/bjnano.15.125 Abstract Thanks to their simple synthesis, controlled physical properties, and minimal toxicity, iron oxide nanoparticles

• in most biological and chemical reactions involved in the production of medical materials [10][11][12][13]. Magnetic nanoparticles (MNPs), such as iron oxides, not only exhibit superparamagnetism and high magnetic susceptibility, they also possess unique physical properties, biocompatibility

• tissue barriers all give iron oxide MNPs an advantage over other metallic nanoparticles. Because of their small size, nanoparticles have a high surface-to-volume ratio, making them more appealing. However, since the large surface area provides numerous active sites for interactions, it can also lead to

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol

• Akash Kumar,
• Ridhima Chadha,
• Abhishek Das,
• Nandita Maiti and
• Rayavarapu Raja Gopal

Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124

• ʟ-carnosine in synthesizing tunable plasmonic silver nanoparticles (ʟ-car-AgNPs). The formation of ʟ-car-AgNPs was confirmed via UV–vis optical absorption spectroscopy, showing single and double plasmonic peaks, depending on the synthesis conditions. Physicochemical characterization using TEM, FTIR

• (2.8 μM) for As3+, and 245.49 ppb (4.7 μM) for Cr3+. Additionally, these nanoparticles demonstrated catalytic activity regarding the degradation of p-nitrophenol (P-NP), achieving complete degradation of 0.25 and 1 mM solutions within 5 and 10 min, respectively. This study reveals the potential of ʟ

• with various contaminants. Keywords: catalysis; heavy metals; ʟ-carnosine; p-nitrophenol; silver nanoparticles; Introduction The persistent rise in environmental pollution, notably from heavy metal ions and organic pollutants, has propelled the development of innovative and efficient environmental

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• for ways to control these insects, avoiding the use of conventional chemical insecticides that are proven to be toxic to nature. In the last years, there has been growing evidence for the potential of silver nanoparticles (AgNPs) to be ecologically benign alternatives to the commercially available

• nanomaterials in non-target species is discussed. Keywords: bioassay; inorganic nanoparticles; mosquito vector; nanotechnology; physicochemical; tropical neglected diseases; Introduction Arboviroses are diseases caused by the pathogens transmitted by arthropods, and their transmission to humans occurs through

• characteristics such as greater absorption capacity, greater bioavailability, controlled release of active ingredients, improved solubility of hydrophobic substances in water, and good kinetic stability [12][13][14]. Metallic nanoparticles have been investigated as a promising approach for vector control. The

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• relationship (QSPR/QSFR) modelling, read-across, and deep learning models. Mikolajczyk et al. [16] implemented a consensus nano-QSPR scheme for the prediction of the ZP of metal oxide nanoparticles (NPs) based on the size and a quantum mechanical descriptor encoding the energy of the highest occupied molecular

Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection

• Thi Kim Ngan Nguyen,
• Tien Dat Doan,
• Huy Hieu Luu,
• Hoang Anh Nguyen,
• Thi Thu Ha Vu,
• Quang Hai Tran,
• Ha Tran Nguyen,
• Thanh Binh Dang,
• Thi Hai Yen Pham and
• Mai Ha Hoang

Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120

• sensors has some limitations associated with the low conductivity of MOFs. Therefore, the coupling with conducting materials, such as carbon-based materials, metal nanoparticles, and polymers, has been performed to enhance the electron charge transfer of MOFs [23][24]; single MOFs combined with carbon

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• hybrid nanoparticles (PLHNPs) have emerged as a novel delivery system that combines the advantages of both polymeric and lipid-based nanoparticles to overcome these challenges. This review explores the potential of PLHNPs to enhance the delivery and efficacy of phytochemicals for biomedical applications

• diseases. Keywords: bioavailability; phytochemical; polymer lipid hybrid nanoparticles; solubility; stability; surface modification; Introduction Phytochemicals are naturally occurring compounds found in plants (from the Greek word “phyton” meaning plant) [1]. These bioactive compounds are responsible

• , rapid metabolism, and instability under physiological conditions [9][10][11]. These challenges necessitate the development of advanced delivery systems to harness the full potential of phytochemicals in therapeutic applications. Polymer lipid hybrid nanoparticles (PLHNPs) represent an innovative class

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• transitions and the zones of radiation stability for nanoparticles. We utilize nanoparticles exhibiting transitions from the body-centered cubic α phase to the face-centered cubic β phase, and the reverse transition from β phase to α phase, as a model system for first-order phase transformations. We

• materials. Keywords: α-phase; β-phase; chemical rate theory; Fe; nanoparticle; nucleation; phase stability diagram; polymorphic phase transision; radiation stability; thermodynamics; vacancy saturation; Introduction Solid metal or ceramic nanoparticles with a diameter in the range of 1–100 nm, when placed

• or amorphization in metallic/ceramic nanoparticles, leading to changes in the crystal structure? Is it feasible to establish a fundamental basis to explain the behavior of materials under irradiation? Most nuclear materials have not been tested beyond an irradiation dose of 200 displacements per atom

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations. Keywords: antibody delivery; biopharmaceutical delivery; blood–brain barrier (BBB); CNS diseases; drug delivery; hybrid nanoparticles

• ; intranasal delivery; liposomes; nanomedicine; nanostructured lipid carriers (NLCs); polymer nanoparticles; RNA delivery; solid lipid nanoparticles (SLNs); Introduction The central nervous system (CNS) consists of the brain and the spinal cord and is considered the body’s processing and control center. While

• techniques to overcome the BBB can be invasive and noninvasive. As part of the invasive methods, disruption of the BBB with osmotic pressure and intrathecal delivery have been proposed [16]. As examples of noninvasive methods, intranasal drug delivery and bypassing the BBB by nanoparticles can be counted

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• defects [70][71]. These defects are intrinsic and nonavoidable during the fabrication of ZnO nanostructures, and are usually dependent on a surface area-to-volume ratio of nanoparticles. Because of this reason, the relative intensity ratio of UV to visible lines can be used to evaluate the ZnO crystal

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• nanoparticle-based systems capable of efficient detection and degradation. However, conventional approaches utilizing strong capping agents like cetrimonium bromide (CTAB) on nanoparticles lead to limitations due to the rigid nature of CTAB. This restricts its utility in heavy metal detection and 4-NP

• metals and efficient degradation of 4-NP. For enabling linker-free/ligand-free detection of heavy metal ions and catalytic degradation of 4-NP, CTAB was engineered as a versatile capping agent on gold and silver nanoparticles. Various factors, including nanoparticle characteristics such as shape, size

• , metal composition, centrifugation, and NaOH amount, were investigated for their impact on the performance of CTAB-capped nanoparticles in heavy metal detection and 4-NP degradation. CTAB-Au nanospheres demonstrated limited heavy metal ion detection capability but exhibited remarkable efficiency in

Mn-doped ZnO nanopowders prepared by sol–gel and microwave-assisted sol–gel methods and their photocatalytic properties

• Cristina Maria Vlăduț,
• Crina Anastasescu,
• Silviu Preda,
• Oana Catalina Mocioiu,
• Simona Petrescu,
• Jeanina Pandele-Cusu,
• Dana Culita,
• Veronica Bratan,
• Ioan Balint and
• Maria Zaharescu

Beilstein J. Nanotechnol. 2024, 15, 1283–1296, doi:10.3762/bjnano.15.104

• dielectric properties of material [17]. Therefore, instantaneous decomposition of the precursors occurs, leading to the formation of a supersaturated solution. Consequently, appropriate conditions for obtaining materials with well-defined properties (i.e., monodispersed nanoparticles from rapid and brief

• samples were thermally treated at 350 °C and 500 °C for 1 h each. Scanning electron microscopy The morphology and chemical composition (inset) of the thermally treated samples is illustrated in Figure 4. Homogeneously distributed, quasi-spherical nanoparticles (mean size diameter of 70 nm) are observed in

• defects of ZnO nanoparticles. The first peak is attributed to band edge free excitons [51] and the second to bound excitons [51][52]. The lower PL signal of the SG sample relative to the MW sample suggests a slower rate of recombination for photogenerated charges and, consequently, a much more efficient

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• anticancer nanomedicines are administered intravenously. This route is fast and precise as the drug enters directly into the systemic circulation, without undergoing absorption processes. When nanoparticles come into direct contact with the blood, however, they interact with physiological components that can

• -depth studies in complex environments to evaluate nanoparticle stability, protein corona formation, hemolytic activity, and targeting capabilities. To address this issue, fluorescent silica nanoparticles (SiO2NPs) are here functionalized with zwitterionic (kinetic stabilizer) and folate groups

• nanoparticles are not hemolytic. Remarkably, the functionalized SiO2NPs are more internalized by tumor cells than their healthy counterparts. Investigations of this nature play a crucial role in garnering results with greater reliability, allowing the development of nanoparticle-based pharmaceutical drugs that

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• synthesizing gold nanoparticles (AuNPs) within a glucosamine/alginate (GluN/Alg) nanocomposite via an ionotropic gelation mechanism in aqueous environment. The resulting nanocomposite, AuNPs@GluN/Alg, underwent thorough characterization using UV–vis, EDX, FTIR, SEM, TEM, SAED, and XRD analyses. The spherical

• nanocomposite as a versatile catalyst with promising applications across various industrial sectors. Keywords: catalysis; gold nanoparticles; organic dyes; organometallic nanocomposites; reduction; Introduction Gold nanoparticles (AuNPs) have garnered significant attention because of their exceptional

• particular, have demonstrated significant control over the nucleation and growth of metallic nanoparticles. Utilizing polysaccharide-mediated procedures for AuNP synthesis offers several advantages over conventional methods, including cost-effectiveness, energy efficiency, low toxicity, and eco-friendliness

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• Andre F. Lima Giselle Z. Justo Alioscka A. Sousa Department of Biochemistry, Federal University of São Paulo, São Paulo, SP 04044-020, Brazil 10.3762/bjnano.15.98 Abstract Ultrasmall nanoparticles (usNPs) have emerged as promising theranostic tools in cancer nanomedicine. With sizes comparable to

• . Keywords: active targeting; cancer; nanoclusters; renal clearance; ultrasmall nanoparticles; Review 1 Introduction Nanotechnology has opened new avenues for tackling unmet challenges in medicine [1][2][3]. In the field of oncology, a notable application involves the use of engineered nanoparticles (NPs

• ultrasmall and renal clearable 64Cu-radiolabeled nanoparticles with ECL1i [134]. These particles were employed not only for targeted PET imaging but also for loading and delivery of gemcitabine (64Cu-Cu@CuOx-ECL1i-Gem) into pancreatic ductal adenocarcinoma (PDAC). In this study, an innovative strategy was

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• than free DOX. To date, several types of nanoparticles, such as liposomes, micelles, and metal-organic frameworks, have been studied to encapsulate DOX to obtain effective and non-toxic drugs [7][8]. Great attention has been paid to nanoparticles because of their specific properties, such as small size

• , high stability, low toxicity, modifiable hydrophilicity/hydrophobicity, and the possibility of surface functionalization for targeted localization. Polymeric nanoparticles are a versatile approach to drug delivery (DD) with the potential to circumvent barriers associated with negative impacts on

• durations. While numerous biodegradable polymeric nanoparticles derived from proteins or polysaccharides have been studied for drug delivery and controlled drug release in the recent past, the emphasis of research has now turned towards synthetic polymers, resulting in significant advancements in this field

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• Supratik Kar Siyun Yang Chemometrics and Molecular Modeling Laboratory, Department of Chemistry and Physics, Kean University, 1000 Morris Avenue, Union, NJ 07083, USA 10.3762/bjnano.15.93 Abstract Metal oxide nanoparticles (MONPs) are widely used in medicine and environmental remediation because

• models. Finally, the developed nano-qRASTR model was applied to predict toxicity data for an external dataset comprising 35 MONPs, addressing gaps in zebrafish toxicity assessment. Keywords: metal nanoparticles; metal oxide nanoparticles; nano-qRASTR; periodic table descriptors; QSAR; zebrafish

• range of substances that can be categorized as carbon-based, metal oxides, semiconductors, polymers, clays, emulsions, or metals [2]. Metal oxide nanoparticles (MONPs) are metallic oxides that exist within the nanoscale range and can be intentionally created or occur naturally [3]. Under the rapid

Photocatalytic methane oxidation over a TiO₂/SiNWs p–n junction catalyst at room temperature

• Qui Thanh Hoai Ta,
• Luan Minh Nguyen,
• Ngoc Hoi Nguyen,
• Phan Khanh Thinh Nguyen and
• Dai Hai Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1132–1141, doi:10.3762/bjnano.15.92

• photocatalytic efficiency. For years, doping of metal nanoparticles (NPs) into a semiconductor matrix has been extensively studied to enhance photocatalytic CH4 oxidation performance. Metal NPs in, for example, Au/TiO2, Au@Pd/ZnO, and Pt@Cu/TiO2 composites act as electron scavenger centers and own more free

Direct electron beam writing of silver using a β-diketonate precursor: first insights

• Katja Höflich,
• Krzysztof Maćkosz,
• Chinmai S. Jureddy,
• Aleksei Tsarapkin and
• Ivo Utke

Beilstein J. Nanotechnol. 2024, 15, 1117–1124, doi:10.3762/bjnano.15.90

• . “Experimental” section) for focused electron beam-induced deposition (FEBID). (hfac)AgPMe3 is a white to light yellow solid, which was used before for chemical vapor deposition [32] and for growing silver nanoparticles by atomic layer deposition [33]. Like for other silver precursors, a pronounced halo and a

• . Compared to the typically obtained granular structure of metallic nanoparticles in a carbonaceous matrix, the deposit composition and chemistry evolution are unexpected. The resulting deposit exhibits a carbon-rich body with a surface decorated with silver nanoparticles and an interfacial layer of

• only later fully decomposed. The close-up of the central region of the deposit (C) in Figure 1 shows a dark appearance with uniformly sized nanoparticles of about 5–10 nm. When moving away from the central area, three very distinct regions regarding the halo morphology are found. The first halo region

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• application of nanoscale systems with unique physicochemical properties, including small size, large specific surface area, high reactivity, and quantum effects of the nanoparticles (NPs) [1][2]. Nanomedicine is specifically designated for therapeutics (drug delivery), diagnostics, and imaging, as well as for

• fact that there are over 50 nanotechnology-based medical products approved by regulatory bodies worldwide for various medical purposes, including AmBisome® (liposomal amphotericin B) for fungal infections, Visudyn® (liposomal vertepor) for macular degeneration, and Onpattro® (lipid nanoparticles with

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• . Current biomedical and pharmaceutical science has one focus on developing nanoparticle-based sensors, especially biopolymeric nanoparticles. Alginate is a widely used biopolymer in a variety of applications. The hydrogel-forming characteristic, the chemical structure with hydroxy and carboxylate moieties

• , biocompatibility, biodegradability, and water solubility of alginate have expanded opportunities in material and biomedical sciences. Recently, research on alginate-based nanoparticles and their applications has begun. These materials are gaining popularity because of their wide usage potential in the biomedical

• and pharmaceutical fields. Many review papers describe applications of alginate in the drug delivery field. The current study covers the structural and physicochemical properties of alginate-based nanoparticles. The prospective applications of alginate-based nanomaterials in various domains are