Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• application of organic and inorganic compounds with activity against various diseases [10][11][12]. Faced with a physiological stimulus, the carrier decouples from the transported product and releases it at a specific interaction site (Figure 1-1). However, some challenges are encountered by these compounds

• electrostatic attraction, leading to spontaneous synthesis [46][47][48]. The process depends on electrostatic and hydrophobic interactions, where modulation of the carrier charge determines the strength of interaction and conjugation efficiency with the membrane vesicle [49][50]. A common technique for merging

• homotypic adhesive interactions through selectins, E-cadherins, Thomsen–Friedenreich (TF) antigens, the immunoglobulin superfamily (Ig-SF), and the interaction of SIRP-α with CD47 inhibit the phagocytosis of these cells, thus preventing their capture by dendritic cells [62][65][66]. Nanocarriers associated

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• distances between islands or continents [28][118]. Plants developed diverse morphological mechanisms for the diaspore transport. One of the ways of promoting long-distance dispersal is the proper interaction between the plant diaspores and animals [118][119][120]. Epizoochory is the way of diaspore

• dried at high temperatures requires, on average, only 33% of the force required to dislodge seeds dried in the refrigerator or at room temperature. It can be supposed that the high temperatures destroy the polysaccharide structure and other important chemical bonds responsible for the interaction

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• (Fe3O4 NPs) are widely used in many biomedical applications (e.g., bioimaging, drug delivery, biosensors, diagnostics, and theranostics). However, the use of NPs does not preclude the possibility of selective toxicity and undesirable effects, including accumulation in tissues and direct interaction with

• (0.21 µg/mL) were detected via HPLC [50]. In this study, we synthesized by a chemical method monocrystalline, round Fe3O4 NPs with a diameter of 15 ± 4 nm [50][51]. Interaction of NPs with the plant extract and rutin leads to the formation of complexes, as demonstrated by spectral analysis [50]. The

• with the loss of this activity in the complex or with interaction with endogenous GPx and suppression of its antioxidant properties (Figure 4). Fe3O4 NPs themselves are capable of increasing GPx activity, likely because of their peroxidase-like enzymatic properties (group V) [19]. This scenario

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol

• Akash Kumar,
• Ridhima Chadha,
• Abhishek Das,
• Nandita Maiti and
• Rayavarapu Raja Gopal

Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124

• -car-AgNPs for both heavy metal ion detection and catalytic degradation of P-NP, indicating their suitability for environmental monitoring and remediation applications. Further optimization and research are needed to expand their environmental applications and to understand their interaction mechanisms

• detecting heavy metal ions. This drawback was overcome by using ʟ-carnosine in combination with silver nanoparticles, as their strong interaction was reported previously. Silver nanoparticles with other capping agents can also be used for either heavy metal sensing or degradation of P-NP. A study explored

• simultaneously via ionic interactions between the exposed functional groups of the capping agent and metal ions. This issue can be addressed using ʟ-carnosine-capped nanosilver because the interaction of ʟ-carnosine with different metal ions has already been reported [19]. The electrochemical detection of Hg2

Ultrablack color in velvet ant cuticle

• Vinicius Marques Lopez,
• Wencke Krings,
• Juliana Reis Machado,
• Stanislav Gorb and
• Rhainer Guillermo-Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122

• pigmentation originates from the interaction of light with arrays of microlenses on the cuticle or overlapping brush-like scales positioned just above a densely pigmented absorbing layer. Similar phenomena can be observed in butterflies [11][12], birds [13], and snakes [14][15]. This intricately structured

• assisted absorption to reduce specular reflectance. This demonstrates how organisms have developed sophisticated mechanisms to modulate the interaction between light and biological surfaces, resulting in highly absorptive and minimally reflective colors. These adaptations play a role in animal survival and

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• minimizes the interaction with blood components and immune cells. This reduces the risk of immune reactions and increases the half-life of the nanoparticles in the body. Additionally, PEGylation can improve the solubility of hydrophobic drugs, facilitating their delivery. The hybrid structure of these

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• detailed density functional theory calculations with dispersion correction and on-site Coulomb interaction (DFT(D) + U) to investigate CO2 activation on ψ-graphene and its hydrogenated forms for their application in the electrochemical conversion of CO2 [43]. Faghihnasiri et al. have performed DFT

Ion-induced surface reactions and deposition from Pt(CO)₂Cl₂ and Pt(CO)₂Br₂

• Mohammed K. Abdel-Rahman,
• Patrick M. Eckhert,
• Atul Chaudhary,
• Johnathon M. Johnson,
• Jo-Chi Yu,
• Lisa McElwee-White and
• D. Howard Fairbrother

Beilstein J. Nanotechnol. 2024, 15, 1427–1439, doi:10.3762/bjnano.15.115

• coordination complex compared to the stronger ionic interaction between Pt(II) and the halide ligands. The increasing Pt and halogen fractions in the films as functions of ion irradiation, as seen in Figure 5, are a consequence of the reaction described in Equation 1. During the CO loss process, the C 1s peak

• H2+ and He+ compared to Ar+, we would anticipate significantly less efficient momentum/energy transfer from these lighter ions to the much heavier Pt(CO)2X2 precursors because of the extremely poor mass match in these cases. Furthermore, heavier ions have shallower interaction volumes than lighter

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• photonic devices. Moreover, the enhancement of typically feeble light–matter interaction is enabled by robust light confinement. These characteristics can be exploited to mitigate the intrinsic limitations of photonics technologies compared to electronic and optoelectronic technologies [5]. Distributed

• dioxide in multi-stacked structures provides a pathway for tailoring optical functionalities in various photonic applications. While LiNbO3 offers strong light–matter interaction properties, nonlinearity, and tunability for 1D photonic crystals in the 1550 nm regime for quantum information processing (due

• potentially lower losses and enhanced light–matter interaction. However, overcoming the challenges of refractive index mismatch, limited nonlinearity, and fabrication complexity is crucial for successful implementation. Since LN/SiO2 PhC achieves high reflectivity comparably for fewer bilayers, the

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• almost all large-molecule drugs and most small-molecule drugs. A noninvasive method, nose-to-brain delivery (N2B delivery) has been proposed to overcome this challenge. By exploiting the direct anatomical interaction between the nose and the brain, the drugs can reach the target, the brain. Moreover, the

• regulatory cells for the homeostasis of the BBB. The interaction between astrocytes and pericytes plays a vital role in brain vasculogenesis and the maintenance of the BBB [12]. Overall, the high selectivity of the BBB provides optimal conditions for CNS homeostasis [13]. Because of the presence of the BBB

• for CNS targeting. For example, size, shape, and surface characteristics of a DDS directly affect cellular transport and uptake, biodistribution, and the interaction with biological interfaces [64][65]. Regarding particle size, NPs with a size of approx. 15 nm or below were observed to penetrate the

Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications

• The-Long Phan,
• Le Viet Cuong,
• Vu Dinh Lam and
• Ngoc Toan Dang

Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112

• -density increase would remarkably enhance the UV-emission intensity and cause a slight redshift and broadening of the UV line (due to the Coulomb interaction among carriers and exciton–exciton collision processes [67]), see Figure 8b. However, the PL spectra of the second group consist of both UV and

Investigation of Hf/Ti bilayers for the development of transition-edge sensor microcalorimeters

• Victoria Y. Safonova,
• Anna V. Gordeeva,
• Anton V. Blagodatkin,
• Dmitry A. Pimanov,
• Anton A. Yablokov and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2024, 15, 1353–1361, doi:10.3762/bjnano.15.108

• would allow for the study of the interaction of superfluid helium with neutrinos [3][4]. It is believed that as a result of neutrino scattering from a tritium source on 4He in the superfluid state, excitations with energies in the range of 0.1−10 meV arise in the condensate. There is a non-zero

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• [78][80]. Additionally, the interaction between bee mandibles and propolis highlights the potential for developing anti-adhesive surfaces [81]. Bioinspired surfaces based on honeybee mandibles have been shown to reduce propolis adhesion by over 40% compared to control surfaces, demonstrating

• body parts together [174], primarily involves the interaction between two tergites of the metasoma [174] (Figure 8). This natural mechanism, involving specialized structures such as ridges and scrapers, can generate a wide range of frequencies with precision and efficiency, providing valuable insights

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• does not allow for interactions with ligands via ion–ion interactions. Therefore, multiple surface modifications or linkers must be used for selective interaction between ligand and CTAB-capped gold and silver nanoparticles [7][9]. Contaminants in form of heavy metals and pollutant such as 4

• change in absorption wavelength. The color of gold and silver nanoparticles highly depends on shape, size, and pH value, which are directly influenced by the ligand–metal interaction [22]. Another essential factor is surface capping, which provides colloidal stability and the surface for ionic

• interaction with ligands [23]. Previously, post-synthesis surface-modified CTAB-capped gold and silver nanoparticles were used to detect various compounds, including heavy metals [9][24]. Moudgil et al. showed that that poly-ʟ-lysine-coated CTAB-AgNPs are selective and sensitive for detecting Hg2+ [9]. GSH

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• Abstract Graphene oxide (GO) undergoes multiple transformations when introduced to biological and environmental media. GO surface favors the adsorption of biomolecules through different types of interaction mechanisms, modulating the biological effects of the material. In this study, we investigated the

• interaction of GO with tannic acid (TA) and its consequences for GO toxicity. We focused on understanding how TA interacts with GO, its impact on the material surface chemistry, colloidal stability, as well as, toxicity and biodistribution using the Caenorhabditis elegans model. Employing computational

• modeling, including reactive classical molecular dynamics and ab initio calculations, we reveal that TA preferentially binds to the most reactive sites on GO surfaces via the oxygen-containing groups or the carbon matrix; van der Waals interaction forces dominate the binding energy. TA exhibits a dose

Mn-doped ZnO nanopowders prepared by sol–gel and microwave-assisted sol–gel methods and their photocatalytic properties

• Cristina Maria Vlăduț,
• Crina Anastasescu,
• Silviu Preda,
• Oana Catalina Mocioiu,
• Simona Petrescu,
• Jeanina Pandele-Cusu,
• Dana Culita,
• Veronica Bratan,
• Ioan Balint and
• Maria Zaharescu

Beilstein J. Nanotechnol. 2024, 15, 1283–1296, doi:10.3762/bjnano.15.104

•  10 reveals two significant aspects: (i) The main peak emission for both powders suspended in oxalic acid solutions diminishes. This may be suggestive for the charge carrier type (electrons or holes) acting in the photo-mediated interaction of the surface catalyst with the reactant [53]. (ii) The SG

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• (targeting agent) to provide selective interaction with tumor cell lines in biological media. The stability of these dually functionalized SiO2NPs is preserved in unprocessed human plasma while yielding a decrease in the number of adsorbed proteins. Experiments in murine blood further proved that these

Enhanced catalytic reduction through in situ synthesized gold nanoparticles embedded in glucosamine/alginate nanocomposites

• Chi-Hien Dang,
• Le-Kim-Thuy Nguyen,
• Minh-Trong Tran,
• Van-Dung Le,
• Nguyen Minh Ty,
• T. Ngoc Han Pham,
• Hieu Vu-Quang,
• Tran Thi Kim Chi,
• Tran Thi Huong Giang,
• Nguyen Thi Thanh Tu and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1227–1237, doi:10.3762/bjnano.15.99

• . While gelispheres enhance the physical and mechanical properties of sodium alginate, their poor solubility limits their applicability. Recently, an ionotropic gelation method has been developed to produce nanoparticles from gelispheres through interaction between oligosaccharides (e.g., cyclodextrins

• , offering a potent solution for dye remediation [28]. In our ongoing research, we synthesized for the first time AuNPs using GluN molecules, serving as both interaction agents to cross-link Ca-Alg gelispheres and reducing agents, thereby providing a novel material for the stabilization of AuNPs. The

• reduction of 4-NiP (2.05 × 10−3 s−1, R2 = 0.995). This variance may stem from the hindrance caused by the interaction between the hydroxy group in 4-NiP and functional groups in the polysaccharide chains, impeding the adsorption/desorption dynamics on the surface of the AuNPs. The rate constant for MO

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• interaction with cell surface receptors on cancer cells, the incorporation of targeting ligands onto usNPs must optimize the exposure, orientation, and conformation of the functional portion. For small molecules and peptides in particular, the functional moiety must circumvent both steric hindrance from the

A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents

• Annalena Wolff,
• Nico Klingner,
• William Thompson,
• Yinghong Zhou,
• Jinying Lin and
• Yin Xiao

Beilstein J. Nanotechnol. 2024, 15, 1197–1207, doi:10.3762/bjnano.15.97

• the ion incidence angle and associated changes in interaction volume shape as well as heat generation need to be investigated further. The ion beam usually hits the sample at glancing angles during TEM lamella preparation and cross-sectioning, which leads to anisotropic changes in the interaction

• should carefully evaluate if changes to the ion incidence angle can lead to a further reduction in ion beam-induced heat damage. The effect of the different interaction volume sizes and shapes for various ion species should be studied to better understand where the proposed 1D model works and where a 3D

• simulations for 5 keV gallium ions in collagen The finite element simulator COMSOL was used to simulate the interaction of 5 keV Ga+ with collagen using the time-dependent differential equation of heat conduction for a stationary, homogeneous, and isotropic solid, The time evolution of a single gallium ion’s

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• drug doxorubicin (DOX) has been used in the present study. It is a known antitumor antibiotic of the anthracycline series, which has been approved as anticancer drug in 1974. It has antimitotic and antiproliferative effects. The mechanism of action is interaction with DNA, the formation of free

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• combine these properties to find out if an interaction between two species will occur and to obtain new quantitative relationships. Another helpful descriptor is the global electrophilicity, calculated as ω = χ2/2η [33]. Electrophilicity is related to the energetic stabilization that a species gains by

• theoretical study on the interactions and stability of paracetamol complexes with C60–COOH [35]. Consequently, this work proposes the interaction of C60–COOH fullerene with anticancer drugs. As a complement, a water-soluble fullerene predicted as stable at the normal human body temperature was proposed to

• of drug–C60 were initially considered. The variables to model the interaction with C60–COOH were taken directly from those of drug–C60. For example, AI model 1 with C60–COOH used the variables that had an importance greater than zero from AI model 1 of drug–C60. The most important variables in the

Quantum-to-classical modeling of monolayer Ge₂Se₂ and its application in photovoltaic devices

• Anup Shrivastava,
• Shivani Saini,
• Dolly Kumari,
• Sanjai Singh and
• Jost Adam

Beilstein J. Nanotechnol. 2024, 15, 1153–1169, doi:10.3762/bjnano.15.94

• electron-like wave functions have been generated using the projected augmented wave (PAW) method. A plane-wave basis set has been used to consolidate the interaction between core and valence electrons with an optimized threshold energy of 60 Ry. For efficient and precise calculations, the Brillouin zone

• implication. After getting the value of the deformation potential using Kawaji theory [80], we can formulate the phonon-limited mobility (μ2D) because of the interaction of the charge carriers with low acoustic phonons as [81]: where C denotes the elastic constant of a 2D material and is the geometric mean

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• of an element. In the context of nanoparticles, the size of the metal atoms directly affects the overall size and surface area of the nanoparticles, which are critical factors in their reactivity and interaction with other materials. The ionic radius is essential for understanding the metal’s

• ), suggesting that nanomaterials composed of atoms with larger radii are associated with a decrease in %EIzebrafish. A larger atomic radius might indicate weaker bonding and less effective interaction with the enzyme or its substrate, leading to less enzyme inhibition. This could be due to the diffuse nature of