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Search for "biomedical applications" in Full Text gives 206 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

  • Cornelia Loos,
  • Tatiana Syrovets,
  • Anna Musyanovych,
  • Volker Mailänder,
  • Katharina Landfester,
  • G. Ulrich Nienhaus and
  • Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

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  • Abstract Nanoparticles of various shapes, sizes, and materials carrying different surface modifications have numerous technological and biomedical applications. Yet, the mechanisms by which nanoparticles interact with biological structures as well as their biological impact and hazards remain poorly
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Published 15 Dec 2014

Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects

  • Li Shang,
  • Karin Nienhaus,
  • Xiue Jiang,
  • Linxiao Yang,
  • Katharina Landfester,
  • Volker Mailänder,
  • Thomas Simmet and
  • G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248

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  • , especially in view of possible implications regarding biosafety and biomedical applications of nanomaterials [1][2][3][4][5]. Because NPs have sizes similar to those of biological molecules and assemblies such as proteins or viruses, they are able to invade cells by hijacking the cellular endocytosis
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Published 11 Dec 2014

Inorganic Janus particles for biomedical applications

  • Isabel Schick,
  • Steffen Lorenz,
  • Dominik Gehrig,
  • Stefan Tenzer,
  • Wiebke Storck,
  • Karl Fischer,
  • Dennis Strand,
  • Frédéric Laquai and
  • Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

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  • particles used for catalysis [52][63][64], drug delivery [65], bimodal bioimaging [36][66][67][68], and biomedical applications [69][70] such as cancer treatment [71] are dumbbell-like Au@Fe3O4 nanoparticles. As no ternary Au-Fe-O phase or a gold oxide is present under the experimental conditions, there is
  • precursors were mixed simultaneously. Janus particles as multimodal contrast agents Recent developments in the field of nanoparticles for biomedical applications have increased the interest in multifunctional nanoparticles for theranostics, a combination of therapy and diagnostics, which was realized with
  • an aqueous environment. This is a key point regarding the use of nanoparticles for biomedical applications for sensing biomolecules, cells, and diagnosis of diseases, and intracellular delivery [99][100][101]. There are different surface modification strategies, such as ligand exchange to bind
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Published 05 Dec 2014

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

  • Marcela Elisabeta Barbinta-Patrascu,
  • Stefan Marian Iordache,
  • Ana Maria Iordache,
  • Nicoleta Badea and
  • Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

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  • carbon nanotubes [18]. Bianco et al. [19] showed that carbon nanotube biofunctionalization lead not only to the improved solubility and biocompatibility of CNTs, but also transformed them into platforms for biomedical applications. Carbon nanotubes are generally considered biocompatible and of low
  • molecular sensor (or as a spectral marker in spectroscopic methods) for rapid monitoring of the preparation of the complex biohybrid materials, which provides evidence of the interaction of CNTs with the versatile models of biomembranes for possible biomedical applications. This work encompasses the
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Published 02 Dec 2014

Localized surface plasmon resonances in nanostructures to enhance nonlinear vibrational spectroscopies: towards an astonishing molecular sensitivity

  • Dan Lis and
  • Francesca Cecchet

Beilstein J. Nanotechnol. 2014, 5, 2275–2292, doi:10.3762/bjnano.5.237

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  • ] as well as unique orientational information about molecules at interfaces [36][37][38][39][40][41][42][43][44][45][46][47]. On the other hand, CARS has enabled rapid tissue imaging in biomedical applications. Proper image contrast can be obtained with CARS microscopy within one second and with a
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Published 28 Nov 2014

Biopolymer colloids for controlling and templating inorganic synthesis

  • Laura C. Preiss,
  • Katharina Landfester and
  • Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

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  • polyaminosaccharide chitosan, are probably the most commonly used scaffolds for the preparation of bipolymer/inorganic composites, very especially for biomedical applications. Aimé and Coradin have reviewed the topic in a recent publication [3]. By mixing colloidal inorganic particles formed ex situ with a biopolymer
  • which biocompatibility or biodegradability are an issue, such as biomedical applications. In addition, biopolymers may be also good model systems. In this sense, for instance, peptides or nucleic acids of defined length and structure can be very convenient models for studying polyelectrolyte systems
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Published 17 Nov 2014

Rapid degradation of zinc oxide nanoparticles by phosphate ions

  • Rudolf Herrmann,
  • F. Javier García-García and
  • Armin Reller

Beilstein J. Nanotechnol. 2014, 5, 2007–2015, doi:10.3762/bjnano.5.209

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  • for particles used in biomedical applications [26]. Similar perylene-derived dyes were applied as sensitizers for zinc oxide solar cells [27]. ZnO samples 1 were prepared by a wet method under acidic conditions [28]. In the absence of the fluorescence marker we obtained almost spherical particles of 5
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Published 05 Nov 2014

Carbon nano-onions (multi-layer fullerenes): chemistry and applications

  • Juergen Bartelmess and
  • Silvia Giordani

Beilstein J. Nanotechnol. 2014, 5, 1980–1998, doi:10.3762/bjnano.5.207

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  • promising material for biomedical applications. Recently we demonstrated the cellular imaging of HeLa Kyoto [40] and MCF-7 cells [41] after incubating them with azaBODIPY- or BODIPY-functionalized CNOs (Scheme 8 and Figure 7). In both cases the CNO conjugates were readily internalized by the cells. In the
  • particles have demonstrated high cellular uptake, low cytotoxicity and lower inflammatory potential than CNTs and a very promising future for biomedical applications. HRTEM images of (a) diamond nanoparticles, (b) spherical carbon onions, and (c) polyhedral carbon onions. Diamond nanoparticles are
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Published 04 Nov 2014

Carbon-based smart nanomaterials in biomedicine and neuroengineering

  • Antonina M. Monaco and
  • Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

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  • , particularly in those combining micro- and nanotechnologies in biological and biomedical applications. For example, the field of neuroengineering was established, as a recent new research discipline within the field of neuroscience. Neuroengineering focuses on the development of artificial devices and novel
  • high mechanical strength [7], while at the same time exhibiting a very low weight. Combined with a large surface area, these electronic and mechanical properties give CNTs a great potential for microelectronics and optics, and also for biomedical applications (e.g., as nanoelectrodes for neural
  • single-layer graphene [30], and its large surface area [31], make graphene and graphene oxide (GO) one of the most promising materials for technological and biomedical applications. Carbon-based nanomaterials in biomedical applications The peculiar ability of several nanomaterials to functionally
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Published 23 Oct 2014

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

  • Christoph Bantz,
  • Olga Koshkina,
  • Thomas Lang,
  • Hans-Joachim Galla,
  • C. James Kirkpatrick,
  • Roland H. Stauber and
  • Michael Maskos

Beilstein J. Nanotechnol. 2014, 5, 1774–1786, doi:10.3762/bjnano.5.188

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  • comprehensive and accurate characterization of the material under physiological conditions is crucial to correlate the observed biological impact with defined colloidal properties. As promising candidates for biomedical applications, two SiO2-based nanomaterial systems were chosen for extensive size
  • . Hence, they are highly suitable for tailored biomedical applications, for example, as drug carrier systems, as agents in hyperthermia, or as contrast agents for magnetic resonance imaging (MRI) [52][53]. Silica nanoparticles: As most of the common crystalline SiO2 particles are not in the nanometer-size
  • conditions. This behavior is particularly relevant for biomedical applications since it shows that particles that are precisely defined in size in deionized water or at low salt concentrations can become agglomerated and less defined under physiological conditions. Conclusion The physiological impact of a
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Published 15 Oct 2014

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

  • Michal Babič,
  • Daniel Horák,
  • Lyubov L. Lukash,
  • Tetiana A. Ruban,
  • Yurii N. Kolomiets,
  • Svitlana P. Shpylova and
  • Oksana A. Grypych

Beilstein J. Nanotechnol. 2014, 5, 1732–1737, doi:10.3762/bjnano.5.183

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  • magnetization. This is proven by the quick separation of such particles in a magnetic field and the easy redispersion by Brownian motion into a liquid medium after removing the magnet. It is obvious that the colloidal stability of the particles is a prerequisite to their biomedical applications. Thanks to the
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Published 08 Oct 2014

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

  • Dagmar A. Kuhn,
  • Dimitri Vanhecke,
  • Benjamin Michen,
  • Fabian Blank,
  • Peter Gehr,
  • Alke Petri-Fink and
  • Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174

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  • , Murtenstrasse 50, 3008 Bern, Switzerland Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3000 Bern 9, Switzerland 10.3762/bjnano.5.174 Abstract Precise knowledge regarding cellular uptake of nanoparticles is of great importance for future biomedical applications. Four different endocytotic uptake
  • suitable for biomedical applications [47][48] since they are considered non-toxic at applied physiological concentrations [49]. Finally, two of the most relevant cell types in regard to uptake and interaction of (nano) particles at any barrier system (i.e., macrophages and epithelial) [50][51] were
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Published 24 Sep 2014

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

  • Dickson Joseph,
  • Nisha Tyagi,
  • Christian Geckeler and
  • Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

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  • towards biomedical applications, emphasis is put on the development of protocols which involve green chemistry and do not comprise toxic chemicals in the synthesis procedures to avoid adverse effects during applications [1][2][3]. Metallic nanoparticles show promise in applications such as catalysis
  • , electronics, chemical labeling, optics and sensors. [4][5][6][7][8]. Nanomaterials that are biocompatible have gained research interest for biomedical applications that include cancer treatment [9][10]. Consequently, one of the challenges in synthesizing nanoscale biocompatible materials is designing
  • lower costs and minimal side effects [24]. Because of their biocompatibility, noble metal nanoparticles, particularly AuNPs, are more preferable in various biomedical applications, including highly sensitive diagnostic assays [25], thermal ablation, radiotherapy enhancement [26][27][28], as well as for
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Published 04 Sep 2014

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

  • Markus Heine,
  • Alexander Bartelt,
  • Oliver T. Bruns,
  • Denise Bargheer,
  • Artur Giemsa,
  • Barbara Freund,
  • Ludger Scheja,
  • Christian Waurisch,
  • Alexander Eychmüller,
  • Rudolph Reimer,
  • Horst Weller,
  • Peter Nielsen and
  • Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

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  • .5.155 Abstract Semiconductor quantum dots (QD) and superparamagnetic iron oxide nanocrystals (SPIO) have exceptional physical properties that are well suited for biomedical applications in vitro and in vivo. For future applications, the direct injection of nanocrystals for imaging and therapy represents
  • pro-inflammatory pathways. In conclusion, internalized nanocrystals at least in mouse liver cells, namely endothelial cells, Kupffer cells and hepatocytes are at least not acutely associated with potential adverse side effects, underlining their potential for biomedical applications. Keywords
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Published 02 Sep 2014

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

  • Dominic Docter,
  • Christoph Bantz,
  • Dana Westmeier,
  • Hajo J. Galla,
  • Qiangbin Wang,
  • James C. Kirkpatrick,
  • Peter Nielsen,
  • Michael Maskos and
  • Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

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  • interface in general. Keywords: biobarrier; gastrointestinal tract; high-throughput profiling; nanomedicine; nanotoxicity; Introduction Besides the wide use of nanomaterials in industrial products, biomedical applications of nanoparticles (NP) are steadily increasing [1][2][3][4][5]. However, despite
  • route is the epithelial colonic carcinoma cell line Caco-2, which has features consistent with differentiated small intestinal enterocytes [11][12]. Silica-based NP are not only widely used in food products [13][14], but have also attracted much attention for biomedical applications as imaging moieties
  • , Langenbeckstr. 1, 55101 Mainz, Germany Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Germany 10.3762/bjnano.5.151 Abstract Besides the lung and skin, the gastrointestinal (GI) tract is one of the main targets for accidental exposure or biomedical
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Published 27 Aug 2014

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

  • Paula M. Castillo,
  • Mario de la Mata,
  • Maria F. Casula,
  • José A. Sánchez-Alcázar and
  • Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

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  • polyethylene glycol (PEG) as coating polymer in nano-formulations. PEG has been widely used in the formulation of nanoparticles for biomedical applications, both because of its biocompatibility and its effectiveness in camouflaging nanoparticles from opsonins [35]. Recently, it has been described that PEG
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Published 19 Aug 2014

Nanoporous composites prepared by a combination of SBA-15 with Mg–Al mixed oxides. Water vapor sorption properties

  • Amaury Pérez-Verdejo,
  • Alvaro Sampieri,
  • Heriberto Pfeiffer,
  • Mayra Ruiz-Reyes,
  • Juana-Deisy Santamaría and
  • Geolar Fetter

Beilstein J. Nanotechnol. 2014, 5, 1226–1234, doi:10.3762/bjnano.5.136

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  • hydrophobic–hydrophilic character, among other physicochemical properties. The most studied multifunctional materials are the hybrids, which are good candidates for biomedical applications, e.g., biosensors, artificial bonds and bioadsorbents [4][5]. Instead, a few works report the design of purely inorganic
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Published 07 Aug 2014

Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications

  • Li-wei Liu,
  • Si-yi Hu,
  • Ying Pan,
  • Jia-qi Zhang,
  • Yue-shu Feng and
  • Xi-he Zhang

Beilstein J. Nanotechnol. 2014, 5, 919–926, doi:10.3762/bjnano.5.105

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  • biocompatible polymer nanocarriers for in vivo studies there are Pluronic F127 triblock-copolymer micelle nanoparticles [20][21]. They can serve as a candidate for therapeutic and biomedical applications in vitro and in vivo. A particular material for QDs, CdS, is an important direct-band semiconductor with a
  • luminescence-intensity CdS/ZnS core/shell QDs are suitable for optoelectronic devices and some biological applications [29][30][31][32]. Although CdS/ZnS QDs have been proposed for the use in biological applications, no research was so far reported on their biomedical applications. Our research has developed a
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Published 27 Jun 2014

Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique

  • Alina Maria Holban,
  • Valentina Grumezescu,
  • Alexandru Mihai Grumezescu,
  • Bogdan Ştefan Vasile,
  • Roxana Truşcă,
  • Rodica Cristescu,
  • Gabriel Socol and
  • Florin Iordache

Beilstein J. Nanotechnol. 2014, 5, 872–880, doi:10.3762/bjnano.5.99

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  • nanosystems to obtain improved, antimicrobial coatings for biomedical applications [7][8]. Nonpolar functionalized magnetite nanostructures alone [9][10] or combined with different natural products, such as usnic acid (UA) [11] or essential oils (Mentha piperita [12], Anethum graveolens [13], Salvia
  • the biocompatibility of this material it as a suitable candidate in developing nanostructured bioactive materials for biomedical applications. TEM images of prepared Fe3O4@EUG nanoparticles. Full spectral intensity based on visible images and infrared maps of PLA-CS-Fe3O4@EUG drop cast (a) and PLA-CS
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Published 18 Jun 2014

Visible light photooxidative performance of a high-nuclearity molecular bismuth vanadium oxide cluster

  • Johannes Tucher and
  • Carsten Streb

Beilstein J. Nanotechnol. 2014, 5, 711–716, doi:10.3762/bjnano.5.83

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  • the cluster shell [15][16][17][18][19]. Using this approach, materials for energy conversion and storage [20][21], homogeneous and heterogeneous catalysis [1][14], biomedical applications [22][23][24] and nanostructured functional materials [17][25][26] have been developed. We have recently started
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Published 26 May 2014

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

  • Ulrike Taylor,
  • Wiebke Garrels,
  • Annette Barchanski,
  • Svea Peterson,
  • Laszlo Sajti,
  • Andrea Lucas-Hahn,
  • Lisa Gamrad,
  • Ulrich Baulain,
  • Sabine Klein,
  • Wilfried A. Kues,
  • Stephan Barcikowski and
  • Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

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  • Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45141 Essen, Germany 10.3762/bjnano.5.80 Abstract Intended exposure to gold and silver nanoparticles has increased exponentially over the last decade and will continue to rise due to their use in biomedical applications
  • only one study reported embryotoxic effects of gold clusters after application of a tremendously high dose (1014 NP/embryo) [15]. Thus, our findings confirm the presumption that gold nanoparticles are highly biocompatible and can safely be developed for biomedical applications, such as novel biomarkers
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Published 21 May 2014

Enhanced photocatalytic activity of Ag–ZnO hybrid plasmonic nanostructures prepared by a facile wet chemical method

  • Sini Kuriakose,
  • Vandana Choudhary,
  • Biswarup Satpati and
  • Satyabrata Mohapatra

Beilstein J. Nanotechnol. 2014, 5, 639–650, doi:10.3762/bjnano.5.75

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  • including UV lasers [1], field effect transistors [2], dye sensitized solar cells [3][4], surface enhanced Raman spectroscopy (SERS) [5] and biomedical applications [6][7][8][9][10]. ZnO nanostructures are promising photocatalysts because of their high quantum efficiency, high redox potential, superior
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Published 15 May 2014

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

  • Tianxun Gong,
  • Douglas Goh,
  • Malini Olivo and
  • Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

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  • many biological systems as they are toxic to cells and tissues. As a result, CTAB-coated AuNRs are not suitable to be used for biomedical applications [14][15]. CTAB can be partially removed from the AuNRs surface by centrifugation, but the majority of the CTAB molecules remains on the particle surface
  • hydrophilic and positively charge [18][19]. Therefore, a surface functionalization platform is needed to furnish a AuNR surface with a biocompatible polymer-coating for reducing their cytotoxicity while maintaining colloidal stability and allowing them to be conjugated for biomedical applications. Bio
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Published 30 Apr 2014

Effect of contaminations and surface preparation on the work function of single layer MoS2

  • Oliver Ochedowski,
  • Kolyo Marinov,
  • Nils Scheuschner,
  • Artur Poloczek,
  • Benedict Kleine Bussmann,
  • Janina Maultzsch and
  • Marika Schleberger

Beilstein J. Nanotechnol. 2014, 5, 291–297, doi:10.3762/bjnano.5.32

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  • , two-dimensional materials are being targeted in a variety of research areas like surface physics, electrical engineering, chemistry and biomedical applications [1][2][3][4]. The 2D-material getting the most attention besides graphene are single layers of molybdenum disulfide (SLM) which consist of a
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Published 13 Mar 2014

Extracellular biosynthesis of gadolinium oxide (Gd2O3) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

  • Shadab Ali Khan,
  • Sanjay Gambhir and
  • Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

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  • high temperatures, and employ harsh environments, thus rendering it difficult to find any usage of Gd2O3 nanoparticles in biomedical applications. Our group has already reported the biological synthesis of zirconia, titania, silica and CuAlO2 nanoparticles [12][13][14]. In this work, we employed a
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Published 07 Mar 2014
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