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Search for "drug delivery" in Full Text gives 329 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

Layered double hydroxide/sepiolite hybrid nanoarchitectures for the controlled release of herbicides

  • Ediana Paula Rebitski,
  • Margarita Darder and
  • Pilar Aranda

Beilstein J. Nanotechnol. 2019, 10, 1679–1690, doi:10.3762/bjnano.10.163

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  • components in diverse electrochemical devices (such as supercapacitors, sensors, and biosensors), in drug delivery and controlled-release formulations, or in non-viral gene transfection [21][22][23][24][25][26]. The fact that the stability of LDH varies with the pH value has proved advantageous in some of
  • nanometric LDH particles for controlled drug delivery and other applications. Experimental Starting reagents and materials 4-Chloro-2-methylphenoxyacetic acid (MCPA) was purchased from Sigma-Aldrich (MW 200.62 g·mol−1, 97% purity). Sepiolite from Vallecas-Vicálvaro (Spain) was provided by TOLSA S.A. as
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Published 09 Aug 2019

Materials nanoarchitectonics at two-dimensional liquid interfaces

  • Katsuhiko Ariga,
  • Michio Matsumoto,
  • Taizo Mori and
  • Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

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Published 30 Jul 2019

Highly ordered mesoporous silica film nanocomposites containing gold nanoparticles for the catalytic reduction of 4-nitrophenol

  • Mohamad Azani Jalani,
  • Leny Yuliati,
  • Siew Ling Lee and
  • Hendrik O. Lintang

Beilstein J. Nanotechnol. 2019, 10, 1368–1379, doi:10.3762/bjnano.10.135

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  • ; Introduction Mesoporous silica nanomaterials with pore size between 2 to 50 nm [1] have been recently applied to the development of biomedical adsorbents [2][3][4], drug delivery systems [5][6][7], catalysts [8][9][10], as well as supports for metal nanoparticles [11][12][13] due to their large surface area
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Published 05 Jul 2019

The effect of magneto-crystalline anisotropy on the properties of hard and soft magnetic ferrite nanoparticles

  • Hajar Jalili,
  • Bagher Aslibeiki,
  • Ali Ghotbi Varzaneh and
  • Volodymyr A. Chernenko

Beilstein J. Nanotechnol. 2019, 10, 1348–1359, doi:10.3762/bjnano.10.133

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  • magnetocrystalline anisotropy at room temperature [10]. The anisotropy constant of CoFe2O4 (K = 2 × 105 J·m−3) is nearly one order of magnitude larger than that of Fe3O4 [11][12][13]. Fe3O4 NPs have been studied extensively for bio-medical applications, such as drug delivery [14], magnetic resonance imaging (MRI
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Published 03 Jul 2019

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

  • Małgorzata Świętek,
  • Yi-Chin Lu,
  • Rafał Konefał,
  • Liliana P. Ferreira,
  • M. Margarida Cruz,
  • Yunn-Hwa Ma and
  • Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

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  • [12]. Due to its biocompatibility, it has been investigated in several biomedical applications, e.g., tissue engineering, ophthalmology, and drug delivery. Chitosan modification with phenolic compounds leads to the enhancement of already existing antioxidant properties [13]. The antioxidant properties
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Published 20 May 2019

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

  • Katrin Partikel,
  • Robin Korte,
  • Dennis Mulac,
  • Hans-Ulrich Humpf and
  • Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

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  • them advantageous for targeted drug delivery while minimizing side effects [1]. Among the different materials used to synthesize NPs, the biodegradable polymer poly(DL-lactide-co-glycolide) (PLGA) has attracted consideration due to its minimal systemic toxicity, favorable degradation characteristics
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Published 06 May 2019

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

  • Qura Tul Ain,
  • Samina Hyder Haq,
  • Abeer Alshammari,
  • Moudhi Abdullah Al-Mutlaq and
  • Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

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  • advanced nanomaterials has led to the development of effective drug delivery systems [1][2]. Graphene, a single layer of carbon atoms with a hexagonal 2-dimensional crystal structure, its use in nanoscience and nanotechnology, is of great interest for scientists. The hydrophobic nature of graphene
  • ) [5], poly(ε-caprolactone) (PCL) [6], hydroxypropyl-β-cyclodextrin (HPCD) [7], and poly(L-lactic acid) (PLLA) [8]. Biocompatible GO has many prospective uses in tissue engineering [9], drug delivery [10], cancer therapy [11][12], and treatment of bacterial infections [13][14]. Dinescu et al. designed
  • has been utilized as a potent radiotracer and drug-delivery agent in vivo using positron emission tomography (PET) imaging by Jang and co-workers [31]. Liu et al. [32][33] used PEG for the first time to functionalize GO, which can then be use as a vehicle for anticancer drugs such as doxorubicin. The
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Published 18 Apr 2019

Co-doped MnFe2O4 nanoparticles: magnetic anisotropy and interparticle interactions

  • Bagher Aslibeiki,
  • Parviz Kameli,
  • Hadi Salamati,
  • Giorgio Concas,
  • Maria Salvador Fernandez,
  • Alessandro Talone,
  • Giuseppe Muscas and
  • Davide Peddis

Beilstein J. Nanotechnol. 2019, 10, 856–865, doi:10.3762/bjnano.10.86

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  • of potential applications, e.g., from catalysis [5] and microwaves applications [6] to biomedicine, such as MRI [7], hyperthermia [8], and drug delivery [7][9] applications. Nanometer-sized magnetic materials exhibit different properties compared their bulk counterparts [10][11]. Below a critical
  • different magnetic anisotropy opens interesting perspectives for applications in biomedical fields (e.g., MRI, drug delivery, hyperthermia) [20][21] and energy harvesting. Experimental Synthesis Several samples consisting of manganese ferrite nanoparticles with different cobalt doping, i.e., Mn1−xCoxFe2O4
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Published 12 Apr 2019

Tungsten disulfide-based nanocomposites for photothermal therapy

  • Tzuriel Levin,
  • Hagit Sade,
  • Rina Ben-Shabbat Binyamini,
  • Maayan Pour,
  • Iftach Nachman and
  • Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

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  • effect, other ligands on the cerium ion can be replaced by different polymers and linkers. The resulting nanocomposites can be used for biomedical applications, such as gene silencing [52], magnetic imaging, and drug delivery. Here we present a new and simple-to-fabricate WS2-NT-CAN-mag (WS2-NT-CM
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Published 02 Apr 2019

Ultrathin hydrophobic films based on the metal organic framework UiO-66-COOH(Zr)

  • Miguel A. Andrés,
  • Clemence Sicard,
  • Christian Serre,
  • Olivier Roubeau and
  • Ignacio Gascón

Beilstein J. Nanotechnol. 2019, 10, 654–665, doi:10.3762/bjnano.10.65

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  • applications [5], including gas storage [6], membranes for separation processes [7], heterogeneous catalysis [8], sensing [9] or drug delivery [10], among others. Many of these applications require the formation of MOF films onto different kinds of surfaces with precise control of film thickness and
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Published 06 Mar 2019

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

  • Kartheek Katta,
  • Dmitry Busko,
  • Yuri Avlasevich,
  • Katharina Landfester,
  • Stanislav Baluschev and
  • Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

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  • ; singlet oxygen; Introduction Hybrid polymeric core–shell nanoparticles with encapsulated fluorescent dye molecules are frequently employed for life-science applications, such as cell labeling and drug delivery [1][2][3][4][5]. In recent years, polymeric hybrid nanoparticles and nanocapsules with tailored
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Published 22 Feb 2019

Mechanical and thermodynamic properties of Aβ42, Aβ40, and α-synuclein fibrils: a coarse-grained method to complement experimental studies

  • Adolfo B. Poma,
  • Horacio V. Guzman,
  • Mai Suan Li and
  • Panagiotis E. Theodorakis

Beilstein J. Nanotechnol. 2019, 10, 500–513, doi:10.3762/bjnano.10.51

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  • use. The related technological applications range from drug delivery [18] to structural scaffolds [19] in which the role of the fibril may be to immobilize small molecules such as enzymes [20]). The applications are motivated by the unique properties of fibrils, such as the spontaneous formation under
  • needs to be avoided, for example, syntheses, active processes (drug delivery) or responses to an external perturbation (change in temperature). To this end, the interplay between mechanical and thermodynamic properties will determine the overall behaviour of the fibrils, which depends on the arrangement
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Published 19 Feb 2019

Temperature-dependent Raman spectroscopy and sensor applications of PtSe2 nanosheets synthesized by wet chemistry

  • Mahendra S. Pawar and
  • Dattatray J. Late

Beilstein J. Nanotechnol. 2019, 10, 467–474, doi:10.3762/bjnano.10.46

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  • , field emitters, battery materials, light harvesting and energy storage devices, catalyst for H2 generation, and drug delivery applications [7][8][9][10][11][12]. Most of the transition metal dichalcogenides (TMDCs) are semiconducting in nature with MX2 type – where M is a metal, M = W, Mo, Sn, Nb, V
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Published 13 Feb 2019

Targeting strategies for improving the efficacy of nanomedicine in oncology

  • Gonzalo Villaverde and
  • Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

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  • drug-loaded liposomes for glioblastoma treatment. Glioblastoma, localized in the brain, represents one of the major challenges in drug delivery due to the necessity to pass the blood brain barrier (BBB). BBB inhibits the passage of 98% of the medicines administered through the systemic route and
  • constitutes a formidable barrier for tissue targeting not only in nanomedicine but also in common drug delivery [63]. In this case, liposomes were modified with Angiopep-2 and tLyP-1 homing and penetrating peptides for the simultaneous delivery of siRNA and (docetaxel) DTX. Angiopep-2 showed affinity to the
  • between the motives yield the desired interaction with the receptor and allow for strongest interactions compared to nonspecific interactions (Figure 8). Conclusion The last few decades have witnessed the emergence of nanomedicine in the oncological field. The use of nanoparticles as drug delivery systems
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Published 14 Jan 2019

Characterization and influence of hydroxyapatite nanopowders on living cells

  • Przemyslaw Oberbek,
  • Tomasz Bolek,
  • Adrian Chlanda,
  • Seishiro Hirano,
  • Sylwia Kusnieruk,
  • Julia Rogowska-Tylman,
  • Ganna Nechyporenko,
  • Viktor Zinchenko,
  • Wojciech Swieszkowski and
  • Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

Graphical Abstract
  • regenerative medicine. The use of nanosized hydroxyapatites in biomedical applications is constantly growing due to their good mechanical properties and enhanced efficiency of gene transfection in drug delivery. Calcium phosphates are sensitive to the preparation conditions [11][12][13][14][15]. They can be
  • with thermal treatment during the process. State of agglomeration and solubility are mainly influenced by the drying methods. A uniform size of agglomerates with a highly developed surface area (achieved, e.g., by spray drying) and hence better uptake by the cells can be used as an advantage for drug
  • delivery or more effective gene transfection based on hydroxyapatite. The degree of crystallinity can be a factor in determining how long an agglomerate will stay inside the cell and what will be the drug-release rate. Hydroxyapatites with exceptionally large surface area could be also used for
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Published 27 Dec 2018

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

  • Anouchka Plan Sangnier,
  • Romain Aufaure,
  • Laurence Motte,
  • Claire Wilhelm,
  • Erwann Guenin and
  • Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

Graphical Abstract
  • under irradiation within the first biological window (650–900 nm). The Au@alendronate nanoplatform thus provided a combined antitumor activity through drug delivery and photothermal therapy. Au@alendronate NPs inhibited in vitro the proliferation of prostate cancer cells (PC3) in a dose-dependent manner
  • lowered in the presence of laser irradiation. The IC50 was reduced to 1 µM (instead of 100 µM), while at intermediate concentration of 100 µM, cell death was total. It clearly evidences the efficiency of the combined drug delivery and photothermal treatment of Au@alendronate NPs. In summary, we developed
  • efficient antitumor activity of Au@alendronate NPs through combining drug delivery in the form of a nanoplatform carrying alendronate and photothermal therapy. Indeed, Au@alendronate NPs will accumulate within cells because of the enhanced permeability retention effect: An enhanced permeability of blood
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Published 27 Nov 2018

Size-selected Fe3O4–Au hybrid nanoparticles for improved magnetism-based theranostics

  • Maria V. Efremova,
  • Yulia A. Nalench,
  • Eirini Myrovali,
  • Anastasiia S. Garanina,
  • Ivan S. Grebennikov,
  • Polina K. Gifer,
  • Maxim A. Abakumov,
  • Marina Spasova,
  • Makis Angelakeris,
  • Alexander G. Savchenko,
  • Michael Farle,
  • Natalia L. Klyachko,
  • Alexander G. Majouga and
  • Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

Graphical Abstract
  • be adjusted by heterogeneous nucleation of NPs on noble metal seeds [21][22]. Additionally, such bifunctional Fe3O4–Au NPs are potentially applicable for targeted drug delivery, enhanced hyperthermia, multimodal imaging and theranostics [8][23][24][25][26][27]. In this work, we present the first size
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Published 16 Oct 2018

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

  • Zdeněk Plichta,
  • Yulia Kozak,
  • Rostyslav Panchuk,
  • Viktoria Sokolova,
  • Matthias Epple,
  • Lesya Kobylinska,
  • Pavla Jendelová and
  • Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

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  • free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery. Keywords: cytotoxicity; doxorubicin; magnetic; nanoparticles; poly[N-(2-hydroxypropyl)methacrylamide]; Introduction Severe
  • toxicity [5][6]. Superparamagnetic iron oxide nanoparticles with well-defined sizes, morphologies and surface are extremely useful in many different areas, in particular in biomedicine. As drug-delivery vehicles, such particles offer significant advantages compared to conventional drug formulations [7][8
  • from MRI contrast agents to drug-delivery systems, local heat sources in magnetic hyperthermia therapy of tumors, magnetically assisted transfection of cells, and magnetic field-assisted separation techniques. Let us to note that MRI is already widely used in human medicine and several iron-oxide-based
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Published 25 Sep 2018

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

  • Shanid Mohiyuddin,
  • Saba Naqvi and
  • Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

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  • /bjnano.9.233 Abstract In the past few decades, the successful theranostic application of nanomaterials in drug delivery systems has significantly improved the antineoplastic potency of conventional anticancer therapy. Several mechanistic advantages of nanomaterials, such as enhanced permeability
  • alternative to the antimitotic drug, which causes severe side effects when administrated alone. Keywords: 5-FU; anticancer drug delivery; apoptosis; calcium phosphate nanoparticles; cell cycle; nanomedicine; Introduction Malignant neoplasms are reported as the second most common cause of mortality around
  • immediately on improving the efficacy. This need could possibly be met by a nanoscale-carrier-facilitated drug delivery system. This rapidly growing field of research has gained interest all over the world with its effective and targeted drug delivery application [3]. Polymer-based nanoformulations have
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Published 20 Sep 2018

Effect of electrospinning process variables on the size of polymer fibers and bead-on-string structures established with a 23 factorial design

  • Paulina Korycka,
  • Adam Mirek,
  • Katarzyna Kramek-Romanowska,
  • Marcin Grzeczkowicz and
  • Dorota Lewińska

Beilstein J. Nanotechnol. 2018, 9, 2466–2478, doi:10.3762/bjnano.9.231

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  • among others as: coatings with hydrophobic properties [19], membranes for fog harvesting [20], drug delivery systems with encapsulated therapeutic substances [21]. Therefore, it is fully justified to dedicate a study to the analysis of conditions in which the beads can be optimally obtained. Although a
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Published 17 Sep 2018

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

  • Alina M. Ermakova,
  • Julia E. Morozova,
  • Yana V. Shalaeva,
  • Victor V. Syakaev,
  • Aidar T. Gubaidullin,
  • Alexandra D. Voloshina,
  • Vladimir V. Zobov,
  • Irek R. Nizameev,
  • Olga B. Bazanova,
  • Igor S. Antipin and
  • Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

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  • use as a supramolecular drug-delivery system. Keywords: calixresorcinarene; drug encapsulation; hemotoxicity; methoxy poly(ethylene glycol); temperature-controlled release; Introduction One of the acute problems of modern medicinal therapy is the development of novel drug-delivery systems with low
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Published 27 Jul 2018

Fabrication of photothermally active poly(vinyl alcohol) films with gold nanostars for antibacterial applications

  • Mykola Borzenkov,
  • Maria Moros,
  • Claudia Tortiglione,
  • Serena Bertoldi,
  • Nicola Contessi,
  • Silvia Faré,
  • Angelo Taglietti,
  • Agnese D’Agostino,
  • Piersandro Pallavicini,
  • Maddalena Collini and
  • Giuseppe Chirico

Beilstein J. Nanotechnol. 2018, 9, 2040–2048, doi:10.3762/bjnano.9.193

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  • explored in numerous studies to eradicate cancer cells, controlled drug delivery and enhancement of cell growth [1][2][3][4][5]. Among the many types of such nanoparticles, gold nanostars (GNSs) (having a well-tunable LSPR position in the biotransparent NIR window (750–1300 nm) and ease of surface
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Published 23 Jul 2018

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

  • Aikaterini-Rafailia Tsiapla,
  • Varvara Karagkiozaki,
  • Veroniki Bakola,
  • Foteini Pappa,
  • Panagiota Gkertsiou,
  • Eleni Pavlidou and
  • Stergios Logothetidis

Beilstein J. Nanotechnol. 2018, 9, 1986–1994, doi:10.3762/bjnano.9.189

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  • work, a drug-delivery nanoplatform system consisting of polymeric celluloce acetate (CA) scaffolds loaded with dexamethasone was fabricated through electrospinning. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) indicated the successful fabrication of these structures
  • anti-inflammatory drug onto the engineered implants and degradation study was conducted in order to assess the mass loss of polymers. This drug-delivery nanoplatform as coating on titanium implants may be a promising approach not only to alleviate but also to prevent implant-associated acute
  • inflammations along with a simultaneous controlled release of the drug. Keywords: drug delivery; electrospinning; nanocoatings; orthopedics; tissue engineering; Introduction The application of nanotechnology in medicine, known as nanomedicine, aims to overcome problems associated with diseases at the
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Published 13 Jul 2018

Synthesis of a MnO2/Fe3O4/diatomite nanocomposite as an efficient heterogeneous Fenton-like catalyst for methylene blue degradation

  • Zishun Li,
  • Xuekun Tang,
  • Kun Liu,
  • Jing Huang,
  • Yueyang Xu,
  • Qian Peng and
  • Minlin Ao

Beilstein J. Nanotechnol. 2018, 9, 1940–1950, doi:10.3762/bjnano.9.185

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  • popular magnetic material being systematically researched in various aspects from drug delivery to catalyst separation [18]. As a typical heterogeneous Fenton-like catalyst in H2O2 activation systems, it is reported that when coupling with MnO2, the Fe3O4–MnO2 pair presents a synergistic effect, which can
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Published 06 Jul 2018

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO2 nanotubes with a hydrophobic layer

  • Caihong Liang,
  • Jiang Wen and
  • Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

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  • exhibit promising application as a localized, prolonged drug delivery platform. Keywords: Ag doping; drug delivery; hydrophobic layer; prolonged drug release; TiO2 nanotubes; visible-light-controlled release; Introduction Titanium dioxide nanotubes (TNTs) are often employed as drug carriers, owing to
  • their well-defined geometry, stable structure [1], high surface-to-volume ratio, highly hydrophilic wetting characteristic [2][3], and remarkable photocatalysis properties [4]. However, the traditional drug delivery systems still exhibit many obvious drawbacks such as low drug solubility, uncontrolled
  • distribution and systemic toxicity towards non-target tissues [5]. As a result, in order to improve their drug-release ability for prolonged or controlled drug delivery, numerous methods including chemical and structural modification have been applied to modify the surface of TNTs [6][7][8][9]. By altering the
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Published 14 Jun 2018
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