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Search for "Alzheimer’s disease" in Full Text gives 18 result(s) in Beilstein Journal of Nanotechnology.

Shape, membrane morphology, and morphodynamic response of metabolically active human mitochondria revealed by scanning ion conductance microscopy

  • Eric Lieberwirth,
  • Anja Schaeper,
  • Regina Lange,
  • Ingo Barke,
  • Simone Baltrusch and
  • Sylvia Speller

Beilstein J. Nanotechnol. 2025, 16, 951–967, doi:10.3762/bjnano.16.73

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  • [6][7][8][9]. These processes are integral to maintaining cellular homeostasis [10], and disruptions in mitochondrial function are implicated in numerous diseases, including Parkinson’s disease [11][12][13], cardiovascular diseases [14][15][16], Alzheimer’s disease [12][17][18], obesity [19], and
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Published 30 Jun 2025

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

  • Shiwani Randhawa,
  • Trilok Chand Saini,
  • Manik Bathla,
  • Rahul Bhardwaj,
  • Rubina Dhiman and
  • Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

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  • , 201002, India 10.3762/bjnano.16.44 Abstract The amyloid cascade hypothesis posits that amyloid-β oligomers (AβOs) are the most neurotoxic species in Alzheimer’s disease (AD). These oligomers, characterized by their high β-sheet content, have been shown to significantly disrupt cell membranes, induce
  • into their potential for clinical application. This comprehensive overview highlights the current advancements in NM-based therapies for AD and outlines future research directions aimed at optimizing these innovative treatments. Keywords: Alzheimer’s disease; amyloid; amyloid-β oligomers; detection
  • ; dissociation; nanomaterials; Review Introduction The etiology of Alzheimer’s disease (AD) has traditionally been linked to the presence of amyloid-β 42 (Aβ42), a protein widely recognized as a key marker of the disease. However, a growing body of recent scientific evidence suggests that it may be the amyloid
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Published 22 Apr 2025

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

  • Naths Grazia Sukubo,
  • Paolo Bigini and
  • Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

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Published 31 Jan 2025

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

  • Selin Akpinar Adscheid,
  • Akif E. Türeli,
  • Nazende Günday-Türeli and
  • Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

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  • such as multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease [3]. This group of diseases affects both patients and society and causes one in nine deaths worldwide [4]. For example, solely in 2019, there were nearly 10 million deaths, and 349 million disability-adjusted life years were
  • stabilized with tocopherol polyethylene glycol succinate (TPGS) were proposed against Alzheimer’s disease. TPGS, a water-soluble precursor of vitamin E, was used in the formulation to reduce the amyloid-beta-induced oxidative stress [114]. In vivo tests on Wistar rats highlighted that the mucoadhesive
  • treating multiple sclerosis (MS), Ocrevus, based on the CD20-targeting mAb ocrelizumab, is projected to have the highest growth in sales by 2025 [136]. Moreover, aducanumab, a mAb IgG1, was approved for treating Alzheimer’s disease in 2021 [137]. Even though there are successful examples, using the full
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Published 12 Nov 2024

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

  • Hsuan-Ang Tsai,
  • Tsai-Miao Shih,
  • Theodore Tsai,
  • Jhe-Wei Hu,
  • Yi-An Lai,
  • Jui-Fu Hsiao and
  • Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

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  • has shown significant treatment efficacy for central nervous system (CNS) disorders including depression, schizophrenia, Alzheimer’s disease, and post-traumatic stress disorder. The physicochemical properties of DCS, however, limit the options of formulation and medicinal applications of DCS, and
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Published 25 Apr 2024

Classification and application of metal-based nanoantioxidants in medicine and healthcare

  • Nguyen Nhat Nam,
  • Nguyen Khoi Song Tran,
  • Tan Tai Nguyen,
  • Nguyen Ngoc Trai,
  • Nguyen Phuong Thuy,
  • Hoang Dang Khoa Do,
  • Nhu Hoa Thi Tran and
  • Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

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  • diseases. Neurological diseases Overproduction of ROS and RNS in the brain is involved in neurological diseases such as Parkinson’s disease, Alzheimer’s disease, traumatic brain injury, and stroke. Neurological diseases are recognized as a major threat to human health and are considered incurable diseases
  • lipoprotein receptor-related protein overexpressed on cells that comprise the BBB. Figure 3 illustrates the biodistribution and ROS scavenging activity of edaravone-encapsulated nanospherical albumin (EeNA) [91]. Alzheimer’s disease is a neurological disease that slowly destroys thinking skills and memory
  • [119]. The main pathogenic mechanisms of Alzheimer’s disease involve not only ROS overproduction but also amyloid beta (Aβ) fibril accumulation. Liu et al. reported a nanosystem employing polydopamine and ruthenium (PDA-Ru) as key elements for ROS scavenging and decomposition of mature Aβ fibrils [120
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Published 12 Apr 2024

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

  • Xiaoyan Ma,
  • Haoning Gong,
  • Kenji Ogino,
  • Xuehai Yan and
  • Ruirui Xing

Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23

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  • between antioxidative and oxidative systems, leads to permanent and irreversible damage of cellular components, such as proteins, lipids, and nucleic acids [1]. Furthermore, oxidative stress leads to diseases including Alzheimer’s disease [2], cardiac disease [3], atherosclerosis [4], kidney disease [5
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Published 01 Mar 2022

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

  • Maria Suciu,
  • Corina M. Ionescu,
  • Alexandra Ciorita,
  • Septimiu C. Tripon,
  • Dragos Nica,
  • Hani Al-Salami and
  • Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

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  • fluorescence) of Alzheimer’s disease Aβ plaque accumulations. They observed that the nanoparticles are not only appropriate for imaging but they also prevent plaque accumulation and break the already formed aggregates. Feng et al. [163] developed a SPION sensor coupled with a synthetic protein that recognizes
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Published 27 Jul 2020

Key for crossing the BBB with nanoparticles: the rational design

  • Sonia M. Lombardo,
  • Marc Schneider,
  • Akif E. Türeli and
  • Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

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  • . According to the World Health Organization (WHO), in 2000, brain diseases such as Alzheimer’s disease and other dementias ranked 14th among the causes of death worldwide with approximately 0.8 million deceased [1]. This number more than doubled in the last few years. In 2016, these diseases were responsible
  • for 2.0 million deceased, ranking Alzheimer’s disease 5th. Furthermore, according to the WHO, in 2016 stroke was still the second most frequent cause of death worldwide with approximately 5.8 million deceased. These tremendous numbers will continue to grow due to an aging population, with the rise of
  • possible to increase the BBB targeting ability of NLCs by adsorbing lactoferrin at their surface [90]. In a study by Meng et al., results have shown that lactoferrin-modified NLCs were able to accumulate in the brain more than twice as much as pristine NLCs in an Alzheimer’s disease rat model [90]. Thus
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Published 04 Jun 2020

Luminescent gold nanoclusters for bioimaging applications

  • Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

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  • . reported the in vivo formation of fluorescent gold nanoclusters for imaging the brain affected by Alzheimer’s disease (AD) [102]. The redox microenvironment in the AD brain is characterized by relatively low oxygen metabolism and more free radicals compared to that of a healthy brain. When AD occurs, a
  • of mice brain with Alzheimer’s disease. C) Fluorescence imaging of (a) the control group of AD mice (without given HAuCl4). (b–e) Fluorescence imaging of the same AD model mice after tail-vein injection of HAuCl4 solution after different periods of time (1, 6, 18 and 30 h). D) Fluorescence imaging of
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Published 30 Mar 2020

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

  • Liang Xu,
  • Dekang Xu,
  • Ziying Li,
  • Yu Gao and
  • Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

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  • activation of estrogen receptor-β [6]. Additionally, studies demonstrated that Di has unique preventive/therapeutic outcomes not only against tumors, but also for other diseases such as diabetes [7], myocardial infarction (AMI) [8], acute liver injury [9], goiter [10], and Alzheimer’s disease (AD) [11]. In
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Published 24 Sep 2019

Low cost tips for tip-enhanced Raman spectroscopy fabricated by two-step electrochemical etching of 125 µm diameter gold wires

  • Antonino Foti,
  • Francesco Barreca,
  • Enza Fazio,
  • Cristiano D’Andrea,
  • Paolo Matteini,
  • Onofrio Maria Maragò and
  • Pietro Giuseppe Gucciardi

Beilstein J. Nanotechnol. 2018, 9, 2718–2729, doi:10.3762/bjnano.9.254

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  • “Sviluppo e Applicazioni di Materiali e Processi Innovativi per la Diagnostica e il Restauro di beni culturali, DELIAS”. C.D’A. and P.M. acknowledge the Tuscany Region within the project “Surface-enhanced Raman spectroscopy for the early diagnosis of Alzheimer’s disease SUPREMAL” (PAR FAS 2007- 2013 Action
  • Line 1.1- Action 1.1.2) and the European Community within the EuroNanoMed3 ERANET cofund (H2020) project “Surface-enhanced Raman scattering with nanophotonic and biomedical amplifying systems for an early diagnosis of Alzheimer’s disease pathology SPEEDY” (ID 221).
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Published 22 Oct 2018

Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology

  • Clelia Galati,
  • Natalia Spinella,
  • Lucio Renna,
  • Danilo Milardi,
  • Francesco Attanasio,
  • Michele Francesco Maria Sciacca and
  • Corrado Bongiorno

Beilstein J. Nanotechnol. 2017, 8, 2446–2453, doi:10.3762/bjnano.8.243

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  • sensitivity; peptide; silicon oxide; TEM; Introduction According to the World Health Organization (WHO), the number of people living with Alzheimer’s disease (AD) worldwide is now greater than 47 million, and this number is expected to grow to 75 million by 2030. Alzheimer’s disease leads to nerve-cell death
  • microarrays (small molecule, peptide, and antibody) for multiplex detection. In this study, the HES platform has exhibited a high usefulness for studying the behavior of peptides aimed to identify potential therapeutics for Alzheimer’s disease. Conclusion Binding assays have been performed in a microarray
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Published 20 Nov 2017

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

  • Silvia Varela-Aramburu,
  • Richard Wirth,
  • Chian-Hui Lai,
  • Guillermo Orts-Gil and
  • Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

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  • related to Alzheimer’s disease [19]. Gold nanoclusters (NCs) are gold nanoparticles ranging in size between 1 and 3 nm, with interesting physicochemical properties and increased surface area for drug delivery applications [20]. There are several methods to synthesize gold nanoparticles. In addition to the
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Published 08 Sep 2016

Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles

  • Igor M. Pongrac,
  • Marina Dobrivojević,
  • Lada Brkić Ahmed,
  • Michal Babič,
  • Miroslav Šlouf,
  • Daniel Horák and
  • Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 926–936, doi:10.3762/bjnano.7.84

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  • [1]. The transplantation of NSCs represents a possible strategy for replacing cell loss in patients suffering from different neurologic diseases such as stroke, spinal cord injury, Alzheimer’s disease or amyotrophic lateral sclerosis [2][3][4][5][6][7]. The development of non-invasive techniques to
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Published 27 Jun 2016

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

  • Wicem Argoubi,
  • Maroua Saadaoui,
  • Sami Ben Aoun and
  • Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

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  • fractal gold nanostructures for electrodes endowed with very large surface areas useful for the sensitive detection of apolipoprotein E, which is a protein biomarker for Alzheimer’s disease [18]. The preparation of the platforms was achieved in a straightforward manner in few steps. Firstly, home-prepared
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Published 01 Sep 2015

Carbon-based smart nanomaterials in biomedicine and neuroengineering

  • Antonina M. Monaco and
  • Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

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  • . Yang and colleagues [32], for example, exploited the ability of CNTs to cross the blood–brain barrier to deliver acetylcholine into the lysosomes of neurons in the experimental treatment of Alzheimer’s disease in mice. However, the biological applications of CNTs require their complete purification
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Published 23 Oct 2014

Self-organizing bioinspired oligothiophene–oligopeptide hybrids

  • Alexey K. Shaytan,
  • Eva-Kathrin Schillinger,
  • Elena Mena-Osteritz,
  • Sylvia Schmid,
  • Pavel G. Khalatur,
  • Peter Bäuerle and
  • Alexei R. Khokhlov

Beilstein J. Nanotechnol. 2011, 2, 525–544, doi:10.3762/bjnano.2.57

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  • ; oligothiophenes; self-assembly; Introduction Amyloid and amyloid-like fibrillar aggregates, formed by natural proteins or oligopeptides, have attracted much attention both due to their involvement in medical pathologies (such as Alzheimer’s disease, Parkinson’s disease, etc. [1][2][3]) and their possible
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Published 05 Sep 2011
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