Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• such as multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease [3]. This group of diseases affects both patients and society and causes one in nine deaths worldwide [4]. For example, solely in 2019, there were nearly 10 million deaths, and 349 million disability-adjusted life years were

• situ esculin-loaded nanoliposomes for intranasal administration for treating Parkinson’s disease. Ex vivo studies further confirmed the enhanced permeation of the nanoliposomal formulation compared to the suspension form by approximately 40% [99]. Solid lipid NPs and nanostructured lipid carriers Solid

• availability, SLNs and NLCs have been previously studied for delivery through the BBB [104][105]. SLNs and NLCs were also in focus for the development of intranasal formulations. For instance, rotigotine, a drug with low oral bioavailability, was loaded in SLNs to be tested against Parkinson’s disease. The

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• the proportion of the administered drug that enters the target systemic circulation. Another important aspect of drug delivery is its ability to overcome biological barriers and provide the availability in drug-specific body tissues. For example, in the case of Alzheimer’s or Parkinson’s disease, drug

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• compared to healthy individuals is related to Parkinson’s disease [4]. The oxidation of HYP yields xanthine, which can be further oxidized to URI. Meat from shrimp, fish, and some other animals contain large amounts of HYP. High consumption of these foods has been considered to result in elevated levels of

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• diseases. Neurological diseases Overproduction of ROS and RNS in the brain is involved in neurological diseases such as Parkinson’s disease, Alzheimer’s disease, traumatic brain injury, and stroke. Neurological diseases are recognized as a major threat to human health and are considered incurable diseases

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• delivered to a target site through encapsulation into a molecularly imprinted β-CyD polymer [112]. This prodrug for Parkinson’s disease is easily degraded when exposed to water or light but stably protected in the polymeric structure. Alternatively, angiotensin II as an octapeptide hormone for blood

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• oxidative stress response, which makes the p-translucent silkworm a good model to study Parkinson’s disease [92][93]. Mammalian model organisms are mostly used to study the efficacy of new drugs for human-related diseases and also in the screening of antimicrobial drugs [94]. Recent reports indicate

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• the drugs or to use prodrugs. One example of a prodrug is levodopa, a prodrug of dopamine used for the treatment of Parkinson’s disease. However, these options are not always possible depending on the structure of the molecule. Another possibility to increase drug delivery through the BBB is to

Au nanoparticle-based sensor for apomorphine detection in plasma

• Chiara Zanchi,
• Andrea Lucotti,
• Matteo Tommasini,
• Sebastiano Trusso,
• Ugo de Grazia,
• Emilio Ciusani and
• Paolo M. Ossi

Beilstein J. Nanotechnol. 2015, 6, 2224–2232, doi:10.3762/bjnano.6.228

• ]. In this work, we report on the use of gold nanoparticle (NP) arrays deposited on standard glass substrates to quantitatively detect apomorphine (APO) aiming at the realization of a biomedical sensor. APO has been long used in the treatment of patients with complicated Parkinson’s disease (PD). Indeed

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• carbon nanotubes; levodopa; MTT assay; nanomedicine; Parkinson’s disease; PC12 cells; sustained release; Introduction Over the past few years, the revolutionary development of nanomedicine has emerged as one of the most prominent research areas in biomedical science. This interdisciplinary technology is

• , and at the same time, further enhance their degree of biocompatibility [7]. This is because non-functionalized CNTs tend to aggregate into bundles due to van der Waals interactions and hence, they might induce apoptosis (cell death) after administration into the human body. Parkinson’s disease (PD) or

Functionalization of α-synuclein fibrils

• Simona Povilonienė,
• Vida Časaitė,
• Virginijus Bukauskas,
• Arūnas Šetkus,
• Juozas Staniulis and
• Rolandas Meškys

Beilstein J. Nanotechnol. 2015, 6, 124–133, doi:10.3762/bjnano.6.12

• including Parkinson’s disease [8][9], was chosen as a building block element. α-Syn is a small 140 amino acid long protein that is highly soluble and heat-stable. Three regions can be recognized in α-Syn: a highly conservative N-terminal region, a variable internal non-amyloid component (NAC) (which is

Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine

• Hari Krishna Salila Vijayalal Mohan,
• Jianing An and
• Lianxi Zheng

Beilstein J. Nanotechnol. 2014, 5, 2113–2121, doi:10.3762/bjnano.5.220

• sensors [1][2][3]. Of the numerous biomolecules, detection of dopamine (DA) is critical because of its high clinical importance in various brain functions such as learning, memory formation, message transfer in the central nervous system and understanding the pathological processes of Parkinson’s disease

Self-organizing bioinspired oligothiophene–oligopeptide hybrids

• Alexey K. Shaytan,
• Eva-Kathrin Schillinger,
• Elena Mena-Osteritz,
• Sylvia Schmid,
• Pavel G. Khalatur,
• Peter Bäuerle and
• Alexei R. Khokhlov

Beilstein J. Nanotechnol. 2011, 2, 525–544, doi:10.3762/bjnano.2.57

• ; oligothiophenes; self-assembly; Introduction Amyloid and amyloid-like fibrillar aggregates, formed by natural proteins or oligopeptides, have attracted much attention both due to their involvement in medical pathologies (such as Alzheimer’s disease, Parkinson’s disease, etc. [1][2][3]) and their possible