Time of flight secondary ion mass spectrometry imaging of contaminant species in chemical vapour deposited graphene on copper

• Barry Brennan,
• Vlad-Petru Veigang-Radulescu,
• Philipp Braeuninger-Weimer,
• Stephan Hofmann and
• Andrew J. Pollard

Beilstein J. Nanotechnol. 2026, 17, 200–213, doi:10.3762/bjnano.17.13

• substrate, depending on processing conditions employed and the chemical species present on the surface. This has implications for the gas permeation barrier properties of this material, graphene transfer mechanisms, as well as the effectiveness of using the oxidation of the copper foil as a rapid graphene

• evidence of the substrate Cu signal, specifically the signal related to Cu oxide. The gas permeation barrier properties of graphene are well known [47][48], and as such it is possible to compare the level of oxidation of the Cu foil after graphene growth by comparing the regions where the Cu surface is

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• evolution of physicochemical characteristics and surface properties of NLs in biorelevant media. Additionally, in order to point out the influence of specific characteristics on the brain targeting potential of these formulations, we investigated interactions between NLs and blood–brain barrier (BBB, hCMEC

• neurons (ranging from 25.17% to 27.54%). Fluorescence and confocal microscopy micrographs revealed that, once internalized, NLs were concentrated in the perinuclear cell regions. Keywords: blood–brain barrier; cell co-culture; cell uptake; internalization; nanoliposomes; stability; surface

• barrier (BBB) and target specific brain regions [2][3]. However, despite these advantages, only few NLs formulations for brain diseases have completed clinical trials and are commercially available [4]. Among other limitations, one of the most underestimated steps especially in early formulation stages

Capabilities of the 3D-MLSI software tool in superconducting neuron design

• Irina E. Tarasova,
• Nikita S. Shuravin,
• Liubov N. Karelina,
• Fedor A. Razorenov,
• Evgeny N. Zhardetsky,
• Aleksandr S. Ionin,
• Mikhail M. Khapaev and
• Vitaly V. Bol’ginov

Beilstein J. Nanotechnol. 2026, 17, 122–138, doi:10.3762/bjnano.17.8

• is not an impassable barrier on the way to implementation of superconducting neurons. Increasing the neuron integration density in practical devices can be achieved by expanding the screen to cover the entire substrate area. In this case, the actual size of each neuron will be determined by the outer

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• and demonstrate that both R-PE and 5-FU were effectively incorporated into the nanocarriers. Moreover, the observed spectral modifications suggest that the lipid bilayer not only acted as a physical barrier to immediate diffusion but also provided a stabilizing microenvironment that preserved the

• exhibited greater colloidal stability, with slight variations in hydrodynamic size and PDI throughout the incubation period. This behavior suggests that the lipid composition employed provided an efficient steric barrier, minimizing nonspecific interactions with serum proteins. The presence of the PEG

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• coating density and physical barrier performance (ZIF-8 helps prevent Ti3C2Tx aggregation and chemically cross-links with WPU, enhancing mechanical integrity). The final cross-linked coating had a water contact angle of about 154°, indicating high water repellency and self-cleaning capabilities. More

Terahertz-range on-chip local oscillator based on Josephson junction arrays for superconducting quantum-limited receivers

• Fedor V. Khan,
• Lyudmila V. Filippenko,
• Andrey B. Ermakov,
• Mikhail Yu. Fominsky and
• Valery P. Koshelets

Beilstein J. Nanotechnol. 2025, 16, 2296–2305, doi:10.3762/bjnano.16.158

• tunneling through the tunnel barrier increases. This leads to a rise in current at voltages below the gap and the emergence of the so-called quasiparticle steps. This process is known as photon-assisted tunneling. The magnitude of the current on a quasiparticle step within the investigated range is linearly

Geometry-controlled engineering of the low-temperature proximity effect in normal metal–superconductor junctions

• Munisa A. Tomayeva,
• Vyacheslav D. Neverov,
• Andrey V. Krasavin,
• Alexei Vagov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2025, 16, 2265–2273, doi:10.3762/bjnano.16.155

• geometric variations modify the amplitude and spatial profile of the Cooper pair wave function, as well as the effective barrier potential at the interface. These geometric effects influence the balance between Andreev reflection and quasiparticle scattering, modulate pair-breaking mechanisms, and thus

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• technological domains. Thus, a key barrier to the commercialization of nanomaterial-based products is the absence of globally harmonized standards and coherent regulatory frameworks. A few countries actively engaged in nanotechnology have introduced nation-level regulations, but these are often not recognized

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• sandwiched between conductive materials such as graphene, graphite, and gold. The authors fabricated vertical tunnel junctions with h-BN barriers ranging from one to four atomic layers and demonstrated that the tunneling current decreases exponentially with barrier thickness, confirming quantum mechanical

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• ]. This range is considerably favorable for topical formulations, as lower surface tension enhances spreadability and promotes interaction with the stratum corneum and its lipidic barrier. Due to instrumental limitations associated with the high viscosity resulting from NaCMC addition, the surface tension

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• act as a barrier, reducing the uptake of antimicrobial agents, thus, increasing the required inhibitory concentrations. Similar results have been observed for silver, ZnO, and other metal chalcogenide nanoparticles, which show higher MIC/MBC values for E. coli compared to S. aureus [41]. In size

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• patient safety. Shortcomings in standardisation Lack of standardised evaluation Standardising the evaluation of CNM-based nanocarriers for targeted anticancer drug delivery remains a major barrier to clinical translation. The diversity of CNM structures, variability in drug-loading strategies, and

Quantum circuits with SINIS structures

• Mikhail Tarasov,
• Mikhail Fominskii,
• Aleksandra Gunbina,
• Artem Krasilnikov,
• Maria Mansfeld,
• Dmitrii Kukushkin,
• Andrei Maruhno,
• Valeria Ievleva,
• Mikhail Strelkov,
• Daniil Zhogov,
• Konstantin Arutyunov,
• Vyacheslav Vdovin,
• Vladislav Stolyarov and
• Valerian Edelman

Beilstein J. Nanotechnol. 2025, 16, 1931–1941, doi:10.3762/bjnano.16.134

• layers and ensures ease of manufacturing a tunnel barrier, in contrast to Nb-based technology, which requires the formation of an artificial anodic oxide or an additional insulating layer to prevent short circuits, as well as an additional Al layer to form an AlOx or AlN tunnel barrier. Results NIS

• tunnel junction In tunnel structures, the barrier is a dielectric layer between two metal films (often the oxide layer on the surface of the first metal layer is used as a dielectric). The first experimental study of a tunnel junction was carried out in 1960 [21] for an aluminum–aluminum oxide–lead

• created. The process of electron energy relaxation continues until their characteristic times reach the tunneling time determined by the parameters of the SIN transition, that is, the transparency of the barrier, the thickness of the normal metal film, and the diffusion rate of electrons in it. For

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• ]. PEG’s hydrophilic and steric properties are instrumental in reducing the adsorption of proteins onto LNP surfaces. By creating a hydrated barrier, PEG minimizes nonspecific binding, leading to a “stealth” effect that prolongs circulation time and reduces recognition by the mononuclear phagocytic system

• [24]. However, the effectiveness of this barrier depends on PEG density, molecular weight, and chain configuration. The previously mentioned high-density PEG layers in a “brush” conformation are particularly effective at repelling proteins compared to lower-density “mushroom” configurations, which may

• growing body of evidence, while PEG lipids have long been used to maintain LNP stability and reduce nonspecific interactions, their immunogenic liabilities may pose a critical barrier to safe and effective repeated dosing in clinical applications. Therefore, it is important to develop and evaluate

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

Programmable soliton dynamics in all-Josephson-junction logic cells and networks

• Vsevolod I. Ruzhickiy,
• Anastasia A. Maksimovskaya,
• Sergey V. Bakurskiy,
• Andrey E. Schegolev,
• Maxim V. Tereshonok,
• Mikhail Yu. Kupriyanov,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1883–1893, doi:10.3762/bjnano.16.131

• incident soliton propagates through it unimpeded, and the entire line returns to its initial physical state. However, increasing the inductance to L/LJ = 2 (see Figure 2b) switches the system to the Close mode. In this mode, the KICK serve as a significant barrier; when the soliton arrives, the large

• soliton’s energy is large enough to overcome any potential barrier presented by the KICK, ensuring transmission regardless of the inductance value. This results in a universal Open mode at high rates. Crucially, this high-energy passage is not inert; if the KICK is in a bistable regime (such as the T-Mode

• critical current of the specific junction connecting nodes 15 and 16 to (i.e., to 1 in normalized units). The effect of this asymmetric potential barrier is that a soliton initiated in the forward direction (from node 1) successfully overcomes it and is transmitted along the entire line. In contrast, a

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• formulation parameters – such as drug miscibility with the oil phase, droplet size, and size uniformity – have been directly correlated with permeation efficiency across the skin barrier [32][33]. Specifically, the encapsulation of lipophilic compounds like phytol in finely dispersed droplets within oil-in

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• anionic glycoprotein that plays a pivotal role in determining the thickness and structure of the mucus layer. Consequently, its barrier function and permeability to drugs are also influenced. As a consequence, positively charged substances are attracted to mucin by electrostatic forces and retained within

• the mucus layer which acts as a barrier that must be overcome in the oral administration of drugs [7]. Another intrinsic physical barrier of the GIT is the intestinal epithelium (Figure 1), which consists of a single layer of epithelial cells, including enterocytes and secretory cells. Drug passage

• , and maintaining homeostasis within the GIT. The diverse cells of the intestinal epithelium can be explored as therapeutic targets for oral absorption, given the significant roles they play in the epithelial barrier [9]. Nanotechnology is a field that focuses on the study and production of nanometric

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• barrier to aggregation and support long-term colloidal stability [14][37]. The protein release study of venom-loaded PLA cationic nanoparticles occurred in two stages. In the first stage, a burst release effect was due to surface-adsorbed proteins, followed by the diffusion through the external swollen

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• barrier, while MPs of 20 μm can reach internal organs. Exposure occurs through inhalation, posing risks to adults, while children face dangers from MPs in contaminated drinking water. Once inside the body, MPs can trigger neurotoxicity, cytotoxicity, oxidative stress, immune response, metabolic disruption

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• highly dependent on environmental factors such as pH, temperature, and ionic concentration [81]. To maintain functional performance over the intended period, a common strategy is to apply an encapsulation layer over the active components of the device. This encapsulation serves as a temporary barrier

• the mechanical and crystalline properties of such natural waxes, blended composite materials (e.g., candelilla/beeswax or candelilla/PBTPA mixtures) have been investigated for their potential use as barrier coatings [86]. A 300 μm thick edge-encapsulated mixture film was found to protect a 300 nm

• of organic displays, are known for their superior water resistance due to their densely packed atomic structures. However, even these films are susceptible to defects formed during deposition, which compromise their barrier function. To overcome this, display technologies have utilized techniques

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• receptors and ligands, as well as the number of interactions necessary to overcome the energy barrier for cellular uptake. Properly balancing these factors ensures efficient binding and internalization of the nanoparticles by the target cells [50][51]. For example, nanoparticles can be engineered to

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• among the white blood cells [35]. Neutrophils are the first to appear at the site of inflammation and easily cross different biological barriers such as blood–tissue barrier, blood–brain barrier (BBB) or blood–tumor barrier (BTB). Therefore, neutrophil membrane-coated nanoparticles have been

• , where drug delivery is limited by the blood–pancreas barrier. The nanoparticles successfully crossed the barrier, accumulated selectively in pancreatic cancer cells, inhibited tumor growth and its metastasis to the liver [36]. Similarly, neutrophil membrane-coated PLGA nanoparticles were used for the

Functional bio-packaging enhanced with nanocellulose from rice straw and cinnamon essential oil Pickering emulsion for fruit preservation

• Tuyen B. Ly,
• Duong D. T. Nguyen,
• Hieu D. Nguyen,
• Yen T. H. Nguyen,
• Bup T. A. Bui,
• Kien A. Le and
• Phung K. Le

Beilstein J. Nanotechnol. 2025, 16, 1234–1245, doi:10.3762/bjnano.16.91

• exhibits good heat-resistance, mechanical, and water-barrier properties. At an emulsion concentration as low as 10% (v/w) in the casting solution, high UV absorbance capacity (up to 100% UVC), high antibacterial activity (92.4% Escherichia coli inhibition), and good antioxidative properties (up to 43% DPPH

• radical scavenging) were observed. These bioactive properties and the inherent moisture barrier property of the packaging material are utilized for strawberry preservation with a significant preservation time of 21 days compared to control samples that start to grow a white fungus on day 11. This

• applications, influencing barrier properties against moisture transmission. The results show that adding CEO reduces WVP values compared to the control. At 4% (v/w) PE-CEO, WVP decreases by approximately 23.5%, reaching 4.12 × 10−12 g·m−1·s−1·Pa−1 due to increased hydrophobicity and reduced polymer chain