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Search for "biological fluids" in Full Text gives 44 result(s) in Beilstein Journal of Nanotechnology.

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

  • Iqra Zainab,
  • Zohra Naseem,
  • Syeda Rubab Batool,
  • Muhammad Waqas,
  • Ahsan Nazir and
  • Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

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  • surgery [113]. Polyurethane The biocompatibility of polyurethane (PU) makes it well suited for interactions with biological fluids and tissues [114]. Its ability to imitate the mechanical characteristics of natural tissues further enhances its appeal in biomedical applications [115]. The surface of PU can
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Published 24 Apr 2025

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

  • Shiwani Randhawa,
  • Trilok Chand Saini,
  • Manik Bathla,
  • Rahul Bhardwaj,
  • Rubina Dhiman and
  • Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

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  • central to the pathophysiology of AD, and their presence in exosomes can aid in the diagnosis of the disease. By analyzing the presence and levels of AβOs and tau protein in exosomes derived from biological fluids, such as blood or CSF, it may be possible to develop non-invasive diagnostic methods for the
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Published 22 Apr 2025

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

  • Radmila Milenkovska,
  • Nikola Geskovski,
  • Dushko Shalabalija,
  • Ljubica Mihailova,
  • Petre Makreski,
  • Dushko Lukarski,
  • Igor Stojkovski,
  • Maja Simonoska Crcarevska and
  • Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

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  • mediate the internalization in addition to the impact of interaction with the biological fluids (i.e., surface adsorption of molecules). In this respect, in the study of Dabrowski et al. [81], the impact of particle size of graphene on the efficacy of internalization was evaluated in normal (LL-24) and
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Published 19 Feb 2025

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

  • Naths Grazia Sukubo,
  • Paolo Bigini and
  • Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

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Published 31 Jan 2025

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

  • Julia E. Poletaeva,
  • Anastasiya V. Tupitsyna,
  • Alina E. Grigor’eva,
  • Ilya S. Dovydenko and
  • Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

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  • protein corona is present on any nanoparticle (NP) entering biological fluids; however, the existence of a natural protein corona on natural NPs has not been experimentally confirmed. We used our previously developed photomodification method to fix the natural corona on “biological nanoparticles” (bio-NPs
  • obtained direct images of a “natural” protein corona on natural bio-NPs of blood serum for the first time Keywords: chylomicrons; extracellular vesicles; lipoproteins; photomodification; protein corona; Introduction The existence of a protein corona on all nanoparticles (NPs) entering biological fluids
  • system, and the role of the corona in the pathogenesis of chronic diseases are being studied [5][10][11][12][13]. A number of works are devoted to the study of protein corona formation on EVs previously isolated from biological fluids [14][15]. The existence of a “natural” protein corona on EVs in the
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Published 30 Dec 2024

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

  • Iqra Rahat,
  • Pooja Yadav,
  • Aditi Singhal,
  • Mohammad Fareed,
  • Jaganathan Raja Purushothaman,
  • Mohammed Aslam,
  • Raju Balaji,
  • Sonali Patil-Shinde and
  • Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

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  • biological fluids [51]. During the development of these nanocarriers, the concentration of cationic lipids for the inner core, density of the PEG chain on the outer layer, and molecular weight of the polymers are adjusted to modulate their physicochemical characteristics [52][53]. Polymer-caged liposomes As
  • and controlled release of the encapsulated drugs. Among all PLHNPs, these hybrid nanocarriers show the highest stability in the biological fluids and stimuli-responsive release of encapsulated drugs. In addition, the polymeric cage protects the drug from the harsh environment, and encapsulated drugs
  • . This modification provides several advantages. PEGylation increases the stability of the PLHNPs in biological fluids by preventing aggregation and reducing protein adsorption. It also extends the circulation time of nanoparticles in the bloodstream by reducing immune system recognition and clearance
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Published 22 Nov 2024

Dual-functionalized architecture enables stable and tumor cell-specific SiO2NPs in complex biological fluids

  • Iris Renata Sousa Ribeiro,
  • Raquel Frenedoso da Silva,
  • Romênia Ramos Domingues,
  • Adriana Franco Paes Leme and
  • Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

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Published 07 Oct 2024

Atomistic insights into the morphological dynamics of gold and platinum nanoparticles: MD simulations in vacuum and aqueous media

  • Evangelos Voyiatzis,
  • Eugenia Valsami-Jones and
  • Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 995–1009, doi:10.3762/bjnano.15.81

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  • shown. In most applications, NPs suspended in biological fluids and aqueous solutions can serve as a proxy system that is easy to control [86]. The NPs are either bare or coated with a corona, the coverage of which may fluctuate, again leaving the NP surface exposed to the solvent [87]. Thus, it is
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Published 07 Aug 2024

Multiscale modelling of biomolecular corona formation on metallic surfaces

  • Parinaz Mosaddeghi Amini,
  • Ian Rouse,
  • Julia Subbotina and
  • Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

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  • the mechanisms underlying the formation of NP protein corona, a complex layer of biomolecules that surrounds NPs upon their exposure to biological fluids [19][20]. It is widely recognized that composition and configuration of the protein corona play a crucial role in determining the biochemical
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Published 13 Feb 2024

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

  • Mamta Kumari,
  • Amitabha Acharya and
  • Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

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  • specifically with antigens, which are responsible for the production or induction of specific antibodies [17]. The specific binding of antigens to their receptors activates a signaling pathway in B-cells, which leads to the secretion of antibodies into biological fluids [18]. Antibodies have four polypeptide
  • copper-free click reaction to decorate fluorescent silica NPs with bicyclononyne. They exposed the NPs to media that mimicked in vitro culture conditions (10% serum) and biological fluids present in vivo (100% serum). They observed an increase in size and a slight decrease in negative charge in serum
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Published 04 Sep 2023

Industrial perspectives for personalized microneedles

  • Remmi Danae Baker-Sediako,
  • Benjamin Richter,
  • Matthias Blaicher,
  • Michael Thiel and
  • Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

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  • medical device for administering drugs and collecting biological fluids, all while reducing sharps-related risks to healthcare professionals. To date, microneedle patches are relatively simple with a one-size-fits-all approach, regardless of patient demographic and injection site. 3D microfabrication
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Published 15 Aug 2023

Interaction between honeybee mandibles and propolis

  • Leonie Saccardi,
  • Franz Brümmer,
  • Jonas Schiebl,
  • Oliver Schwarz,
  • Alexander Kovalev and
  • Stanislav Gorb

Beilstein J. Nanotechnol. 2022, 13, 958–974, doi:10.3762/bjnano.13.84

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  • to reduce adhesion [16]. Therefore, fresh, untreated bee mandibles were studied in the frozen state, as cryo-SEM has been reported to be a successful method for visualizing biological fluids such as lipids and water-based solutions [26]. Cryo-SEM was performed as described in section “Surface
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Published 14 Sep 2022

A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures

  • Irena Mihailova,
  • Vjaceslavs Gerbreders,
  • Marina Krasovska,
  • Eriks Sledevskis,
  • Valdis Mizers,
  • Andrejs Bulanovs and
  • Andrejs Ogurcovs

Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35

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  • healthcare to analyse changes in the concentration of H2O2 in biological fluids. Also, a promising option to study more complex analytes and to significantly increase the sensitivity is the use of this nanostructured CuO sensor as part of a multisensor system based on several types of metal oxides (e.g
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Published 03 May 2022

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

  • Zahra Nabizadeh,
  • Mahmoud Nasrollahzadeh,
  • Hamed Daemi,
  • Mohamadreza Baghaban Eslaminejad,
  • Ali Akbar Shabani,
  • Mehdi Dadashpour,
  • Majid Mirmohammadkhani and
  • Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

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Published 11 Apr 2022

Engineered titania nanomaterials in advanced clinical applications

  • Padmavati Sahare,
  • Paulina Govea Alvarez,
  • Juan Manual Sanchez Yanez,
  • Gabriel Luna-Bárcenas,
  • Samik Chakraborty,
  • Sujay Paul and
  • Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

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  • excretion [33]. When a TiO2 nanomaterial circulates through the body, certain biomolecules (such as proteins, phospholipids, or DNA contained in biological fluids or present in living cells) get adsorbed onto the surface of it very quickly, which is termed as “protein corona (PC)” formation. This protein
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Published 14 Feb 2022

An overview of microneedle applications, materials, and fabrication methods

  • Zahra Faraji Rad,
  • Philip D. Prewett and
  • Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

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  • their high cost and fabrication difficulties, simpler solid microneedles coated with drugs are currently attracting more attention for drug delivery. However, this design will not be suitable for extracting biological fluids. In addition, controlling the dosage of drugs for delivery will be limited by
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Published 13 Sep 2021

Fate and transformation of silver nanoparticles in different biological conditions

  • Barbara Pem,
  • Marija Ćurlin,
  • Darija Domazet Jurašin,
  • Valerije Vrček,
  • Rinea Barbir,
  • Vedran Micek,
  • Raluca M. Fratila,
  • Jesus M. de la Fuente and
  • Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

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  • biological fluids, obtained from animal experiments. A multimethod approach was used to examine their behaviour and transformation under experimental conditions relevant for in vivo settings by performing dynamic light scattering (DLS), electrophoretic light scattering (ELS), graphite furnace atomic
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Published 07 Jul 2021

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

  • Barbora Svitkova,
  • Vlasta Zavisova,
  • Veronika Nemethova,
  • Martina Koneracka,
  • Miroslava Kretova,
  • Filip Razga,
  • Monika Ursinyova and
  • Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

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  • affect the uptake. Once NPs enter biological fluids (blood or culture medium with serum), proteins immediately adsorb onto the surface of the NPs, forming a layer called protein corona (PC). The PC changes the surface composition and structure of NPs, directly influences the cell–NP interactions
  • involved in PC formation. Hence, coating of MNPs with BSA can be considered as a PC per se. As a dysopsonin protein, albumin promotes a prolonged blood circulation time through blocking the recognition by macrophages [42]. A comprehensive characterization of nanoparticles in biological fluids is, therefore
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Published 23 Mar 2021

Transient coating of γ-Fe2O3 nanoparticles with glutamate for its delivery to and removal from brain nerve terminals

  • Konstantin Paliienko,
  • Artem Pastukhov,
  • Michal Babič,
  • Daniel Horák,
  • Olga Vasylchenko and
  • Tatiana Borisova

Beilstein J. Nanotechnol. 2020, 11, 1381–1393, doi:10.3762/bjnano.11.122

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  • Protein Data Bank (PDB) service (see Supporting Information File 1) [28][29][30][31][32]. Discussion The conditions in biological systems can alter the properties of nanoparticles. Salts of biological fluids influence surface charges, which leads to destabilization and aggregation of nanoparticles [18
  • membrane potential (Figure 4); and a concentration of 0.5 mg/mL was used in laser correlation spectroscopy measurements in biological fluids (Figure 6 and Figure 8). Thus, γ-Fe2O3 nanoparticles in a concentration range of 1 µg/mL to 1 mg/mL were used in biological experiments and a higher concentration
  • penetrate the blood–brain barrier than uncoated ones. Glutamate adsorbed on γ-Fe2O3 nanoparticles in water is expected to be partially released from the nanoparticle surface after contact with biological fluids. Application of magnetic fields can make this a targeted process. Vice versa, γ-Fe2O3
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Published 10 Sep 2020

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

  • Maria Suciu,
  • Corina M. Ionescu,
  • Alexandra Ciorita,
  • Septimiu C. Tripon,
  • Dragos Nica,
  • Hani Al-Salami and
  • Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

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  • invested nowadays in developing coatings with certain characteristics, depending on the final application (e.g., biocompatibility/low toxicity, targeting a certain cell/compartment/molecule, or stability in biological fluids) [16]. SPIONs are superparamagnetic, which means that they are small enough to
  • biological fluids at physiological pH values and which remain stable with low toxicity in vitro [38][46][98][99][100][101][102][103]. Still, Hong and collaborators [104] stress the fact that we should pay more attention to the charge effects of SPIONs because not all types of cytotoxicity can be easily and
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Published 27 Jul 2020

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

  • Ludovica Soddu,
  • Duong N. Trinh,
  • Eimear Dunne,
  • Dermot Kenny,
  • Giorgia Bernardini,
  • Ida Kokalari,
  • Arianna Marucco,
  • Marco P. Monopoli and
  • Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

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  • aggregates in specific exposing conditions by platelet-independent pathways and stresses the importance of the need to characterise nanomaterials in relevant biological fluids (in this case blood plasma or blood). This result should be regarded with concern, since aggregates might induce vessel occlusion in
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Published 03 Apr 2020

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

  • Valentina Francia,
  • Daphne Montizaan and
  • Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

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  • biological fluids such as serum. This represents a further issue since the charge of nanomaterials tends towards neutrality upon corona formation, once they are applied in a biological environment. Thus, nanoparticles that in water possess different charges might end up having all a similar charge, close to
  • , it is important to characterize the nanoparticle dispersion in the biological media in which the nanomedicine will be applied, and to monitor potential agglomeration and stability over time. Additionally, studies in which nanoparticles are incubated on cells without serum or other biological fluids
  • also the subsequent mechanisms of internalization [18][62][63][64][65][68][69]. Similar considerations should be made when characterizing the uptake of nanomedicines administered via other routes. In these cases biological fluids other than serum should be used [185][194]. On a more complex level, it
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Published 14 Feb 2020

Rational design of block copolymer self-assemblies in photodynamic therapy

  • Maxime Demazeau,
  • Laure Gibot,
  • Anne-Françoise Mingotaud,
  • Patricia Vicendo,
  • Clément Roux and
  • Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

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Published 15 Jan 2020

Small protein sequences can induce cellular uptake of complex nanohybrids

  • Jan-Philip Merkl,
  • Malak Safi,
  • Christian Schmidtke,
  • Fadi Aldeek,
  • Johannes Ostermann,
  • Tatiana Domitrovic,
  • Sebastian Gärtner,
  • John E. Johnson,
  • Horst Weller and
  • Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

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  • stability and tumour accumulation of curcumin [17]. Overall, there is a consensus that using colloidally stable nanoparticles is crucial for understanding and controlling cellular uptake, because materials that are prone to aggregation show higher non-specific interactions with biological fluids and cell
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Published 12 Dec 2019

Dynamics of superparamagnetic nanoparticles in viscous liquids in rotating magnetic fields

  • Nikolai A. Usov,
  • Ruslan A. Rytov and
  • Vasiliy A. Bautin

Beilstein J. Nanotechnol. 2019, 10, 2294–2303, doi:10.3762/bjnano.10.221

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  • moments of the particle. However, if nanoparticles remain distributed in biological fluids (blood, serum), the intensity of AMF energy absorption is determined also by the rotation of the nanoparticles as a whole in a viscous liquid [25][26]. Various mathematical approaches are necessary for a theoretical
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Published 22 Nov 2019
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