Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• neuronal mitochondria, as evidenced by fluorescence intensities identified in brain homogenates, and reduced Aβ1 deposition, demonstrating the ability of the nanocomposite to cross the BBB [71]. Inorganic nanoparticles exhibit unique optical, magnetic, and chemical properties and stability. Gold

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• nanomaterials in non-target species is discussed. Keywords: bioassay; inorganic nanoparticles; mosquito vector; nanotechnology; physicochemical; tropical neglected diseases; Introduction Arboviroses are diseases caused by the pathogens transmitted by arthropods, and their transmission to humans occurs through

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• , into the alginate polymer network. This can be achieved through various methods, including reduction reactions, electrochemical deposition, or deposition-precipitation. The resulting hybrid nanomaterials exhibit synergistic properties of both the inorganic nanoparticles and the alginate polymer

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

• Veronika Pálos,
• Krisztina S. Nagy,
• Rita Pázmány,
• Krisztina Juriga-Tóth,
• Bálint Budavári,
• Judit Domokos,
• Dóra Szabó,
• Ákos Zsembery and
• Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

• scaffolds [18][19][20][21]. The antibacterial effectiveness of the fibrous structure is significantly influenced by incorporating salts or nanoparticles. When electrospun fibers are combined with inorganic nanoparticles [22], they can become resistant to bacteria. However, their ability to enhance

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• thickness on particle size, which was modeled by Reichenberger and coworkers [54]. In detail, during LSPC of inorganic nanoparticles in organic solvents, carbon is formed in addition to permanent gases or molecular carbon-based species. While the surface of colloids synthesized in water is only modified by

• , further research on the formation mechanism is crucial for the utilization of laser-synthesized nanoparticles. Although solid carbon has been observed most widely in the form of carbon shells around inorganic nanoparticles formed by LAL, as discussed above, other LSPC processes also produce solid carbon

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• including Abraxane, the first formulation based on protein nanotechnology launched in 2005 [86]. Nearly 10% are inorganic nanoparticles such as the radiosensitizer Hensify, which in 2019 obtained CE Mark approval in the European Union for the treatment of locally advanced soft tissue sarcoma. This category

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• been employed to produce nanoformulations of drugs for endowing a better therapeutic effect. The nanoformulations for drug delivery can be designed using nanocarrier systems, including organic materials (liposomes, nanoemulsions, nanomicelles, and nanofibers) and inorganic nanoparticles (gold, silver

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• established criteria were identified. Inorganic and polymeric nanoparticles were the most prevalent nanosystems used. Gold was the primary material used to produce inorganic nanoparticles, while poly(lactic-co-glycolic acid) and chitosan were commonly used to produce polymeric nanoparticles. None of these

• , and because of that, it is resistant to low pH values [23]. So, when nanoparticles with this material are orally administered, they resist against gastric secretions and release the drug in the intestine. This protects many drugs and increases their bioavailability [24]. Inorganic nanoparticles (IN

• nanoparticles are among the most widely utilized nanotechnological systems. Most research articles utilized gold nanoparticle as inorganic nanoparticles, while PLGA and chitosan are commonly utilized to produce polymeric nanoparticles due to its biocompatibility reported in various animal studies. However

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• membrane from PEO and CS with immobilized carbon quantum dots (CQDs) and Fe3O4 for the efficient removal of mercury ions from water [61]. The synergistic effect of nanofibrous polymer material and inorganic nanoparticles resulted in a maximum monolayer adsorption capacity of 148 mg/g. The Hg2+ sorption

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• . They are able to degrade to an ionic form and again reconstruct to a nanoparticulate form, depending on the biological environment determined by specific body compartments. As suggested for other inorganic nanoparticles by other research groups, AgNPs fail to preserve their specific integrity in in

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

• Barbora Svitkova,
• Vlasta Zavisova,
• Veronika Nemethova,
• Martina Koneracka,
• Miroslava Kretova,
• Filip Razga,
• Monika Ursinyova and
• Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

• 40–50 nm in diameter [14], or glycosylphosphatidylinositol (GPI)-anchored proteins [15]. Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their biocompatibility, colloidal stability, and bioavailability. Moreover, the coating facilitates their further

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• that there was wound healing of the infected site, while untreated areas resulted in necrotic muscular fibers and bacterial infiltration. Applications of other types of nanoparticles for photothermally induced bacteria and biofilm ablation Besides the widely studied gold nanoparticles, other inorganic

• nanoparticles exhibiting efficient photothermal properties have demonstrated promising results in the field of NIR-triggered bacterial eradication. An important advantage is that such nanoparticles are usually made from materials that are less expensive than gold and, in some cases, the time-sustained release

Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

• Mohammad Jaber,
• Asim Mushtaq,
• Kebiao Zhang,
• Jindan Wu,
• Dandan Luo,
• Zihan Yi,
• M. Zubair Iqbal and
• Xiangdong Kong

Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96

• . Particularly, metal and metal-oxide-based disinfectants containing inorganic nanoparticles (NPs) have been broadly used since they simultaneously reduce the toxicity risk related to the organic materials and control the bacterial resistance against antibiotics [8]. Among the various types of nanomaterials

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• , even if the BBB permeation potential of NLCs has only been studied to a small extent [172], it seems that this nanoparticle system might be promising for brain delivery through the systemic pathway. Inorganic nanoparticles Gold nanoparticles: Gold nanoparticles are inorganic particles the shape

• multitude of nanocarrier systems, such as polymeric, lipid-based or inorganic nanoparticles, have been developed and shown able to cross the BBB owing to their tailored surface properties. In numerous studies, the physical coating of nanoparticles with surfactants and the chemical functionalization with

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints

• Elvira Rozhina,
• Ilnur Ishmukhametov,
• Svetlana Batasheva,
• Farida Akhatova and
• Rawil Fakhrullin

Beilstein J. Nanotechnol. 2019, 10, 1818–1825, doi:10.3762/bjnano.10.176

• can be doped with nanoscale inorganic particles) [8][9]; 2) direct anchoring of inorganic nanoparticles to cell surfaces [10][11]; 3) fabrication of “hard” inorganic shells mimicking natural eggshells [12]. Synthetic polymers can be grafted onto the surface of individual cells using atom-transfer

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , phenolic compounds with a higher number of hydroxy groups have enhanced ROS scavenging capability. In addition to low-molecular-weight phenolic compounds of natural origin, some inorganic nanoparticles also have antioxidant properties, e.g., zinc, cerium, magnesium oxide, magnetite, and silver [6][7][8][9

An iridescent film of porous anodic aluminum oxide with alternatingly electrodeposited Cu and SiO₂ nanoparticles

• Menglei Chang,
• Huawen Hu,
• Haiyan Quan,
• Hongyang Wei,
• Zhangyi Xiong,
• Jiacong Lu,
• Pin Luo,
• Yaoheng Liang,
• Jianzhen Ou and
• Dongchu Chen

Beilstein J. Nanotechnol. 2019, 10, 735–745, doi:10.3762/bjnano.10.73

• -area, ordered interference-enabled colored films with uniform structural colors on the surface of inorganic nanoparticles (NPs) that had been prepared to bear surface charges [28]. On the substrates of quartz glass, PET and PP, twenty cycles of the assembly of a SiO2 film led to the formation of dark

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• materials. The core–shell structure of the hybrid organic–inorganic nanoparticles allows for the independent molecular design of each part. For instance, the oxygen permeability of the shell material can be lowered drastically by using semicrystalline nanocellulose [31]. Furthermore, a bovine serum albumin

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

• Tomasz M. Stawski,
• Daniela B. van den Heuvel,
• Rogier Besselink,
• Dominique J. Tobler and
• Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

• inorganic nanoparticles (NPs) and proteins in aqueous media is of paramount interest for colloid chemistry. In particular, the interactions between silica (SiO2) NPs and lysozyme (LZM) have attracted attention, because LZM is well-known to adsorb strongly to silica NPs, while at the same time preserving its

• : composite; lysozyme; scattering; silica; small-angle X-ray scattering (SAXS); Introduction A mechanistic understanding of aggregation in aqueous media leading to the formation of composites of inorganic nanoparticles and proteins is of paramount interest for colloid chemistry, Earth sciences, or the design

Threshold voltage decrease in a thermotropic nematic liquid crystal doped with graphene oxide flakes

• Mateusz Mrukiewicz,
• Krystian Kowiorski,
• Paweł Perkowski,
• Rafał Mazur and
• Małgorzata Djas

Beilstein J. Nanotechnol. 2019, 10, 71–78, doi:10.3762/bjnano.10.7

• -optical performance is doping them with nanoparticles. Hsu et al. showed that the small addition of gold nanoparticles decreases Uth due to the increased electric anisotropy and decreased elastic constant [5]. Haraguchi and collaborators doped the twisted nematic liquid crystal cell with inorganic

• nanoparticles of MgO and SiO2 [6]. Here, the effect was caused by the reduction of the order parameter S. The concentration-dependent enhancement of the electro-optic response was observed for Ti and TiO2 nanoparticles dispersed in NLC [7][8]. The significant effect of ferroelectric Sn2P2S6 on the threshold

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• prior to arriving at the targeted site resulted in serious nonspecific cytotoxicity [4]. Alternative drug delivery strategies using inorganic nanoparticles have also been applied. A magneto-electric nanoparticle (MEN) system was reported as a controlled drug delivery platform for the drug paclitaxel in

Synthesis of metal-fluoride nanoparticles supported on thermally reduced graphite oxide

• Alexa Schmitz,
• Kai Schütte,
• Vesko Ilievski,
• Juri Barthel,
• Laura Burk,
• Rolf Mülhaupt,
• Junpei Yue,
• Bernd Smarsly and
• Christoph Janiak

Beilstein J. Nanotechnol. 2017, 8, 2474–2483, doi:10.3762/bjnano.8.247

• ]. The synthesis of inorganic nanomaterials is thoroughly investigated but still requires well-established, simple protocols with inexpensive and non-toxic chemicals for many of the important inorganic nanoparticles [51][52]. Metal-fluoride nanoparticles, MFx-NPs are important in materials science and

The longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX)

• Florent Pessina and
• Denis Spitzer

Beilstein J. Nanotechnol. 2017, 8, 452–466, doi:10.3762/bjnano.8.49

• wide range of organic compounds. In particular, cocrystals of medical materials are of interest for drug enhancement and were successfully processed through SFE at the nanoscale [118]. Inorganic nanoparticles were also produced on the nanoscale through SFE by Klaumuenzer et al. [119]. ZnO was