A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• -positive ovarian cancer and lung metastases. They demonstrated that pre-polarizing CAR-Ms to an M1 phenotype significantly enhanced their antitumor efficacy, in vitro and in vivo, using murine models of intraperitoneal ovarian cancer and lung metastases. M1-polarized CAR-Ms reduced tumor burden, prolonged

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• to interact with various spectra of intracellular structural regulators of biochemical processes. Rutin and Fe3O4 NPs, individually, do not exhibit direct hepatotoxicity upon intraperitoneal administration in rats, unlike their complexes. Regarding lipid profiles, all agents tested induce a

• individuals each, with intraperitoneal administration every three days for two months of 100 μL of the agents described in Table 3. A non-toxic dose of Fe3O4 NPs of 15 ± 4 nm size was experimentally determined, considering the maximum permissible dose of 40 mg/kg in male laboratory mice [62]. All solutions of

• ) Guidelines on Euthanasia, using intraperitoneal injection of 70% ethanol [61]. For further biochemical analyses, blood was collected from the portal vein into vacutainers with the anticoagulant Na2EDTA. For histological studies, part of each liver tissue sample was fixed in 10% formalin, and another part was

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• assay and MTT assay suggested that the CUR-RGD-PLHNPs exhibited significantly higher anticancer therapeutic potential against B16 cells than the free drug. Further, CUR-RGD-PLHNPs showed much higher in vivo antitumor efficacy against B16 tumor-bearing female BALB/c mice on intraperitoneal injection for

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• upon daily systemic administration through the intraperitoneal route in mice [54]. Another polymeric platform to improve the bioavailability of curcumin was developed through simple nanoemulsification using biodegradable polylactide–poly(ethylene glycol) (PLA-PEG) copolymer NPs [55]. Besides reversing

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• (intraperitoneal and subcutaneous). Therefore, drug dosage forms with these characteristics may present compliance issues and problems with commercialization. Thus, an interesting pathway could be testing the same nanoformulations but using the oral route. After antimonials such as tartar emetic, oxamniquine was

• activity of the sulfated polysaccharide α-ᴅ-glucan, a polysaccharide naturally found in extracts of lichen from Ramalina celastri. This work shows that liposomes with this carbohydrate could eliminate adult worms from infected mice 56 days post-infection when it was administered by the intraperitoneal

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• doses tested in most in vivo studies [40]. After treatment the animals were sacrificed under general anaesthesia (Narketan, Vetoquinol UK Ltd., 80 mg/kg b.w.; Xylapan, Vetoquinol UK Ltd., 12 mg/kg b.w., intraperitoneal) following whole blood and tissue collection. The blood was collected by intracardiac

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• study by Dal Magro et al., the brain bioavailability in mice of SLNs functionalized with an ApoE-derived peptide was studied depending on the administration route of the nanoparticles. The nanoparticles were administered either by the intraperitoneal, the intravenous or the intratracheal route [66

• administration compared to the intravenous and the intraperitoneal route, without inducing any acute inflammatory reaction in the lungs. The mechanism behind this increased brain confinement are not well understood. However, the authors concluded that pulmonary administration seemed to be a feasible strategy for

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• extracted from fungi, to intraperitoneal tumors [39]. It was shown that the sensitizer concentration reached a maximum after 2 h in the targeted organs, as opposed to after at least 6–12 hours in other peritoneal organs, thereby creating a large window of opportunity for treatment with reduced side effects

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• shown in Tables 1–5 and Figures 6–10. One hour after the intraperitoneal administration of PEG-nGO (5 mg/kg), the concentrations of lipid peroxidation marker malondialdehyde (MDA), reduced free radical scavenging enzymes (CAT, SOD, GST), and the tripeptide scavenger glutathione (GSH) was significant (P

• accompanied by reduced activity levels of antioxidant enzymes directly indicated that all organs were in oxidative stress after the intraperitoneal administration of PEG-nGO. These studies further reiterated the cytotoxicity of graphite oxide in vivo. Further safety evaluation and research must be undertaken

• administrated dose of PEG-nGO was estimated from previous studies [28][29]. Three groups were administered PEG-nGO (1 mL, 5 mg/kg) saline suspension while one group was administered saline (1 mL) only through an intraperitoneal (i.p.) injection. All groups were administrated once. The group that was

Hyperthermic intracavitary nanoaerosol therapy (HINAT) as an improved approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC): Technical description, experimental validation and first proof of concept

• Daniel Göhler,
• Stephan Große,
• Alexander Bellendorf,
• Thomas Albert Falkenstein,
• Mehdi Ouaissi,
• Jürgen Zieren,
• Michael Stintz and
• Urs Giger-Pabst

Beilstein J. Nanotechnol. 2017, 8, 2729–2740, doi:10.3762/bjnano.8.272

• chemotherapy for the treatment of peritoneal carcinomatosis. However, recent reports reveal limitations of the currently available technology. Material and Methods: A novel approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC), called hyperthermic intracavitary nanoaerosol therapy (HINAT

• nm) unipolar-charged hyperthermic (41 °C) drug aerosol for quasi uniform drug deposition over the whole peritoneum with significantly deeper drug penetration than that offered by conventional PIPAC. Keywords: HINAT; intracavitary; intraperitoneal; nanoaerosol; PIPAC; pressurized; therapy

• distribute the drug-containing solution homogeneously throughout the tumoral tissue [5]. One promising and upcoming approach to treat end-stage patients suffering from enhanced PC is the Pressurised IntraPeritoneal Aerosol Chemotherapy (PIPAC), where the drug-containing solution is aerosolised within a

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• death. MMC is a cytotoxic antibiotic commonly used for the instillation treatment of non-muscle-invasive bladder cancer [30] as well as for intraperitoneal lavage of peritoneal carcinomatosis from appendiceal, colorectal and gastric cancers [31]. Following enzymatic activation MMC eventually induces a

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• ] treated rats with TiO2 NPs through intraperitoneal injection. After which, rats exhibited altered emotional behavior in a plus maze test; however, histopathological examination demonstrated no significant differences between treated and control groups. The study failed to discuss other mechanisms

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• average, 1885 mm3 of very severe tumor volume was observed. At 12 days after inoculation, PTX, DDMC/PTX4 (particle size 50 nm), DDMC/PTX5 (particle size 290 nm), and saline were administrated by intraperitoneal (I.P.) injection 3 times at a dose of 10 mg PTX/kg on days 12, 14, and 16. MST 50% survival

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• injected into wild type C57BL/6 mice via a tail vein catheter. Nuclei were stained by intraperitoneal injection of the fluorescence dye Hoechst 33342. 30 min after injection, the liver was excised and directly placed on the confocal microscope. As shown in (B), LDL are internalized by hepatocytes (red