Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions

• Arkady V. Krasheninnikov,
• Matthias Batzill,
• Anouar-Akacha Delenda,
• Marija Drndić,
• Chris Ewels,
• Katharina J. Franke,
• Mahdi Ghorbani-Asl,
• Alexander Holleitner,
• Ado Jorio,
• Ute Kaiser,
• Daria Kieczka,
• Hannu-Pekka Komsa,
• Jani Kotakoski,
• Manuel Längle,
• David Lamprecht,
• Yun Liu,
• Steven G. Louie,
• Janina Maultzsch,
• Thomas Michely,
• Katherine Milton,
• Anna Niggas,
• Hanako Okuno,
• Joshua A. Robinson,
• Marika Schleberger,
• Bruno Schuler,
• Alexander Shluger,
• Kazu Suenaga,
• Kristian S. Thygesen,
• Richard A. Wilhelm,
• E. Harriet Åhlgren and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2026, 17, 454–488, doi:10.3762/bjnano.17.31

• beyond a “trial and error” approach. What are the oxidation mechanisms and kinetics of defective surfaces in 2D materials? Substitutional oxygen defects are present in 2D materials synthesized via chemical vapor deposition (CVD) [51]. This can be a result of oxide precursors, which are frequently used

• . Despite the high reactivity of larger S vacancy clusters, several challenges remain in describing the oxidation kinetics. O2 is bound weakly to TMD surfaces with a binding energy of ≈0.14 eV [55][63][64][65]. Ab initio molecular dynamics (MD) simulations show that O2 is therefore mobile on the pristine

• vacancies exhibit reduced effective charges and are more chemically active. This enables barrier-less reactions of O2, explaining the rapid oxidation at larger vacancy clusters. Additional uncertainty in modelling oxidation kinetics arises from the possibility of changes in the spin state of the O2 molecule

Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability

• Thayse Viana de Oliveira,
• Ana Paula Farias Leão,
• Júlia Leão,
• Cesar Liberato Petzhold and
• Ruy Carlos Ruver Beck

Beilstein J. Nanotechnol. 2026, 17, 440–453, doi:10.3762/bjnano.17.30

• nanocarrier incorporation alone, is the primary determinant of enhanced photostability. A limitation of this study is the absence of in vitro release kinetics and skin permeation data, which are essential to fully characterise the biopharmaceutical performance of the films. These experiments were not required

• characterise drug release kinetics and skin permeation/penetration behaviour, which will be essential for advancing this printed multilayer system toward broader application in topical drug-delivery research. (A–C) Rheological behaviour with oscillation frequency data for storage (G′), loss modulus (G″), and

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• limited functional capabilities. This realization has driven the development of additional surface modifications aimed at improving targeting specificity to particular cells or tissues, enhancing stability in the bloodstream, controlling drug release kinetics, and tailoring nanoparticle systems to meet

• capacities ensure adequate PS payloads for sufficient ROS generation at tumor sites, release kinetics govern bioavailability within the tumor microenvironment, spatiotemporal control of photoactivation, and minimization of off-target phototoxicity during systemic circulation. Addressing tumor hypoxia: BNP

Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets

• Paulina Trzaskowska,
• Ewa Rybak,
• Maciej Trzaskowski,
• Kamil Kopeć,
• Jakub Krzemiński,
• Rafał Podgórski,
• Hatice Genc,
• Mehtap Civelek and
• Iwona Cicha

Beilstein J. Nanotechnol. 2026, 17, 365–380, doi:10.3762/bjnano.17.25

• multiplied, as shown in Figure 8b. Similar to our study, surface Ra affecting the initial threshold has been reported by other authors [38]. It is known that both nano/microroughness and wettability of the material surface can influence cell adhesion since these parameters affect the adsorption kinetics of

Advancing nanolithography: a comprehensive review of materials for local anodic oxidation with AFM

• Matteo Lorenzoni

Beilstein J. Nanotechnol. 2026, 17, 275–291, doi:10.3762/bjnano.17.19

• heterostructures. Semiconductors such as silicon and silicon carbide remain foundational due to their controllable oxidation kinetics, while metals like titanium and aluminum offer opportunities for plasmonic and optical applications. 2D materials, including graphene, graphene oxide, and transition metal

• features. Different materials exhibit varying oxidation kinetics, conductivity, and susceptibility to environmental conditions. For example, TMDs such as MoS2 and WSe2 are especially sensitive to phonon scattering, which significantly influences their thermal conductivity, electrical transport properties

Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• environment for catalyst dispersion, thereby enhancing reaction kinetics. This is likely due to the residual oxygen content of rGO (Supporting Information File 1, Figure S6), which enables the effective anchoring of AuNPs and results in higher catalytic efficiency. In addition, the AC-based composites tend to

Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• , Bayesian models and probabilistic methods have become essential for handling incomplete or fluctuating datasets, allowing analysts to quantify the uncertainty around key factors such as release rates, exposure scenarios, and degradation kinetics [53]. These advanced statistical techniques yield more

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• . However, optimizing tight junctions to mirror human BBB characteristics remains a challenge [10][11]. On the other hand, the SH-SY5Y neuroblastoma cell line, which can further differentiate into neuronal-like morphologies, is often used to evaluate nanodelivery systems uptake kinetics and drug efficacy

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• previously described [24]. 2.3.4.3 Release profile of R-PE and 5-FU. The release profile of R-PE and 5-FU from liposomes and immunoliposomes was analyzed using the Korsmeyer–Peppas (Equation 3) model, commonly employed in drug release kinetics studies, using the DDSolver software [24]. The Korsmeyer–Peppas

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• heating capability, a critical requirement for hyperthermia applications. The temperature increases of 6.5 and 9.6 °C under 536 and 796 kHz, respectively, surpass the thermal threshold required to induce apoptosis in cancer cells (42–46 °C). The fast heating kinetics observed here are comparable to those

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• effective exposure of surface facets to the reaction medium. Green-synthesized nanoparticles in various studies have consistently shown elevated FRAP responses compared to their bulk counterparts, due to improved electron transfer kinetics at the nano–bio interface [51][52]. When considered alongside DPPH

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• biological models. Determining the appropriate dosage is another crucial factor as therapeutic performance is influenced by drug loading capacity, drug release kinetics, and loading efficiency. Careful optimisation of these parameters is required to achieve effective drug delivery while minimising harm to

• provide insight into drug release kinetics based on NM properties and formulation. Animal toxicity studies help determine in vivo safety profiles across organ systems, while biodistribution and pharmacokinetic studies elucidate how CNMs are metabolised, cleared, and accumulate in the body, guiding safe

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• were prepared accordingly [50]. For similar hydrolysis and condensation kinetics compared to the organosilane sol–gel precursors (see below), tetraisopropoxysilane (Si(OiPr)4) was used as a sol–gel precursor. After solvent exchange of the wet gel, supercritical drying with carbon dioxide delivered the

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• scaffolds remains challenging, as modifications that improve release kinetics or protect the core can sometimes compromise biocompatibility or cellular interactions [55]. To evaluate the structure of the nanofibers produced, confocal microscopy was used under a fluorescent filter to study the morphologies

• surface distribution may compromise encapsulation efficiency and alter release kinetics [76]. Surface hydrophilicity The hydrophilicity of the membranes was evaluated through contact angle measurements. Figure 10 shows photographs of a water droplet in contact with the surface of the samples: (a

• nanofibers in tissue engineering and controlled drug delivery. Despite these promising results, the present study has some limitations. The encapsulation efficiency and release kinetics of the bioactive compounds were not quantified, and biological assessments were not performed at this stage. Furthermore

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• properties of the surrounding liquid and NPs, and kinetics of relaxation processes in the surrounding medium), thus providing a playground for tailoring NP properties. In general, laser pulses of moderate fluences and longer durations are preferable for shape modification, providing mild conditions and

• by estimation of the absorbed and dissipated heat fluxes from the laser heated NPs. Apart from the laser parameters, these fluxes are determined by NP size and composition as well as by properties of the surrounding liquid which define the kinetics of relaxation processes. The balance between

• into account. [73]. The presence of the gaseous bubble around the heated particles influences the kinetics of the relaxation processes as well as the absorption of the laser beam by the NPs. In [67], the conditions required for melting silver and copper NPs with the formation of a metastable AgCu alloy

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• shell of LNPs plays a pivotal role. As hydrophilic and protective shield during LNP circulation and in vivo activities, the conformation and binding kinetics of PEG layer are both important, particularly in modulating protein adsorption and subsequent interactions with cellular uptake pathways [23

Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions

• Josef Novák,
• Eva Štěpanovská,
• Petr Malinský,
• Vlastimil Mazánek,
• Jan Luxa,
• Ulrich Kentsch and
• Zdeněk Sofer

Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123

• -order kinetic equation: where C represents the final concentration at time t, C0 is the initial concentration of rhodamine B, and k is the apparent rate constant of degradation [11]. The relation ln(A/A0) was used to represent the degradation rate kinetics, where A is the measured optical absorbance

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• made PNs a topic of growing interest in light of their small size and unique physicochemical properties [22][23]. These systems offer advantages for drug delivery, including the ability to protect labile compounds, control release kinetics, improve drug solubility and stability, enhance oral

• overall release kinetics [24][32][33]. From a pharmacokinetic perspective, the size, surface charge, and morphology of PNs can modulate their transit through the GIT, and such properties can be tuned during nanoparticle preparation. The choice of manufacturing method considers not only these parameters

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• , bare copper rapidly oxidized to Cu2O at room temperature and further to CuO at ~200 °C. However, with hBN or graphene layers, oxidation was significantly delayed. Both 2D materials retard the oxidation of Cu by more than 120 °C, but with different kinetics. The behavior of hBN/Cu is relatively simple

• simultaneously. This is summarized in Figure 5 where the 2D intensity plot vs temperature of O 1s and N 1s or C 1s, for hBN or graphene, respectively, are reported. Time-resolved catalysis Catalysts are inherently dynamic systems. The optimal catalyst should have a nanostructure that enhances activation kinetics

• under operando conditions. Additionally, the kinetics of charge transfer and the role of specific chemical species or components functioning as charge donors or acceptors during photocatalytic reactions can be clarified using APXPS. At MAX IV, external light sources (e.g., UV lamps or solar simulators

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• on the particle size; thus, small particles have a larger surface area for dissolution, providing faster release kinetics [39]. Uniformity of particle size is also important for the stability of the formulation, as well as for the choice of administration route. The intravenous and intramuscular

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• capabilities due to electrostatic interactions, making them highly effective in capturing MPs. Their fast adsorption kinetics support rapid water purification, and surface modifications can further enhance their performance and selectivity. These membranes are also versatile and applicable in various treatment

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• , which demonstrates effective mineralization even at high pollutant loads. This trend aligns with the photocatalytic degradation kinetics (Figure 5b), where the reaction rate constant was the highest at lower concentrations (0.169 h−1 for 50 ppm vs 0.103 h−1 for 200 ppm). While the degradation rate was

• ofloxacin in water with various initial concentrations (50, 75, 100, and 200 ppm) assisted by CC/NW-450 °C under UV irradiation. (b) The corresponding fit curves assume pseudo-first-order reaction kinetics. (c) TOC removal after 6 and 12 h. (d) Cycling performance. Initial OFL concentration: 50 ppm

• ppm ofloxacin assisted by TiO2 nanowires on carbon cloth (CC/NW-450 °C), TiO2 nanowires on Ti plate (Tip/NW-450 °C), and the benchmark P25 on Ti plate (P25). (b) The corresponding fit results assuming pseudo-first-order reaction kinetics. Supporting Information Supporting Information File 26

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• materials, both functional and structural, that are inherently designed to disintegrate upon exposure to aqueous or enzymatically active environments. These systems are tailored to follow specific degradation kinetics, governed by hydrolysis or enzymatic cleavage depending on the chemical nature of each

• transient systems must be optimized to balance electrical performance, biodegradation kinetics, and mechanical integrity. Moreover, to transcend basic sensing and stimulation functions, and to enable capabilities such as computation, memory, and autonomous decision-making, the development of high