Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions

• Arkady V. Krasheninnikov,
• Matthias Batzill,
• Anouar-Akacha Delenda,
• Marija Drndić,
• Chris Ewels,
• Katharina J. Franke,
• Mahdi Ghorbani-Asl,
• Alexander Holleitner,
• Ado Jorio,
• Ute Kaiser,
• Daria Kieczka,
• Hannu-Pekka Komsa,
• Jani Kotakoski,
• Manuel Längle,
• David Lamprecht,
• Yun Liu,
• Steven G. Louie,
• Janina Maultzsch,
• Thomas Michely,
• Katherine Milton,
• Anna Niggas,
• Hanako Okuno,
• Joshua A. Robinson,
• Marika Schleberger,
• Bruno Schuler,
• Alexander Shluger,
• Kazu Suenaga,
• Kristian S. Thygesen,
• Richard A. Wilhelm,
• E. Harriet Åhlgren and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2026, 17, 454–488, doi:10.3762/bjnano.17.31

• controlled defect engineering. We will see that it is not each single factor, spatial precision, uniformity of defect species, and scalability, that creates the challenge, but their combination. STM is a tool that provides atomic precision and has been used successfully for atomic manipulation. Recent

• experiments were able to create extended lattices of CO molecules on Cu(111), whereby, for instance, the surface-state free electron gas could be transformed into an electronic structure mimicking the one of graphene [154]. Also, precise manipulation at large scale (thousands of defects) for vacancies in a

• chemisorption layer of Cl on Cu(111) was reported [155]. These experiments suggest that it could be possible to apply such atomic manipulation methods to 2D materials. Figure 8 provides an example of how this can be accomplished. Figure 8a is an STM topograph of MBE-grown MoS2 islands on graphene, on which

Ferroelectric nanodot reservoir for neuromorphic computing

• Anna Razumnaya,
• Yuri Tikhonov,
• Dmitrii Naidenko,
• Léo Boron,
• Valerii Vinokur and
• Igor Lukyanchuk

Beilstein J. Nanotechnol. 2026, 17, 352–364, doi:10.3762/bjnano.17.24

• manipulation, the charge-driving electrode may be fabricated from a semiconducting material with partial screening, allowing for both global and locally addressable control. This configuration supports combined time- and space-multiplexed data handling, expanding the functional versatility of ferroelectric

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

Multilayered hyperbolic Au/TiO₂ nanostructures for enhancing the nonlinear response around the epsilon-near-zero point

• Fernando Arturo Araiza-Sixtos,
• Mauricio Gomez-Robles,
• Rafael Salas-Montiel and
• Raúl Rangel-Rojo

Beilstein J. Nanotechnol. 2026, 17, 251–261, doi:10.3762/bjnano.17.17

• , negative refractive index, and near-zero permittivity. The main benefit of HMMs is that, with the correct manipulation of the design, we are able to choose the wavelength in which we would like these phenomena to appear. Hyperbolic dispersion can be achieved by combining a dielectric, which has a

• that, with the right manipulation of the geometry, we are able to make the electric permittivity near zero (“epsilon near zero”, ENZ). The ENZ point causes light to travel through the medium with constant phase, it enhances the electric field, and it enhances the nonlinear response by combining

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• systems behave in biological environments is limited, and further research is needed to explore the fundamental mechanisms of nano–bio interactions and develop strategies for their manipulation. In order to obtain valuable insights into the behavior of nanodelivery systems, as well as the nano–bio

• sensitivity of the bioanalyzer is high and it covers a wide range of concentrations, the results obtained for this formulation may be due to problems with denaturation of proteins present in the formed PC, as well as the manipulation and processing of the sample. Namely, false negatives might arise because

Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy

• Aydan Çiçek,
• Markus Kratzer,
• Christian Teichert and
• Christian Mitterer

Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1

• of copper nanoparticles to silicon substrates deposited under varying conditions using DC magnetron sputter inert gas condensation. Atomic force microscopy was utilized as a tool for the manipulation of the nanoparticles and to measure lateral forces for their displacement, with cantilever

• calibration achieved through wedge and diamagnetic lateral force calibrator methods. The work of adhesion was quantified by integrating the obtained lateral forces over the distance moved during manipulation, revealing a non-monotonic dependency on nanoparticle size with maximum adhesion observed for

• [15][16][17]. However, achieving consistently accurate manipulation of NPs has inherent limitations due to limited knowledge of the exact geometry of the AFM tip as well as the complex interactions involving surface contact area and interfacial friction between the AFM tip, NPs, and the substrate [18

Visualizing nanostructures in supramolecular hydrogels: a correlative study using confocal and cryogenic scanning electron microscopy

• Shaun M. Smith,
• Ferdinando Malagreca,
• Jacqueline Hicks,
• Giuseppe Mantovani,
• David B. Amabilino,
• Christopher Parmenter and
• Lluïsa Pérez-García

Beilstein J. Nanotechnol. 2025, 16, 2274–2284, doi:10.3762/bjnano.16.156

• morphology. Minimal compression or sample manipulation is needed for DPP-BC@Gel CLSM imaging, so the morphology seen in CLSM agrees well with the near-native state captured by cryo-SEM. Despite ZnPc@Gel looking poorly defined in CLSM images, cryo-SEM micrographs (Figure 5) consistently revealed a dense

Hartree–Fock interaction in superconducting condensate fractals

• Edward G. Nikonov,
• Yajiang Chen,
• Mauro M. Doria and
• Arkady A. Shanenko

Beilstein J. Nanotechnol. 2025, 16, 2177–2182, doi:10.3762/bjnano.16.150

• Edward G. Nikonov Yajiang Chen Mauro M. Doria Arkady A. Shanenko HSE University, 101000 Moscow, Russia Meshcheryakov Laboratory of Information Technologies, Joint Institute for Nuclear Research, Dubna, Russia Zhejiang Key Laboratory of Quantum State Control and Optical Field Manipulation

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• colloid, preventing aggregation [7]. Charge manipulation can be achieved by applying electric fields or varying laser beam polarization. It can also be used at later stages of the NP formation, ensuring self-assembly and growth into oriented structures. In general, the growth of NPs produced by laser

• synthesis, but also transformation of the NP shapes during ageing and storage. According to the described mechanism, the induction of nonspherical shapes is possible by either variation of the conditions of plasma propagation and expansion or by manipulation of the growth and assembly of the formed NP seed

• manipulation in PLAL synthesis 3.1 Control of the liquid composition and parameters One of the versatile routes towards shape-controlled laser-assisted synthesis is the variation of the liquid parameters, including solution composition, pH values, and temperature. The most commonly used strategies are based

Programmable soliton dynamics in all-Josephson-junction logic cells and networks

• Vsevolod I. Ruzhickiy,
• Anastasia A. Maksimovskaya,
• Sergey V. Bakurskiy,
• Andrey E. Schegolev,
• Maxim V. Tereshonok,
• Mikhail Yu. Kupriyanov,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1883–1893, doi:10.3762/bjnano.16.131

• JJ-based architectures face fundamental density constraints imposed by magnetic flux manipulation requirements and complex mutual inductive crosstalks. Circuits composed entirely of Josephson junctions (all-JJ circuits) [10][11][12][13][14][15][16] represent a promising platform for energy-efficient

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• ; sustainable development; Introduction Nanotechnology is an interdisciplinary field of science that involves the manipulation of materials at the nanoscale, typically ranging from 1 to 100 nm in inorganic nanomaterials, to generate structures with unique physicochemical properties [1][2][3]. Among the most

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• barriers, their biocompatibility, and low toxicity [18]. Their manipulation at the nanoscale changes specific surface properties, possibly improving the ability to cross biological barriers targeting the affected tissues [18][19]. In this context, nanoparticle controlled release based on biodegradable

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• techniques for the removal of MPs. Nanoparticle-based removal Advancements in characterization and synthesis techniques have enabled the manipulation of materials at the nanoscale, leading to innovations across various domains, including energy, electronics, and biomedical applications. Figure 5 depicts

Deep learning for enhancement of low-resolution and noisy scanning probe microscopy images

• Samuel Gelman,
• Irit Rosenhek-Goldian,
• Nir Kampf,
• Marek Patočka,
• Maricarmen Rios,
• Marcos Penedo,
• Georg Fantner,
• Amir Beker,
• Sidney R. Cohen and
• Ido Azuri

Beilstein J. Nanotechnol. 2025, 16, 1129–1140, doi:10.3762/bjnano.16.83

• approach to obtain high-resolution images and overcome the slow scanning times is to apply image manipulation techniques to upscale low-resolution images to high (pixel) resolution. In a set of studies [16][17][18][19], traditional methods and deep learning models were successfully used to reconstruct high

• by image manipulation of the other. Then, we applied a set of traditional methods and SR pre-trained deep learning models on the low-resolution AFM images to obtain their enhanced-resolution image pairs. We performed a comparative study between traditional methods and SR pre-trained deep learning

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• materials is achieved through the selection and combination of a range of techniques, including the manipulation of atoms and molecules, physical and chemical material transformation, self-assembly and self-organization, orientation and organization by external forces and fields, micro- and nanoscale

• . Liquid crystal nanoarchitectonics is not merely concerned with the manipulation of liquid crystal structures; it also encompasses the transfer of such structures to alternative materials, thereby influencing their nanostructure [238][239][240]. Metal oxides of earth-abundant elements are of significant

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• introduces specific questions and results pertaining to the understanding of laser material processing relevant to NP synthesis and manipulation. Since a manifold of individual mechanistic processes can be initiated by intense pulsed laser excitation, it is challenging to disentangle the structural

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• Conventional production and modification methods typically involve the manipulation of a single independent variable while holding all other variables constant [19]. However, chemical processes frequently involve a multitude of interacting factors, necessitating the simultaneous evaluation of potential

Engineered PEG–PCL nanoparticles enable sensitive and selective detection of sodium dodecyl sulfate: a qualitative and quantitative analysis

• Soni Prajapati and
• Ranjana Singh

Beilstein J. Nanotechnol. 2025, 16, 385–396, doi:10.3762/bjnano.16.29

• manipulation of particles with a size less than 100 nm. These tiny particles possess unique physicochemical features, including optical, electrical, magnetic, and catalytic properties [23]. Indeed, the advanced properties of nanoparticles enables them to be used in different areas, such as biosensing, drug

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• utilized in various specialized applications, such as scaffolds in tissue engineering [185], controlling drug release mechanisms through the manipulation of core and shell compositions [186], and protecting sensitive biomolecules in food packaging [187]. The combination of core–shell chitosan-based

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

• approach and the tool are highlighted. Keywords: data collection and quality control; data provenance; experimental workflow visualisation; FAIR; nanomaterial life cycle stages; study design; Introduction The manipulation of matter at the nanoscale and the emergence of nanoscale materials, whose

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• nanotechnology, introduced by Richard Feynman in 1959 during an American Physical Society meeting [1][2], involves the manipulation of matter at the atomic level. The term "nanometer" was initially proposed by Richard Zsigmondy in the context of measuring gold colloids. Nanotechnology is generally defined as the

• manipulation of matter on a nanoscale, typically ranging from 1 to 100 nm [2]. At this scale, nanoparticles can effectively interact with DNA and protein molecules [3][4]. Matter can exhibit distinct physical, chemical, and biological properties at the nanoscale compared to the macroscale, with significant

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• specific computational methods, operating on structured input files and producing output files as results. Other operations may require the manipulation of files and data structures. In the case of the considered workflow, we need, for example, input files containing information about the structure of the

• molecule under study. This information is further processed by specialized software, implementing computational methods, which provide an output in terms of molecular properties. These methods can include, for example, structure manipulation tools (such as simulation box builders) and MD-specific

• structured in terms of instances of the Atom class, which contains information about individual atoms of the molecule. In turn, the position of individual atoms corresponds to instances of the CartesianCoordinates class. (iii) Information on the tools for the manipulation of data structure and on MD

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• are zero-bandgap, like goldene [15] and ψ-graphene [16]. The absence of bandgaps in 2D materials makes them unsuitable for conventional semiconductor applications and limits their use in photonics and optical devices [17]. Therefore, bandgap engineering (manipulation of electronic band structures

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• electromagnetic simulation. The forbidden-frequency region indifferent from the bulk material has been observed around 1.55 µm. A high refractive index and non-linear optical and electro-optical properties enable LN to be used for more efficient manipulation of light. The highly reflective quarternary stack can

• play an important role in diverse fields such as photonics, optomechanics, optoelectronics, signal processing, and quantum technologies, spanning the spectrum from photon generation (including single-photon sources and lasers) to their manipulation (encompassing waveguiding, beam splitting, filters

• interface engineering are crucial for success [25][26][27]. The primary motivation for choosing lithium niobate is to utilize materials whose optical properties are sensitive to one or more externally controllable factors, such as electric or magnetic fields, enabling the manipulation of the structure

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• pheomelanin) [21][22][23] (but see [24][25] for other pigments). Especially structural coloration provides a wealth of inspiration for creating vivid, durable colors without the use of dyes. This natural phenomenon involves the manipulation of light by micro- and nanostructures on the cuticle (e.g

• observed in big-headed ants (Pheidole) offer insights into creating robust and efficient cutting tools that can perform specialized tasks with precision [71]. Other species awaiting study may possess even greater potential for fine object manipulation. For example, Probolomyrmex and Thaumatomyrmex (Figure