Influence of ion beam current on the structural, optical, and mechanical properties of TiO₂ coatings: ion beam-assisted vs conventional electron beam evaporation

• Agata Obstarczyk and
• Urszula Wawrzaszek

Beilstein J. Nanotechnol. 2025, 16, 1097–1112, doi:10.3762/bjnano.16.81

• ; Introduction One of the commonly used methods for the deposition of various materials for thin film optical coatings, is electron beam evaporation (EBE) [1][2][3][4][5]. Today, in many applications, including medicine, telecommunications, optoelectronics, photovoltaics, the requirements for optical coatings

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• enhance its potential as a nano–bio interface in tissue engineering and regenerative medicine [28][29]. The crystalline structure of hexagonal boron nitride (hBN) consists of in-plane B–N bonds that are sp2 hybridized, polarized, and strongly covalent. Its most stable form is a hexagonal lattice of

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• nanoarchitectonics also makes a contribution to the field of medicine. For instance, patients with diabetic bone defects require novel and efficacious medical implant material strategies to enhance their prognosis. It is imperative to minimize the risk of implant failure due to excessive oxidative stress and the

• materials nanoarchitectonics, spanning the fields of electronics and medicine. Gel nanoarchitectonics Gels are representative soft materials that exhibit flexibility and softness. They are soft and flexible substances comprising polymers and molecular aggregates that are predominantly solvated and

A calix[4]arene-based supramolecular nanoassembly targeting cancer cells and triggering the release of nitric oxide with green light

• Cristina Parisi,
• Loredana Ferreri,
• Tassia J. Martins,
• Francesca Laneri,
• Samantha Sollima,
• Antonina Azzolina,
• Antonella Cusimano,
• Nicola D’Antona,
• Grazia M. L. Consoli and
• Salvatore Sortino

Beilstein J. Nanotechnol. 2025, 16, 1003–1013, doi:10.3762/bjnano.16.75

• for tumor cell-targeted drug delivery while sparing normal cells, an essential requirement for a more effective, safe, and precise medicine. Host–guest supramolecular complex and NO photorelease The NOPD 2 is totally insoluble in water. For sake of clarity, Figure 3A shows its absorption spectrum in

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• , this adsorbent offers a sustainable alternative to synthetic materials that pose environmental risks. In addition to wastewater treatment, this material could be utilized in medicine, pharmaceuticals, air purification, and environmental monitoring. Results and Discussion Experimental optimization

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• , focused on improving human health through innovative technologies [1]. It is a broad interdisciplinary field that includes biology, medicine, engineering, and materials science, which all work together to address the intricate medical needs of societies [2]. The ultimate goal of biomedical research is to

• the development of implants, medical devices, and drug delivery systems that solve challenging issues from health to medicine [5]. Because of innovations in tissue engineering, genetic engineering, and nanotechnology, scientists can now see into the innermost functions of living organisms with a level

• that respond to light are novel technologies in medicine. They are administered to improve the healing of wounds by responding to particular light wavelengths. Such sophisticated materials are enabled by micro- and nanoscale structures that enhance their tissue interactions and provide more focused

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• . Emerging strategies, including stimuli-responsive polymers and advanced nanoparticle systems, offer potential solutions to these challenges. The review underscores the transformative potential of polymer-enhanced ASO delivery in personalised medicine, emphasising the importance of continued innovation to

• potential use in precision medicine over the past decade. Review Synthetic polymers for enhanced ASOs delivery Polymer-assisted platforms for enhanced delivery have attracted considerable attention because of their versatile drug delivery capabilities and their diverse chemical composition, which enables

Quantification of lead through rod-shaped silver-doped zinc oxide nanoparticles using an electrochemical approach

• Ravinder Lamba,
• Gaurav Bhanjana,
• Neeraj Dilbaghi,
• Vivek Gupta and
• Sandeep Kumar

Beilstein J. Nanotechnol. 2025, 16, 422–434, doi:10.3762/bjnano.16.33

• medicine, electronics, environmental remediation, and energy [10][11]. The use of certain metal dopants to modify the chemical, optical, and electrical features of a material has gained considerable interest in the realm of semiconductor technology. A recent study has conducted thorough investigations into

Size control of nanoparticles synthesized by pulsed laser ablation in liquids using donut-shaped beams

• Abdel Rahman Altakroury,
• Oleksandr Gatsa,
• Farbod Riahi,
• Zongwen Fu,
• Miroslava Flimelová,
• Andrei Samokhvalov,
• Stephan Barcikowski,
• Carlos Doñate-Buendía,
• Alexander V. Bulgakov and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 407–417, doi:10.3762/bjnano.16.31

• nanoparticles (NPs) with defined particle sizes and narrow size distribution width is driven by the growing integration of nanomaterials into various industrial applications, such as medicine [1][2][3], catalysis [4][5], sensors [6][7], and additive manufacturing [8]. The performance of NPs typically depends on

• medicine for gold [9][29], strengthened ceramics and steels for high-temperature applications for Y2O3 [45][46][47], and catalysis and energy storage for HEAs [48][49]. The produced NPs are compared with those obtained with Gaussian beams. The evolution of the PLAL-generated cavitation bubble dynamics was

Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans

• Tuyen Huu Nguyen,
• Hong Thanh Pham,
• Kieu Kim Thanh Nguyen,
• Loan Hong Ngo,
• Anh Ngoc Tuan Mai,
• Thu Hoang Anh Lam,
• Ngan Thi Kim Phan,
• Dung Tien Pham,
• Duong Thuy Hoang,
• Thuc Dong Nguyen and
• Lien Thi Xuan Truong

Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23

• -resistant bacteria and the associated adverse effects, such as allergies, have increased the prevalence of using natural compounds to treat bacterial diseases. Among these, berberine, a plant-based alkaloid traditionally used in medicine, has been recognized for its antibacterial, antiviral, and anti

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• from researchers [26]. It is abundantly found in the shells of crustaceans and is the most abundant biopolymer after cellulose [27]. Figure 2 shows the chemical structure of chitosan. Chitosan has been studied extensively and is recognized as a prominent material in the fields of medicine, food, and

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• . 45, 1000 Skopje, Republic of North Macedonia Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Str. Arhimedova No. 5, 1000 Skopje, Republic of North Macedonia University Clinic of Radiotherapy and Oncology, Faculty of Medicine, Ss

• . Cyril and Methodius University in Skopje, Blv. Mother Theresa No. 17, 1000 Skopje, Republic of North Macedonia Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Str. 50th Division No. 6, 1000 Skopje, Republic of North Macedonia 10.3762/bjnano.16.18 Abstract In the present study

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• Jiayuan Zhuang Linhui Jia Chenghao Li Rui Yang Jiapeng Wang Wen-an Wang Heng Zhou Xiangxia Luo Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, P. R. China School of Public Health, Yangzhou University, Yangzhou 225009, P. R. China School of Marine Science

• and Engineering, Hainan University, Haikou 570228, P. R. China Medical College, Yangzhou University, Yangzhou 225009, P. R. China The first school of clinical medicine, Lanzhou University, Lanzhou 730000, P. R. China Gansu Provincial Hospital of TCM, Lanzhou 730000, P. R. China 10.3762/bjnano.16.16

TiO₂ immobilized on 2D mordenite: effect of hydrolysis conditions on structural, textural, and optical characteristics of the nanocomposites

• Marina G. Shelyapina,
• Rosario Isidro Yocupicio-Gaxiola,
• Gleb A. Valkovsky and
• Vitalii Petranovskii

Beilstein J. Nanotechnol. 2025, 16, 128–140, doi:10.3762/bjnano.16.12

• the Research Park of Saint Petersburg State University (Centre for X-ray Diffraction Studies; Interdisciplinary Resource Centre for Nanotechnology; Centre for Physical Methods of Surface Investigation; Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• Naths Grazia Sukubo Paolo Bigini Annalisa Morelli School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza, Italy Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano, Italy 10.3762/bjnano

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

• ). In medicine [7][8] and agriculture [9][10], loading of nanomaterials with active ingredients and targeting the materials to key sites for action are enabled through surface functionalisation and the small size of nanomaterials, which allows them to access all areas. An important consequence of the

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• aurein 1.2 peptide (≥95% purity) was synthesized by GL Biochem (Shanghai, China). 4T1 mouse mammary carcinoma cells (ATCC® CRL-2539) were generously provided by Dr. Muhammad Hasan Bashari, Faculty of Medicine, Padjadjaran University, Indonesia. Preparation of liposomal formulations In this study, we

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

• Julia E. Poletaeva,
• Anastasiya V. Tupitsyna,
• Alina E. Grigor’eva,
• Ilya S. Dovydenko and
• Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

• Julia E. Poletaeva Anastasiya V. Tupitsyna Alina E. Grigor'eva Ilya S. Dovydenko Elena I. Ryabchikova Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Lavrent’ev av., 8, Novosibirsk, 630090, Russian Federation 10.3762/bjnano.15.130 Abstract A

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• strategy for personalized medicine. Keywords: cancer; drug delivery; human health; mimetics; nanotechnology; Introduction Human exposure to nanoparticles has naturally occurred for millennia, with a notable intensification following the industrial revolution [1]. The foundational concept of modern

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• The increasing interests in natural, biodegradable, non-toxic materials that can find application in diverse industry branches, for example, food, pharmacy, medicine, or materials engineering, has steered the attention of many scientists to plants, which are a known source of natural hydrogels

• mucilage produced by plant diaspores became of high interest in diverse sectors, such as medicine, cosmetics, food, biomedicine, pharmaceutics, nanomaterials, and bioinspired nanotechnology [11][17][18][19][20]. Mucilage is a natural, biodegradable, non-toxic plant product, odourless, colourless, and

• as food, agriculture, and medicine [20][114][115]. Diverse other substances and systems with antimicrobial activity (antibiotics, essential oils, phenolics, and metal nanoparticles) can be incorporated into the mucilage hydrogels, which after some additional modifications can be used for the

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• samples on the liver of Wistar rats was identified. Keywords: biocompatibility; hepatotoxicity; iron oxide (Fe3O4) nanoparticle; rutin; Teucrium polium (T. polium); Introduction Leveraging nanotechnology, personalized medicine, and interdisciplinary collaboration is essential for overcoming the complex

• challenges associated with human health. Nanotechnology offers great opportunities in medicine because of the physicochemical properties at the nanoscale. There are efforts to apply unique quantum phenomena at the nanoscale in the fields of medicine, biomedical sciences, bioengineering, food technology

• , biochemistry, biophysics, and other disciplines within biology and medicine [1][2][3][4][5]. The development of nanotechnology has provided resources for various applications in the medical field, leading to significant advances in diagnosis, biological detection, therapy, and drug delivery [6][7][8][9]. An

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia Department of Orthopaedics, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-602105, Tamil Nadu, India Pharmacy Department, Tishk

• therapeutic efficacy [44]. The development of PLHNPs for phytochemical delivery holds significant promise across various biomedical applications. PLHNPs can be utilized in cancer therapy, cardiovascular disease management, neurodegenerative disorder treatment, and other areas of medicine where phytochemicals

• in Ayurvedic and Chinese medicine because of its numerous health benefits. CUR is known for a wide range of therapeutic effects, which include anti-inflammatory, antioxidant, antimicrobial, anticancer, cardioprotective, neuroprotective, anti-diabetic, and anti-arthritic properties [77][78]. Despite

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• ; toxicity mitigation; Introduction Graphene oxide (GO) has many potential applications in electronics, advanced materials, bio-medicine, energy, agriculture, and environmental technology [1][2][3]. It consists of a graphene sheet with surface oxygen functional groups such as epoxide, ketone, hydroxy

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• concentrated red blood cell (RBC) (type B+) plastic bags, collected according to their consent form for blood donation, were provided by the Hemocenter from the Faculty of Medicine at the University of Campinas, São Paulo, Brazil. First, the RBCs were washed three times with PBS (pH 7.4, 10 mM) followed by

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• . Keywords: active targeting; cancer; nanoclusters; renal clearance; ultrasmall nanoparticles; Review 1 Introduction Nanotechnology has opened new avenues for tackling unmet challenges in medicine [1][2][3]. In the field of oncology, a notable application involves the use of engineered nanoparticles (NPs