Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• microfluidics and high-shear-force homogenization [110]. As DDS, nanoemulsions can be reservoirs for encapsulating hydrophobic substances [111]. Moreover, emulsions of emulsions or double emulsions can be prepared by dispersing the droplets of primary emulsion into another liquid phase. Double emulsions can be

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

Beyond biomimicry – next generation applications of bioinspired adhesives from microfluidics to composites

• Dan Sameoto

Beilstein J. Nanotechnol. 2024, 15, 965–976, doi:10.3762/bjnano.15.79

• and hope that “if we build it, they will come”. Perhaps we should expand our concept on what could be the desirable end applications for such materials and focus efforts on finding better end applications in which these materials can truly shine; a few of those applications like microfluidics and

• the use of biomimetic adhesives. These subtopics are microfluidics, soft robotics, and reconfigurable composites. Microfluidics involves the manipulation and flow of fluids on a very small scale, typically with nanoliters or less of fluid and with feature sizes ranging from a few hundred microns down

• to sub-micrometer size [8][9]. It has been an active area of academic research for well over 30 years. Microfluidics technology has eventually enabled a variety of new innovations, including COVID-19 rapid tests [10], microfluidic displays [11], and low-cost diagnostics [12]. Soft robotics is a newer

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• F127-folate to enhance their therapeutic efficacy. Size and charge of the nanoparticles PLGA nanoparticles can be synthesized by several methods, such as single emulsion evaporation, double emulsion evaporation, or microfluidics using different surfactants, including PVA, F127, sodium cholate, or SDS

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• microfluidics, are still too costly for routine research in developing countries [138][139]. The therapeutic performance of intravenous nanomedicines strongly depends on the anatomical pathological context, mainly on the extent of inflammation or retention permeation effect, and the extracellular matrix

Electrostatic pull-in application in flexible devices: A review

• Teng Cai,
• Yuming Fang,
• Yingli Fang,
• Ruozhou Li,
• Ying Yu and
• Mingyang Huang

Beilstein J. Nanotechnol. 2022, 13, 390–403, doi:10.3762/bjnano.13.32

• researchers a more comprehensive understanding of the pull-in phenomenon and the development of its applications. Also, the review is meant to provide a reference for engineers to design and optimize devices. Keywords: electrostatics; MEMS; microfluidics; NEM switches; pull-in; Introduction It has become

A review on slip boundary conditions at the nanoscale: recent development and applications

• Ruifei Wang,
• Jin Chai,
• Bobo Luo,
• Xiong Liu,
• Jianting Zhang,
• Min Wu,
• Mingdan Wei and
• Zhuanyue Ma

Beilstein J. Nanotechnol. 2021, 12, 1237–1251, doi:10.3762/bjnano.12.91

• , electrophoresis, streaming current or potential, and sedimentation potential have played crucial roles in the development of microfluidics and nanofluidics [73][74][75]. Among them, the electro-osmotic flow refers to the motion of an electrolyte solution relative to the stationary charged surface due to an

The role of convolutional neural networks in scanning probe microscopy: a review

• Ido Azuri,
• Irit Rosenhek-Goldian,
• Neta Regev-Rudzki,
• Georg Fantner and
• Sidney R. Cohen

Beilstein J. Nanotechnol. 2021, 12, 878–901, doi:10.3762/bjnano.12.66

• detected differences in the actin cytoskeleton structures between cancerous and normal breast cells that were not discerned by the human eye [105]. Nitta et al. developed an intelligent real-time cell sorter, by combining deep-learning with microfluidics. They achieved automated classification of

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Paper-based triboelectric nanogenerators and their applications: a review

• Jing Han,
• Nuo Xu,
• Yuchen Liang,
• Mei Ding,
• Junyi Zhai,
• Qijun Sun and
• Zhong Lin Wang

Beilstein J. Nanotechnol. 2021, 12, 151–171, doi:10.3762/bjnano.12.12

Electrokinetic characterization of synthetic protein nanoparticles

• Daniel F. Quevedo,
• Cody J. Lentz,
• Adriana Coll de Peña,
• Yazmin Hernandez,
• Nahal Habibi,
• Rikako Miki,
• Joerg Lahann and
• Blanca H. Lapizco-Encinas

Beilstein J. Nanotechnol. 2020, 11, 1556–1567, doi:10.3762/bjnano.11.138

• , biodegradability, and functionality. Even though ASPNPs have the potential to be used in a variety of applications, such as in the treatment of glioblastoma, there is currently no high-throughput technology for the processing of these particles. Insulator-based electrokinetics employ microfluidics devices that

• ; bicompartmental particles; dielectrophoresis; electrokinetics; electrophoresis; electro-osmosis; microfluidics; protein nanoparticles; Introduction Over the past 30 years, nanoparticles have been developed for a wide variety of scientific applications, ranging from medical imaging to drug delivery and enzyme

• developed. In the last decade, the area of microfluidics, which is the field of science that studies the manipulation of minute volumes of fluids (i.e., from microliters to picoliters) [17], has experienced a significant growth in bioanalytical applications [17][18]. Electrokinetics (EK) and electric-field

Analysis of catalyst surface wetting: the early stage of epitaxial germanium nanowire growth

• Owen C. Ernst,
• Felix Lange,
• David Uebel,
• Thomas Teubner and
• Torsten Boeck

Beilstein J. Nanotechnol. 2020, 11, 1371–1380, doi:10.3762/bjnano.11.121

• applications. Surface treatment, for example, modifies the wetting behaviour of active fluids on composite materials or porous media to increase the efficiency and selectivity of catalytic processes [1]. Droplet-based microfluidics, including on-chip and off-chip incubation in immiscible phases, even developed

Ultrasensitive detection of cadmium ions using a microcantilever-based piezoresistive sensor for groundwater

• Dinesh Rotake,
• Anand Darji and
• Nitin Kale

Beilstein J. Nanotechnol. 2020, 11, 1242–1253, doi:10.3762/bjnano.11.108

• the WHO limit of 3 μg/L. Keywords: BioMEMS; heavy metal ions (HMIs); limit of detection (LOD); microcantilevers; microfluidics; micro-electromechanical systems (MEMS); piezoresistive sensors; SAM (self-assembled monolayers); World Health Organization (WHO); Introduction Water is fundamentally

Thermophoretic tweezers for single nanoparticle manipulation

• Jošt Stergar and
• Natan Osterman

Beilstein J. Nanotechnol. 2020, 11, 1126–1133, doi:10.3762/bjnano.11.97

• modeling gives a quantitative prediction of the effect. Traps can be dynamically created and relocated, which we demonstrate by the controlled independent manipulation of two nanoparticles. Keywords: laser; microfluidics; nano-manipulation; thermophoresis; trapping; tweezers; Introduction In science and

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

• animal testing ethics (the “3 R’s” stand for replacement, reduction and refinement aiming at limiting the number of in vivo experiments requiring the sacrifice of animals). 3D systems such as spheroids or cell-derived matrices and using microfluidics have thus been suggested for PDT [28][29]. Based on

Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• was loaded (EE% of ≈68%) very efficiently into the nanoparticles. Finally, the permeability of muco-penetrating PLGA NPs through pulmonary human mucus was assessed; small NPs with a diameter of less than 100 nm showed fast permeation, underlining the potential of microfluidics for such pharmaceutical

• applications. Keywords: curcumin; human pulmonary mucus; microfluidics; muco-penetrating nanoparticles; nanomedicine; permeability; PLGA nanoparticles; Introduction In the last decades, the application of nanotechnology in medicine has gained significant attention, especially in the biomedical field for

• channel geometry. Additionally, fast mixing (as in microfluidics) has shown a variety of advantages over conventional methods (bench-top) regarding the physicochemical and encapsulation properties of the nanoparticles [36]. A LabSmith system (LabSmith, Inc., Livermore, USA) was used for the manufacture of

Direct growth of few-layer graphene on AlN-based resonators for high-sensitivity gravimetric biosensors

• Jimena Olivares,
• Teona Mirea,
• Lorena Gordillo-Dagallier,
• Bruno Marco,
• José Miguel Escolano,
• Marta Clement and
• Enrique Iborra

Beilstein J. Nanotechnol. 2019, 10, 975–984, doi:10.3762/bjnano.10.98

• properly functionalized [1][2], the small sample volumes they require for operation when combined with microfluidics [3], their high-speed response and label-free operation [4]. Piezoelectric resonators based on thin films of, e.g., AlN or ZnO offer significantly greater sensitivities than conventional

• resonators (SMR), providing acoustic isolation through acoustic reflectors instead of air cavities, are well suited for in-liquid operation and microfluidics integration [3]. A critical step in the manufacturing of gravimetric biosensors is the functionalization of their active surface, which provides the

Nanostructured liquid crystal systems and applications

• Alexei R. Khokhlov and
• Alexander V. Emelyanenko

Beilstein J. Nanotechnol. 2018, 9, 2644–2645, doi:10.3762/bjnano.9.245

• systems ferroelectric LC systems confined LC systems and defects hydrodynamics and microfluidics of LC systems applications of liquid crystals We believe that this thematic issue will be of interest to many readers working in different fields of research, including interdisciplinary research. We are

Block copolymers for designing nanostructured porous coatings

• Roberto Nisticò

Beilstein J. Nanotechnol. 2018, 9, 2332–2344, doi:10.3762/bjnano.9.218

• Roberto Nistico Department of Applied Science and Technology DISAT, Polytechnic of Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy 10.3762/bjnano.9.218 Abstract Highly ordered porous coatings find applications in many fields, such as nanotechnology, microfluidics and nanofluidics

• -assembly; Review Introduction Porous materials have received much attention because they can be successfully applied in many fields, such as nanotechnology, membrane separation, microfluidics and nanofluidics, sensing, catalysis, and biomedicine [1][2][3][4][5]. The manufacture of well-ordered devices at

• advances were summarized in order to provide a simple toolbox to follow for the preparation of (in)organic isoporous thin coatings exploitable for the development of novel well-ordered devices for membrane science and microfluidics applications. The interesting properties of amphiphilic block copolymers

Evaluation of replicas manufactured in a 3D-printed nanoimprint unit

• Manuel Caño-García,
• Morten A. Geday,
• Manuel Gil-Valverde,
• Xabier Quintana and
• José M. Otón

Beilstein J. Nanotechnol. 2018, 9, 1573–1581, doi:10.3762/bjnano.9.149

• microelectronics, optics, photonic integrated circuits, plasmonics or microfluidics [3]. NIL is customarily split into three categories, “hard”, “soft” and “hybrid” NIL [4], depending on the kind of mold employed in the transfer. Hard NIL uses molds made of quartz or silicon, and allows for the transfer of

Preparation and morphology-dependent wettability of porous alumina membranes

• Dmitry L. Shimanovich,
• Alla I. Vorobjova,
• Daria I. Tishkevich,
• Alex V. Trukhanov,
• Maxim V. Zdorovets and
• Artem L. Kozlovskiy

Beilstein J. Nanotechnol. 2018, 9, 1423–1436, doi:10.3762/bjnano.9.135

• ]. Recently membranes with special surface wettability have been investigated because of their potential application in microfluidics, self-cleaning and droplet-based technologies [19][29]. As shown in [30], by changing only the surface morphology of unmodified, bare PAMs, the wetting behavior could be

Perfusion double-channel micropipette probes for oxygen flux mapping with single-cell resolution

• Yang Gao,
• Bin Li,
• Riju Singhal,
• Adam Fontecchio,
• Ben Pelleg,
• Zulfiya Orynbayeva,
• Yury Gogotsi and
• Gary Friedman

Beilstein J. Nanotechnol. 2018, 9, 850–860, doi:10.3762/bjnano.9.79

• simple idea of hydrodynamic confinement has been discussed in the microfluidics literature [28][36] and in some biological applications [33][37][38], some of which employed a concentric double-channel pipette [38]. Here, we report experimental observation of hydrodynamic confinement at the tip of the

Optimal fractal tree-like microchannel networks with slip for laminar-flow-modified Murray’s law

• Dalei Jing,
• Shiyu Song,
• Yunlu Pan and
• Xiaoming Wang

Beilstein J. Nanotechnol. 2018, 9, 482–489, doi:10.3762/bjnano.9.46

• -like microchannel network with N branches and m levels, the total hydraulic resistance of the fluid flow in the entire network can be obtained using the electric circuit analogy based on the physical similarities between microfluidics and electronics as follows [17][27]. where RH is the total hydraulic

Wafer-scale bioactive substrate patterning by chemical lift-off lithography

• Chong-You Chen,
• Chang-Ming Wang,
• Hsiang-Hua Li,
• Hong-Hseng Chan and
• Wei-Ssu Liao

Beilstein J. Nanotechnol. 2018, 9, 311–320, doi:10.3762/bjnano.9.31

• change-required recognition, and bulky biological species binding are all accomplished with minimum nonspecific adhesion. Furthermore, multiplexed arrays via the integration of microfluidics are also achieved, which enables diverse applications of as-prepared substrates. By embracing the properties of

• integration of microfluidics with CLL operation is also introduced. In addition, this strategy enables straightforward creation of wafer-scale bioactive substrates via one-step surface defect-rich matrix generation, which greatly advances the creation of a biofunctional platform manufacturing for practical

• bars are 20 μm. Schematic illustration of multiplexed bioactive surface fabrication by the combination of chemical lift-off lithography (CLL) and microfluidics: (A) CLL treatment with an activated featureless PDMS stamp. (B) Probe insertion by the combination of a microfluidic device. (C) The

Review on optofluidic microreactors for artificial photosynthesis

• Xiaowen Huang,
• Jianchun Wang,
• Tenghao Li,
• Jianmei Wang,
• Min Xu,
• Weixing Yu,
• Abdel El Abed and
• Xuming Zhang

Beilstein J. Nanotechnol. 2018, 9, 30–41, doi:10.3762/bjnano.9.5

• systems, followed by discussions on pending problems for real applications. Keywords: artificial photosynthesis; carbon dioxide fixation; coenzyme regeneration; microfluidics; optofluidics; water splitting; Review Introduction The emerging energy crisis, the greenhouse effect and food shortage are

• catalytic materials, modification of the existed catalytic materials (e.g., noble-gas doping, co-catalyst impregnation, noble-metal loading, plasmonic sensitization and Z-scheme systems), and optofluidics (or microfluidics) based APS. It should be noted that many efforts have been made to develop bio