Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• the name suggests, the structural arrangement of these nanocarriers involves the surface coating of liposomes with biodegradable polymers/copolymers. The surface modification not only imparts surface functionality to the nanocarrier but also enhances its therapeutic efficacy by site-specific targeting

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• concentrations of 3.0 and 5.0 mg·mL–1. Theoretically, since these SiO2NPs do not have surface functionality, it is expected to have a low hemolytic capacity due to the protein corona formation, as observed for concentrations of 0.5 and 1.0 mg·mL–1. One hypothesis for the increased hemolytic capacity of non

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• clusters and organic ligands via coordination bonds [89][90][91][92]. The variety of combinations between metal ions and organic linkers or structural motifs allows for tunable pore size/shape and adjustable surface functionality [93][94]. These structural characteristics make MOFs one of the most ideal

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• proteins, which makes them a better option based on the fact that surface functionality of CDs can be achieved without adding extra substances for doping, modification and surface passivation [54]. A summary of CDs synthesized from carbon-rich plant extract without surface-passivating agents and their

Unravelling the interfacial interaction in mesoporous SiO₂@nickel phyllosilicate/TiO₂ core–shell nanostructures for photocatalytic activity

• Bridget K. Mutuma,
• Xiluva Mathebula,
• Isaac Nongwe,
• Bonakele P. Mtolo,
• Boitumelo J. Matsoso,
• Rudolph Erasmus,
• Zikhona Tetana and
• Neil J. Coville

Beilstein J. Nanotechnol. 2020, 11, 1834–1846, doi:10.3762/bjnano.11.165

• porous silica surface and the successful growth of sheet-like NiPS particles on top of the SiO2 matrix. The addition of TiO2 (51 m2/g) as expected, led to a lower surface area of the mSiO2@NiPS/TiO2 composite (103 m2/g) compared to the mSiO2@NiPS core–shell nanostructures. Bandgap energy and surface

• functionality of nanomaterials greatly influence their photoactivity. UV–vis diffuse reflectance spectroscopy is a useful technique for probing the optoelectronic properties, band structure and molecular energy levels of semiconductors. It gives relevant information on the optical activity of nanomaterials as

Warped graphitic layers generated by oxidation of fullerene extraction residue and its oxygen reduction catalytic activity

• Machiko Takigami,
• Rieko Kobayashi,
• Takafumi Ishii,
• Yasuo Imashiro and
• Jun-ichi Ozaki

Beilstein J. Nanotechnol. 2019, 10, 1391–1400, doi:10.3762/bjnano.10.137

• the increase in oxygen surface functionality with oxidation time. The role of WGLs in ORR was also found to lower the heat of O2-adsorption to a suitable value for O2 activation and to accelerate heterogeneous electron transfer. The present study highlights important considerations for the design of

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• inorganic components on the surface have attracted great interest because of the possibility to tune size, composition, porosity, stability, surface functionality, and colloidal stability [6][7][8][9][10][11][12]. Generally, fluorescent dye molecules are sensitive to the external environment, which leads to

Tuning adhesion forces between functionalized gold colloidal nanoparticles and silicon AFM tips: role of ligands and capillary forces

• Sven Oras,
• Sergei Vlassov,
• Marta Berholts,
• Rünno Lõhmus and
• Karine Mougin

Beilstein J. Nanotechnol. 2018, 9, 660–670, doi:10.3762/bjnano.9.61

• received. Common NPs functionalization methods can be tuned to allow improvements of the modification of NPs surface functionality by choosing the appropriate number of steps: from one step (in situ synthesis) up to several (ex situ), if necessary. The one-step method described in [49] was applied for the

Methods for preparing polymer-decorated single exchange-biased magnetic nanoparticles for application in flexible polymer-based films

• Laurence Ourry,
• Delphine Toulemon,
• Souad Ammar and
• Fayna Mammeri

Beilstein J. Nanotechnol. 2017, 8, 408–417, doi:10.3762/bjnano.8.43

• perfectly epitaxial fashion with an antiferromagnetic CoO polycrystalline shell about 1 nm thick, as described in previous work [16]. We then controlled their surface functionality to tentatively design well-tailored nano-building-blocks for the aforementioned devices. To reduce mutual magnetic attraction

Template-controlled mineralization: Determining film granularity and structure by surface functionality patterns

• Nina J. Blumenstein,
• Jonathan Berson,
• Stefan Walheim,
• Petia Atanasova,
• Johannes Baier,
• Joachim Bill and
• Thomas Schimmel

Beilstein J. Nanotechnol. 2015, 6, 1763–1768, doi:10.3762/bjnano.6.180

• monolayers with different chemical functionality. We demonstrate the template-modulated morphological properties of the growing film, as the surface functionality dictates the granularity of the growing film. This, in turn, is a key property influencing other film properties such as conductivity

• of the nanoparticles, which nucleate in solution and subsequently deposit on the functionalized substrate. Keywords: bioinspired synthesis; polymer-blend lithography; surface functionality; template-controlled self-assembly; zinc oxide thin film; Introduction Self-organization plays an important

• topographically flat (<1 nm roughness), but chemically patterned surface as a template, it was possible to guide the deposition – mainly by means of surface polarity. While deposition took place at sites with amino functionalization, no deposition was observed at locations with a fluorinated surface functionality

Protein corona – from molecular adsorption to physiological complexity

• Lennart Treuel,
• Dominic Docter,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

• presence and nature of this corona. The relation between the original surface functionality of the NP and the nature of the corona is far from trivial and still remains very elusive [1][2][3][4][5][6][7]. It has been shown that not only the NP surface chemistry but also features such as NP size [8] and

• importance of the original surface functionality of the NPs for their interaction with proteins. In addition, a further aspect emerges from the implications of these results: Only a stable and persistent molecular NP surface functionality can play a significant role in shaping the in vivo protein corona

• . While polymer coatings are regarded as relatively stable under such conditions, other ligands can well be replaced in equilibrium-type reactions, even under chemically less complex conditions [13]. It has been discussed before, how the formation of a protein corona can change the surface functionality

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• cells could be loaded with drugs containing particles for enhancing the differentiation in one direction or improving the graft efficiency [26][27]. Before using these complex nanoparticle systems, all potential risks (e.g., toxicity and alteration in cell functionality) concerning the material, surface

• functionality, etc. should be investigated. Additionally, even for industrial applications (e.g., coatings in automotive and other types of industries) toxicology studies are warranted. In this study, we demonstrated that polystyrene and polylactide particles are taken up not only by hMSCs, but also at a

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• treatment conditions are the most appropriate for enhancing the surface functionality without affecting the morphological properties and chemical structure of the polymer. Mechanical behavior of the plasma-treated scaffolds A basic principle in regenerative medicine is to maintain the structural integrity

Modification of a single-molecule AFM probe with highly defined surface functionality

• Fei Long,
• Bin Cao,
• Ashok Khanal,
• Shiyue Fang and
• Reza Shahbazian-Yassar

Beilstein J. Nanotechnol. 2014, 5, 2122–2128, doi:10.3762/bjnano.5.221

• area would result in a highly defined surface functionality of the probe down to single molecule level with high reproducibility. Keywords: atomic force microscopy; click reaction; force spectroscopy; single molecule modification; Introduction Single-molecule force spectroscopy (SMFS) has become one

• probe surface. In this paper, we report a new method for the modification of a single-molecule probe with highly defined surface functionality by using copper-catalyzed alkyne–azide cycloaddition (Figure 1). A probe with a monolayer of terminal alkynes was easily prepared by immersing an amino

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

• Sebastian Ahlberg,
• Alexandra Antonopulos,
• Jörg Diendorf,
• Ralf Dringen,
• Matthias Epple,
• Rebekka Flöck,
• Wolfgang Goedecke,
• Christina Graf,
• Nadine Haberl,
• Jens Helmlinger,
• Fabian Herzog,
• Frederike Heuer,
• Stephanie Hirn,
• Christian Johannes,
• Stefanie Kittler,
• Manfred Köller,
• Katrin Korn,
• Wolfgang G. Kreyling,
• Fritz Krombach,
• Jürgen Lademann,
• Kateryna Loza,
• Eva M. Luther,
• Marcelina Malissek,
• Martina C. Meinke,
• Daniel Nordmeyer,
• Anne Pailliart,
• Jörg Raabe,
• Fiorenza Rancan,
• Barbara Rothen-Rutishauser,
• Eckart Rühl,
• Carsten Schleh,
• Andreas Seibel,
• Christina Sengstock,
• Lennart Treuel,
• Annika Vogt,
• Katrin Weber and
• Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

• is complicated because these properties depend on a number of parameters, such as size, shape, charge, dispersion state, and surface functionality. Therefore, the comparison of the results from different groups is typically difficult because either different particles were used or different chemical

Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications

• Li-wei Liu,
• Si-yi Hu,
• Ying Pan,
• Jia-qi Zhang,
• Yue-shu Feng and
• Xi-he Zhang

Beilstein J. Nanotechnol. 2014, 5, 919–926, doi:10.3762/bjnano.5.105

• bandgap (Eg) of 2.42 eV. By tailoring its composition and size, or surface functionality, it is possible to enhance luminescence emission and quantum yield of these QDs. The use of a coating agent can make CdS more stable. ZnS QDs are less cytotoxic than CdTe and CdSe QDs of the same size and surface

Polymer blend lithography: A versatile method to fabricate nanopatterned self-assembled monolayers

• Cheng Huang,
• Markus Moosmann,
• Jiehong Jin,
• Tobias Heiler,
• Stefan Walheim and
• Thomas Schimmel

Beilstein J. Nanotechnol. 2012, 3, 620–628, doi:10.3762/bjnano.3.71

• surface functionality (functional group) can be defined. Two-phase templates By means of a spin-coating process of a polymer-blend solution at a humidity of 45%, a purely laterally phase-separated film consisting of the two polymer components is produced (Figure 3a). In Figure 3b an SEM image of a polymer

Variations in the structure and reactivity of thioester functionalized self-assembled monolayers and their use for controlled surface modification

• Inbal Aped,
• Yacov Mazuz and
• Chaim N. Sukenik

Beilstein J. Nanotechnol. 2012, 3, 213–220, doi:10.3762/bjnano.3.24

• dimension to the versatility and utility of the SAMs [4][5][6][7]. Our laboratory has reported in situ transformations of siloxane-anchored SAMs in which SAM surface functionality was changed from benzene rings to arylsulfonic acids [8][9], from nitrate esters to hydroxyls [10], and from carboxylate esters

Fabrication of multi-parametric platforms based on nanocone arrays for determination of cellular response

• Lindarti Purwaningsih,
• Tobias Schoen,
• Tobias Wolfram,
• Claudia Pacholski and
• Joachim P. Spatz

Beilstein J. Nanotechnol. 2011, 2, 545–551, doi:10.3762/bjnano.2.58

• surface functionality are shown to last over several days, leading to the conclusion that the features of our substrates can also be used for longer term experiments. Finally, initial neural cell adhesion is found to be more prominent on substrates with short intercone distances, which is an important