Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• modifications and structural modifications. Material modifications include mixing with other polymers, plasticizers, and additives [155], as well as surface modification [156] and post-treatment processes such as cross-linking and heat treatment [157]. Structural modifications encompass fiber alignment

• selecting the plasma source and controlling discharge conditions such as voltage, pressure, and gas flow rate, various functional groups can be introduced on the fiber surface, enabling tailored modifications that enhance polymer biocompatibility. Punamshree et al. [162] performed surface modification of

• compared to electrospun fibers without nanoclay. This improvement is due to the dispersion of nanoparticles within the polymer matrices, which plays an important role in enhancing the physical and mechanical properties of electrospun nanofiber [169]. The purpose of surface modification is to increase the

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• ) and caveolin-mediated endocytosis (GO with diameter below 100 nm). In addition, accumulation in the glia cells due to the enhanced permeability and retention effect was observed. However, it is emphasized that surface modification, including modification of surface charge and particle size, can

• . The same was also confirmed in a systematic review related to the cell toxicity and immunological effects of CNs, in which the toxicity of CNs followed the order: fullerenes < carbon black nanoparticles < MWCNTs < SWCNTs < graphene [69]. Regarding the surface modification, findings from all studies

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• neovasculature, and uveal melanomas, showing enhanced contrast and resolution of photoacoustic images [202]. Surface modification and control over shape and size can alter the LSPR characteristics of AuNPs, resulting in a shift in the light absorption peak. Matching pulsed laser wavelength and LSPR peaks helps

Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258

• Prashantkumar Siddappa Chakra,
• Aishwarya Banakar,
• Shriram Narayan Puranik,
• Vishwas Kaveeshwar,
• C. R. Ravikumar and
• Devaraja Gayathri

Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8

• , indicating robust colloidal stability, contrasting with the moderately negative zeta potential (−15.3 mV) reported by Selvarajan and Mohanasrinivasan [24], which shows possible variations in ZnO NP characteristics, size distribution, surface modification, and experimental conditions. Nonetheless, both

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• adverse reactions. The toxicity of MNPs depends on various factors such as size, shape, structure, surface modification, concentration, dosage, biodistribution, bioavailability, solubility, immunogenicity, and pharmacokinetics [23][24]. Their use in some clinical applications is limited by low solubility

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• diseases. Keywords: bioavailability; phytochemical; polymer lipid hybrid nanoparticles; solubility; stability; surface modification; Introduction Phytochemicals are naturally occurring compounds found in plants (from the Greek word “phyton” meaning plant) [1]. These bioactive compounds are responsible

• hydrophilic drugs are entrapped in the lipid shell. PLHNPs demonstrate relatively greater loading capacity for lipophilic compounds than other nanoparticle systems [12][19]. Moreover, the surface modification of PLHNPs with targeting ligands, such as antibodies, peptides, or aptamers, has been explored to

• the name suggests, the structural arrangement of these nanocarriers involves the surface coating of liposomes with biodegradable polymers/copolymers. The surface modification not only imparts surface functionality to the nanocarrier but also enhances its therapeutic efficacy by site-specific targeting

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• of a liquid layer, which reduced protein adhesion. While activation is decreased on hydrophilic surfaces, it is elevated on negatively charged surfaces like glass [49]. FXIIa concentration was determined at each step of our surface modification process. In this work, we used BSA-coated surfaces as a

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• NaCl (Figure 4g,h). Although centrifuged and as-prepared AuNR20.5 and AuNR21.0 showed a noticeable difference in the absorption spectrum compared to the control (Figure 4g,h). Previously, several reports confirmed the use of NaOH and NaCl in nanoparticle synthesis or surface modification for different

• and AuNR11.0) without NaOH showed no metal detection (Supporting Information File 1, Figure S15 and Figure S16). The robust nature of CTAB on nanoparticle surfaces is well known, thus resisting the interaction with target molecules without surface modification. In our case, NaOH was used to weaken

• CTAB micelles without hampering the physicochemical properties of the synthesized nanoparticles. This weakening of CTAB solves the persistent problem of surface modification or the use of linker molecules with CTAB-capped nanoparticles for sensing applications. In addition, the nanorod size might be

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• . Furthermore, we study in detail TA interactions with GO’s surface employing computational modeling to analyze the interaction mechanisms and GO’s surface modification by TA. The application of in silico methodologies is advantageous in understanding phenomena that cannot be easily accessed experimentally but

• is well known that in more diluted suspensions, nanomaterials tend to present better dispersibility, and it is expected that GO remains stable in EPA medium for a longer time. Computational simulation of GO–TA interactions To analyze the surface modification of GO by TA and gain insights into the

• GO, as well as an understanding of how the environment and interactions impact these properties. The combined approach of MD and ab initio calculations provided comprehensive insights into the surface modification process and the underlying mechanisms involved in the interactions between GO and TA

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• the antifibrosis compound myricetin in pro-liposome nanocarriers to improve its solubility, stability, and low oral bioavailability [57]. As illustrated in Figure 3, the surface modification of pro-liposome with ᴅ-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E-TPGS) enhanced the stability

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• capability of the nanomaterials. Low LODs, high reproducibility, and simple procedures for surface modification and analysis can be considered as the advantages of the proposed DPV method. Images of aqueous suspension of TiO2/GQDs samples (a) under white light and (b) under UV light. (c) Photoluminescence

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• polyynes can be found in the recent review article by Marabotti and coworkers [64]. Solid carbon formation and nanoparticle surface modification While the oxidation of nanoparticles formed by LSPC can be attributed to redox reactions that result in water splitting [50][51], the mechanism for the carbon

• the surfactants (or inorganic anions) used, the carbon stemming from the organic solvent molecules acts as a surface modification of the nanoparticles and is often obtained as carbon shells. The carbon shell can be amorphous carbon [100][101], graphitic carbon [104][149][150][151][152], or carbide [99

• produce graphite structures. The carbon shell is a surface modification and, as such, affects the nanoparticles’ catalyst properties either positively [37][155] or negatively [149]. A low number of graphene layers on the surface of the nanoparticles was found to enhance the catalytic activity during

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• of metal-based nanoantioxidants and the reduction of detrimental effects of these nanomaterials on human health. Surface modification can become an effective method to decrease the toxicity of nanomaterials through coating with biocompatible polymers such as chitosan, polydopamine, and polyethylene

Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar⁺ ion beam: a comparative study

• Indra Sulania,
• Harpreet Sondhi,
• Tanuj Kumar,
• Sunil Ojha,
• G R Umapathy,
• Ambuj Mishra,
• Ambuj Tripathi,
• Richa Krishna,
• Devesh Kumar Avasthi and
• Yogendra Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 367–375, doi:10.3762/bjnano.15.33

• analysis of Si and Ge samples irradiated with a fluence of 9 × 1017 ions/cm2 was performed in cross-sectional mode. The TEM image clearly reveals the surface modification occurred due to Ar ion irradiation. At fewer places, Ar bubbles of ≈15 nm were also visible (marked with a dotted section) in Si. It was

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• three times with distilled water, and the PDA/Fe3O4 NPs were dried in a vacuum oven at 55 °C. Surface functionalization of PDA/Fe3O4 nanoparticles with SH-PEG For the surface modification process with SH-PEG, 50 mg of PDA/Fe3O4 NPs were added to 50 mL of Tris-HCl solution. Then, 100 mg of thiol

• of passive targeting in magnetic fields for photothermal cancer therapy, with PDA holds great promise for future applications. Therefore, surface modification with PDA is recognized as a favorable alternative for enhancing the biocompatibility of non-biodegradable substances. A study focused on

• band structures at 1500 and 1000 cm–1 in the FTIR analysis of SH-PEG provides evidence for the surface modification of PDA/Fe3O4 NPs with SH-PEG. The FTIR analysis results indicate the successful functionalization of PDA/Fe3O4 NPs with SH-PEG molecules. This will enable the passively targeted delivery

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• surface modification, leading to a prolonged pulmonary retention of dexamethasone-loaded nanoparticulate drug carriers for the treatment of acute pulmonary inflammation [39]. This is in accordance with a study from Zheng et al. where crosslinked insulin-loaded hydrogel zwitterionic nanoparticles with

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• into cancer cells, making them a promising option for cancer therapy. In addition, the surface modification of microparticles using substances such as antibodies and polymers suggests the potential for enhanced uptake, as previously demonstrated [55][56]. Nevertheless, further research should explore

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• HBOCs have been devised. Crosslinking of different Hb chains, polymerization of Hb molecules [16][17][18], surface modification [19], and techniques for encapsulation [20][21] already brought us somewhat closer towards a safe use of HBOCs [22]. However, a persistent problem is the severely limited

Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons

• Janina Kopyra and
• Hassan Abdoul-Carime

Beilstein J. Nanotechnol. 2023, 14, 980–987, doi:10.3762/bjnano.14.81

• , where they are decomposed under the focused kiloelectronvolt electron beam. In this technique, both the primary ionizing particles and the secondary species (e.g., ballistic electrons) with energies below 20 eV [6][7] lead to the decomposition of the molecules and the subsequent surface modification

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• of nanoscale chemotherapeutics is accomplished by two different approaches, namely the exploitation of leaky tumor vasculature (EPR effect) and the surface modification of nanoparticles (NPs) with various tumor-homing peptides, aptamers, oligonucleotides, and monoclonal antibodies (mAbs). Because of

• surface charge [36][37]. Surface modification strategies include, for example, adsorption, covalent conjugation, and biotin–avidin interaction, which will be discussed below in detail with examples. Adsorption Adsorption of antibodies on the surface of NPs is a non-covalent reversible binding method

• identify new molecular markers for the rapid detection and treatment of various types of cancers. NPs enhance the drug accumulation at the target site due to their advantages, including higher surface-to-volume ratio, ease of surface modification and functionalization, precise control of structure and size

Silver-based SERS substrates fabricated using a 3D printed microfluidic device

• Phommachith Sonexai,
• Minh Van Nguyen,
• Bui The Huy and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2023, 14, 793–803, doi:10.3762/bjnano.14.65

• developed system. The substrate was prepared from Ag NPs by decorating the surface of porous silicon with Ag NPs using self-assembled monolayers (SAMs). The SAM method offers precise control, versatility, simplicity, stability, and compatibility, making it a valuable technique for surface modification in

ZnO-decorated SiC@C hybrids with strong electromagnetic absorption

• Liqun Duan,
• Zhiqian Yang,
• Yilu Xia,
• Xiaoqing Dai,
• Jian’an Wu and
• Minqian Sun

Beilstein J. Nanotechnol. 2023, 14, 565–573, doi:10.3762/bjnano.14.47

• parameters of SiC can be effectively adjusted by means of morphology design [9][10][11], doping [12][13][14], and surface modification [15][16][17], thereby improving their EM absorption properties. However, the design of SiC-based absorbers with relatively high reflection loss (RLmin < −60 dB) and, at the

Conjugated photothermal materials and structure design for solar steam generation

• Chia-Yang Lin and
• Tsuyoshi Michinobu

Beilstein J. Nanotechnol. 2023, 14, 454–466, doi:10.3762/bjnano.14.36

• observations (Figure 12a). These materials can stably float at the air–water interface (Figure 12b). The water contact angle of the bulk materials was as high as 130° without any surface modification (Figure 12c). Hydrophobic foams are considered to have advantages over hydrophilic foams, such as a greater