As an interdisciplinary field consisting mainly of nanotechnology and data science, nanoinformatics has significantly advanced over the last decade, playing an increasingly important role in research and development in nanomedicine and environmental health impact assessment of nanomaterials. In addition, efforts in nanoinformatics research have provided in a multitude of tools and resources that are being made available through nanoinformatics cyberinfrastructures and web platforms. However, much of the current research and advances in nanoinformatics are not documented in dedicated resources and, given the interdisciplinary nature of nanoinformatics, are dispersed throughout a wide range of sources and journals. As a consequence, researchers and practitioners in other fields of nanotechnology have been at a disadvantage not having easy access to the most recent resources and tools provided by the nanoinformatics research community. Accordingly, this Thematic Series is devoted to bring together the state-of-the-art in nanoinformatics with a particular focus on the latest related developments and applications for environmental health and biomedicine.