Catalytic asymmetric formal synthesis of beraprost

• Yusuke Kobayashi,
• Ryuta Kuramoto and
• Yoshiji Takemoto

Beilstein J. Org. Chem. 2015, 11, 2654–2660, doi:10.3762/bjoc.11.285

• yield (Table 1, entry 8). With both the AIOM adducts 5 and 6 in hand, we next investigated the construction of the tricyclic core (Scheme 3 and Scheme 4). The cross-Claisen condensation of 6 with lithium tert-butyl acetate afforded the corresponding β-ketoester, which was then treated with 2-azido-1,3

A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids

• Johanna Trenner and
• Evgeny V. Prusov

Beilstein J. Org. Chem. 2015, 11, 323–327, doi:10.3762/bjoc.11.37

• ] variant of Lacey–Dieckmann [8] condensation (Scheme 1) [9][10]. Reaction of either β-ketoester 4 or Meldrum’s acid derivative 9 with suitably protected glycine esters (5,6,10), followed by base-induced condensation furnished the desired tetramic acid model compounds as crystalline solids after treatment

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

• Yiyang Liu,
• Marc Liniger,
• Ryan M. McFadden,
• Jenny L. Roizen,
• Jacquie Malette,
• Corey M. Reeves,
• Douglas C. Behenna,
• Masaki Seto,
• Jimin Kim,
• Justin T. Mohr,
• Scott C. Virgil and
• Brian M. Stoltz

Beilstein J. Org. Chem. 2014, 10, 2501–2512, doi:10.3762/bjoc.10.261

• (±)-32 in racemic form. We anticipated the interception of (−)-32 [57] in Danishefsky’s route using enantioselective palladium-catalyzed allylic alkylation to set the quaternary stereocenter. The formal total synthesis of (−)-dysidiolide (29) commenced with known allyl β-ketoester 4 (Scheme 7), which was

• -cyclohexanedione (40), which was converted to isobutyl vinylogous ether 41 under acid promotion (Scheme 9) [65]. The β-ketoester 42 was prepared using a two-step sequence of acylation and alkylation, then treated with the (S)-t-Bu-PHOX catalyst system (with [Pd(dmdba)2]) to generate (+)-43 in 86% ee. The challenge

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

• Thilo Focken and
• Stephen Hanessian

Beilstein J. Org. Chem. 2014, 10, 1848–1877, doi:10.3762/bjoc.10.195

• to allyl diethylphosphonoformate (114) afforded β-ketoester 115, which in turn was condensed with commercially available azetidinone 116 to give 117 as a mixture of diastereomers. Protection of the nitrogen with TBS triflate followed by deprotection of the allyl carboxylate with formic acid under

Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

• Patrick Rabe,
• Tim A. Klapschinski,
• Nelson L. Brock,
• Christian A. Citron,
• Paul D’Alvise,
• Lone Gram and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2014, 10, 1796–1801, doi:10.3762/bjoc.10.188

• . Oxidative cleavage of the glycol with NaIO4 resulted in a β-ketoester aldehyde that upon treatment with silica gel underwent an intramolecular aldol condensation to a mixture of 10a and 11a that were separable by column chromatography. Oxidation with DDQ gave tert-butyl tropone-2-carboxylate (12a) that was

• cycloheptanone derivatives with rigorously simplified structures as compared to TDA were included in this study. The β-ketoester 27 containing a Michael acceptor was synthesised from methyl cycloheptanone-2-carboxylate (26) by oxidation with Cu(OAc)2 and Pb(OAc)2 according to a known procedure [16]. The compound

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• (77a), the aldehyde function (77b), or the β-ketoester function (77c) (Scheme 29) [101][102]. In contrast to the N-1-substituted homo-C-nucleosides 78, the C-4 or C-6-substituted C-nucleosides (i.e., compounds 79 or 80, respectively) were obtained with the diastereoisomeric excess varied from 33% to 50

• of the sugar aldehyde 77b or the sugar β-ketoester 77c, respectively. The debenzylated forms of C-nucleosides 78, 79 and 80 (as single diastereoisomers) were evaluated in vitro and in vivo as antimitotic agents [41]. They appeared to be less active than the reference (4S)-monastrol. Pyranose-derived

Recent applications of the divinylcyclopropane–cycloheptadiene rearrangement in organic synthesis

• Sebastian Krüger and
• Tanja Gaich

Beilstein J. Org. Chem. 2014, 10, 163–193, doi:10.3762/bjoc.10.14

• alcohol to yield aldehyde 34. Addition of double deprotonated methyl acetoacetate gave β-ketoester 35. Diazotransfer followed by double protection resulted in the formation of compound 36. Rh-catalyzed intramolecular cyclopropanation of this compound gave bicycle 37. Selective removal of the secondary

Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

• Haijun Qu,
• Xuejian Li,
• Fan Mo and
• Xufeng Lin

Beilstein J. Org. Chem. 2013, 9, 2846–2851, doi:10.3762/bjoc.9.320

• Biginelli [3][4]. Among them, the Biginelli multicomponent reaction, involving a multicomponent condensation of aldehyde, β-ketoester, and urea, provides an easy access to the preparation of DHPMs, because multicomponent reactions (MCRs) are considered with high facileness, efficiency and economy in organic

The chemistry of isoindole natural products

• Klaus Speck and
• Thomas Magauer

Beilstein J. Org. Chem. 2013, 9, 2048–2078, doi:10.3762/bjoc.9.243

• Rh(II)-catalyzed C–H and OH insertion reactions (Scheme 4). The preparation of both enantiomeric furanose building blocks commenced with the Rh2(OAc)4-catalyzed OH insertion of 39, respectively 40 into the α-diazo-β-ketoester 40. A tandem [3,3]/[1,2]-rearrangement cascade, followed by reductive

Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters

• Lin Yan,
• Zhiqiang Han,
• Bo Zhu,
• Caiyun Yang,
• Choon-Hong Tan and
• Zhiyong Jiang

Beilstein J. Org. Chem. 2013, 9, 1853–1857, doi:10.3762/bjoc.9.216

• compounds with chiral quaternary carbon centres containing a fluorine atom. Results and Discussion In the preliminary experiments, we investigated the reaction of α-fluoro-β-ketoester 1a with MBH carbonate 2a as the model substrate, in the presence of several commercially available Cinchona alkaloids as

• of the allylic alkylation with respect to various MBH carbonates 2 and α-fluoro-β-ketoester 1a was investigated (Table 2, entries 7–20). The desired allylic alkylation adducts 3ab–o were achieved in moderate to good yields with good to excellent enantioselectivities and moderate

• centres containing a fluorine atom, were successfully prepared in 50–93% yields with 84–96% ee and a dr of 3:1 to 4:1. The absolute configurations of adducts still have to be determined and will be reported in due course. Experimental Representative procedure for the synthesis of 3aa: α-Fluoro-β-ketoester

A reductive coupling strategy towards ripostatin A

• Kristin D. Schleicher and
• Timothy F. Jamison

Beilstein J. Org. Chem. 2013, 9, 1533–1550, doi:10.3762/bjoc.9.175

• recognized that reaction of the enolate of ester 45, a compound previously synthesized in just two steps, and subsequent oxidation could give the β-ketoester 61. Decarboxylation of this compound would provide rapid access to the key iodocyclization substrate 55. Aldehyde 62 was prepared by reduction of the

• thiazolidinethione 60 with DIBAL-H (Scheme 15). Treatment of the ester with LDA, followed by trapping with the aldehyde, afforded the aldol adduct as a mixture of up to four possible diastereomers. This was then oxidized under Ley’s conditions [62] to the β-ketoester 61, itself a mixture of two diastereomers

• analogous procedure for aldol reaction and oxidation the TMSE β-ketoester was obtained (Scheme 17). Treatment with an excess of TBAF in THF at room temperature overnight resulted in formation of the β-hydroxyketone 63. Although the yield for this transformation remained moderate, it was higher than that

Mechanistic studies on the CAN-mediated intramolecular cyclization of δ-aryl-β-dicarbonyl compounds

• Brian M. Casey,
• Dhandapani V. Sadasivam and
• Robert A. Flowers II

Beilstein J. Org. Chem. 2013, 9, 1472–1479, doi:10.3762/bjoc.9.167

• products in moderate to good yields. Additionally, cyclization of the β-ketoester 1b proceeded efficiently, generating 2b in an 85% yield. Previous work by Rickards and co-workers on a related system reported strong electronic effects when electron-donating substituents were incorporated onto the δ-aryl

Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation

• Lynnie Trzoss,
• Jing Xu,
• Michelle H. Lacoske and
• Emmanuel A. Theodorakis

Beilstein J. Org. Chem. 2013, 9, 1135–1140, doi:10.3762/bjoc.9.126

• under Meerwein’s conditions to afford β-ketoester 17. Treatment of 17 with TMSOTf/Et3N followed by enolate alkylation [82] under TBAF/MeI conditions afforded the desired C-5 quaternary center of 18 as a single isomer (35% over four steps). Global reduction of 18 with lithium aluminium hydride produced

Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach

• Pankaj Chauhan and
• Swapandeep Singh Chimni

Beilstein J. Org. Chem. 2012, 8, 2132–2141, doi:10.3762/bjoc.8.240

• catalyst activates and orients the β-ketoester. Morita–Baylis–Hillman (MBH) reaction The Morita–Baylis–Hillman (MBH) reaction provides a very useful and interesting method for the synthesis of β-hydroxycarbonyl compounds with an α-alkylidene group [49][50][51][52][53]. Mechanochemical methods of neat

• of the solvent-free organocatalytic pestle and mortar grinding methodology for the enantioselective amination of β-ketoester 13a with di-isopropylazodicarboxylate (25) (Scheme 12) [48]. Using 5 mol % of X the chiral adduct 26 bearing an amino group at a quaternary stereocentre was obtained in 97

• . Enantioselective amination of β-ketoester by using pestle and mortar. Acknowledgements Our research work was supported by the research project sanctioned to S. S. C. by the Department of Science and Technology (DST) India [SR/S1/OC 35/2011]. Financial support from UGC, India, under CAS-I is gratefully

Recyclable fluorous cinchona alkaloid ester as a chiral promoter for asymmetric fluorination of β-ketoesters

• Wen-Bin Yi,
• Xin Huang,
• Zijuan Zhang,
• Dian-Rong Zhu,
• Chun Cai and
• Wei Zhang

Beilstein J. Org. Chem. 2012, 8, 1233–1240, doi:10.3762/bjoc.8.138

• the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification. Keywords: asymmetric fluorination; β-ketoester; fluorous cinchona ester; organocatalysis; recyclable chiral promoter; Introduction Fluorinated organic

• hand, we explored the fluorination reaction using ethyl 2-methyl-3-oxo-3-phenylpropanoate (1a) as a model compound. Nonfluorous quinine esters, such as C-2 and C-3, cinchona alkaloids C-4 and C-5, and fluorous pyrrolidine ester C-6, were also evaluated (Figure 2). The results of the fluorination of β

• -ketoester 1a with Selectfluor and different promoters are listed in Table 1. It was found that using MeCN as a solvent with 1 equiv of C-1 gave fluorinated product 2a in 49% yield and 65% ee (Table 1, entry 1). Compared to other promoters (Table 1, entries 2–5), C-1 gave fluorinated products in a slightly

Intramolecular carbenoid ylide forming reactions of 2-diazo-3-keto-4-phthalimidocarboxylic esters derived from methionine and cysteine

• Marc Enßle,
• Stefan Buck,
• Roland Werz and
• Gerhard Maas

Beilstein J. Org. Chem. 2012, 8, 433–440, doi:10.3762/bjoc.8.49

• trap HCl) with the acid chloride of 6a. Although the yield was modest (28%), it was still better and gave fewer byproducts than the β-ketoester route. The phthaloylation of 5a–c was achieved with phthalic anhydride in the presence of a catalytic amount of triethylamine to lower the reaction temperature

Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters

• Lukas Hintermann,
• Mauro Perseghini and
• Antonio Togni

Beilstein J. Org. Chem. 2011, 7, 1421–1435, doi:10.3762/bjoc.7.166

• of a β-ketoester substructure (Figure 1c) [16]. Fluorinated agrochemicals and drugs are now produced industrially on a large scale by a range of methods, including reactions with notoriously reactive fluorine gas in the production of the anticancer drug fluorouracil (Figure 1d) [17]. However, many

• reactions were developed, before Differding and Lang found the first stoichiometric asymmetric fluorination of β-ketoester enolates with a chiral N–F (N-fluoroamine) reagent in 1988 [21]. Later work by Davis [22][23], Takeuchi [24] and their respective coworkers extended this chemistry, while Haufe and

• for α-methyl-β-ketoester 4, which was fluorinated in high yield with the aid of TiCl4 as a catalyst (Scheme 4a). With the same catalyst, β-ketoester 5 suffered partial cleavage of the ester group, but the milder Lewis acid CpTiCl3 induced a clean fluorination with high selectivity towards

PEG-embedded KBr₃: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

• Sanny Verma,
• Suman L. Jain and
• Bir Sain

Beilstein J. Org. Chem. 2011, 7, 1334–1341, doi:10.3762/bjoc.7.157

• ethanol, which could be the real catalyst for the present transformation. The probable mechanistic pathway is shown in Scheme 3, which is in analogy to the established mechanism as reported in the literature [30][31]. According to the proposed pathway, aniline reacts with β-ketoester and aldehyde in the

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

• Marcus Baumann,
• Ian R. Baxendale,
• Steven V. Ley and
• Nikzad Nikbin

Beilstein J. Org. Chem. 2011, 7, 442–495, doi:10.3762/bjoc.7.57

• indole synthesis a hydrazine, which is most commonly derived from the corresponding diazonium salt, is reacted with a suitable carbonyl compound. Alternatively, the Japp–Klingemann reaction can be used to directly couple the diazonium salt with a β-ketoester to obtain a hydrazone which can then undergo

Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B

• Silke Dubberke,
• Muhammad Abbas and
• Bernhard Westermann

Beilstein J. Org. Chem. 2011, 7, 421–425, doi:10.3762/bjoc.7.54

• cyclohexenone (+)-7, which is the key building block in our synthesis, was the incorporation of a C2 unit into β-ketoester (−)-1c (Scheme 3). This was achieved by adding ethynyl magnesium bromide in THF at room temperature. The cyclohexenol (+)-6 can be isolated in 79% yield with a diastereomeric ratio of 96:4

• synthesized enantiomerically pure in a two step procedure starting from optically pure β-ketoester (−)-1c in an overall yield of 65%. Furthermore, we have shown that the oxidative allylic rearrangement of cycloalkenols can be carried out easily despite a high degree of functionalization and steric

• ), 178 (23), 150 (21), 119 (65), 91 (50); Anal. Calcd for C12H14O3 (206.2): C, 69.89; H, 6.84. Found: C, 69.72; H, 7.03. (9E)- and (9Z)-trisporic acid B. PLE (pig liver esterase)-catalyzed saponification of β-ketoesters 1. Synthesis and PLE-catalyzed saponification of β-ketoester 1c. Synthesis of key

Approaches towards the synthesis of 5-aminopyrazoles

• Ranjana Aggarwal,
• Vinod Kumar,
• Rajiv Kumar and
• Shiv P. Singh

Beilstein J. Org. Chem. 2011, 7, 179–197, doi:10.3762/bjoc.7.25

• -ketonitriles 16 with a substituted hydrazine in the presence of Et3N in ethanol under reflux conditions. The intermediate 16 was obtained from β-ketoester 15 on treatment with TFA, which in turn was synthesized by condensing 4-(phenylsulfonamidomethyl)cyclohexane carboxylic acid or benzoic acid 13

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

• Norio Shibata,
• Andrej Matsnev and
• Dominique Cahard

Beilstein J. Org. Chem. 2010, 6, No. 65, doi:10.3762/bjoc.6.65

• Scheme 14. Reagent 18 was obtained as a 1:1 mixture of diastereoisomers originating from the chirality at the sulfur atom. The trifluoromethylation of a β-ketoester by 18 was then carried out in the presence of DBU to furnish the trifluoromethylated β-ketoester in 43% yield but as a racemate (Scheme 14

• dicyanoalkylidenes by S-(trifluoromethyl)benzothiophenium salts. Synthesis of chiral S-(trifluoromethyl)benzothiophenium salt 18 and attempt of enantioselective trifluoromethylation of a β-ketoester. Synthesis of O-(trifluoromethyl)dibenzofuranium salts. Photochemical O- and N-trifluoromethylation by 20b. Thermal O

Zeolite catalyzed solvent- free one-pot synthesis of dihydropyrimidin- 2(1H)-ones – A practical synthesis of monastrol

• Mukund G. Kulkarni,
• Sanjay W. Chavhan,
• Mahadev P. Shinde,
• Dnyaneshwar D. Gaikwad,
• Ajit S. Borhade,
• Attrimuni P. Dhondge,
• Yunnus B. Shaikh,
• Vijay B. Ningdale,
• Mayur P. Desai and
• Deekshaputra R. Birhade

Beilstein J. Org. Chem. 2009, 5, No. 4, doi:10.3762/bjoc.5.4

• monastrol, a potent inhibitor of kinesin Eg5. Keywords: Biginelli reaction; DHPMs; neat; MCR; zeolite; Introduction The Biginelli reaction is a well-known multicomponent reaction involving a one-pot cyclocondensation of an aldehyde, β-ketoester and urea/thiourea [1][2][3]. Multicomponent reactions (MCRs

Sordarin, an antifungal agent with a unique mode of action

• Huan Liang

Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31

• (Scheme 9). The latter was directly converted to a β-ketoester by reaction with ethyl diazoacetate in the presence of SnCl2. A final Knoevenagel cyclization afforded substance 45. The enantioselective synthesis implemented an improved procedure that relied on alkylation of the metallohydrazone of 43 with

Synthesis of crispine A analogues via an intramolecular Schmidt reaction

• Ajoy Kapat,
• Ponminor Senthil Kumar and
• Sundarababu Baskaran

Beilstein J. Org. Chem. 2007, 3, No. 49, doi:10.1186/1860-5397-3-49

• 6 can be readily prepared from the β-ketoester 7, which in turn can be synthesized from the dimethoxybenzoic acid 8 as shown in Scheme 4.[30] 3,4-Dimethoxybenzoic acid (8) on treatment with paraformaldehyde in the presence of conc. H2SO4 followed by reduction with LAH gave the corresponding diol 9

• readily converted to the corresponding β-ketoester 7 via Dieckmann cyclization and the resultant product was purified by recrystallization using H2O-EtOH solvent system (Scheme 5). Our attempts towards the alkylation of β-ketoester 7 with 1-chloro-3-iodopropane under different reaction conditions were

• its analogues. Intramolecular Schmidt reaction of olefin azide. Retrosynthetic approach for crispine A analogues. Synthesis of β-ketoester 7. Alkylation of ketal-ester 12. Synthesis of azido-ketone 6. The intramolecular Schmidt cyclization of azido-ketone 6. Synthesis of acid analogue of crispine A