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Search for "cross-coupling reaction" in Full Text gives 216 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Radical chemistry in polymer science: an overview and recent advances

  • Zixiao Wang,
  • Feichen Cui,
  • Yang Sui and
  • Jiajun Yan

Beilstein J. Org. Chem. 2023, 19, 1580–1603, doi:10.3762/bjoc.19.116

Graphical Abstract
  • ]. The semiquinone radicals formed during the oxidation of catechol can undergo a cross-coupling reaction to form polymers (Scheme 1). One example is the radical polymerization of urushiol. The earliest recorded application of natural radical polymerization can be traced back to the manufacture of
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Published 18 Oct 2023

N-Sulfenylsuccinimide/phthalimide: an alternative sulfenylating reagent in organic transformations

  • Fatemeh Doraghi,
  • Seyedeh Pegah Aledavoud,
  • Mehdi Ghanbarlou,
  • Bagher Larijani and
  • Mohammad Mahdavi

Beilstein J. Org. Chem. 2023, 19, 1471–1502, doi:10.3762/bjoc.19.106

Graphical Abstract
  • as a sulfenylating source gave the target product in 93% yield. Knochel and co-workers found that copper acetate can catalyze the cross-coupling reaction between (hetero)aryl, alkyl and benzylic zinc halides 36 with N-thiophthalimides 14 (Scheme 18) [55]. Various metal catalysts, including CrCl2
  • low reactivity of these phthalimides, 10 mol % of catalyst was required. Cross-coupling reaction of sulfoximines 44 with N‑(arylthio)succinimides 1 catalyzed by a nanomaterial containing hexagonal boron nitride (h-BN) and γ-cyclodextrin-supported copper(II) acetate (h-BN@γ-CD@Cu(OAc)2) was developed
  • an effective catalysis system (Scheme 29) [63]. Kinetic studies in this cross coupling-reaction indicated that N-(arylthio)succinimides 1 with electron-deficient arene 4 undergoe thioarylation catalyzed by Fe(NTf2)3. Related molecules bearing an electron-rich arene showed an autocatalytic pathway
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Published 27 Sep 2023

Visible-light-induced nickel-catalyzed α-hydroxytrifluoroethylation of alkyl carboxylic acids: Access to trifluoromethyl alkyl acyloins

  • Feng Chen,
  • Xiu-Hua Xu,
  • Zeng-Hao Chen,
  • Yue Chen and
  • Feng-Ling Qing

Beilstein J. Org. Chem. 2023, 19, 1372–1378, doi:10.3762/bjoc.19.98

Graphical Abstract
  • the substrate scope of this photoinduced nickel-catalyzed cross coupling reaction. As illustrated in Scheme 2, a broad array of aliphatic carboxylic acids reacted smoothly in this protocol, providing the corresponding trifluoromethyl aliphatic acyloins in moderate to excellent yields. This mild
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Published 11 Sep 2023

Non-noble metal-catalyzed cross-dehydrogenation coupling (CDC) involving ether α-C(sp3)–H to construct C–C bonds

  • Hui Yu and
  • Feng Xu

Beilstein J. Org. Chem. 2023, 19, 1259–1288, doi:10.3762/bjoc.19.94

Graphical Abstract
  • , tetrahydrofuran or tetrahydropyran can smoothly react with many methyl aryl ketones to obtain the desired coupling products (Scheme 6a) [54]. The mechanism of the dehydrogenation cross-coupling reaction may undergo a radical pathway. Initially, the tert-butoxy radical produced by the dissociation of t-BuOOH may
  • alkylation of S,S-functionalized internal olefins was achieved by a C(sp2)–H/C(sp3)–H cross-coupling reaction using DTBP as oxidant and DABCO·6H2O as an additive in the presence of FeCl3 (Scheme 22) [83]. The reaction provides a convenient route to tetrasubstituted alkenes and proceeds via a typical radical
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Published 06 Sep 2023

Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SO2F2)

  • Xian-Lin Chen and
  • Hua-Li Qin

Beilstein J. Org. Chem. 2023, 19, 901–908, doi:10.3762/bjoc.19.68

Graphical Abstract
  • was not accomplished either by NMR analysis or chromatography. Conclusion In conclusion, we have developed an SO2F2-mediated ring-opening cross-coupling reaction of cyclobutanone oxime derivatives with alkenes for the synthesis of a class of novel elongated nitriles. The newly constructed δ-olefin
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Published 22 Jun 2023

Pyridine C(sp2)–H bond functionalization under transition-metal and rare earth metal catalysis

  • Haritha Sindhe,
  • Malladi Mounika Reddy,
  • Karthikeyan Rajkumar,
  • Akshay Kamble,
  • Amardeep Singh,
  • Anand Kumar and
  • Satyasheel Sharma

Beilstein J. Org. Chem. 2023, 19, 820–863, doi:10.3762/bjoc.19.62

Graphical Abstract
  • on subsequent deprotonation gives the branched alkylated product 4. Whereas, in case of styrene 3 a 1,2-insertion takes place possibly due to the formation of the stable benzallylic species 8, which on deprotonation gives the linear alkylated product 5. The C–H activation/C–C cross-coupling reaction
  • , acrylates, allenes, and alkynes as coupling partners achieving the functionalized C(sp2)–H-olefinated pyridine frameworks via metal catalysis. ortho-C–H Alkenylation In 2012, Huang and co-workers [74] disclosed a ligand-free oxidative cross-coupling reaction of pyridine with acrylates, acrylamides, and
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Published 12 Jun 2023

Construction of hexabenzocoronene-based chiral nanographenes

  • Ranran Li,
  • Di Wang,
  • Shengtao Li and
  • Peng An

Beilstein J. Org. Chem. 2023, 19, 736–751, doi:10.3762/bjoc.19.54

Graphical Abstract
  • ]azepine and tetrabromothiophene-S,S-dioxide, followed by oxidative aromatization in the presence DDQ to afford compound 25 in an overall 75% yield. Suzuki−Miyaura cross-coupling reaction of compound 25 with (4-ethylphenyl)boronic acid in the presence of Pd(CH3CN)2Cl2, SPhos, and K3PO4 then furnished the
  • Sonogashira cross-coupling reaction of phenylacetylene 50 and 1,4-dibromotetrafluorobenzene. The resulting bis[aryl(ethynyl)]tetrafluorobenzene 59 was able to undergo a 2-fold [4 + 2] cycloaddition reaction with cyclopentadienone 2, affording polyaromatic 60 in a 70% yield. The final step was the Scholl
  • , following the similar synthetic procedure from the dibromo 74 only gave achiral meso isomers (P,P,M,M) [52]. Wang and co-workers synthesized the triangular NG 82 by oxidative cyclodehydrogenation of the hexaphenylbenzene-trimer 81 [53]. As shown in Scheme 9, two-fold Sonogashira cross-coupling reaction of
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Published 30 May 2023

Total synthesis of insect sex pheromones: recent improvements based on iron-mediated cross-coupling chemistry

  • Eric Gayon,
  • Guillaume Lefèvre,
  • Olivier Guerret,
  • Adrien Tintar and
  • Pablo Chourreu

Beilstein J. Org. Chem. 2023, 19, 158–166, doi:10.3762/bjoc.19.15

Graphical Abstract
  • carbon–carbon iron-catalyzed cross coupling as a key step were developed, capitalizing on the low toxicity and the cheap cost of this abundant metal [10]. For instance, in 1971, Kochi developed an iron-catalyzed alkyl–alkenyl cross-coupling reaction between aliphatic Grignard reagents and vinyl bromides
  • cross coupling reaction developed by Kochi, leading to better yields, with no need to use an excess of one of the coupling partners (Scheme 2b) [12]. The yields obtained using this ligand-free method are comparable to those obtained in recent palladium-mediated alkyl–vinyl cross-couplings using
  • ) as a co-solvent. Nevertheless, capitalizing on these results, Cahiez further developed this iron-catalyzed cross coupling reaction with dienol phosphates as electrophiles, which are thermally more stable than dienyl halides [20]. It was found that when dienol phosphates were used as electrophiles
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Published 14 Feb 2023

A new route for the synthesis of 1-deazaguanine and 1-deazahypoxanthine

  • Raphael Bereiter,
  • Marco Oberlechner and
  • Ronald Micura

Beilstein J. Org. Chem. 2022, 18, 1617–1624, doi:10.3762/bjoc.18.172

Graphical Abstract
  • the cross coupling reaction. We also mention that we did not decide for a direct transformation [27][28] of 6-iodo-1-deazapurine into 6-hydroxy-1-deazapurine for reasons of solubility and desired regioselectivity of the subsequent nitration reaction. 1-Deazahypoxanthine Synthesis of 1
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Published 29 Nov 2022

Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane)

  • Yukiko Karuo,
  • Atsushi Tarui,
  • Kazuyuki Sato,
  • Kentaro Kawai and
  • Masaaki Omote

Beilstein J. Org. Chem. 2022, 18, 1567–1574, doi:10.3762/bjoc.18.167

Graphical Abstract
  • HF from 1 provides 2 as an E/Z mixuture (E/Z = 1:1). We speculated that the stability of the E isomer was equal to that of the Z isomer under these conditions. To expand the scope of this reaction, we subjected product 2 to a Sonogashira cross-coupling reaction (Scheme 3). This gave a highly
  • -coupling reaction of 2a with trimethylsilylacetylene. Optimization of reaction conditions for obtaining 2a from 3a and halothane. Scope of reaction with various substituted phenols (3b–p). Supporting Information Supporting Information File 352: Characterization data for 2b–p and copies of 1H, 13C, and 19F
  • (s, 1F), −78.4 (s, 1F); EIMS m/z: 268, 270 [M]+; HREIMS: [M]+ calcd for C13H14ClFSi, 268.0486, 270.0457; found, 268.0490, 270.0452. Medicines containing a difluoromethylene group. Fluoroalkene analogs of some drugs. Reaction of phenol with polyfluoroalkanes. Proposed mechanism. Sonogashira cross
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Published 21 Nov 2022

An alternative C–P cross-coupling route for the synthesis of novel V-shaped aryldiphosphonic acids

  • Stephen J. I. Shearan,
  • Enrico Andreoli and
  • Marco Taddei

Beilstein J. Org. Chem. 2022, 18, 1518–1523, doi:10.3762/bjoc.18.160

Graphical Abstract
  • order of addition of reactants to perform the transition-metal-catalyzed C–P cross-coupling reaction, often referred to as the Tavs reaction, employing NiCl2 as a pre-catalyst in the phosphonylation of aryl bromide substrates using triisopropyl phosphite. This new method was employed in the synthesis of
  • three novel aryl diphosphonate esters which were subsequently transformed to phosphonic acids through silylation and hydrolysis. Keywords: arylphosphonic acids; cross-coupling reaction; phosphonate esters; transition-metal catalysis; Introduction Phosphonates and phosphonic acids are a very
  • , respectively), which allows for reactions to be run at high temperatures, thus enhancing the rate of the reaction. While the reaction mixture is refluxing, the alkyl phosphite is added in several small portions. The work we present differs from the conventional nickel-catalyzed cross-coupling reaction in two
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Published 07 Nov 2022

Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

  • Kendra Drayton-White,
  • Siyue Liu,
  • Yu-Chia Chang,
  • Sakashi Uppal and
  • Kevin D. Moeller

Beilstein J. Org. Chem. 2022, 18, 1488–1498, doi:10.3762/bjoc.18.156

Graphical Abstract
  • peptide so that the thiol group in the sidechain could be used to place the molecule the array with the use of an electrochemically initiated Cu(I)-catalyzed cross-coupling reaction (Scheme 1) [9]. To this end, the Cu(I) catalyst needed for the reaction was generated at the electrodes by the reduction of
  • for the confinement strategy to keep up. The result is a loss in confinement. It is important to point out that the reaction shown in Scheme 1 is not a typical electrosynthetic reaction. The cross-coupling reaction shown is a Cu(I)-catalyzed transformation that requires no recycling of a reagent
  • 12 electrodes each functionalized with pyrene-butanol at various places on the array. For the placement reaction, the Cu(I)-catalyzed cross-coupling reaction used above (Scheme 1) was employed for 4 cycles (90 s on and 180 s off). The chemistry placed enough of the alcohol by the electrodes for the
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Published 20 Oct 2022

Electrochemical formal homocoupling of sec-alcohols

  • Kosuke Yamamoto,
  • Kazuhisa Arita,
  • Masashi Shiota,
  • Masami Kuriyama and
  • Osamu Onomura

Beilstein J. Org. Chem. 2022, 18, 1062–1069, doi:10.3762/bjoc.18.108

Graphical Abstract
  • /mol, 0 °C, under air. a100 mA cc. b6 F/mol, imidazole (0.075 equiv). c6 F/mol. d8 F/mol, imidazole (0.1 equiv) e8 F/mol, MeCN/MeOH (4:1, 5 mL) without H2O. Investigation of cross-coupling reaction. Large-scale experiment. Control experiments. aDetermined by 1H NMR using 1,3,5-trimethoxybenzene as an
  • -coupling reaction of two different benzyl alcohols (Scheme 3). Pleasingly, the reaction using a 1:1 mixture of 1a and 1f under the standard reaction conditions provided the cross-coupling product 2af (dr = 94:6) together with the homocoupling products 2a and 2f. To demonstrate the scalability of the
  • diastereoselectivity [47]. Benzhydrol derivatives (1n–p) were found to be good substrates for the present reaction, affording the corresponding benzopinacols (2n–p) in good yields after the passage of 8 F/mol in a mixed solvent of MeCN/MeOH. Next, we examined the possibility to extend the present process to the cross
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Published 22 Aug 2022

Synthesis of novel alkynyl imidazopyridinyl selenides: copper-catalyzed tandem selenation of selenium with 2-arylimidazo[1,2-a]pyridines and terminal alkynes

  • Mio Matsumura,
  • Kaho Tsukada,
  • Kiwa Sugimoto,
  • Yuki Murata and
  • Shuji Yasuike

Beilstein J. Org. Chem. 2022, 18, 863–871, doi:10.3762/bjoc.18.87

Graphical Abstract
  • selenides [25]. In this reaction, unlike the former, bis(imidazo[1,2-a]pyridin-3-yl) diselenides are generated through C–H selenation at the 3-position of 2-arylimidazopyridines with Se powder, followed by the cross-coupling reaction between diselenides and triarylbismuthines. These one-pot reactions are
  • imidazopyridinyl selenides A Cu-catalyzed cross-coupling reaction using benzene ring substituted diaryl diselenides with terminal alkynes in the presence of bases is effective for synthesizing aryl alkynyl selenides [27][28][29][30][31]. We previously reported a simple method for the synthesis of bis(2-arylimidazo
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Published 19 Jul 2022

DDQ in mechanochemical C–N coupling reactions

  • Shyamal Kanti Bera,
  • Rosalin Bhanja and
  • Prasenjit Mal

Beilstein J. Org. Chem. 2022, 18, 639–646, doi:10.3762/bjoc.18.64

Graphical Abstract
  • , followed by hydride abstraction to generate the desired product 2a. On the other hand, the formation of quinazolin-4(3H)-ones starts with the formation of an imine intermediate and then it will follow the similar mechanistic pathway. To explore the synthetic utility of the oxidative C–N cross-coupling
  • reaction, we have performed the large-scale synthesis under the solvent-free (ball milling) conditions as shown in Figure 6. In this context, milling of the substrate (E)-N-(2-((4-bromobenzylidene)amino)phenyl)-4-methylbenzenesulfonamide (1c, 2.795 mmol) in the presence of 1.2 equiv of DDQ delivered 1.098
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Published 01 Jun 2022

Substituent effect on TADF properties of 2-modified 4,6-bis(3,6-di-tert-butyl-9-carbazolyl)-5-methylpyrimidines

  • Irina Fiodorova,
  • Tomas Serevičius,
  • Rokas Skaisgiris,
  • Saulius Juršėnas and
  • Sigitas Tumkevicius

Beilstein J. Org. Chem. 2022, 18, 497–507, doi:10.3762/bjoc.18.52

Graphical Abstract
  • of aryl moieties into methylthio-substituted nitrogen heterocycles such as tCBz-mPYR are a Ni(0)-catalyzed cross-coupling reaction with Grignard reagents [34][36] or the Liebeskind–Srogl reaction employing arylboronic acids [37][38][39]. Taking into account a large assortment of arylboronic acids and
  • the simplicity of the method, we chose the Liebeskind–Srogl cross-coupling reaction for the synthesis of the target 2-arylpyrimidine derivatives. Thus, heating tCbz-mPYR with phenyl-, 4-cyanophenyl-, 3-cyanophenyl-, or 3-bromophenylboronic acid at 130 °C in dioxane in the presence of Pd(PPh3)4, copper
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Published 05 May 2022

Borylated norbornadiene derivatives: Synthesis and application in Pd-catalyzed Suzuki–Miyaura coupling reactions

  • Robin Schulte and
  • Heiko Ihmels

Beilstein J. Org. Chem. 2022, 18, 368–373, doi:10.3762/bjoc.18.41

Graphical Abstract
  • (HRMS). To assess the suitability of the boronic esters 2a and 2b to be used as building blocks in Suzuki–Miyaura reactions, the Pd-catalyzed cross-coupling reaction of norbornadiene 2a and bromobenzene (4a) was examined under different conditions (Table 1, Scheme 2). First experiments were conducted
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Published 01 Apr 2022

Unexpected chiral vicinal tetrasubstituted diamines via borylcopper-mediated homocoupling of isatin imines

  • Marco Manenti,
  • Leonardo Lo Presti,
  • Giorgio Molteni and
  • Alessandra Silvani

Beilstein J. Org. Chem. 2022, 18, 303–308, doi:10.3762/bjoc.18.34

Graphical Abstract
  • intermediate spontaneously turns into the carbanion C, thus realizing the imine umpolung and allowing the cross-coupling reaction with the remaining electrophilic ketimine 1. The complete diastereoselectivity would arise from the mutual approach of the two oxindole nuclei from the less hindered side, that is
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Published 10 Mar 2022

Recent developments and trends in the iron- and cobalt-catalyzed Sonogashira reactions

  • Surendran Amrutha,
  • Sankaran Radhika and
  • Gopinathan Anilkumar

Beilstein J. Org. Chem. 2022, 18, 262–285, doi:10.3762/bjoc.18.31

Graphical Abstract
  • the bench stability of the nanoparticles, and hence methylmagnesium bromide was introduced to retain the catalytic activity. Heterogeneous green protocols Rizi and co-workers reported a silica-supported green heterogeneous Fe(III) catalyst for the cross-coupling reaction of aryl iodides and
  • /hydroalkoxylation of alkynes was also reported (Scheme 8). Vogel and co-workers demonstrated the Sonogashira cross-coupling reaction of aryl iodides with terminal alkynes by utilizing cheap, non-toxic iron salts and copper iodide (Scheme 9) [26]. The reaction of 4-iodotoluene with phenylacetylene was chosen as the
  • product yield was obtained. The ligands tested in the cross-coupling reaction were shown to have a dramatic impact on the yield of the final product. Electron-rich aryl iodides showed higher yields than electron-deficient ones. In addition, 2-thiophenyl iodide also showed good yields of the products with
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Published 03 Mar 2022

Recent advances and perspectives in ruthenium-catalyzed cyanation reactions

  • Thaipparambil Aneeja,
  • Cheriya Mukkolakkal Abdulla Afsina,
  • Padinjare Veetil Saranya and
  • Gopinathan Anilkumar

Beilstein J. Org. Chem. 2022, 18, 37–52, doi:10.3762/bjoc.18.4

Graphical Abstract
  • oxidative cyanation of aza-Baylis–Hillman adducts. Synthesis of 1° alkyl nitriles using [Ru(bpy)3](PF6)2 as the photocatalyst. Synthesis of 2° and 3° alkyl nitriles using [Ru(bpy)3](PF6)2 as the photocatalyst. Photoredox cross coupling reaction. Synthesis of α-amino nitriles from amines via a one-pot
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Published 04 Jan 2022

DABCO-promoted photocatalytic C–H functionalization of aldehydes

  • Bruno Maia da Silva Santos,
  • Mariana dos Santos Dupim,
  • Cauê Paula de Souza,
  • Thiago Messias Cardozo and
  • Fernanda Gadini Finelli

Beilstein J. Org. Chem. 2021, 17, 2959–2967, doi:10.3762/bjoc.17.205

Graphical Abstract
  • through this step were used in a well-stablished nickel-catalyzed cross-coupling reaction [19][27][28][29][30] with aryl bromides as a proof of concept, leading to the synthesis of aryl ketones. We also present computational calculations of the HAT reaction step with the DABCO radical cation as the
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Published 21 Dec 2021

Iron-catalyzed domino coupling reactions of π-systems

  • Austin Pounder and
  • William Tam

Beilstein J. Org. Chem. 2021, 17, 2848–2893, doi:10.3762/bjoc.17.196

Graphical Abstract
  • first Fe-catalyzed cross-coupling reaction between Grignard reagents and vinyl halides [37]. As of late, the development of Fe-catalyzed cross-coupling methodology and mechanistic rationales have burgeoned [38]. Today, the rate of growth within the field of iron catalysis is much greater than that
  • iron-catalyzed cross-coupling reactions of alkyl halides began in 2004 when Nakamura first reported the TMEDA-mediated Fe-catalyzed cross-coupling reaction between secondary bromides with aryl Grignard reagents [52]. Since then, several reports of alkyl halide cross-coupling reactions have been
  • reported [53]. In 2015, Kang and co-workers described a FeCl2-catalyzed tandem cyclization/cross-coupling reaction of alkyl iodides 1 with aryl Grignard reagents 2 to give arylmethyl-substituted pyrrolidines and tetrahydrofurans 3 in poor to excellent yield (Scheme 3) [54]. The concept of alkyl halide
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Published 07 Dec 2021

Ligand-dependent stereoselective Suzuki–Miyaura cross-coupling reactions of β-enamido triflates

  • Tomáš Chvojka,
  • Athanasios Markos,
  • Svatava Voltrová,
  • Radek Pohl and
  • Petr Beier

Beilstein J. Org. Chem. 2021, 17, 2657–2662, doi:10.3762/bjoc.17.179

Graphical Abstract
  • stereoselective outcome of the Suzuki cross-coupling reaction of various (Z)-β-enamido triflates (Scheme 1B). Results and Discussion We initiated our study by examining the Suzuki cross-coupling of vinyl triflate 1a and 3-nitrophenylboronic acid. First, the influence of the catalyst on the stereoselective outcome
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Published 29 Oct 2021

Electrocatalytic C(sp3)–H/C(sp)–H cross-coupling in continuous flow through TEMPO/copper relay catalysis

  • Bin Guo and
  • Hai-Chao Xu

Beilstein J. Org. Chem. 2021, 17, 2650–2656, doi:10.3762/bjoc.17.178

Graphical Abstract
  • electrocatalytic dehydrogenative cross-coupling reaction of tetrahydroisoquinolines with terminal alkynes in continuous flow (Scheme 1D). These reactions require low loadings of supporting electrolyte and proceed through Cu/TEMPO relay catalysis without need for additional ligands. Results and Discussion The
  • electrochemistry is an ideal tool for promoting dehydrogenative cross-coupling reactions as no external chemical oxidants are needed [11][12][13][14][15][16][17][18][19]. In this context, Mei and co-workers have reported an elegant TEMPO/[L*Cu] co-catalyzed asymmetric electrochemical dehydrogenative cross-coupling
  • reaction of tetrahydroisoquinolines with terminal alkynes (Scheme 1C) [10]. The chiral ligand was found to be critical for the stereoinduction as well as product formation for these electrochemical reactions that are conducted in batch. Continuous-flow electrochemical microreactors offer several advantages
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Published 28 Oct 2021

Visible-light-mediated copper photocatalysis for organic syntheses

  • Yajing Zhang,
  • Qian Wang,
  • Zongsheng Yan,
  • Donglai Ma and
  • Yuguang Zheng

Beilstein J. Org. Chem. 2021, 17, 2520–2542, doi:10.3762/bjoc.17.169

Graphical Abstract
  • copper-catalyzed C–O cross-coupling reaction. Results of mechanistic studies indicated that in this case a CuI–phenoxide complex is a competent intermediate in the photoinduced C–O bond formation. In 2020, Nguyen and co-worker [90] reported copper-catalyzed C–O cross-coupling of glycosyl bromides with
  • -base photocatalysis. Olefinic C–H functionalization and allylic alkylation. Cross-coupling of unactivated alkenes and CF3SO2Cl. Chlorosulfonylation/cyanofluoroalkylation of alkenes. Hydroamination of alkenes. Cross-coupling reaction of alkenes, alkyl halides with nucleophiles. Cross-coupling of alkenes
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Published 12 Oct 2021
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