Search results

Search for "acid hydrolysis" in Full Text gives 57 result(s) in Beilstein Journal of Organic Chemistry.

A novel high-yield synthesis of aminoacyl p-nitroanilines and aminoacyl 7-amino-4-methylcoumarins: Important synthons for the synthesis of chromogenic/fluorogenic protease substrates

  • Xinghua Wu,
  • Yu Chen,
  • Herve Aloysius and
  • Longqin Hu

Beilstein J. Org. Chem. 2011, 7, 1030–1035, doi:10.3762/bjoc.7.117

Graphical Abstract
  • and Boc-Phe-OH in excellent yields (Table 2, entries 5–7). It should also be pointed out that we previously determined the extent of racemization in the one-pot 3-step selenocarboxylate/azide amidation procedure using acid hydrolysis of the product amide with 6 N HCl followed by derivatization with o
PDF
Album
Supp Info
Full Research Paper
Published 27 Jul 2011

Metathesis access to monocyclic iminocyclitol-based therapeutic agents

  • Ileana Dragutan,
  • Valerian Dragutan,
  • Carmen Mitan,
  • Hermanus C.M. Vosloo,
  • Lionel Delaude and
  • Albert Demonceau

Beilstein J. Org. Chem. 2011, 7, 699–716, doi:10.3762/bjoc.7.81

Graphical Abstract
  • tetrahydropyridine scaffold 72 allowed an efficient synthesis of 1-deoxynojirimycin 62, and its stereoisomers 65 and 66. Thus, acid hydrolysis of the epoxy ring in the anti isomer 73 (H2SO4/dioxane/H2O, 0.2:3:2) gave 1-deoxynojirimycin (62) and 1-deoxyaltronojirimycin (65) in a 1:1 ratio and in 89% yield. Conversely
PDF
Album
Review
Published 27 May 2011

Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues

  • Lucie Brulikova and
  • Jan Hlavac

Beilstein J. Org. Chem. 2011, 7, 678–698, doi:10.3762/bjoc.7.80

Graphical Abstract
  • treatment of 5-bromo-2,4-diethoxypyrimidine (65) with either perfluorobutyl or perfluorohexyl iodide in the presence of activated copper bronze in DMSO. This reaction afforded 5-(perfluoroalkyl)pyrimidines 66 and 67 in high yields. Subsequent acid hydrolysis of 66 and 67 provided 5-(perfluoroalkyl
PDF
Album
Review
Published 26 May 2011

A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

  • Nimalini D. Moirangthem and
  • Warjeet S. Laitonjam

Beilstein J. Org. Chem. 2010, 6, 1056–1060, doi:10.3762/bjoc.6.120

Graphical Abstract
  • malononitrile gave intermediate A, which undergoes intramolecular cyclization to form the intermediate B, and then acid hydrolysis of B afforded 2. Further evidence is that the reaction of 5-ethoxymethylene-1,3-diaryl-2-thiobarbituric acids with malononitrile under the standard conditions. This reaction only
PDF
Album
Supp Info
Full Research Paper
Published 09 Nov 2010
Graphical Abstract
  • of 23, from which the Boc-group was removed by acid hydrolysis to afford derivative 24. Protein conjugations were performed by reaction of 24 (20 equiv) with human serum albumin (HSA). Compound 20 was similarly activated with dimethyl squarate and conjugated to HSA. MALDI-TOF MS of the HSA-conjugates
PDF
Album
Supp Info
Full Research Paper
Published 26 Jul 2010

The enantiospecific synthesis of (+)-monomorine I using a 5-endo- trig cyclisation strategy

  • Malcolm B. Berry,
  • Donald Craig,
  • Philip S. Jones and
  • Gareth J. Rowlands

Beilstein J. Org. Chem. 2007, 3, No. 39, doi:10.1186/1860-5397-3-39

Graphical Abstract
  • 14a and 14b could be achieved by acid hydrolysis (Scheme 4 and Table 1). However, as with the tosyl-based methodology, such reaction conditions were incompatible with the terminal alkene-substituted pyrrolidine 14c. Therefore alternative deprotection conditions were investigated. Attempted base
PDF
Album
Supp Info
Full Research Paper
Published 08 Nov 2007

Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel

  • Karunananda Bombuwala,
  • Thomas Kinstle,
  • Vladimir Popik,
  • Sonal O. Uppal,
  • James B. Olesen,
  • Jose Viña and
  • Carol A. Heckman

Beilstein J. Org. Chem. 2006, 2, No. 13, doi:10.1186/1860-5397-2-13

Graphical Abstract
  • paclitaxel binding to tubulin. This group needed to be protected during derivatization. Since acid hydrolysis of the acetamide group in (2) also results in a loss of the methyl group on the adjacent tropolone ring [36], the method of Lebeau and coworkers was used to transform the amide group into the
PDF
Album
Supp Info
Full Research Paper
Published 30 Jun 2006
Other Beilstein-Institut Open Science Activities