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Search for "1,3-dicarbonyl compounds" in Full Text gives 84 result(s) in Beilstein Journal of Organic Chemistry.

Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

  • Zong-Bo Xie,
  • Na Wang,
  • Ming-Yu Wu,
  • Ting He,
  • Zhang-Gao Le and
  • Xiao-Qi Yu

Beilstein J. Org. Chem. 2012, 8, 534–538, doi:10.3762/bjoc.8.61

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  • , East China Institute of Technology, Fuzhou, China, 344000; Fax: (+86)794-8258320; Tel:(+86)794-8258320 10.3762/bjoc.8.61 Abstract An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent
  • method. Herein, we report a green protocol for the Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under catalyst- and solvent-free conditions (Scheme 1). Utilizing this simple, rapid, low-cost and effective procedure, various nitro diketone derivatives were synthesized in high yields
  • were used as the acceptors to react with 1,3-dicarbonyl compounds under the optimized conditions. The results are given in Table 1. It can be seen that a wide range of substrates were able to participate in the reaction. A series of substituted β-nitrostyrenes with electron-withdrawing or electron
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Published 11 Apr 2012

Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating

  • Kamal Usef Sadek,
  • Ramadan Ahmed Mekheimer,
  • Tahany Mahmoud Mohamed,
  • Moustafa Sherief Moustafa and
  • Mohamed Hilmy Elnagdi

Beilstein J. Org. Chem. 2012, 8, 18–24, doi:10.3762/bjoc.8.3

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  • 50918, Jeddah 21533, Kingdom of Saudi Arabia Chemistry Department, Faculty of Science, Kuwait University, PO Box 5969, Safat, 13060 Kuwait 10.3762/bjoc.8.3 Abstract The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal
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Published 04 Jan 2012

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

  • Yiwen Yang,
  • Chunxiang Kuang,
  • Hui Jin,
  • Qing Yang and
  • Zhongkui Zhang

Beilstein J. Org. Chem. 2011, 7, 1656–1662, doi:10.3762/bjoc.7.195

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  • based on the condensation of hydrazines with 1,3-dicarbonyl compounds or their equivalents. However, the 1,3-dipolar cycloaddition offers a more convenient synthetic route. Sydnones are easily accessible aromatic compounds and versatile synthetic intermediates. They can be used as unusual, alternative
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Published 12 Dec 2011

Hypervalent iodine(III)-induced methylene acetoxylation of 3-oxo-N-substituted butanamides

  • Wei-Bing Liu,
  • Cui Chen,
  • Qing Zhang and
  • Zhi-Bo Zhu

Beilstein J. Org. Chem. 2011, 7, 1436–1440, doi:10.3762/bjoc.7.167

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  • , the reactions of other N-(alkylsubstituted)-3-oxobutanamides were investigated, such as that of N-methyl-3-oxobutanamide (1l), which led to 1-(methylcarbamoyl)-2-oxopropyl acetate in 89% yield. Furthermore, we applied this method to non-carbamoyl 1,3-dicarbonyl compounds. These substrates, namely 1
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Published 19 Oct 2011

Development of the titanium–TADDOLate-catalyzed asymmetric fluorination of β-ketoesters

  • Lukas Hintermann,
  • Mauro Perseghini and
  • Antonio Togni

Beilstein J. Org. Chem. 2011, 7, 1421–1435, doi:10.3762/bjoc.7.166

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  • ketones in the presence of antimony chloride have appeared [59], while Umemoto used Lewis acids in substoichiometric amounts (0.4 equiv of ZnCl2 or AlCl3) to accelerate fluorinations of 1,3-dicarbonyl compounds with N-fluoropyridinium salts [72]. In 1998, Chambers and Hutchinson reported the reaction of
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Published 17 Oct 2011

PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

  • Sanny Verma,
  • Suman L. Jain and
  • Bir Sain

Beilstein J. Org. Chem. 2011, 7, 1334–1341, doi:10.3762/bjoc.7.157

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  • that it is more environmentally friendly [4][5][8][9]. Among the various known multicomponent reactions, the MCRs that involve 1,3-dicarbonyl compounds, aldehydes, and nucleophilic compounds have received particular interest in recent years owing to their potential to provide different condensation
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Published 28 Sep 2011

Recent advances in the gold-catalyzed additions to C–C multiple bonds

  • He Huang,
  • Yu Zhou and
  • Hong Liu

Beilstein J. Org. Chem. 2011, 7, 897–936, doi:10.3762/bjoc.7.103

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  • -arylhydroxylamines with 1,3-dicarbonyl compounds in situ) to give 3-carbonylated benzofuran derivatives 300 [153]. Trisubstituted isoxazoles 303 were obtained from alkynyl oxime ether 301 through a gold-catalyzed domino reaction involving cyclization and subsequent Claisen-type rearrangement [154]. The presence of
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Published 04 Jul 2011

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

  • Jonathan P. Brand,
  • Clara Chevalley and
  • Jérôme Waser

Beilstein J. Org. Chem. 2011, 7, 565–569, doi:10.3762/bjoc.7.65

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  • -alkynylanilines can be followed by 1,4-addition to enones [15][16], iodination [17] or reaction with 1,3-dicarbonyl compounds [18]. Perumal recently demonstrated that aldehydes and nitroalkenes can be used as electrophilic partners [19][20]. Triple bonds can also serve as a second electrophile for the
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Published 04 May 2011

A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis

  • Magnus Rueping and
  • Boris J. Nachtsheim

Beilstein J. Org. Chem. 2010, 6, No. 6, doi:10.3762/bjoc.6.6

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  • benzylation of arenes and heteroarenes. A gold(III)-catalyzed route to beclobrate. Catalytic FC-type alkylations of 1,3-dicarbonyl compounds. Iron(III)-catalyzed synthesis of phenprocoumon. Bi(OTf)3-catalyzed FC alkylation of benzyl alcohols developed by Rueping et al. (A) Bi(OTf)3-catalyzed intramolecular FC
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Published 20 Jan 2010
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