Effects of the aldehyde-derived ring substituent on the properties of two new bioinspired trimethoxybenzoylhydrazones: methyl vs nitro groups

• Dayanne Martins,
• Roberta Lamosa,
• Talis Uelisson da Silva,
• Carolina B. P. Ligiero,
• Sérgio de Paula Machado,
• Daphne S. Cukierman and
• Nicolás A. Rey

Beilstein J. Org. Chem. 2023, 19, 1713–1727, doi:10.3762/bjoc.19.125

• –H) and δoop(O–H) modes were assigned, respectively, at 1376 and 720 cm−1 for hdz-CH3, and at 1359 and 747 cm−1 for hdz-NO2. Interestingly, DFT showed that, while these vibrations are “clean” in hdz-CH3, they were coupled with NBA ring movements in hdz-NO2. Therefore, the IR results confirm the

• hydrazone, it is evident that deprotonation is almost complete at pH 7.4. For this reason, the intramolecular H-bond identified both in the solid state (XRD, IR) and in solution (1H NMR) is probably absent under physiological or pseudo-physiological conditions. Although still stable at pH 7.4, the hdz-NO2

• maintained in DMSO-d6 solution. It is worth noting that the presence of the electron-withdrawing nitro substituent in hdz-NO2 makes the interaction stronger. An IR spectroscopy study, which was supported by computational calculations, as well as a complete NMR characterization of both compounds, align with

Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect

• Ken-ichi Nakashima,
• Naohito Abe,
• Masayoshi Oyama,
• Hiroko Murata and
• Makoto Inoue

Beilstein J. Org. Chem. 2023, 19, 1604–1614, doi:10.3762/bjoc.19.117

• formula of C45H64O28SNa (calcd 1107.3197). The IR spectrum showed absorption peaks corresponding to hydroxy groups (νmax = 3414 cm−1) and carbonyl groups (νmax = 1782 and 1695 cm−1). The 1H NMR signals (Table 1) were characteristic of a breynogenin moiety, namely, a methyl group [δH 0.92 (d, J = 6.9 Hz

• Hitachi U-2900 spectrometer. ECD spectra were acquired with a JASCO J-820 spectropolarimeter and IR spectra were recorded using a Shimadzu FTIR-8400S spectrophotometer. NMR spectra were acquired with a JEOL JNM-ECZ 400S spectrometer with tetramethylsilane as an internal standard. ESI–MS data were obtained

• compound 4 (1.2 mg). Breynin J (1): amorphous, colorless powder. [α]D22 −8.0 (c 0.05, MeOH); UV λmax (MeOH) nm (log ε): 257 (4.09); IR (KBr) cm−1: 3414, 2969, 2936, 2888, 1782, 1695, 1609, 1516, 1456, 1395, 1348, 1314, 1279, 1167, 1117, 1078, 1036, 854, 831, 773, 741, 700, 667, 619, 550, 511, 471; 1H and

C–H bond functionalization: recent discoveries and future directions

• Indranil Chatterjee

Beilstein J. Org. Chem. 2023, 19, 1568–1569, doi:10.3762/bjoc.19.114

• the abstraction of intramolecular hydrogen atoms. Radical chemistry is a viable alternative to the two-electron process, involving C–H bond functionalization in the absence of any ligand and using low-cost redox-active metals (Fe, Cu, Mn, etc.) rather than heavy metals (Rh, Ir, etc.). Although radical

Functions of enzyme domains in 2-methylisoborneol biosynthesis and enzymatic synthesis of non-natural analogs

• Binbin Gu,
• Lin-Fu Liang and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2023, 19, 1452–1459, doi:10.3762/bjoc.19.104

• ppm) for 1H NMR and the 13C signal of C6D6 (δ = 128.06 ppm) for 13C NMR [39]. Coupling constants are given in Hz. IR spectra were recorded on a Bruker α infrared spectrometer with a diamond ATR probehead. Peak intensities are given as s (strong), m (medium), w (weak) and br (broad). Optical rotations

Consecutive four-component synthesis of trisubstituted 3-iodoindoles by an alkynylation–cyclization–iodination–alkylation sequence

• Nadia Ledermann,
• Alae-Eddine Moubsit and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2023, 19, 1379–1385, doi:10.3762/bjoc.19.99

• ), 7.23–7.26 (m, 1H), 7.46–7.54 (m, 5H); 13C NMR (150 MHz, CDCl3) δ 1.9 (Cquat), 32.4 (CH3), 106.7 (CH), 110.8 (CH), 111.5 (CH), 128.6 (Cquat), 129.3, 130.9, 131.5 (Cquat), 134.5 (Cquat), 143.5 (Cquat), 160.0 (Cquat); IR (cm−1) ν̃: 604 (w), 619 (w), 662 (w), 689 (s), 733 (m), 756 (s), 789 (m), 860 (w

• ), 128.5 (CH), 128.6 (CH), 129.1 (CH), 130.5 (Cquat), 131.0 (CH), 131.4 (Cquat), 131.7 (CH), 137.6 (Cquat), 142.9 (Cquat); IR (cm−1) ν̃: 611 (m), 621 (w), 664 (w), 679 (m), 691 (s), 702 (s), 754 (s), 787 (m), 806 (s), 870 (w), 916 (w), 970 (w), 1022 (w), 1069 (w), 1103 (w), 1148 (w), 1179 (w), 1209 (w

• (CH), 129.1 (CH), 129.8 (CH), 131.3 (CH), 132.2 (Cquat), 132.2 (Cquat), 135.1 (Cquat), 137.4 (Cquat), 137.6 (Cquat); IR (cm−1) ν̃: 698 (s), 721 (m), 741 (s), 783 (w), 810 (m), 918 (w), 939 (m), 1005 (w), 1020 (m), 1037 (w), 1072 (w), 1088 (m), 1117 (w), 1138 (w), 1227 (w), 1261 (w), 1306 (w), 1329 (m

Non-noble metal-catalyzed cross-dehydrogenation coupling (CDC) involving ether α-C(sp³)–H to construct C–C bonds

• Hui Yu and
• Feng Xu

Beilstein J. Org. Chem. 2023, 19, 1259–1288, doi:10.3762/bjoc.19.94

• in functionalizing unactivated C(sp3)–H substrates, including ethers [109][110][111][112][113][114]. In 2018, Wang et al. reported the photocatalytic CDC α-alkylation of N-heteroarenes in acetone solution, using noble-metal Ir as a photocatalyst to induce the reaction (Scheme 41) [115]. Subsequently

•  43d) [126]. Further, in the presence of [Ir{dF(CF3)ppy}2(dtbbpy)]PF6 as a photocatalyst, Na2S2O8 as oxidant, and TFA as an additive, under the irradiation of 26 W CFL at room temperature, the CDC reaction of various heterocyclic aromatics with α-C(sp3)–H bonds of ethers could be accomplished (Scheme

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction

• Ziying Xiao,
• Fengshun Xu,
• Jing Sun and
• Chao-Guo Yan

Beilstein J. Org. Chem. 2023, 19, 1234–1242, doi:10.3762/bjoc.19.91

• structures of the obtained dispiro compounds 3a–m were fully characterized by IR, HRMS, 1H and 13C NMR spectroscopy. Because of the three chiral carbon atoms in the product, several diastereomers might be formed in the reaction. However, TLC monitoring and 1H NMR spectra of the crude products clearly

• , 127.9, 127.5, 127.5, 127.1, 127.1, 127.0, 126.2, 125.9, 125.6, 124.9, 110.9, 110.3, 102.3, 62.3, 60.3, 50.0, 49.4, 44.4, 44.2, 42.5, 42.4, 32.9, 29.0, 27.6, 13.5 ppm; IR (KBr) ν: 3504, 3024, 3010, 2995, 2985, 1847, 1711, 1603, 1517, 1400, 1299, 1250, 1053, 953, 841 cm−1; HRMS (ESI-TOF): [M + Na]+ calcd

• , 173.0, 142.8, 142.2, 140.6, 134.7, 134.3, 133.9, 130.2, 130.0, 129.1, 128.8, 128.7, 128.5, 128.4, 127.5, 127.3, 127.1, 127.0, 126.4, 126.2, 126.1, 126.0, 112.1, 109.8, 109.7, 87.2, 61.8, 53.7, 50.0, 44.5, 44.4, 43.6, 30.7, 29.9, 26.3, 21.6, 20.9 ppm; IR (KBr) ν: 3756, 3056, 3023, 2984, 2988, 1832, 1792

Unravelling a trichloroacetic acid-catalyzed cascade access to benzo[f]chromeno[2,3-h]quinoxalinoporphyrins

• Chandra Sekhar Tekuri,
• Pargat Singh and
• Mahendra Nath

Beilstein J. Org. Chem. 2023, 19, 1216–1224, doi:10.3762/bjoc.19.89

• visible and near IR regions [11][12][13][14]. Similarly, simple quinoxaline-based heterocycles have shown their potential as photosensitizers to induce toxicity in a single cell green algae such as Chlamydomonas reinhardtii [15] and also displayed efficacy against Mycobacterium tuberculosis and other

• copper(II) porphyrins 3–8. Finally, the structures of all newly synthesized benzo[f]chromeno[2,3-h]quinoxalinoporphyrins 3–16 and benzo[f]quinoxalinoporphyrin 17 were assigned on the basis of IR, 1H and 13C NMR, and HRMS data analysis. Photophysical characteristics The UV–vis spectra of the newly

• reported in hertz (Hz). Infrared (IR) spectra of the synthesized compounds were recorded in film or KBr on Perkin Elmer IR spectrometer and absorption maxima (υmax) are given in cm−1. UV–vis absorption and fluorescence spectra were recorded on an Analytik Jena’s Specord 250 UV–vis spectrophotometer and a

Enabling artificial photosynthesis systems with molecular recycling: A review of photo- and electrochemical methods for regenerating organic sacrificial electron donors

• Grace A. Lowe

Beilstein J. Org. Chem. 2023, 19, 1198–1215, doi:10.3762/bjoc.19.88

• be discussed. The oxidation potentials of these compounds in non-aqueous media vs Fc/Fc+ are shown in Figure 5. The excited-state reduction potential of Ir(ppy)3 in DMF (V vs Fc/Fc+) has been added to the plot for comparison [70], as well as the redox potentials for Ru(bpy)3 in acetonitrile [20]. Ir

• and possibly Ir(ppy)3. The tunability of benzimidazoles is particularly helpful when developing photocatalysis systems with new photosensitizers and their capability to undergo PCET in certain environments could be an advantage for some systems. Acridine compounds are also analogues of NADH and have

• establish a redox catalysis cycle [76]. In non-aqueous media DDQ has a low oxidation potential (0.14 V vs Fc/Fc+ in acetonitrile) so that DDQ could potentially reductively quench Ir(ppy)3 and Ru(bpy)3 and regenerate

Exploring the role of halogen bonding in iodonium ylides: insights into unexpected reactivity and reaction control

• Carlee A. Montgomery and
• Graham K. Murphy

Beilstein J. Org. Chem. 2023, 19, 1171–1190, doi:10.3762/bjoc.19.86

• have been evaluated extensively through both qualitative and quantitative means. Methods of evaluation have included X-ray crystallography and spectroscopy (e.g., microwave, IR, Raman, NMR, NQR), as well as through computational determination of their electrostatic VS,max potentials (Figure 2), their

Photoredox catalysis harvesting multiple photon or electrochemical energies

• Mattia Lepori,
• Simon Schmid and
• Joshua P. Barham

Beilstein J. Org. Chem. 2023, 19, 1055–1145, doi:10.3762/bjoc.19.81

Synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines via a base-induced rearrangement of functionalized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazines

• Dmitry B. Vinogradov,
• Alexei N. Izmest’ev,
• Angelina N. Kravchenko,
• Yuri A. Strelenko and
• Galina A. Gazieva

Beilstein J. Org. Chem. 2023, 19, 1047–1054, doi:10.3762/bjoc.19.80

• in the thiazine ring leads to the cleavage of the triazine C–N bond. Further proton transfer gives product 9. The structures of the synthesized compounds 3a,b,j and 5a–k,m were confirmed by IR, 1H and 13C NMR spectroscopy, and high-resolution mass spectrometry. the potassium salts 3c–i,k,m were

CO₂ complexation with cyclodextrins

• Cecilie Høgfeldt Jessen,
• Jesper Bendix,
• Theis Brock Nannestad,
• Heloisa Bordallo,
• Martin Jæger Pedersen,
• Christian Marcus Pedersen and
• Mikael Bols

Beilstein J. Org. Chem. 2023, 19, 1021–1027, doi:10.3762/bjoc.19.78

• get more information about the CO2 content in the crystal samples we also analyzed the crystals by thermogravimetric analysis. The crystal samples where heated to 26–200 °C at different rates and weight loss observed while the gas release was monitored by IR spectroscopy. Two distinguished weight

• decrease steps were seen in the TGA curve and very evident from the dTGA curve (Figure 3). The first weight decrease was seen around 50–75 °C and accounted for 5–6%, while the second weight decrease step normally was observed at 75–100 °C and accounte for 2–3%. IR analysis of the gas outlet showed both the

The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition

• Xiu-Yu Chen,
• Hui Zheng,
• Ying Han,
• Jing Sun and
• Chao-Guo Yan

Beilstein J. Org. Chem. 2023, 19, 982–990, doi:10.3762/bjoc.19.73

• Hz, 1H, CH), 2.44 (s, 3H, CH3) ppm; 13C NMR (100 MHz, CDCl3) δ 168.7, 166.2, 164.9, 150.2, 146.1, 145.7, 138.7, 129.3, 128.8, 128.1, 128.0, 127.8, 127.5, 127.3, 127.0, 126.3, 126.1, 125.1, 124.7, 124.6, 106.3, 104.6, 102.8, 61.3, 57.6, 56.0, 53.0, 51.6, 50.0, 44.8, 39.5, 17.9 ppm. IR (KBr) ν: 3732

• NMR (100 MHz, CDCl3) δ 169.3, 160.9, 160.7, 156.2, 152.0, 146.4, 144.5, 137.2, 136.1, 128.7, 128.5, 128.1, 127.9, 123.4, 101.1, 61.5, 61.4, 56.6, 53.8, 51.8, 51.0, 38.9, 17.3, 14.1, 14.1 ppm; IR (KBr) ν: 3746, 2983, 2945, 1729, 1651, 1557, 1434, 1347, 1251, 1129, 1088, 841, 732, 709 cm−1; HRESIMS (m/z

• , CH3), 0.99 (t, J = 7.2 Hz, CH3) ppm; 13C NMR (100 MHz, CDCl3) δ 172.2, 166.1, 163.5, 158.0, 149.9, 146.3, 137.8, 137.4, 135. 9, 129.2, 128.5, 128.0, 127.2, 123.0, 101.9, 75.5, 62.9, 61.1, 61.0, 58.3, 50.3, 49.2, 14.1, 13.8, 13.4 ppm; IR (KBr) ν: 3069, 2981, 1736, 1660, 1552, 1514, 1344, 1222, 1121

Photoredox catalysis enabling decarboxylative radical cyclization of γ,γ-dimethylallyltryptophan (DMAT) derivatives: formal synthesis of 6,7-secoagroclavine

• Alessio Regni,
• Francesca Bartoccini and
• Giovanni Piersanti

Beilstein J. Org. Chem. 2023, 19, 918–927, doi:10.3762/bjoc.19.70

• of all ergot alkaloids, specifically the decarboxylative cyclization of DMAT, is still a puzzle even though a radical mechanism has been proposed (Figure 1a) [72][73]. Results and Discussion Herein, we propose that visible light irradiation of the cationic iridium photocatalyst Ir[dF(CF3)ppy]2(dtbbpy

• compound 5 in hand, the required radical–radical coupling was investigated next, and some of the representative results are shown in Table S1 (see Supporting Information File 1). Irradiation from blue light-emitting diodes (LEDs) in the presence of 2 mol % of the photocatalyst [Ir(dF(CF3)ppy)2(dtbpy)]PF6

• a tentative mechanism (Figure 2). First, the radical cation I was generated via the oxidation of indole 5 by the excited Ir-based photocatalyst, followed by sequential regioselective proton transfer on the benzylic dimethylallyl unit C–H bond of the C4 side-chain, thereby generating II. Here, the

First synthesis of acylated nitrocyclopropanes

• Kento Iwai,
• Rikiya Kamidate,
• Khimiya Wada,
• Haruyasu Asahara and
• Nagatoshi Nishiwaki

Beilstein J. Org. Chem. 2023, 19, 892–900, doi:10.3762/bjoc.19.67

• ) in CDCl3 using TMS as an internal standard. The assignments of the 13C NMR signals were performed by DEPT experiments. IR spectra were recorded on a JASCO FT/IR-4200 spectrometer equipped with an ATR detector. High-resolution mass spectra were obtained on AB SCIEX Triplet TOF 4600 and Bruker Compact

• ), 7.59 (t, J = 7.5 Hz, 1H), 7.96 (d, J = 7.8 Hz, 2H); 13C NMR (100 MHz, CDCl3) δ 13.5 (CH3), 21.1 (CH3), 36.5 (CH), 49.8 (C), 62.7 (CH2), 67.8 (CH), 127.5 (C), 128.2 (CH), 128.3 (CH), 129.1 (CH), 129.5 (CH), 134.1 (CH), 135.1 (C), 138.3 (C), 164.3 (C), 186.6 (C); IR (ATR): 1362, 1557, 1682, 1695 cm−1

• ), 21.1 (CH3), 57.0 (CH), 60.6 (CH2), 107.7 (C), 108.9 (CH), 127.0 (CH), 127.7 (C), 128.0 (CH), 129.9 (CH), 130.0 (CH), 134.9 (C), 138.3 (C), 162.7 (C), 163.5 (C); IR (ATR): 1371, 1572, 1697 cm−1; HRESIMS–TOF (m/z): [M + H]+ calcd for C14H15NO4, 354.1336; found, 354.1324. Ethyl 4-(4-methylphenyl)-5-nitro

Pyridine C(sp²)–H bond functionalization under transition-metal and rare earth metal catalysis

• Haritha Sindhe,
• Malladi Mounika Reddy,
• Karthikeyan Rajkumar,
• Akshay Kamble,
• Amardeep Singh,
• Anand Kumar and
• Satyasheel Sharma

Beilstein J. Org. Chem. 2023, 19, 820–863, doi:10.3762/bjoc.19.62

• addition of 1 gives the silyl-iridium complex 52. The insertion of aldehyde 50 into the Ir–Si bond of 52 provides the pyridyl alkyl iridium species 53 that finally by C–C formation via reductive elimination furnishes the desired products 51 along with the formation of an iridium hydride species (Scheme 11b

Eschenmoser coupling reactions starting from primary thioamides. When do they work and when not?

• Lukáš Marek,
• Jiří Váňa,
• Jan Svoboda and
• Jiří Hanusek

Beilstein J. Org. Chem. 2023, 19, 808–819, doi:10.3762/bjoc.19.61

• solutions (DMSO-d6, MeOD-d4, D2O), it was impossible to measure its NMR spectra and the only characterization involves MALDI–MS, IR, and melting point. The salt 6a was then treated in various solvents with or without additive (thiophile, base/acid) to give diverse products of cyclization (8a or 8a-Me), ECR

• . Elemental analyses were performed on a Flash 2000 Organic Elemental Analyser (Thermofisher). For samples containing chlorine, mercurimetric titration was used. IR spectra were recorded on a Nicolet iS50 equipped with an ATR diamond crystal (neat solid samples). Flash chromatography was performed using a

Strategies in the synthesis of dibenzo[b,f]heteropines

• David I. H. Maier,
• Barend C. B. Bezuidenhoudt and
• Charlene Marais

Beilstein J. Org. Chem. 2023, 19, 700–718, doi:10.3762/bjoc.19.51

• disorders) [16] (Figure 2). 10,11-Dihydrodibenzo[b,f]azepine-based ligand 7 and a methyl analogue thereof are known to form pincer complexes with Pd, Ir, Rh and Ln [5], whereas a copper(II) wagon wheel complex of 8 was reported in a molecular organic framework (MOF) (Figure 3) [6]. 4,4'-(5-(Pyridin-2-yl

• ). Carbamoylation of 151 gives the intermediate oxcarbazepine 152, whereafter hydrolysis of the methyl enol ether affords oxcarbazepine (153) [32][56]. 6.2.2 Ring functionalisation: Weng et al. [80] reported the synthesis of dihydrodibenzo[b,f]azepine (2a)-based pincer ligands for Rh and Ir metal complexes. The

Photocatalytic sequential C–H functionalization expediting acetoxymalonylation of imidazo heterocycles

• Deepak Singh,
• Shyamal Pramanik and
• Soumitra Maity

Beilstein J. Org. Chem. 2023, 19, 666–673, doi:10.3762/bjoc.19.48

• boron complex (B2pin2), and using an expensive metal-based photocatalyst [fac-Ir(ppy)3] under inert atmosphere. We have recently demonstrated that aerial oxygen could be captured by alkyl radicals to install a keto-functionality onto alkenes in an organophotocatalytic way [23]. We aimed to extend this

Cassane diterpenoids with α-glucosidase inhibitory activity from the fruits of Pterolobium macropterum

• Sarot Cheenpracha,
• Ratchanaporn Chokchaisiri,
• Lucksagoon Ganranoo,
• Sareeya Bureekaew,
• Thunwadee Limtharakul and
• Surat Laphookhieo

Beilstein J. Org. Chem. 2023, 19, 658–665, doi:10.3762/bjoc.19.47

• )-en-12,16-olide (2) [18]. Compound 1 was isolated as an amorphous white powder. The molecular formula was determined as C20H28O3 from the HRESI–TOF–MS analysis with a [M + H]+ ion peak at m/z 317.2107 (calcd C20H29O3, 317.2111) and was considered to have 7 degrees of unsaturation. Its IR absorptions

• colorless oil. The molecular formula was assigned to be C44H60O9 based on the HRESI–TOF–MS analysis with a [M + H]+ ion peak at m/z 733.4305 (calcd for C44H61O9, 733.4310) and NMR data, implying 15 degrees of unsaturation. The IR absorption band at 1724 cm−1 suggested the presence of α,β-unsaturated γ

• UV–vis spectrophotometer. ECD spectra were acquired on a JASCO J-1500 circular dichroism spectrometer. FTIR spectra were obtained using a PerkinElmer FTS FT-IR spectrophotometer. NMR spectra were obtained on a Bruker NEO 500 MHz NMR Ultra Shield. Chemical shifts are referenced in parts per million (δ

C3-Alkylation of furfural derivatives by continuous flow homogeneous catalysis

• Grédy Kiala Kinkutu,
• Catherine Louis,
• Myriam Roy,
• Juliette Blanchard and
• Julie Oble

Beilstein J. Org. Chem. 2023, 19, 582–592, doi:10.3762/bjoc.19.43

• changing the redox state of the aldehyde function, we have developed a number of directed Ru(0)-catalyzed C3-functionalizations of furfurylimines, such as alkylation [21], arylation [22], alkenylation [23] and acylation [24], as well as an Ir-catalyzed directed C3-silylation (Scheme 1a) [25]. These batch

Direct C2–H alkylation of indoles driven by the photochemical activity of halogen-bonded complexes

• Martina Mamone,
• Giuseppe Gentile,
• Jacopo Dosso,
• Maurizio Prato and
• Giacomo Filippini

Beilstein J. Org. Chem. 2023, 19, 575–581, doi:10.3762/bjoc.19.42

• ) and carbon–heteroatom (C–X) bonds has been and still is a central topic in organic synthesis [1][2]. Historically, organic chemists have extensively relied on the use of noble-metal-based catalysts (e.g., Pd, Rh, Ir, among others) to achieve such type of functionalization [3][4][5]. However, reliance

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

• Josipa Matić,
• Tana Tandarić,
• Marijana Radić Stojković,
• Filip Šupljika,
• Zrinka Karačić,
• Ana Tomašić Paić,
• Lucija Horvat,
• Robert Vianello and
• Lidija-Marija Tumir

Beilstein J. Org. Chem. 2023, 19, 550–565, doi:10.3762/bjoc.19.40

• mmol) were used according to the general procedure. Phen-Py-1 was obtained as a white solid (9.4 mg, 56%). mp = 131–132 °C; Rf = 0,8 (CH2Cl2/MeOH 9:1); IR (KBr) νmax/cm−1: 3418 (s), 3294 (s), 3038 (m), 2947 (m), 2858 (m), 1738 (s), 1643 (s), 1582 (m), 1535 (m), 1435 (m), 1377 (m), 1209 (m), 843 (s

• ) were used according to the general procedure. Phen-Py-2 was obtained as a white solid (15.9 mg, 84%). mp = 230–231 °C; Rf = 0.8 (CH2Cl2:MeOH 9:1); IR (KBr) νmax/cm−1: 3435 (s), 3261 (s), 1740 (m), 1634 (s), 1531 (m), 849 (m), 760 (m); 1H NMR (CDCl3) δ 8.59 (d, J = 8.5 Hz, 1H, Phen-10), 8.51 (d, J = 7.3

Transition-metal-catalyzed domino reactions of strained bicyclic alkenes

• Austin Pounder,
• Eric Neufeld,
• Peter Myler and
• William Tam

Beilstein J. Org. Chem. 2023, 19, 487–540, doi:10.3762/bjoc.19.38

• reactivity with a few examples failing to provide the desired product when 4-CzIPN was used as the photocatalyst; however, the products were isolated when [Ir(dF(CF3)ppy)2(bpy)]PF6 was used. Based on experimental observations and control reactions, the authors proposed the reaction begins with the