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Search for "high-resolution mass spectrometry" in Full Text gives 134 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

  • Vaida Milišiūnaitė,
  • Rūta Paulavičiūtė,
  • Eglė Arbačiauskienė,
  • Vytas Martynaitis,
  • Wolfgang Holzer and
  • Algirdas Šačkus

Beilstein J. Org. Chem. 2019, 15, 679–684, doi:10.3762/bjoc.15.62

Graphical Abstract
  • ]pyrazoles was explored (Scheme 2). For substrates 3b–j, the reactions were complete after 14 hours at 120 °C, and products 4b–j were generated in fair to excellent yields. The structural assignments of 4a–j were based on multinuclear NMR and IR spectroscopy as well as high-resolution mass spectrometry (HRMS
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Published 14 Mar 2019

Polyaminoazide mixtures for the synthesis of pH-responsive calixarene nanosponges

  • Antonella Di Vincenzo,
  • Antonio Palumbo Piccionello,
  • Alberto Spinella,
  • Delia Chillura Martino,
  • Marco Russo and
  • Paolo Lo Meo

Beilstein J. Org. Chem. 2019, 15, 633–641, doi:10.3762/bjoc.15.59

Graphical Abstract
  • CaNS-I and CaNS-II, respectively. Owing to their complex nature, mixtures I and II were first characterized by means of HR-ESIMS techniques. High-resolution mass spectrometry, in fact, enables to unambiguously identify the molecular formula of each compound present in the mixtures, and to determine
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Published 12 Mar 2019

Synthesis and fluorescent properties of N(9)-alkylated 2-amino-6-triazolylpurines and 7-deazapurines

  • Andrejs Šišuļins,
  • Jonas Bucevičius,
  • Yu-Ting Tseng,
  • Irina Novosjolova,
  • Kaspars Traskovskis,
  • Ērika Bizdēna,
  • Huan-Tsung Chang,
  • Sigitas Tumkevičius and
  • Māris Turks

Beilstein J. Org. Chem. 2019, 15, 474–489, doi:10.3762/bjoc.15.41

Graphical Abstract
  • determined using QuantaMaster 40 steady state spectrofluorometer (Photon Technology International, Inc.) equipped with 6 inch integrating sphere by LabSphere, using a florescence standard of quinine sulfate in 0.1 M H2SO4 as a reference. High-resolution mass spectrometry (HRMS) analyses were carried out on a
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Published 15 Feb 2019

LCST phase behavior of benzo-21-crown-7 with different alkyl chains

  • Yan Deng,
  • Xing Li,
  • Qiao Zhang,
  • Zheng Luo,
  • Chengyou Han and
  • Shengyi Dong

Beilstein J. Org. Chem. 2019, 15, 437–444, doi:10.3762/bjoc.15.38

Graphical Abstract
  • and molecular structures. Results and Discussion Two series of B21C7s, comprising carbamate-based linkers 3a–e and urea-based linkers 5a–e, were designed and synthesized, as shown in Scheme 1 and Scheme 2. All structures were confirmed by NMR spectroscopy and high-resolution mass spectrometry (details
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Letter
Published 14 Feb 2019

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives

  • Mikhail V. Makarov and
  • Marie E. Migaud

Beilstein J. Org. Chem. 2019, 15, 401–430, doi:10.3762/bjoc.15.36

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Published 13 Feb 2019

One-pot synthesis of epoxides from benzyl alcohols and aldehydes

  • Edwin Alfonzo,
  • Jesse W. L. Mendoza and
  • Aaron B. Beeler

Beilstein J. Org. Chem. 2018, 14, 2308–2312, doi:10.3762/bjoc.14.205

Graphical Abstract
  • characterization for all new compounds described herein. Acknowledgements Financial support from Boston University and National Science Foundation (ABB CHE-1555300) is gratefully acknowledged. We thank Dr. Norman Lee (Boston University) for high-resolution mass spectrometry data. NMR (CHE-0619339) and MS
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Published 03 Sep 2018

Hypervalent iodine compounds for anti-Markovnikov-type iodo-oxyimidation of vinylarenes

  • Igor B. Krylov,
  • Stanislav A. Paveliev,
  • Mikhail A. Syroeshkin,
  • Alexander A. Korlyukov,
  • Pavel V. Dorovatovskii,
  • Yan V. Zubavichus,
  • Gennady I. Nikishin and
  • Alexander O. Terent’ev

Beilstein J. Org. Chem. 2018, 14, 2146–2155, doi:10.3762/bjoc.14.188

Graphical Abstract
  • higher (25% on average) than that of N-hydroxysuccinimide (2b). Structures of the iodo-oxyimides 3aa–ka, 3ab–db, 3fb, 3hb and 3kb were confirmed by 1D and 2D NMR spectroscopy, IR spectroscopy, high-resolution mass spectrometry and elemental analysis. An additional confirmation of the structure of 3ca was
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Published 16 Aug 2018

A self-assembled photoresponsive gel consisting of chiral nanofibers

  • Lei Zou,
  • Dan Han,
  • Zhiyi Yuan,
  • Dongdong Chang and
  • Xiang Ma

Beilstein J. Org. Chem. 2018, 14, 1994–2001, doi:10.3762/bjoc.14.174

Graphical Abstract
  • beginning, which can be detected by high-resolution mass spectrometry (Figure S7, Supporting Information File 1). Then, the dimers and single molecules 3 were able to assemble together through π–π stacking and hydrogen bonding to fabricate the nanofibers. Finally, those fibers twisted with each other to
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Published 01 Aug 2018

Water-soluble SNS cationic palladium(II) complexes and their Suzuki–Miyaura cross-coupling reactions in aqueous medium

  • Alphonse Fiebor,
  • Richard Tia,
  • Banothile C. E. Makhubela and
  • Henok H. Kinfe

Beilstein J. Org. Chem. 2018, 14, 1859–1870, doi:10.3762/bjoc.14.160

Graphical Abstract
  • AgOTf to provide the desired SNS-Pd(II) complex 17a in quantitative yield (Scheme 1). The structure of the complex was established using NMR spectroscopy and high-resolution mass spectrometry. Among others, the downfield shift of all the protons in the complex, when compared to the corresponding protons
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Published 23 Jul 2018

Preparation and X-ray structure of 2-iodoxybenzenesulfonic acid (IBS) – a powerful hypervalent iodine(V) oxidant

  • Irina A. Mironova,
  • Pavel S. Postnikov,
  • Rosa Y. Yusubova,
  • Akira Yoshimura,
  • Thomas Wirth,
  • Viktor V. Zhdankin,
  • Victor N. Nemykin and
  • Mekhman S. Yusubov

Beilstein J. Org. Chem. 2018, 14, 1854–1858, doi:10.3762/bjoc.14.159

Graphical Abstract
  • problems, IBS was previously characterized by 1H and 13C NMR, IR spectroscopy, high-resolution mass spectrometry, and elemental analysis. However, all previously reported attempts to grow single crystals of IBS from methanol or acetonitrile resulted in reduction with the formation of 2
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Published 20 Jul 2018

Synthesis and photophysical studies of a multivalent photoreactive RuII-calix[4]arene complex bearing RGD-containing cyclopentapeptides

  • Sofia Kajouj,
  • Lionel Marcelis,
  • Alice Mattiuzzi,
  • Adrien Grassin,
  • Damien Dufour,
  • Pierre Van Antwerpen,
  • Didier Boturyn,
  • Eric Defrancq,
  • Mathieu Surin,
  • Julien De Winter,
  • Pascal Gerbaux,
  • Ivan Jabin and
  • Cécile Moucheron

Beilstein J. Org. Chem. 2018, 14, 1758–1768, doi:10.3762/bjoc.14.150

Graphical Abstract
  • the ArH, ArCH2 and OPr group are differentiated. Moreover, complex 7 was also characterized by high-resolution mass spectrometry (HRMS). The ESI mass spectrum displays two intense signals at m/z 764.736 and m/z 1642.456 that are attributed respectively to the doubly charged 72+ and singly charged [7
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Published 16 Jul 2018

Hypervalent iodine-guided electrophilic substitution: para-selective substitution across aryl iodonium compounds with benzyl groups

  • Cyrus Mowdawalla,
  • Faiz Ahmed,
  • Tian Li,
  • Kiet Pham,
  • Loma Dave,
  • Grace Kim and
  • I. F. Dempsey Hyatt

Beilstein J. Org. Chem. 2018, 14, 1039–1045, doi:10.3762/bjoc.14.91

Graphical Abstract
  • . Acknowledgements This research was supported by Faculty Development Grants and a Frederick Bettelheim Research Award from Adelphi University to I. F. Dempsey Hyatt. We are grateful to Dr. Brian Stockman for his NMR expertise and Dr. Daniel A. Todd for acquisition of the high resolution mass spectrometry data at
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Published 14 May 2018

An uracil-linked hydroxyflavone probe for the recognition of ATP

  • Márton Bojtár,
  • Péter Zoltán Janzsó-Berend,
  • Dávid Mester,
  • Dóra Hessz,
  • Mihály Kállay,
  • Miklós Kubinyi and
  • István Bitter

Beilstein J. Org. Chem. 2018, 14, 747–755, doi:10.3762/bjoc.14.63

Graphical Abstract
  • alkaline hydrogen peroxide to obtain the clickable fluorophore. All new compounds were characterized by NMR and high-resolution mass spectrometry. Optical spectroscopy The solubility of the UHF probe was very poor in water which resulted in the decrease of fluorescence over time upon dilution from the
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Published 03 Apr 2018

AuBr3-catalyzed azidation of per-O-acetylated and per-O-benzoylated sugars

  • Jayashree Rajput,
  • Srinivas Hotha and
  • Madhuri Vangala

Beilstein J. Org. Chem. 2018, 14, 682–687, doi:10.3762/bjoc.14.56

Graphical Abstract
  • and 100 MHz spectrometer, respectively using CDCl3 as the solvent. Chemical shifts (δ) are given in ppm. For perbenzoate compounds 10–15, tetramethyl silane was used as internal standard. Electrospray ionization (ESI) was used for high resolution mass spectrometry (HRMS). An FTIR spectrometer was used
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Published 22 Mar 2018

Synthesis and stability of strongly acidic benzamide derivatives

  • Frederik Diness,
  • Niels J. Bjerrum and
  • Mikael Begtrup

Beilstein J. Org. Chem. 2018, 14, 523–530, doi:10.3762/bjoc.14.38

Graphical Abstract
  • Bruker 500 MHz spectrometer at 298 K with methanol-d4, DMSO-d6 or hexafluorobenzene as internal standard. High-resolution mass spectrometry (HRMS) was performed on a Bruker MALDI–TOF spectrometer. General procedure Benzoyl chloride (10.0 mmol) in Et2O (10 mL) was added dropwise to a solution of
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Published 27 Feb 2018

Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts

  • Jan Wallbaum and
  • Daniel B. Werz

Beilstein J. Org. Chem. 2017, 13, 2577–2583, doi:10.3762/bjoc.13.254

Graphical Abstract
  • were made by combination of H,H-COSY, HSQC, HMBC and NOESY experiments. In some cases signals in the 13C NMR spectrum are missing because of bad relaxation of the respective signals. ESI high-resolution mass spectrometry was carried out on a FTICR instrument. IR spectra were measured on an ATR
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Published 01 Dec 2017

A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic

  • Marcus Baumann,
  • Ian R. Baxendale and
  • Fabien Deplante

Beilstein J. Org. Chem. 2017, 13, 2549–2560, doi:10.3762/bjoc.13.251

Graphical Abstract
  • % of tallest signal). Low and high-resolution mass spectrometry was performed using the indicated techniques on instruments equipped with Acquity UPLC and a lock-mass electrospray ion source. For accurate mass measurements the deviation from the calculated formula is reported in ppm. Melting points
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Published 29 Nov 2017

The chemistry and biology of mycolactones

  • Matthias Gehringer and
  • Karl-Heinz Altmann

Beilstein J. Org. Chem. 2017, 13, 1596–1660, doi:10.3762/bjoc.13.159

Graphical Abstract
  • activity. Further purification of this material by reversed-phase HPLC and subsequent characterization by high-resolution mass spectrometry and two-dimensional NMR spectroscopy unveiled a 12-membered macrolactone substituted with two polyketide-derived side chains (Figure 1). Based on its mycobacterial
  • Leadlay and co-workers applying LC−sequential and high-resolution mass spectrometry in combination with deuterium exchange experiments [54]. Instead of the additional hydroxy group proposed by the Small group, these studies provided strong evidence for mycolactone D (3) to feature an extra methyl group at
  • originally been proposed by the Small group (11, Figure 3) after partial TLC purification and subsequent high-resolution mass spectrometry and 1H NMR spectroscopy (although no NMR data are shown in their report) [50]. Shortly afterwards, the Leadlay group proposed structure 6 (Figure 2) based on tandem mass
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Published 11 Aug 2017

1-Imidoalkylphosphonium salts with modulated Cα–P+ bond strength: synthesis and application as new active α-imidoalkylating agents

  • Jakub Adamek,
  • Roman Mazurkiewicz,
  • Anna Węgrzyk and
  • Karol Erfurt

Beilstein J. Org. Chem. 2017, 13, 1446–1455, doi:10.3762/bjoc.13.142

Graphical Abstract
  • , respectively, as zero ppm. All chemical shifts (δ) are reported in ppm, and coupling constants (J) are given in hertz (Hz). High-resolution mass spectrometry (HRMS) analyses were performed on a Waters Xevo G2 Q-TOF mass spectrometer equipped with an ESI source operating in the positive ion mode. The accurate
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Published 24 Jul 2017

A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline

  • Olga Bakulina,
  • Alexander Ivanov,
  • Vitalii Suslonov,
  • Dmitry Dar’in and
  • Mikhail Krasavin

Beilstein J. Org. Chem. 2017, 13, 1413–1424, doi:10.3762/bjoc.13.138

Graphical Abstract
  • reaction with homophthalic anhydride (HPA). The compounds obtained contain a benzene-fused, privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline core and are distinctly encumbered from steric perspective. The novel compounds have been characterized by NMR spectroscopy, high-resolution mass
  • spectrometry and X-ray crystallography and certain regularities in the NMR behavior have been established, leading a set of rules for stereochemical assignment based on the NMR data. A Mannich-type adduct between HPA and an imine (previously only postulated as a crucial intermediate en route to CCR products
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Published 18 Jul 2017

Unpredictable cycloisomerization of 1,11-dien-6-ynes by a common cobalt catalyst

  • Abdusalom A. Suleymanov,
  • Dmitry V. Vasilyev,
  • Valentin V. Novikov,
  • Yulia V. Nelyubina and
  • Dmitry S. Perekalin

Beilstein J. Org. Chem. 2017, 13, 639–643, doi:10.3762/bjoc.13.62

Graphical Abstract
  • structure to that of 1a,b. We can speculate that COOEt groups of 1l formed a chelate complex with ZnI2 and therefore strongly diminished its Lewis acidity, which is necessary for catalyst activation. All the compounds obtained were characterized by 1H and 13C NMR spectroscopy as well as high-resolution mass
  • -spectrometry (for ethers, which are oils) or elemental analysis (for tosylamides, which are crystalline solids). The structures of the starting dienyne 1h and the cyclohexene trans-2b were established by X-ray crystallography. The structures of cis-2b and 3b had been reported previously [11][43]. Conclusion To
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Published 31 Mar 2017

Structure–efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

  • Sophie Letort,
  • Michaël Bosco,
  • Benedetta Cornelio,
  • Frédérique Brégier,
  • Sébastien Daulon,
  • Géraldine Gouhier and
  • François Estour

Beilstein J. Org. Chem. 2017, 13, 417–427, doi:10.3762/bjoc.13.45

Graphical Abstract
  • imidazole reduced the accessibility of substrates 11 and 12 to position 3. Thus, compounds 13 and 14 were isolated in comparable yields of 37% and 27%, respectively and this time without significantly different reactivities observed for the precursors 9 and 10. High resolution mass spectrometry (ESI+ HRMS
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Published 06 Mar 2017

Decarboxylative and dehydrative coupling of dienoic acids and pentadienyl alcohols to form 1,3,6,8-tetraenes

  • Ghina’a I. Abu Deiab,
  • Mohammed H. Al-Huniti,
  • I. F. Dempsey Hyatt,
  • Emma E. Nagy,
  • Kristen E. Gettys,
  • Sommayah S. Sayed,
  • Christine M. Joliat,
  • Paige E. Daniel,
  • Rupa M. Vummalaneni,
  • Andrew T. Morehead Jr,
  • Andrew L. Sargent and
  • Mitchell P. Croatt

Beilstein J. Org. Chem. 2017, 13, 384–392, doi:10.3762/bjoc.13.41

Graphical Abstract
  • North Carolina Biotechnology Center (BRG-1205) and University of North Carolina at Greensboro is gratefully acknowledged. The authors thank Dr. Franklin J. Moy for assisting with analysis of NMR data and Dr. Daniel A. Todd for acquisition of the high resolution mass spectrometry data at the Triad Mass
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Published 28 Feb 2017

Characterization of the synthetic cannabinoid MDMB-CHMCZCA

  • Carina Weber,
  • Stefan Pusch,
  • Dieter Schollmeyer,
  • Sascha Münster-Müller,
  • Michael Pütz and
  • Till Opatz

Beilstein J. Org. Chem. 2016, 12, 2808–2815, doi:10.3762/bjoc.12.279

Graphical Abstract
  • : 2.1 mm, particle size: 2.7 μm; Supelco) was used at a temperature of 40 °C. The capillary voltage was set to 3500 V and the capillary exit voltage was set according to the respective target mass. High-resolution mass spectrometry High-resolution ESI mass spectrometry was performed on a Waters QTof
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Published 21 Dec 2016

Amidofluorene-appended lower rim 1,3-diconjugate of calix[4]arene: synthesis, characterization and highly selective sensor for Cu2+

  • Rahman Hosseinzadeh,
  • Mohammad Nemati,
  • Reza Zadmard and
  • Maryam Mohadjerani

Beilstein J. Org. Chem. 2016, 12, 1749–1757, doi:10.3762/bjoc.12.163

Graphical Abstract
  • -dicyclohexylcarbodiimide (DCC) in dichloromethane at room temperature gave the desired receptor L in 81% yield (Scheme 2). All the compounds including receptor L has been characterized by various spectral techniques such as 1H, 13C NMR and high resolution mass spectrometry (HRMS) (see Supporting Information File 1
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Published 04 Aug 2016
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