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Search for "organization" in Full Text gives 180 result(s) in Beilstein Journal of Organic Chemistry.
Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents
Beilstein J. Org. Chem. 2016, 12, 769–795, doi:10.3762/bjoc.12.77
Interactions between 4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular structures in aqueous solutions
Beilstein J. Org. Chem. 2016, 12, 549–563, doi:10.3762/bjoc.12.54
- through a re-organization of solvating water molecules. Undoubtedly, a combination of these two effects could be considered. At this point, since the obtained UV–vis results are not sufficiently clear to definitely prove the formation of S4TdR/CDs inclusion complexes, in which the pyrimidine ring is
Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen
Beilstein J. Org. Chem. 2016, 12, 144–153, doi:10.3762/bjoc.12.16
- the World Health Organization essential medicines list and despite numerous side effects it remains one of the most effective antimalarial drugs on the market [37][38]. Its classical synthesis (Scheme 2, top) is based on the lithiation of 4-bromo-2,8-bis(trifluoromethyl)quinoline (7a) and quenching
A journey in bioinspired supramolecular chemistry: from molecular tweezers to small molecules that target myotonic dystrophy
Beilstein J. Org. Chem. 2016, 12, 125–138, doi:10.3762/bjoc.12.14
- personal growth, having learned how to work with a wide range of people and manage a complex organization. The expressions “herding cats” and “drinking from a fire hose” are apropos descriptors as it was more than a full time job and extremely demanding in other ways. Although it was hard to take time away
Bright molecules for sensing, computing and imaging: a tale of two once-troubled cities
Beilstein J. Org. Chem. 2015, 11, 2774–2784, doi:10.3762/bjoc.11.298
- molecular-mass oligonucleotides [81], both of which involve high levels of organization in space-time. The challenge we faced was to emulate this deep-seated animal behaviour with small molecules with no organization other than to spread them out on paper [82]. Such spreading would create a graphical user
Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides
Beilstein J. Org. Chem. 2015, 11, 2509–2520, doi:10.3762/bjoc.11.272
- largest classes of drugs. Most antimetabolite drugs are nucleoside derivatives that substitute for endogenous nucleosides and prevent DNA and protein replication [1]. Many of the drugs described by the World Health Organization as "essential medicines" are nucleoside derivatives [2] and nearly 20% of all
Size-controlled and redox-responsive supramolecular nanoparticles
Beilstein J. Org. Chem. 2015, 11, 2388–2399, doi:10.3762/bjoc.11.260
- NaCl) using CD-PEI and Fc8-PAMAM keeping the total concentration constant at [CD] = 100 µM and [Fc] = 50 µM (in Fc and CD moieties from Fc8-PAMAM and CD-PEI, respectively). Acknowledgements This research was supported by the Council for Chemical Sciences of the Netherlands Organization for Scientific
Preparation of Pickering emulsions through interfacial adsorption by soft cyclodextrin nanogels
Beilstein J. Org. Chem. 2015, 11, 2355–2364, doi:10.3762/bjoc.11.257
- that the adsorption of the CD nanogels at the oil–water interface stabilizes the emulsion. Organization of CD nanogels at the interface To characterize the interfacial structure and to examine the stability of interfacial assembly of the CD nanogels, laser or scanning microscopy observation was
Urethane tetrathiafulvalene derivatives: synthesis, self-assembly and electrochemical properties
Beilstein J. Org. Chem. 2015, 11, 2343–2349, doi:10.3762/bjoc.11.255
- XRD pattern of T1 showed three sharp peaks at 7.4°, 14.9° and 22.1°, which suggested that a lamellar stacking organization was formed [4]. This was not the case for the XRD pattern of T2. In general, intermolecular hydrogen bonding is the main driving force behind self-assembly. Although T2 contains
Synthesis, structure, and mechanical properties of silica nanocomposite polyrotaxane gels
Beilstein J. Org. Chem. 2015, 11, 2194–2201, doi:10.3762/bjoc.11.238
- following structural analysis. Small-angle X-ray scattering measurement Synchrotron small-angle X-ray scattering (SAXS) experiments were carried out at the beamline 6A of Photon Factory, HighEnergy Accelerator Research Organization, KEK (Tsukuba, Japan). The wavelength λ of the incident X-ray beam was 1.50
- Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan). The small-angle X-ray scattering experiments were performed at beamlines BL-6A at the Photon Factory, High Energy Accelerator Research Organization, KEK, with the approval of the Photon Factory Program
Conformational equilibrium in supramolecular chemistry: Dibutyltriuret case
Beilstein J. Org. Chem. 2015, 11, 2105–2116, doi:10.3762/bjoc.11.227
- observations are in line with computations that are very useful in drawing conclusions. The use of benzoates with regularly changed properties may be the method of choice in analysis of complexes. The pre-organization of molecules used in supramolecular chemistry is, in general, important to this field. On the
Glycoluril–tetrathiafulvalene molecular clips: on the influence of electronic and spatial properties for binding neutral accepting guests
Beilstein J. Org. Chem. 2015, 11, 1023–1036, doi:10.3762/bjoc.11.115
- realized on this system [59]. By comparison with these results observed for molecular clip 15 [58], it is clear that clips 1–3 exhibit [(TTF)2]+˙ mixed-valence dimer and/or (TTF+˙)2 dimer species but their self-association organization could not be yet demonstrated. The presence of more or less sterically
Multivalency as a chemical organization and action principle
Beilstein J. Org. Chem. 2015, 11, 848–849, doi:10.3762/bjoc.11.94
- -organization of matter, in biological recognition processes as well as in signal transduction in biological systems. The targeted development of multivalent molecules is not only used for the strong inhibition of proteins and prevention of pathogen infections, but also allows for the selective production of
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
Beilstein J. Org. Chem. 2015, 11, 773–783, doi:10.3762/bjoc.11.87
- –ligand interactions also activate a series of other biochemical signals, such as the Ras-ERK cascade, and PI3-K and Rho family proteins [37]. Another tyrosine kinase Src also appears to be important for the regulation of focal adhesion organization [38]. Both FAK and Src play an important role to
First principle investigation of the linker length effects on the thermodynamics of divalent pseudorotaxanes
Beilstein J. Org. Chem. 2015, 11, 687–692, doi:10.3762/bjoc.11.78
- , 298.15 K) and equilibrium constant K for the systems from the double mutant cycle.a Acknowledgements Support by the German Research Foundation (DFG) through the Collaborative Research Center (CRC) 765 'Multivalency as chemical organization and action principle: new architectures, functions and
Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency
Beilstein J. Org. Chem. 2015, 11, 668–674, doi:10.3762/bjoc.11.75
- galectin-mediated organization of cell surface glycoconjugates influences glycan dynamics and essential biological processes like signaling [8]. Therefore, in order to advance our understanding of carbohydrate-mediated biological response, we are seeking further molecular architectures that allow us
- appropriate carbohydrate conjugation the same molecular architecture could be applied for organization of a divalent glycoconjugate (Figure 1B). We selected thymine as a photocontrollable element as it can undergo [2 + 2] photocycloaddition upon irradiation with light of hν ≥ 290 nm [5][9][10]. Furthermore
- Information File 1). Conclusion In line with our former work on the orientational control of carbohydrate ligands assembled on a surface [6], we seeked the synthesis of multivalent glycoconjugates that allow the organization of multivalency. To start this new approach, we have introduced a divalent
Trifluoromethyl-substituted tetrathiafulvalenes
Beilstein J. Org. Chem. 2015, 11, 647–658, doi:10.3762/bjoc.11.73
- ], demonstrating that the CF3 moiety does not play here a crucial role in the solid state organization. Note that both charge transfer complex (2)2(TCNQ) and cation radical salt (2)(FeCl4) are expected to behave as insulators, because of zero charge transfer in the former and full charge-transfer in the latter. We
Potential of acylated peptides to target the influenza A virus
Beilstein J. Org. Chem. 2015, 11, 589–595, doi:10.3762/bjoc.11.65
- indicates the formation of rather large structures different from a simple sphere-like micelle. To verify and characterize the assembly of our peptides into higher-order structures, we studied exemplarily the organization of C18-PeBGF by dynamic light scattering (DLS) and transmission electron microscopy
- , under those conditions we observed supramolecular aggregates with a size larger than 1 µm indicating the strong potential of C18-PeBGF to organize as rather large assemblies. To visualize the organization of those assemblies, we employed TEM. To facilitate the structure identification, we used an even
IR and electrochemical synthesis and characterization of thin films of PEDOT grown on platinum single crystal electrodes in [EMMIM]Tf2N ionic liquid
Beilstein J. Org. Chem. 2015, 11, 348–357, doi:10.3762/bjoc.11.40
- ) has shown an enhancement in stability, organization and electroactivity [12][13][14]. These characteristics are obtained mainly because of the dry medium, their wide electrochemical window, and their low nucleophilicity. Therefore, during the electrosynthesis of conducting polymers the overoxidation
Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view
Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28
- metastases. Nevertheless, the morphology and pathophysiology of these blood vessels differs significantly from physiological ones as they are less effective and show a lower state of organization and control [3]. Since the discovery of the mechanism of angiogenesis and its crucial role in tumor development
Mono- and multilayers of molecular spoked carbazole wheels on graphite
Beilstein J. Org. Chem. 2014, 10, 2783–2788, doi:10.3762/bjoc.10.295
- octyloxy side chains are (most probably) adsorbed on the HOPG substrate in the intermolecular pores of the first layer. The results clearly indicate that not only the HOPG acts as a template for the organization of the first molecular adlayer, but the adsorption pattern is transferred to the second layer
- be ascribed to a mechanical interlocking together with a high van der Waals interaction due to the large molecule size. It is worth to note that these investigations may also give insight into the spoked wheel organization in the bulk material. Conclusion Precursor 1 and MSW 2 self-assemble at the OA
Self-assembled monolayers of shape-persistent macrocycles on graphite: interior design and conformational polymorphism
Beilstein J. Org. Chem. 2014, 10, 2774–2782, doi:10.3762/bjoc.10.294
- macrocycle distances are mainly determined by their size and symmetry. This is an excellent example that the graphite acts as a template for the macrocycle organization independent from their specific interior. Keywords: conformational polymorphism; self-assembled monolayers; shape-persistent macrocycles
- analogs) that guarantee a sufficient compound solubility. The macrocycles can be co-assembled with other compounds at the surface [3][4], and they can also template the subsequent organization of guest molecules and thus a growth into the third dimension [5][6]. One of the most often used substrates for
Synthesis and immunological evaluation of protein conjugates of Neisseria meningitidis X capsular polysaccharide fragments
Beilstein J. Org. Chem. 2014, 10, 2367–2376, doi:10.3762/bjoc.10.247
- Organization (WHO) to consider MenX as a substantial threat [9]. However, it was only in 2010 that, following a very large MenX outbreak in Burkina Faso, the WHO-Inter-country Support Team (WHO-IST) weekly bulletins on meningitis started to specifically document MenX epidemics [10]. Interestingly, while MenA
Molecular ordering at electrified interfaces: Template and potential effects
Beilstein J. Org. Chem. 2014, 10, 2243–2254, doi:10.3762/bjoc.10.233
- effects, in the structure formation process of DBV cations on these modified Cu electrode surfaces. Keywords: cyclic voltammogram; scanning tunneling microscopy; self-assembly; template effect; viologen; Introduction The precise control of the self-organization of molecular layers on either conducting
- molecular self-organization on surfaces and to simulate the working principles of the derived molecular devices. This so-called “bottom-up” strategy, i.e., the formation of supramolecular structures from vapor deposited simpler building blocks has become an important research direction in ultra-high vacuum
- also more economic than operating a vacuum evaporation system, in particular if the organic building blocks come in water-soluble form. In principle, the self-organization process of molecular adsorbates is driven by the interplay between adsorbate–adsorbate and adsorbate–substrate interactions. While
The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases
Beilstein J. Org. Chem. 2014, 10, 1657–1669, doi:10.3762/bjoc.10.173
- at the catalytic centers of UP and TP, on the one hand, and PNP, on the other hand. In addition, it appears to be obvious that TP imposes the most stringent requirement for the spatial organization of the α-D-pentofuranose-1-phosphates in the transition state of the synthetic reaction. One-pot
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