Search results

Search for "bicyclic" in Full Text gives 389 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

  • Ronja Driller,
  • Daniel Garbe,
  • Norbert Mehlmer,
  • Monika Fuchs,
  • Keren Raz,
  • Dan Thomas Major,
  • Thomas Brück and
  • Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

Graphical Abstract
  • diterpenes synthesized by the respective synthase mutants are missing the bond between C2 and C6 compared to cyclooctatin (5). Hence, they are comprising a 5,11-fused bicyclic skeleton. In contrast, cembranoids are monocyclic compounds consisting of a 14 membered ring structure. Common to all compounds
PDF
Album
Review
Published 02 Oct 2019

Isolation of fungi using the diffusion chamber device FIND technology

  • Benjamin Libor,
  • Henrik Harms,
  • Stefan Kehraus,
  • Ekaterina Egereva,
  • Max Crüsemann and
  • Gabriele M. König

Beilstein J. Org. Chem. 2019, 15, 2191–2203, doi:10.3762/bjoc.15.216

Graphical Abstract
  • ), 122.1 (C-4), 143.0 (C-10) and 129.5 (C-11) evidenced two carbon–carbon double bonds. Together with a carbonyl carbon at δC 206.6 and a carboxylic carbon at δC 177.8, the two remaining DOU were accounted to a bicyclic ring system. After assigning the proton resonances to the 13C resonances of directly
PDF
Album
Supp Info
Full Research Paper
Published 19 Sep 2019

Genome mining in Trichoderma viride J1-030: discovery and identification of novel sesquiterpene synthase and its products

  • Xiang Sun,
  • You-Sheng Cai,
  • Yujie Yuan,
  • Guangkai Bian,
  • Ziling Ye,
  • Zixin Deng and
  • Tiangang Liu

Beilstein J. Org. Chem. 2019, 15, 2052–2058, doi:10.3762/bjoc.15.202

Graphical Abstract
  • by genome mining and determined the structure of its corresponding products. One new 5/6 bicyclic sesquiterpene and its esterified derivative were characterised by GC–MS and 1D and 2D NMR spectroscopy. To the best of our knowledge, this is the first well-identified sesquiterpene synthase from T
  • characterised by GC–MS and 1D and 2D NMR, revealing a 5/6 bicyclic sesquiterpene and its C-11 esterified structure. Based on a literature search, to our knowledge, this is the first report of the characterisation of a sesquiterpene synthase in T. viride. In addition, this study demonstrates the effectiveness of
  • 5/6 bicyclic sesquiterpene with the molecular formula C15H26O (Figure 1). Interestingly, compound 1 contained a quaternary carbon with two methyl groups, which is uncommon for the cyclization mechanism of sesquiterpenoids and needs further investigation. Compound 2 was purified as a white powder. 1H
PDF
Album
Supp Info
Full Research Paper
Published 28 Aug 2019

A review of the total syntheses of triptolide

  • Xiang Zhang,
  • Zaozao Xiao and
  • Hongtao Xu

Beilstein J. Org. Chem. 2019, 15, 1984–1995, doi:10.3762/bjoc.15.194

Graphical Abstract
  • form the A- and D-ring. The second one involves the reaction of the bicyclic intermediate 13 and 2-isopropyl-1,4-benzoquinone (14) to form the B- and C-ring. Finally, a regio- and stereoselective reduction, methylation and dehydration procedure and a selenylation, oxidation and elimination procedure
PDF
Album
Review
Published 22 Aug 2019
Graphical Abstract
  • -copaene, β-copaene, α-cubebene, β-cubebene and the bicyclic δ-cadinene were biosynthesized via (S)-(−)-germacrene D rather than via (R)-(+)-germacrene D as intermediate. Keywords: biosynthesis; deuterium labeling; germacrene; HS-SPME; terpenes; TOF–MS; Introduction The aroma profile of grape berries at
  • the time of physiological ripening is very complex and significantly influenced by potent flavoring substances of isoprenoid origin like mono- and sesquiterpenes [1][2]. Sesquiterpenes form a structurally diverse subgroup of terpenes consisting of three isoprene units [3]. Since the bicyclic
  • photoinduced [2 + 2]-cycloaddition is very unlikely. The biosynthesis of β-bourbonene can be performed by cationic cyclization, as shown in Scheme 4. A total of 5 bicyclic, aromatic sesquiterpene hydrocarbons (21–25) with a cadinane skeleton were found in exocarp of the grape variety Lemberger, whose identity
PDF
Album
Supp Info
Full Research Paper
Published 14 Aug 2019

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

  • Iwona E. Głowacka,
  • Aleksandra Trocha,
  • Andrzej E. Wróblewski and
  • Dorota G. Piotrowska

Beilstein J. Org. Chem. 2019, 15, 1722–1757, doi:10.3762/bjoc.15.168

Graphical Abstract
  • can serve as the starting material to a variety of orthogonally protected derivatives of 2,3-diaminopropanoic acid. The bicyclic amino acid (S)-127 is a major metabolite of isazofos in corn grain and for toxicological studies both enantiomers were required [17]. To this end the aziridine ester (2S,1′R
  • )-5a was reacted with 3-bromo-5-methoxy-1H-1,2,4-triazole (128) to give N-protected bicyclic amino ester 129 which was next converted into (S)-(+)-127 in two standard steps (Scheme 33) [17]. Its enantiomer was prepared from (2R,1′S)-5a. Lacosamide ((R)-130) is a derivative of ᴅ-serine and has found
  • transition state was involved. Acid-induced aziridine ring openings and subsequent conjugate additions to the α,β-unsaturated lactone led to the formation of cis-fused [5,5']bicyclic compounds 186a or 186b. Reduction of the lactone moiety in 186a and subsequent deprotection gave (2S,3R,4S,5R)-184. In order
PDF
Album
Review
Published 23 Jul 2019

Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents

  • Leticia Monjas,
  • Peter Fodran,
  • Johanna Kollback,
  • Carlo Cassani,
  • Thomas Olsson,
  • Maja Genheden,
  • D. G. Joakim Larsson and
  • Carl-Johan Wallentin

Beilstein J. Org. Chem. 2019, 15, 1468–1474, doi:10.3762/bjoc.15.147

Graphical Abstract
  • structure–activity relationship studies towards novel antibiotics targeting 4-amino-4-deoxychorismate (ADC) synthase. Specifically, it is demonstrated that the synthetically challenging bicyclic motif is essential for activity towards methicillin-resistant Staphylococcus aureus (MRSA). Keywords
PDF
Album
Supp Info
Letter
Published 02 Jul 2019

Switchable selectivity in Pd-catalyzed [3 + 2] annulations of γ-oxy-2-cycloalkenones with 3-oxoglutarates: C–C/C–C vs C–C/O–C bond formation

  • Yang Liu,
  • Julie Oble and
  • Giovanni Poli

Beilstein J. Org. Chem. 2019, 15, 1107–1115, doi:10.3762/bjoc.15.107

Graphical Abstract
  • combination may allow direct access to either fused bicyclic cyclopentanic (pentalene-, indene-, or azulene-type) structures via a γ-C-allylation/β-C-1,4 addition process, or annulated furan-based motifs through a γ-C-allylation/β-O-1,4 addition process, both motifs being incorporated into biologically
PDF
Album
Supp Info
Full Research Paper
Published 16 May 2019

Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds

  • Victoria V. Lipson,
  • Tetiana L. Pavlovska,
  • Nataliya V. Svetlichnaya,
  • Anna A. Poryvai,
  • Nikolay Yu. Gorobets,
  • Erik V. Van der Eycken,
  • Irina S. Konovalova,
  • Svetlana V. Shiskina,
  • Alexander V. Borisov,
  • Vladimir I. Musatov and
  • Alexander V. Mazepa

Beilstein J. Org. Chem. 2019, 15, 1032–1045, doi:10.3762/bjoc.15.101

Graphical Abstract
  • (Table 2). The corresponding bicyclic amine 10a was obtained by the prolonged treatment of the product 4a with catalytic amounts of TFA in acetonitrile followed by the addition of an aqueous solution of NH3. The structures of cyclized products 9 and 10 were confirmed by spectral methods. The signals of
  • allows to classify them as compounds of the same type containing a fused aminoimidazo[1,2-c]pyrrole moiety. Finally, the structure of azomethines 16 was confirmed by X-ray diffraction data of the sample compound 16a (Figure 5). All atoms of the bicyclic fragment lie in the plane within 0.01 Å. The
  • structures of spiroxindoles 19 and 20 were confirmed by X-ray diffraction data of the sample compound 19a (Figure 7). Compound 19a exists in the crystal phase as solvate with dimethylformamide and water in a 1:1:1 ratio. The spiro-joined bicyclic fragments are turned relatively to each other in such a way
PDF
Album
Supp Info
Full Research Paper
Published 06 May 2019

Mechanochemical synthesis of poly(trimethylene carbonate)s: an example of rate acceleration

  • Sora Park and
  • Jeung Gon Kim

Beilstein J. Org. Chem. 2019, 15, 963–970, doi:10.3762/bjoc.15.93

Graphical Abstract
  • for the rate enhancement under ball-milling conditions. As another highly reactive organic catalyst, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was investigated next. The bicyclic guanidine base TBD has shown better efficiencies than DBU in many chemical transformations including the polymerization of
PDF
Album
Supp Info
Full Research Paper
Published 23 Apr 2019

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

  • Maryam Khalesi,
  • Azim Ziyaei Halimehjani and
  • Jürgen Martens

Beilstein J. Org. Chem. 2019, 15, 852–857, doi:10.3762/bjoc.15.82

Graphical Abstract
  • post-multicomponent reactions, diversities of bicyclic drug-like heterocyclic compounds can be obtained [26]. Results and Discussion In continuation of our interest on the synthesis of novel pseudo-peptides [27][28][29] via multicomponent reactions, herein we investigate the Ugi-4C-3CR of levulinic
PDF
Album
Supp Info
Full Research Paper
Published 04 Apr 2019

Solid-phase synthesis of biaryl bicyclic peptides containing a 3-aryltyrosine or a 4-arylphenylalanine moiety

  • Iteng Ng-Choi,
  • Àngel Oliveras,
  • Lidia Feliu and
  • Marta Planas

Beilstein J. Org. Chem. 2019, 15, 761–768, doi:10.3762/bjoc.15.72

Graphical Abstract
  • Iteng Ng-Choi Angel Oliveras Lidia Feliu Marta Planas LIPPSO, Departament de Química, University of Girona, Maria Aurèlia Capmany 69, Girona 17003, Spain 10.3762/bjoc.15.72 Abstract A methodology for the solid-phase synthesis of biaryl bicyclic peptides containing a Phe-Phe, a Phe-Tyr or a Tyr
  • resulting biaryl monocyclic peptidyl resin leading to the formation of the expected biaryl bicyclic peptide. This study provides the first solid-phase synthesis of this type of bicyclic compounds being amenable to prepare a diversity of synthetic or natural biaryl bicyclic peptides. Keywords: borylation
  • ; cross-coupling; cyclization; macrocycles; solid-phase synthesis; Introduction Monocyclic and bicyclic peptides are acquiring a relevant interest in current drug discovery. They display improved biological properties over their acyclic counterparts and, at the same time, they are suitable to modulate
PDF
Album
Supp Info
Full Research Paper
Published 22 Mar 2019

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

  • Vaida Milišiūnaitė,
  • Rūta Paulavičiūtė,
  • Eglė Arbačiauskienė,
  • Vytas Martynaitis,
  • Wolfgang Holzer and
  • Algirdas Šačkus

Beilstein J. Org. Chem. 2019, 15, 679–684, doi:10.3762/bjoc.15.62

Graphical Abstract
  • synthetic methods has been developed for the construction of carbon–heteroatom bonds using these types of catalysts. For example, the gold(I) catalyst [(Ph3PAu)3O]BF4 was applied in the regioselective intramolecular cyclization of alkynols to construct bicyclic ethers [37], while the silver(I) catalyst
PDF
Album
Supp Info
Full Research Paper
Published 14 Mar 2019

Reusable and highly enantioselective water-soluble Ru(II)-Amm-Pheox catalyst for intramolecular cyclopropanation of diazo compounds

  • Hamada S. A. Mandour,
  • Yoko Nakagawa,
  • Masaya Tone,
  • Hayato Inoue,
  • Nansalmaa Otog,
  • Ikuhide Fujisawa,
  • Soda Chanthamath and
  • Seiji Iwasa

Beilstein J. Org. Chem. 2019, 15, 357–363, doi:10.3762/bjoc.15.31

Graphical Abstract
  • proceeded smoothly at room temperature, affording the corresponding bicyclic cyclopropane ring-fused lactones and lactams in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee). After screening of various catalysts, the Ru(II)-Amm-Pheox complex having an ammonium group proved to be
  • amide derivatives, prepared from the corresponding allylic alcohols by the Fukuyama method [50] were investigated as shown in Scheme 1. The catalytic system was applicable to a wide variety of substrates, which reacted smoothly to give the corresponding bicyclic products. For example, diazo Weinreb
  • amide derivatives bearing electron-donating or electron-withdrawing groups at the ortho, meta, or para positions could be converted to the corresponding bicyclic products in excellent yields (up to 99%) and enantioselectivities (up to 98% ee, Scheme 1, 2g−m). A diazo compound with two chlorine
PDF
Album
Supp Info
Letter
Published 06 Feb 2019

Synthesis of nonracemic hydroxyglutamic acids

  • Dorota G. Piotrowska,
  • Iwona E. Głowacka,
  • Andrzej E. Wróblewski and
  • Liwia Lubowiecka

Beilstein J. Org. Chem. 2019, 15, 236–255, doi:10.3762/bjoc.15.22

Graphical Abstract
  • equimolar amounts of easily separable cycloadducts 75 and 76 (Scheme 19) [81]. The bicyclic framework in the latter compound was first reduced and the hydroxy group was protected as acetate. Then the oxidative cleavage of the C=C bond gave diacid 77 (readily purified as dimethyl ester 78) which is a
PDF
Album
Review
Published 25 Jan 2019

Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA

  • Sibylle Frei,
  • Adam K. Katolik and
  • Christian J. Leumann

Beilstein J. Org. Chem. 2019, 15, 79–88, doi:10.3762/bjoc.15.9

Graphical Abstract
  • -DNA (6’-diF-bc4,3-DNA). The difluorinated thymidine phosphoramidite building block was synthesized starting from an already known gem-difluorinated tricyclic glycal. This tricyclic siloxydifluorocyclopropane was converted into the [4.3.0]bicyclic nucleoside via cyclopropane ring-opening through the
  • addition of an electrophilic iodine during the nucleosidation step followed by reduction. The gem-difluorinated bicyclic nucleoside was then converted into the corresponding phosphoramidite building block which was incorporated into oligonucleotides. Thermal denaturation experiments of these
  • gem-difluorinated bicyclic nucleoside 6 as the main side product. Since nucleoside 6 possessed the desired stereochemistry at the 1’- and the 5’-positions, we investigated the mechanism of its formation in more detail to be able to increase its yield. To determine in which of the two steps the
PDF
Album
Supp Info
Full Research Paper
Published 08 Jan 2019

Mechanistic studies of an L-proline-catalyzed pyridazine formation involving a Diels–Alder reaction with inverse electron demand

  • Anne Schnell,
  • J. Alexander Willms,
  • S. Nozinovic and
  • Marianne Engeser

Beilstein J. Org. Chem. 2019, 15, 30–43, doi:10.3762/bjoc.15.3

Graphical Abstract
  • formation of the enamine I seems plausible. It is an electron-rich dienophile which could undergo a [4 + 2] cycloaddition with the electron-poor aryl-substituted tetrazine 2 in a Diels–Alder reaction with inverse electron demand. The bicyclic Diels–Alder intermediate II then might undergo a retro-Diels
  • theoretical methods [52]. Their results are in agreement with the catalytic cycle presented in Scheme 1. However, the question is raised whether the bicyclic Diels–Alder species II is a real intermediate or rather a transition state of a concerted formation of the dihydropyridazine intermediate III directly
  • than the intensity of product 3 and declines very slowly as the reaction progresses (Figure 3b). However, no signals for the intermediates I1 (enamine) and II1 (bicyclic Diels–Alder intermediate) were found. Intermediate I1 (m/z 156) has been observed before by Marquez et al. in ESIMS experiments of an
PDF
Album
Supp Info
Full Research Paper
Published 03 Jan 2019

6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

  • Sibylle Frei,
  • Andrei Istrate and
  • Christian J. Leumann

Beilstein J. Org. Chem. 2018, 14, 3088–3097, doi:10.3762/bjoc.14.288

Graphical Abstract
  • unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc4,3-DNA). Two 6’F-bc4,3 phosphoramidite building blocks (T and C) were synthesized starting from a previously described [3.3.0]bicyclic sugar. The conversion of this sugar to a gem-difluorinated tricyclic intermediate via difluorocarbene addition followed
  • duplexes. Results and Discussion Synthesis of the phosphoramidite building blocks Our strategy for the construction of the two phosphoramidite building blocks 10 and 16 envisaged as a key step the formation of a [4.3.0]bicyclic fluoroenone from a tricyclic siloxydifluorocyclopropane through a ring
  • enlargement via selective cyclopropane ring opening [46][47][48][49]. Consequently, the synthesis started from the previously described bicyclic silyl enol ethers 1α/β (Scheme 1) [50][51]. The two anomers of 1 were individually transformed into the trimethylsilyl (TMS)-protected sugars 2α/β by adapting and
PDF
Album
Supp Info
Full Research Paper
Published 20 Dec 2018

Ring-opening metathesis of some strained bicyclic systems; stereocontrolled access to diolefinated saturated heterocycles with multiple stereogenic centers

  • Zsanett Benke,
  • Melinda Nonn,
  • Márton Kardos,
  • Santos Fustero and
  • Loránd Kiss

Beilstein J. Org. Chem. 2018, 14, 2698–2707, doi:10.3762/bjoc.14.247

Graphical Abstract
  • Orgánica, Facultad de Farmàcia, Universidad de Valencia, Av. Vicente Andrés Estellés, s/n 46100 Valencia, Spain 10.3762/bjoc.14.247 Abstract Ring-opening metathesis (ROM) of various unsaturated, constrained bicyclic ring systems has been investigated with the use of commercial ruthenium-based catalysts
  • . Starting from various cyclodienes, the corresponding derived bicyclic lactone, lactam, and isoxazoline derivatives were submitted to ROM under ethenolysis. These functionalized, strained bicyclic systems afforded novel highly-functionalized diolefinated heterocyclic scaffolds in ROM reactions with
  • structurally restricted cycloalkene β-amino acids or unsaturated bicyclic β-lactams, followed by cross-coupling metathesis (CM) of the newly created C–C double bonds (Scheme 1). Our current goal was to expand the study of the ROM protocol of functionalized strained ring systems to the investigation of
PDF
Album
Supp Info
Full Research Paper
Published 24 Oct 2018

Synthesis of cis-hydrindan-2,4-diones bearing an all-carbon quaternary center by a Danheiser annulation

  • Gisela V. Saborit,
  • Carlos Cativiela,
  • Ana I. Jiménez,
  • Josep Bonjoch and
  • Ben Bradshaw

Beilstein J. Org. Chem. 2018, 14, 2597–2601, doi:10.3762/bjoc.14.237

Graphical Abstract
  • ), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain 10.3762/bjoc.14.237 Abstract A straightforward synthetic entry to functionalized hydrindane compounds based on a rapid assembly of the core nucleus by a Danheiser cycloaddition is reported. Valuable bicyclic building blocks containing the fused five
  • have been used to build the hydrindane bicyclic system, but incorporating a different functionalization pattern in the cyclic compounds. Proposed here is a new methodological approach to functionalized 3a-substituted hydrindane synthesis based on a Danheiser annulation involving a [3 + 2] cycloaddition
  • assemble the 6,5-bicyclic nucleus of hydrindane compounds, expanding the usefulness of the versatile decahydroquinoline building block 1. Although the compounds were prepared in racemic form, optically active substances are also accessible from enantiopure 1 [23]. The overall sequence shows the potential
PDF
Album
Supp Info
Letter
Published 09 Oct 2018

Synthesis of eunicellane-type bicycles embedding a 1,3-cyclohexadiene moiety

  • Alex Frichert,
  • Peter G. Jones and
  • Thomas Lindel

Beilstein J. Org. Chem. 2018, 14, 2461–2467, doi:10.3762/bjoc.14.222

Graphical Abstract
  • an [8.4.0] bicyclic skeleton (1, Figure 1). In many cases, an additional oxygen bridge is present between positions 4 and 7, or 2 and 9, but there are also interesting eunicellanes without oxygen bridge, the majority of which has been isolated from marine corals. These comprise the solenopodins A–D
  • of bicyclic diterpenoids sharing the eunicellane skeleton. Closure of the ten-membered ring by pinacol cyclization proved to be possible, if the six-membered ring is either aromatic or a 1,3-cyclohexadiene, but failed for systems with two sp3 centers as bridgeheads. The ten-membered ring of benzene
  • beginning, and of precursors in which one of the centers will be sp2- and the other sp3-hybridized. Examples of the latter have already been obtained in form of allenes 32 and 34 that will now have to be elaborated further. Bicyclic eunicellane-type diterpenes. Synthetic eunicellane-type compounds with
PDF
Album
Supp Info
Full Research Paper
Published 20 Sep 2018

Microfluidic light-driven synthesis of tetracyclic molecular architectures

  • Javier Mateos,
  • Nicholas Meneghini,
  • Marcella Bonchio,
  • Nadia Marino,
  • Tommaso Carofiglio,
  • Xavier Companyó and
  • Luca Dell’Amico

Beilstein J. Org. Chem. 2018, 14, 2418–2424, doi:10.3762/bjoc.14.219

Graphical Abstract
  • manipulation involved the treatment of 4a with PhMgBr, converting the lactone moiety into the corresponding aromatic ketone. Product 8a formed in 71% yield without diastereoisomeric loss. Finally, LiAlH4 reduction of 4a furnished the bicyclic 1,3-diol 9a in quantitative yield, again without the need of
PDF
Album
Supp Info
Letter
Published 17 Sep 2018

Non-metal-templated approaches to bis(borane) derivatives of macrocyclic dibridgehead diphosphines via alkene metathesis

  • Tobias Fiedler,
  • Michał Barbasiewicz,
  • Michael Stollenz and
  • John A. Gladysz

Beilstein J. Org. Chem. 2018, 14, 2354–2365, doi:10.3762/bjoc.14.211

Graphical Abstract
  • first metathesis step does not require a syn relationship (per VIII), the same possibility can be entertained for the second (see IX). This would lead to an isomeric bicyclic compound with "crossed chains". We have sought to access such species by conducting metatheses of substrates of the types in
PDF
Album
Supp Info
Full Research Paper
Published 07 Sep 2018

Hydroarylations by cobalt-catalyzed C–H activation

  • Rajagopal Santhoshkumar and
  • Chien-Hong Cheng

Beilstein J. Org. Chem. 2018, 14, 2266–2288, doi:10.3762/bjoc.14.202

Graphical Abstract
  • and co-workers developed a cobalt-catalyzed hydroarylation of 2-vinyloxiranes with indoles 7 to form C2-allylated products 46, albeit in low stereoselectivity (Scheme 29b) [83]. Similarly, Cheng et al. reported a hydroarylation reaction of arenes 7 with a bicyclic alkene to form ring-opening products
  • form bicyclic cobaltacycle H1. After the reversible coordination of arene 55 with H1 to generate intermediate H2, ortho C–H cobaltation provides complex H3, which changed into product 56 and Co(I) catalyst by reductive elimination of H3. 5. Hydroarylation of C=X (X = N, O) bonds 5.1 Low-valent cobalt
PDF
Album
Review
Published 29 Aug 2018

Selective formation of a zwitterion adduct and bicarbonate salt in the efficient CO2 fixation by N-benzyl cyclic guanidine under dry and wet conditions

  • Yoshiaki Yoshida,
  • Naoto Aoyagi and
  • Takeshi Endo

Beilstein J. Org. Chem. 2018, 14, 2204–2211, doi:10.3762/bjoc.14.194

Graphical Abstract
  • particular, CO2 capture–release behaviors of bicyclic and six-membered cyclic amidine derivatives have been well studied compared to that of five-membered derivatives, because the high ring strain of five-membered cyclic amidine derivatives was unfavorable for the binding between CO2 and the amidine moiety
  • guanidine derivative and CO2 was isolated and characterized for the first time, although there were a few reports about the bicyclic guanidine derivatives such as TBD. Results and Discussion CO2 fixation behavior of N-benzyl cyclic guanidine depending on dry and wet conditions First, CO2 fixation by N
PDF
Album
Supp Info
Full Research Paper
Published 23 Aug 2018
Other Beilstein-Institut Open Science Activities