Search results

Search for "sensing" in Full Text gives 194 result(s) in Beilstein Journal of Organic Chemistry.

A versatile route to polythiophenes with functional pendant groups using alkyne chemistry

  • Xiao Huang,
  • Li Yang,
  • Rikard Emanuelsson,
  • Jonas Bergquist,
  • Maria Strømme,
  • Martin Sjödin and
  • Adolf Gogoll

Beilstein J. Org. Chem. 2016, 12, 2682–2688, doi:10.3762/bjoc.12.265

Graphical Abstract
  • ][4][5][6][7][8][9], as well as ion sensing devices [10], biosensors [11], and thermoelectric polymers [12]. Therefore, the chemistry of its building block 3,4-ethylenedioxythiophene (EDOT) and the functionalization of the basic structure have been attracting interest as well [13]. The vast amount of
PDF
Album
Supp Info
Full Research Paper
Published 09 Dec 2016

A direct method for the N-tetraalkylation of azamacrocycles

  • Andrew J. Counsell,
  • Angus T. Jones,
  • Matthew H. Todd and
  • Peter J. Rutledge

Beilstein J. Org. Chem. 2016, 12, 2457–2461, doi:10.3762/bjoc.12.239

Graphical Abstract
  • , as part of ongoing efforts to develop multi-functionalised cyclam derivatives for fluorescence sensing [25][26][27][28][40][41] and other biomedical applications [14][15][16][42][43]. However, we found the previously reported methods to be at best capricious when it comes to substitution with
  • . Utilisation of the N-tetrapropargyl products 3 and 8 to generate ‘click’-triazolylcyclam/cyclen derivatives for fluorescence sensing and other applications is underway and will be reported in due course. Ball-and-stick depiction of the crystal structure obtained for [(3)H2](ClO4)2, generated with X-Seed [51
PDF
Album
Supp Info
Letter
Published 18 Nov 2016

Hydroxy-functionalized hyper-cross-linked ultra-microporous organic polymers for selective CO2 capture at room temperature

  • Partha Samanta,
  • Priyanshu Chandra and
  • Sujit K. Ghosh

Beilstein J. Org. Chem. 2016, 12, 1981–1986, doi:10.3762/bjoc.12.185

Graphical Abstract
  • surface area, small pore size and low skeletal density [9][10][11][12]. This type of materials has already been used for various purposes of applications such as gas storage, gas separation, catalysis, sensing, clean energy, etc. [13][14][15][16][17][18]. Relatively weaker coordination bonds in MOFs have
PDF
Album
Supp Info
Letter
Published 02 Sep 2016

From supramolecular chemistry to the nucleosome: studies in biomolecular recognition

  • Marcey L. Waters

Beilstein J. Org. Chem. 2016, 12, 1863–1869, doi:10.3762/bjoc.12.175

Graphical Abstract
  • highly amenable to structure–function studies, since only a new monomer must be synthesized, rather than an entirely new receptor. With my interest in trimethyllysine provided a significant problem in which DCC seemed to be a promising solution. It turns out that the main tool for sensing protein post
PDF
Album
Review
Published 17 Aug 2016

Organic chemistry meets polymers, nanoscience, therapeutics and diagnostics

  • Vincent M. Rotello

Beilstein J. Org. Chem. 2016, 12, 1638–1646, doi:10.3762/bjoc.12.161

Graphical Abstract
  • with great precision. Bringing together these two very disparate skill sets is, however, quite uncommon. This autobiographical review provides some insight into how my program evolved, as well as giving some idea of where we are going. Keywords: organic synthesis, supramolecular, nanoparticle sensing
  • to doing the occasional eccentric experiment. Building nanonoses As we were developing our delivery vehicle platforms, we were starting to think about sensing applications. One of the things that we observed in our protein binding work was that our nanoparticles had varying affinities for different
  • had two limitations. The second issue we had was lack of choices in emission color – blue and green are easy, yellow is challenging, and getting a red conjugated polymer with a respectable quantum yield is nigh impossible. We had an idea, however, that we could use multi-channel sensing to increase
PDF
Album
Review
Published 02 Aug 2016

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

  • Bernardas Morkunas,
  • Balint Gal,
  • Warren R. J. D. Galloway,
  • James T. Hodgkinson,
  • Brett M. Ibbeson,
  • Yaw Sing Tan,
  • Martin Welch and
  • David R. Spring

Beilstein J. Org. Chem. 2016, 12, 1428–1433, doi:10.3762/bjoc.12.137

Graphical Abstract
  • . aeruginosa infections. Evidence suggests that the active compound reduces the level of pyocyanin production by inhibiting the cell–cell signalling mechanism known as quorum sensing. This could have interesting implications; quorum sensing regulates a range of additional elements associated with the
  • pathogenicity of P. aeruginosa and there is a wide range of other potential applications where the inhibition of quorum sensing is desirable. Keywords: antibacterial; antivirulence; Pseudomonas aeruginosa; pyocyanin; quorum sensing; Findings The Gram-negative bacterium Pseudomonas aeruginosa is a clinically
  • inhibition of this phenotype by a member of this structural sub-class. Thus, a promising new scaffold for pyocyanin inhibition has been identified. A cell–cell signalling process known as quorum sensing regulates pyocyanin production by P. aeruginosa [8][9][20]. This bacterium uses (at least) three different
PDF
Album
Supp Info
Letter
Published 11 Jul 2016

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

  • Andrew W. Truman

Beilstein J. Org. Chem. 2016, 12, 1250–1268, doi:10.3762/bjoc.12.120

Graphical Abstract
  • thiolactone is generated in AIP biosynthesis (Figure 9). Autoinducing peptides are secreted molecules that form part of a quorum-sensing system in Staphylococcus [121]. Heterologous expression in E. coli showed that only AgrD (precursor peptide) and AgrB (peptidase) are required for AIP biosynthesis, although
  • candidate enzymes. A number of these cyclisations are found in partially characterised pathways, such as the S–C cross-link in α-amanitin (Figure 8B) that is formed between cysteine and tryptophan residues (the tryptathionine linkage [131]). The ComQXPA quorum sensing (QS) system [132] found in Bacillus
PDF
Album
Review
Published 20 Jun 2016

Stimuli-responsive HBPS-g-PDMAEMA and its application as nanocarrier in loading hydrophobic molecules

  • Yongsheng Chen,
  • Li Wang,
  • Haojie Yu,
  • Zain-Ul-Abdin,
  • Ruoli Sun,
  • Guanghui Jing,
  • Rongbai Tong and
  • Zheng Deng

Beilstein J. Org. Chem. 2016, 12, 939–949, doi:10.3762/bjoc.12.92

Graphical Abstract
  • nanocarriers for loading guest molecules is dynamic. It has been widely studied in applications including drug controlled release, smart sensing, catalysis, and modeling. In this paper, a graft copolymer (hyperbranched polystyrene)-g-poly[2-(dimethylamino)ethyl methacrylate] (HBPS-g-PDMAEMA) was synthesized
  • -responsive nanocarriers; Introduction Stimuli-responsive polymers have attracted much attention due to their broad applications including drug controlled release [1][2][3][4][5], sensing [6][7] and 4D printing [8][9]. Nanocarriers prepared from amphiphilic stimuli-responsive polymers are promising
PDF
Album
Full Research Paper
Published 10 May 2016

Self and directed assembly: people and molecules

  • Tony D. James

Beilstein J. Org. Chem. 2016, 12, 391–405, doi:10.3762/bjoc.12.42

Graphical Abstract
  • collaborate and in particular we worked together to improve the chiral discriminating systems. In order to improve the chiral systems we designed sensors using a d-PET rather than the normal a-PET fluorescence sensing mechanism. With d-PET systems the fluorophore is the electron donor and the protonated amine
  • ) who as it happens had employed Susumu Arimori after he left my group at the end of 2001 as a Post-Doctoral Research Fellow. The two weeks on the road also allowed Steve and me to discuss research. Steve is interested in chiral catalysis and I am interested in chiral sensing so a collaborative project
  • International Conference on Molecular Machines and Sensor (ICMMS). Therefore, we Jianzhang Zhao and Tony James (with Steven Bull and John Fossey) applied for funding to host a Thematic Workshop during 2008 on “Catalysis and Sensing for our Environment” (CASE) in Bath. We were very lucky in obtaining the funding
PDF
Album
Review
Published 01 Mar 2016

Art, auto-mechanics, and supramolecular chemistry. A merging of hobbies and career

  • Eric V. Anslyn

Beilstein J. Org. Chem. 2016, 12, 362–376, doi:10.3762/bjoc.12.40

Graphical Abstract
  • that propels the automobile. The expanded version of a 1953 in-line six-cylinder bottom-end from an Mk VII Jaguar owner’s manual is a powerful image that accentuates the idea of emergent properties. As described below, the field of differential sensing, in which our group works extensively, takes the
  • for sensing purposes. The impetus for doing so was driven by an attempt to have a higher impact with our work, but, admittedly, was also due to serendipity. Several events moved our group’s research toward sensing applications. One was having a synthesis to create 9 as an RNA hydrolysis catalyst
  • fluorophores bound in the cavity of cyclodextrins to measure Keq values, our idea was to instead exploit the displacement as the sensing modality. Thus, the idea of an indicator-displacement assay (IDA) was born [58][59]. As with so many “new” ideas in chemistry, the approach had actually been used before, by
PDF
Album
Review
Published 26 Feb 2016

My maize and blue brick road to physical organic chemistry in materials

  • Anne J. McNeil

Beilstein J. Org. Chem. 2016, 12, 229–238, doi:10.3762/bjoc.12.24

Graphical Abstract
  • providing a portable and potentially inexpensive method for sensing. Considering how naïve my understanding of gelation was at the time, I am still surprised that my proposal idea worked almost exactly as described. Molecular gels form through the self-assembly of small molecules into supramolecular
  • for sensing in real time. Increased NO concentrations led to gels within a minute, but these concentrations were outside the useful range for breath analysis. Nevertheless, these initial studies laid the foundation for our next effort, which was focused on developing a more sophisticated approach to
  • were interested in applying our new gelators in sensing platforms. Because analyte-mediated sensors rely on a chemical transformation to take place prior to gel formation, the reaction rate should be fast, or ideally instantaneous. While most of our sensors were designed with this criterion in mind, we
PDF
Album
Review
Published 08 Feb 2016

Bright molecules for sensing, computing and imaging: a tale of two once-troubled cities

  • A. Prasanna de Silva

Beilstein J. Org. Chem. 2015, 11, 2774–2784, doi:10.3762/bjoc.11.298

Graphical Abstract
  • electron transfer) sensing/switching as a design tool, b) the construction of a market-leading blood electrolyte analyzer and c) the invention of molecular logic-based computation as an experimental field, are delineated. Efforts to extend the philosophy of these approaches into issues of small object
  • identification, nanometric mapping, animal visual perception and visual art are also outlined. Keywords: blood electrolyte analyzer; luminescent PET sensing/switching; molecular logic-based computation; photoinduced electron transfer; small molecular edge detection; Review Prologue Colombo, Sri Lanka: A civil
  • compete for the deactivation of the same excited state, it was equally clear that a luminescence signal could be switched ‘on’ by chemical command. Therefore, we were fortunate to be able to introduce a general design tool of luminescent PET sensing/switching [11][12][13][14][15], which even handled
PDF
Album
Review
Published 29 Dec 2015

Recent advances in metathesis-derived polymers containing transition metals in the side chain

  • Ileana Dragutan,
  • Valerian Dragutan,
  • Bogdan C. Simionescu,
  • Albert Demonceau and
  • Helmut Fischer

Beilstein J. Org. Chem. 2015, 11, 2747–2762, doi:10.3762/bjoc.11.296

Graphical Abstract
  • confer an optimal set of capabilities that recommend them for diverse emerging application areas, e.g., as electro-optical and magnetic devices, for energy storage, nanomaterials, sensing, catalytic and drug-delivery systems [6][12][13][14]. Numerous synthetic routes have been explored to achieve the
  • electrochemistry, sensing, catalysis, nanomaterials, etc. [37][38][39][40]. Not surprisingly, therefore, attention of researchers has turned first on metallopolymers containing ferrocene [33][34][41][42][43]. Review Iron-containing polymers Following the first successful application of Mo–alkylidene catalysts by
  • used to prepare modified Pt electrodes with high stability and good qualitative sensing of ATP2− anions. It was supposed that the triethylene glycol domains in the block copolymers favor the amidoferrocene–ATP interactions by encapsulation. Astruc assumed that during the recognition process different H
PDF
Album
Review
Published 28 Dec 2015

Smart molecules for imaging, sensing and health (SMITH)

  • Bradley D. Smith

Beilstein J. Org. Chem. 2015, 11, 2540–2548, doi:10.3762/bjoc.11.274

Graphical Abstract
  • -authored a book chapter entitled “Applications of Synthetic Receptors for Biomolecules [45].” The chapter grouped the most common applications into four general groups; Separations, Imaging and Sensing, Catalysis, and Pharmaceutical Activity – important topics that will continue to attract the attention of
PDF
Album
Review
Published 10 Dec 2015

Conformational equilibrium in supramolecular chemistry: Dibutyltriuret case

  • Karina Mroczyńska,
  • Małgorzata Kaczorowska,
  • Erkki Kolehmainen,
  • Ireneusz Grubecki,
  • Marek Pietrzak and
  • Borys Ośmiałowski

Beilstein J. Org. Chem. 2015, 11, 2105–2116, doi:10.3762/bjoc.11.227

Graphical Abstract
  • studied by MS [44] while its interaction preferences with anions in solution are not known. On the other hand the tris-urea derivatives with a spacer between NHCONH groups were used in several supramolecular complexes including those with encapsulated anions [45][46], sensing nerve agents [47] or in self
PDF
Album
Supp Info
Full Research Paper
Published 05 Nov 2015

Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners

  • Mohamed Ramadan El Sayed Aly,
  • Hosam Ali Saad and
  • Shams Hashim Abdel-Hafez

Beilstein J. Org. Chem. 2015, 11, 1922–1932, doi:10.3762/bjoc.11.208

Graphical Abstract
  • their immunostimulant activities [21]. Finally, the ability of cholesterol derivatives to self-assembly and gelation as supramolecular gels was reviewed [22]. They are beneficially applicable in materials science, reaction media, sensing and responsive materials, energy supply, biomedicine, and tissue
PDF
Album
Supp Info
Full Research Paper
Published 16 Oct 2015

Polythiophene and oligothiophene systems modified by TTF electroactive units for organic electronics

  • Alexander L. Kanibolotsky,
  • Neil J. Findlay and
  • Peter J. Skabara

Beilstein J. Org. Chem. 2015, 11, 1749–1766, doi:10.3762/bjoc.11.191

Graphical Abstract
  • trapping by the TTF unit. This hole trapping was explained to be the reason for a negative Seebeck coefficient of the non-doped polymer 13e and was used for sensing trinitrotoluene (TNT) using the drain-source current-increase response to TTF-TNT complexation in an OFET fabricated from 13e with 5% of PQT12
PDF
Album
Review
Published 28 Sep 2015

Star-shaped tetrathiafulvalene oligomers towards the construction of conducting supramolecular assembly

  • Masahiko Iyoda and
  • Masashi Hasegawa

Beilstein J. Org. Chem. 2015, 11, 1596–1613, doi:10.3762/bjoc.11.175

Graphical Abstract
  • hand, the conductivities of the corresponding neutral nanoobjects are determined by pulse-radiolysis or flash-photolysis time-resolved microwave conductivity techniques [48][49]. Current-sensing atomic force microscopy (CS-AFM) and combination of scanning tunneling microscopy and spectroscopy (STM/STS
PDF
Album
Supp Info
Review
Published 10 Sep 2015

A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis

  • Darko Kresovic,
  • Florence Schempp,
  • Zakaria Cheikh-Ali and
  • Helge B. Bode

Beilstein J. Org. Chem. 2015, 11, 1412–1417, doi:10.3762/bjoc.11.152

Graphical Abstract
  • , 60438 Frankfurt am Main, Germany 10.3762/bjoc.11.152 Abstract The biosynthesis of photopyrones, novel quorum sensing signals in Photorhabdus, has been studied by heterologous expression of the photopyrone synthase PpyS catalyzing the head-to-head condensation of two acyl moieties. The biochemical
  • sensing; Introduction Chemical compounds containing an α-pyrone moiety are widespread in nature [1][2] and show a high diversity in their biological activity. Members of this class of compounds have been identified with antimicrobial, cytotoxic [3] and antitumor activities [4], as HIV protease inhibitors
PDF
Album
Supp Info
Full Research Paper
Published 12 Aug 2015

Tetrathiafulvalene-based azine ligands for anion and metal cation coordination

  • Awatef Ayadi,
  • Aziz El Alamy,
  • Olivier Alévêque,
  • Magali Allain,
  • Nabil Zouari,
  • Mohammed Bouachrine and
  • Abdelkrim El-Ghayoury

Beilstein J. Org. Chem. 2015, 11, 1379–1391, doi:10.3762/bjoc.11.149

Graphical Abstract
  • N3–H3···O1 hydrogen bonding. Titration experiments with inorganic anions showed that both ligands are suitable candidates for the sensing of fluoride anions. Ligand L2 was reacted with a Re(I) cation to yield the corresponding rhenium tricarbonyl complex 3. In the crystal structure of the newly
  • prepared electroactive rhenium complex the TTF is neutral and the rhenium cation is hexacoordinated. The electrochemical behavior of the three compounds indicates that they are promising for the construction of crystalline radical cation salts. Keywords: azine ligand; fluoride sensing; rhenium
  • -responsive receptors for neutral and/or charged guest sensing applications have been prepared [18][19][20][21][22]. On this ground, chemosensors capable of recognizing anionic and/or cationic species constitute an important area of increasing research in supramolecular chemistry, considering the ubiquitous
PDF
Album
Supp Info
Full Research Paper
Published 07 Aug 2015

Impact of multivalent charge presentation on peptide–nanoparticle aggregation

  • Daniel Schöne,
  • Boris Schade,
  • Christoph Böttcher and
  • Beate Koksch

Beilstein J. Org. Chem. 2015, 11, 792–803, doi:10.3762/bjoc.11.89

Graphical Abstract
  • controlled assembly of nanoparticles by means of biomolecules is crucial for biological and medical applications such as sensing [4], bioimaging [5], and medical diagnostics [6]. Although nanoparticles are also applied as targeted biomarkers and drug-delivery agents to tumor cells [7], only very little is
PDF
Album
Supp Info
Full Research Paper
Published 15 May 2015

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

  • Mathieu L. Lepage,
  • Antoine Mirloup,
  • Manon Ripoll,
  • Fabien Stauffert,
  • Anne Bodlenner,
  • Raymond Ziessel and
  • Philippe Compain

Beilstein J. Org. Chem. 2015, 11, 659–667, doi:10.3762/bjoc.11.74

Graphical Abstract
  • ][44][45][46][47]. We have recently argued the case that the fluoro-substitution of boraindacene was a mean to considerably increase the solubility, the stability and the steric hindrance avoiding the formation of aggregates [48]. In some cases, special sensing properties [49] may be induced by
PDF
Album
Supp Info
Full Research Paper
Published 06 May 2015

Fluoride-driven ‘turn on’ ESPT in the binding with a novel benzimidazole-based sensor

  • Kai Liu,
  • Xiaojun Zhao,
  • Qingxiang Liu,
  • Jianzhong Huo,
  • Bolin Zhu and
  • Shihua Diao

Beilstein J. Org. Chem. 2015, 11, 563–567, doi:10.3762/bjoc.11.61

Graphical Abstract
  • recognition and sensing, was suggested to be responsible for the fluorescence enhancement with a blue shift of 35 nm in the emission spectrum. Keywords: anion recognition; deprotonation; ESPT; fluoride; ‘turn on’ fluorescence; Introduction Design and synthesis of selective and efficient sensors for various
  • anions involved in biological, industrial and environmental processes have drawn a lot of attention [1][2][3]. In recent years, much effort has been devoted to the development of anion fluorescent sensors [4]. Of particular interest concerning anion recognition and sensing was fluoride [5][6][7], as it
  • proton transfer (ESPT), as an extensively exploited mechanism in many biological and chemical processes, has been employed poorly in anion recognition and sensing [2][11][12][13][14][15][16]. In the ESPT molecules, a five or six-membered intramolecular hydrogen-bonded ring formed, and a proton/hydrogen
PDF
Album
Supp Info
Letter
Published 24 Apr 2015

Electrochemical oxidation of cholesterol

  • Jacek W. Morzycki and
  • Andrzej Sobkowiak

Beilstein J. Org. Chem. 2015, 11, 392–402, doi:10.3762/bjoc.11.45

Graphical Abstract
  • of sensing, which have a distinct advantage over conventional enzymatic processes, have recently been developed. Some of these methods are based on the indirect electrochemical oxidation of cholesterol by using bromine species in organic media [69][70]. In a recent method, methylene blue formed an
  • inclusion complex with β-cyclodextrin functionalized graphene and emerged as a cholesterol sensing matrix. Methylene blue was then replaced by the cholesterol molecule and moved out in the buffer solution, where it was detected electrochemically by using the differential pulse voltammetric technique [71
  • design of mixed biocatalyst pathways for the comprehensive oxidation of cholesterol, and, at the same time, the acquisition of frequent answers with an individual application for biosensorics is of major interest. Sophisticated sensing arrangements including single and complex selective agents may be
PDF
Album
Review
Published 25 Mar 2015

Synthesis and chemosensing properties of cinnoline-containing poly(arylene ethynylene)s

  • Natalia A. Danilkina,
  • Petr S. Vlasov,
  • Semen M. Vodianik,
  • Andrey A. Kruchinin,
  • Yuri G. Vlasov and
  • Irina A. Balova

Beilstein J. Org. Chem. 2015, 11, 373–384, doi:10.3762/bjoc.11.43

Graphical Abstract
  • type of response, conjugated polymers for sensing are termed as amplifying fluorescent polymers (AFPs) [4]. The mechanism of the response amplification can be explained in terms of the "molecular wire" concept [2][3][4][5][6][7][8][9]. Binding of a single analyte molecule to a single recognition site
  • . Such materials find widespread use in sensing of metal ions and anions, detection of explosives and various biomolecules [2−4]. Among the great variety of known conjugated polymers, poly(arylene ethynylene)s (PAEs) are one of the most promising materials in the search for new chemical sensors [7]. A
  • wide range of PAEs has been developed in the last decade [2][3][4], for example polymers with ether, ester or carboxylic acid functions [11] and N-containing heterocyclic scaffolds [12] for metal ion sensing; polymers with polycyclic aromatics and rigid groups for the detection of explosives [13]; and
PDF
Album
Supp Info
Full Research Paper
Published 20 Mar 2015
Other Beilstein-Institut Open Science Activities