Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• ), and v) they are biodegradable and do not pollute the environment. Their main fields of application are: agriculture, food industry, biotechnology, pharmaceutical industry, chemical and biological analysis, chemical synthesis, catalysis, materials, cosmetic industry, environmental protection

Autonomous assembly of synthetic oligonucleotides built from an expanded DNA alphabet. Total synthesis of a gene encoding kanamycin resistance

• Kristen K. Merritt,
• Kevin M. Bradley,
• Daniel Hutter,
• Mariko F. Matsuura,
• Diane J. Rowold and
• Steven A. Benner

Beilstein J. Org. Chem. 2014, 10, 2348–2360, doi:10.3762/bjoc.10.245

• ) ultralong DNA (UL-DNA) constructs, including whole chromosomes. Experimental Materials and methods Design The sequence for an aminoglycoside 3’-phosphotransferase that encodes resistance to kanamycin is commonly used in cloning vectors and was obtained from the National Center for Biotechnology Information

Sacrolide A, a new antimicrobial and cytotoxic oxylipin macrolide from the edible cyanobacterium Aphanothece sacrum

• Naoya Oku,
• Miyako Matsumoto,
• Kohsuke Yonejima,
• Keijiroh Tansei and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2014, 10, 1808–1816, doi:10.3762/bjoc.10.190

• Naoya Oku Miyako Matsumoto Kohsuke Yonejima Keijiroh Tansei Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan Suizenjinori-Hompo Tanseidoh, 5-13-3 Tsuboi, Chuo-ku, Kumamoto, Kumamoto 860-0863

Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

• Barbara Palka,
• Angela Di Capua,
• Maurizio Anzini,
• Gyté Vilkauskaité,
• Algirdas Šačkus and
• Wolfgang Holzer

Beilstein J. Org. Chem. 2014, 10, 1759–1764, doi:10.3762/bjoc.10.183

• Barbara Palka Angela Di Capua Maurizio Anzini Gyte Vilkauskaite Algirdas Sackus Wolfgang Holzer Division of Drug Synthesis, Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria Department of Biotechnology, Chemistry and

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• ][9], anti-infective agents [10][11][12], or molecular probes [13][14]. Taking into account the importance of nucleoside analogs in medicine and biotechnology, there is a considerable interest in the development of simple and efficient synthesis of these compounds. Multicomponent reactions (MCRs

Bifunctional dendrons for multiple carbohydrate presentation via carbonyl chemistry

• Davide Bini,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2014, 10, 1686–1691, doi:10.3762/bjoc.10.177

• Davide Bini Francesco Nicotra Laura Cipolla Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy 10.3762/bjoc.10.177 Abstract The synthesis of new dendrons of the generations 0, 1 and 2 with a double bond at the focal point and a

Pd/C-catalyzed aerobic oxidative esterification of alcohols and aldehydes: a highly efficient microwave-assisted green protocol

• Marina Caporaso,
• Giancarlo Cravotto,
• Spyros Georgakopoulos,
• George Heropoulos,
• Katia Martina and
• Silvia Tagliapietra

Beilstein J. Org. Chem. 2014, 10, 1454–1461, doi:10.3762/bjoc.10.149

• interfaces and surfaces NIS, University of Turin, Via P. Giuria 7–9, 10125 Torino, Italy Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48. Vas. Constantinou Ave., 11635 Athens, Greece 10.3762/bjoc.10.149 Abstract We herein describe an environmentally

Synthesis, characterization and DNA interaction studies of new triptycene derivatives

• Sourav Chakraborty,
• Snehasish Mondal,
• Rina Kumari,
• Sourav Bhowmick,
• Prolay Das and
• Neeladri Das

Beilstein J. Org. Chem. 2014, 10, 1290–1298, doi:10.3762/bjoc.10.130

• curve with 5 and 6. Supporting Information File 286: Synthesis and characterization of compounds 1–8. Acknowledgements N.D. and P.D. thank the Department of Science and Technology, Govt. of India (DST No.: SR/FT/CS-028/2009 and SR/FT/LS-036/2010), Department of Biotechnology, Govt. of India (BT/PR3444

Stereocontrolled synthesis of 5-azaspiro[2.3]hexane derivatives as conformationally “frozen” analogues of L-glutamic acid

• Beatrice Bechi,
• David Amantini,
• Cristina Tintori,
• Maurizio Botta and
• Romano di Fabio

Beilstein J. Org. Chem. 2014, 10, 1114–1120, doi:10.3762/bjoc.10.110

• Beatrice Bechi David Amantini Cristina Tintori Maurizio Botta Romano di Fabio Università degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico, Via A. Moro 2, 53100, Siena, Italy Present address: Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Oxford

Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

• Wolfgang Hüttel,
• Jonathan B. Spencer and
• Peter F. Leadlay

Beilstein J. Org. Chem. 2014, 10, 361–368, doi:10.3762/bjoc.10.34

• isolated from 250 mL culture medium of S. cinnamonensis deletion mutants. Acknowledgements We thank Drs Yuliya Demydchuk, Barbara Harvey, Andrew Gallimore and Hui Hong for helpful discussions and Dr J. E. Davies for X-ray structure determinations. This work was supported by the Biotechnology and

Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

• Louis P. Sandjo,
• Eckhard Thines,
• Till Opatz and
• Anja Schüffler

Beilstein J. Org. Chem. 2014, 10, 251–258, doi:10.3762/bjoc.10.20

• Louis P. Sandjo Eckhard Thines Till Opatz Anja Schuffler Johannes-Gutenberg-University Mainz, Institute of Organic Chemistry, Duesbergweg 10–14, D-55128 Mainz, Germany Institute of Biotechnology and Drug Research, Erwin-Schroedinger-Strasse 56, D-67663, Kaiserslautern, Germany Johannes-Gutenberg

• -University Mainz, Institute of Biotechnology and Drug Research, Duesbergweg 10–14, D-55128 Mainz, Germany 10.3762/bjoc.10.20 Abstract Four new polyketides have been identified in culture filtrates of the fungal strain Penicillium sp. IBWF104-06 isolated from a soil sample. They are structurally based on the

• by morphology. Strain IBWF104-06 has been deposited in the culture collection of the Institute of Biotechnology and Drug Research (IBWF e.V.), Kaiserslautern, Germany. For maintenance, the fungus was grown on agar slants on YMG agar (yeast extract 4.0 g/L, malt extract 10 g/L, glucose 10 g/L, the pH

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

• Silke Felix,
• Louis P. Sandjo,
• Till Opatz and
• Gerhard Erkel

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

• Silke Felix Louis P. Sandjo Till Opatz Gerhard Erkel Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Straße 56, D-67663 Kaiserslautern, Germany Institute of Organic Chemistry, University of Mainz, Duesbergweg 10–14, D-55128 Mainz, Germany, Department of Molecular

• Biotechnology and Systems Biology, University of Kaiserslautern, Paul-Ehrlich-Straße 23, D-67663 Kaiserslautern, Germany 10.3762/bjoc.9.323 Abstract Survivin, a member of the IAP (inhibitor of apoptosis) gene family, is overexpressed in virtually all human cancers and is functionally involved in the inhibition

• Biotechnology and Drug Research (IBWF e.V.), Kaiserslautern, Germany. The strain IBWF002-96 showed all characteristics of the genus Aspergillus, the species however could not be unequivocally determined. ITS sequence analysis of the ITS1-5.8S rDNA-ITS2 region of nuclear DNA [35] showed high similarity to an

Cu-Mediated trifluoromethylation of benzyl, allyl and propargyl methanesulfonates with TMSCF₃

• Xueliang Jiang and
• Feng-Ling Qing

Beilstein J. Org. Chem. 2013, 9, 2862–2865, doi:10.3762/bjoc.9.322

• Xueliang Jiang Feng-Ling Qing Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai

Biosynthesis of rare hexoses using microorganisms and related enzymes

• Zijie Li,
• Yahui Gao,
• Hideki Nakanishi,
• Xiaodong Gao and
• Li Cai

Beilstein J. Org. Chem. 2013, 9, 2434–2445, doi:10.3762/bjoc.9.281

• Zijie Li Yahui Gao Hideki Nakanishi Xiaodong Gao Li Cai The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China Division

• by the Natural Science Foundation of China Project (21302069), the Key Grant Project of Chinese Ministry of Education (313027), the Self-Determined Research Program of Jiangnan University (JUSRP1003) and the Open Project Program of the Key Laboratory of Industrial Biotechnology (Ministry of Education

Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus – conversion of selected spirocyclic terpenoids and computational analysis

• Verena Weidmann,
• Mathias Schaffrath,
• Holger Zorn,
• Julia Rehbein and
• Wolfgang Maison

Beilstein J. Org. Chem. 2013, 9, 2233–2241, doi:10.3762/bjoc.9.262

• Chemistry and Food Biotechnology, Heinrich-Buff-Ring 58, 35392 Gießen Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany 10.3762/bjoc.9.262 Abstract Allylic oxidations of olefins to enones allow the efficient synthesis of value-added products from simple

Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support

• Jagdish D. Tibhe,
• Hui Fu,
• Timothy Noël,
• Qi Wang,
• Jan Meuldijk and
• Volker Hessel

Beilstein J. Org. Chem. 2013, 9, 2168–2179, doi:10.3762/bjoc.9.254

• Materials The enzyme L-allo-threonine aldolase (L-low-TA) (EC 4.1.2.48) having concentration of 3 mg/mL and activity of 0.135 U/mg has a strong preference for L-allo-threonine from Thermotoga maritima and was kindly donated by the Junior Research Group ‘‘Industrial Biotechnology’’ (University of Leipzig

• experimental observations. Acknowledgements The authors are thankful to the ProAChim project in the frame of ERA-NET Industrial Biotechnology (ERA IB, No. 035581) for providing funding and would also like to thank Dr. Nicole Weizenmann from Junior Research Group ‘‘Industrial Biotechnology’’, Institute of

Damage of polyesters by the atmospheric free radical oxidant NO₃^•: a product study involving model systems

• Catrin Goeschen and
• Uta Wille

Beilstein J. Org. Chem. 2013, 9, 1907–1916, doi:10.3762/bjoc.9.225

• Catrin Goeschen Uta Wille ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute, The University of Melbourne, 30 Flemington Road, Parkville, VIC 3010, Australia 10.3762/bjoc.9.225 Abstract Manufactured polymer materials are used in

Natural products in synthesis and biosynthesis

• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2013, 9, 1897–1898, doi:10.3762/bjoc.9.223

• problem is that the plant produces only small and variable amounts, thereby making the isolation procedure difficult and expensive. Neither biotechnology nor chemistry were able to provide a solution on their own, but the combination of the heterologous production of an advanced intermediate in yeast [6

A practical synthesis of long-chain iso-fatty acids (iso-C₁₂–C₁₉) and related natural products

• Mark B. Richardson and
• Spencer J. Williams

Beilstein J. Org. Chem. 2013, 9, 1807–1812, doi:10.3762/bjoc.9.210

• Mark B. Richardson Spencer J. Williams School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia 10.3762/bjoc.9.210 Abstract A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C12–C19) was developed

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

• Xu-Wen Li,
• Jennifer Herrmann,
• Yi Zang,
• Philippe Grellier,
• Soizic Prado,
• Rolf Müller and
• Bastien Nay

Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176

• Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany 10.3762/bjoc.9.176 Abstract Aurachins are myxobacterial 3-farnesyl-4(1H)-quinolone derived

Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles

• Marta K. Kurpet,
• Aleksandra Dąbrowska,
• Małgorzata M. Jarosz,
• Katarzyna Kajewska-Kania,
• Nikodem Kuźnik and
• Jerzy W. Suwiński

Beilstein J. Org. Chem. 2013, 9, 1517–1525, doi:10.3762/bjoc.9.173

• Marta K. Kurpet Aleksandra Dabrowska Malgorzata M. Jarosz Katarzyna Kajewska-Kania Nikodem Kuznik Jerzy W. Suwinski Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, Gliwice 44-100, Poland Centre of Polymer and Carbon

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

• Tony Taldone,
• Anna Rodina,
• Erica M. DaGama Gomes,
• Matthew Riolo,
• Hardik J. Patel,
• Raul Alonso-Sabadell,
• Danuta Zatorska,
• Maulik R. Patel,
• Sarah Kishinevsky and
• Gabriela Chiosis

Beilstein J. Org. Chem. 2013, 9, 544–556, doi:10.3762/bjoc.9.60

• at 1,000 rpm at 4 °C for 5 min. Cells were then fixed with 4% paraformaldehyde in PBS at room temperature for 15 min and then washed twice with PBS. Cells were permeabilized with 50 μg/µL digitonin (Gold Biotechnology special grade Cat# D-180-250) in PBS at room temperature for 15 min. Cells were

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

• Lena Möller,
• Christian Hess,
• Jiří Paleček,
• Yi Su,
• Axel Haverich,
• Andreas Kirschning and
• Gerald Dräger

Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33

• for Biotechnology and Artificial Organs (LEBAO) Hannover Medical School (MHH), 30625 Hannover, Germany 10.3762/bjoc.9.33 Abstract Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

• Matthias G. J. Baud,
• Thomas Leiser,
• Vanessa Petrucci,
• Mekala Gunaratnam,
• Stephen Neidle,
• Franz-Josef Meyer-Almes and
• Matthew J. Fuchter

Beilstein J. Org. Chem. 2013, 9, 81–88, doi:10.3762/bjoc.9.11

• Matthias G. J. Baud Thomas Leiser Vanessa Petrucci Mekala Gunaratnam Stephen Neidle Franz-Josef Meyer-Almes Matthew J. Fuchter Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom Department of Chemical Engineering and Biotechnology, University of Applied Sciences

Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions

• Kyle F. Biegasiewicz,
• Michelle L. Ingalsbe,
• Jeffrey D. St. Denis,
• James L. Gleason,
• Junming Ho,
• Michelle L. Coote,
• G. Paul Savage and
• Ronny Priefer

Beilstein J. Org. Chem. 2012, 8, 1814–1818, doi:10.3762/bjoc.8.207

• ARC Centre of Excellence for Free-Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia CSIRO Materials Science and Engineering, Clayton South MDC 3169, Australia College of Pharmacy, Western New England University, Springfield