Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

• Wolfgang Hüttel,
• Jonathan B. Spencer and
• Peter F. Leadlay

Beilstein J. Org. Chem. 2014, 10, 361–368, doi:10.3762/bjoc.10.34

• isolated from 250 mL culture medium of S. cinnamonensis deletion mutants. Acknowledgements We thank Drs Yuliya Demydchuk, Barbara Harvey, Andrew Gallimore and Hui Hong for helpful discussions and Dr J. E. Davies for X-ray structure determinations. This work was supported by the Biotechnology and

Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

• Louis P. Sandjo,
• Eckhard Thines,
• Till Opatz and
• Anja Schüffler

Beilstein J. Org. Chem. 2014, 10, 251–258, doi:10.3762/bjoc.10.20

• Louis P. Sandjo Eckhard Thines Till Opatz Anja Schuffler Johannes-Gutenberg-University Mainz, Institute of Organic Chemistry, Duesbergweg 10–14, D-55128 Mainz, Germany Institute of Biotechnology and Drug Research, Erwin-Schroedinger-Strasse 56, D-67663, Kaiserslautern, Germany Johannes-Gutenberg

• -University Mainz, Institute of Biotechnology and Drug Research, Duesbergweg 10–14, D-55128 Mainz, Germany 10.3762/bjoc.10.20 Abstract Four new polyketides have been identified in culture filtrates of the fungal strain Penicillium sp. IBWF104-06 isolated from a soil sample. They are structurally based on the

• by morphology. Strain IBWF104-06 has been deposited in the culture collection of the Institute of Biotechnology and Drug Research (IBWF e.V.), Kaiserslautern, Germany. For maintenance, the fungus was grown on agar slants on YMG agar (yeast extract 4.0 g/L, malt extract 10 g/L, glucose 10 g/L, the pH

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

• Silke Felix,
• Louis P. Sandjo,
• Till Opatz and
• Gerhard Erkel

Beilstein J. Org. Chem. 2013, 9, 2866–2876, doi:10.3762/bjoc.9.323

• Silke Felix Louis P. Sandjo Till Opatz Gerhard Erkel Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Straße 56, D-67663 Kaiserslautern, Germany Institute of Organic Chemistry, University of Mainz, Duesbergweg 10–14, D-55128 Mainz, Germany, Department of Molecular

• Biotechnology and Systems Biology, University of Kaiserslautern, Paul-Ehrlich-Straße 23, D-67663 Kaiserslautern, Germany 10.3762/bjoc.9.323 Abstract Survivin, a member of the IAP (inhibitor of apoptosis) gene family, is overexpressed in virtually all human cancers and is functionally involved in the inhibition

• Biotechnology and Drug Research (IBWF e.V.), Kaiserslautern, Germany. The strain IBWF002-96 showed all characteristics of the genus Aspergillus, the species however could not be unequivocally determined. ITS sequence analysis of the ITS1-5.8S rDNA-ITS2 region of nuclear DNA [35] showed high similarity to an

Cu-Mediated trifluoromethylation of benzyl, allyl and propargyl methanesulfonates with TMSCF₃

• Xueliang Jiang and
• Feng-Ling Qing

Beilstein J. Org. Chem. 2013, 9, 2862–2865, doi:10.3762/bjoc.9.322

• Xueliang Jiang Feng-Ling Qing Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai

Biosynthesis of rare hexoses using microorganisms and related enzymes

• Zijie Li,
• Yahui Gao,
• Hideki Nakanishi,
• Xiaodong Gao and
• Li Cai

Beilstein J. Org. Chem. 2013, 9, 2434–2445, doi:10.3762/bjoc.9.281

• Zijie Li Yahui Gao Hideki Nakanishi Xiaodong Gao Li Cai The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China Division

• by the Natural Science Foundation of China Project (21302069), the Key Grant Project of Chinese Ministry of Education (313027), the Self-Determined Research Program of Jiangnan University (JUSRP1003) and the Open Project Program of the Key Laboratory of Industrial Biotechnology (Ministry of Education

Elucidation of the regio- and chemoselectivity of enzymatic allylic oxidations with Pleurotus sapidus – conversion of selected spirocyclic terpenoids and computational analysis

• Verena Weidmann,
• Mathias Schaffrath,
• Holger Zorn,
• Julia Rehbein and
• Wolfgang Maison

Beilstein J. Org. Chem. 2013, 9, 2233–2241, doi:10.3762/bjoc.9.262

• Chemistry and Food Biotechnology, Heinrich-Buff-Ring 58, 35392 Gießen Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany 10.3762/bjoc.9.262 Abstract Allylic oxidations of olefins to enones allow the efficient synthesis of value-added products from simple

Flow synthesis of phenylserine using threonine aldolase immobilized on Eupergit support

• Jagdish D. Tibhe,
• Hui Fu,
• Timothy Noël,
• Qi Wang,
• Jan Meuldijk and
• Volker Hessel

Beilstein J. Org. Chem. 2013, 9, 2168–2179, doi:10.3762/bjoc.9.254

• Materials The enzyme L-allo-threonine aldolase (L-low-TA) (EC 4.1.2.48) having concentration of 3 mg/mL and activity of 0.135 U/mg has a strong preference for L-allo-threonine from Thermotoga maritima and was kindly donated by the Junior Research Group ‘‘Industrial Biotechnology’’ (University of Leipzig

• experimental observations. Acknowledgements The authors are thankful to the ProAChim project in the frame of ERA-NET Industrial Biotechnology (ERA IB, No. 035581) for providing funding and would also like to thank Dr. Nicole Weizenmann from Junior Research Group ‘‘Industrial Biotechnology’’, Institute of

Damage of polyesters by the atmospheric free radical oxidant NO₃^•: a product study involving model systems

• Catrin Goeschen and
• Uta Wille

Beilstein J. Org. Chem. 2013, 9, 1907–1916, doi:10.3762/bjoc.9.225

• Catrin Goeschen Uta Wille ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute, The University of Melbourne, 30 Flemington Road, Parkville, VIC 3010, Australia 10.3762/bjoc.9.225 Abstract Manufactured polymer materials are used in

Natural products in synthesis and biosynthesis

• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2013, 9, 1897–1898, doi:10.3762/bjoc.9.223

• problem is that the plant produces only small and variable amounts, thereby making the isolation procedure difficult and expensive. Neither biotechnology nor chemistry were able to provide a solution on their own, but the combination of the heterologous production of an advanced intermediate in yeast [6

A practical synthesis of long-chain iso-fatty acids (iso-C₁₂–C₁₉) and related natural products

• Mark B. Richardson and
• Spencer J. Williams

Beilstein J. Org. Chem. 2013, 9, 1807–1812, doi:10.3762/bjoc.9.210

• Mark B. Richardson Spencer J. Williams School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia 10.3762/bjoc.9.210 Abstract A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C12–C19) was developed

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

• Xu-Wen Li,
• Jennifer Herrmann,
• Yi Zang,
• Philippe Grellier,
• Soizic Prado,
• Rolf Müller and
• Bastien Nay

Beilstein J. Org. Chem. 2013, 9, 1551–1558, doi:10.3762/bjoc.9.176

• Products, Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) and Pharmaceutical Biotechnology, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany 10.3762/bjoc.9.176 Abstract Aurachins are myxobacterial 3-farnesyl-4(1H)-quinolone derived

Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles

• Marta K. Kurpet,
• Aleksandra Dąbrowska,
• Małgorzata M. Jarosz,
• Katarzyna Kajewska-Kania,
• Nikodem Kuźnik and
• Jerzy W. Suwiński

Beilstein J. Org. Chem. 2013, 9, 1517–1525, doi:10.3762/bjoc.9.173

• Marta K. Kurpet Aleksandra Dabrowska Malgorzata M. Jarosz Katarzyna Kajewska-Kania Nikodem Kuznik Jerzy W. Suwinski Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, Krzywoustego 4, Gliwice 44-100, Poland Centre of Polymer and Carbon

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

• Tony Taldone,
• Anna Rodina,
• Erica M. DaGama Gomes,
• Matthew Riolo,
• Hardik J. Patel,
• Raul Alonso-Sabadell,
• Danuta Zatorska,
• Maulik R. Patel,
• Sarah Kishinevsky and
• Gabriela Chiosis

Beilstein J. Org. Chem. 2013, 9, 544–556, doi:10.3762/bjoc.9.60

• at 1,000 rpm at 4 °C for 5 min. Cells were then fixed with 4% paraformaldehyde in PBS at room temperature for 15 min and then washed twice with PBS. Cells were permeabilized with 50 μg/µL digitonin (Gold Biotechnology special grade Cat# D-180-250) in PBS at room temperature for 15 min. Cells were

Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

• Lena Möller,
• Christian Hess,
• Jiří Paleček,
• Yi Su,
• Axel Haverich,
• Andreas Kirschning and
• Gerald Dräger

Beilstein J. Org. Chem. 2013, 9, 270–277, doi:10.3762/bjoc.9.33

• for Biotechnology and Artificial Organs (LEBAO) Hannover Medical School (MHH), 30625 Hannover, Germany 10.3762/bjoc.9.33 Abstract Covalent multistep coating of poly(methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

• Matthias G. J. Baud,
• Thomas Leiser,
• Vanessa Petrucci,
• Mekala Gunaratnam,
• Stephen Neidle,
• Franz-Josef Meyer-Almes and
• Matthew J. Fuchter

Beilstein J. Org. Chem. 2013, 9, 81–88, doi:10.3762/bjoc.9.11

• Matthias G. J. Baud Thomas Leiser Vanessa Petrucci Mekala Gunaratnam Stephen Neidle Franz-Josef Meyer-Almes Matthew J. Fuchter Department of Chemistry, Imperial College London, London SW7 2AZ, United Kingdom Department of Chemical Engineering and Biotechnology, University of Applied Sciences

Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions

• Kyle F. Biegasiewicz,
• Michelle L. Ingalsbe,
• Jeffrey D. St. Denis,
• James L. Gleason,
• Junming Ho,
• Michelle L. Coote,
• G. Paul Savage and
• Ronny Priefer

Beilstein J. Org. Chem. 2012, 8, 1814–1818, doi:10.3762/bjoc.8.207

• ARC Centre of Excellence for Free-Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra ACT 0200, Australia CSIRO Materials Science and Engineering, Clayton South MDC 3169, Australia College of Pharmacy, Western New England University, Springfield

Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

• H. Bauke Albada,
• Alina-Iulia Chiriac,
• Michaela Wenzel,
• Maya Penkova,
• Julia E. Bandow,
• Hans-Georg Sahl and
• Nils Metzler-Nolte

Beilstein J. Org. Chem. 2012, 8, 1753–1764, doi:10.3762/bjoc.8.200

• Microbiology, Immunology, and Parasitology, Pharmaceutical Microbiology Section, University of Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany Microbial Biology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany 10.3762/bjoc.8.200 Abstract A series

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

• Chao Che,
• Song Li,
• Bo Yang,
• Shengchang Xin,
• Zhixiong Yu,
• Taofeng Shao,
• Chuanye Tao,
• Shuo Lin and
• Zhen Yang

Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94

• Chao Che Song Li Bo Yang Shengchang Xin Zhixiong Yu Taofeng Shao Chuanye Tao Shuo Lin Zhen Yang Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China Shenzhen Shengjie Biotech Co., Ltd., Shenzhen 518055

Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

• Florian Grundmann,
• Veronika Dill,
• Andrea Dowling,
• Aunchalee Thanwisai,
• Edna Bode,
• Narisara Chantratita,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 749–752, doi:10.3762/bjoc.8.85

• Florian Grundmann Veronika Dill Andrea Dowling Aunchalee Thanwisai Edna Bode Narisara Chantratita Richard ffrench-Constant Helge B. Bode Department of Molecular Biotechnology, Goethe-Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany Biosciences, University of Exeter

Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment

• Christiane E. Kupper,
• Ruben R. Rosencrantz,
• Birgit Henßen,
• Helena Pelantová,
• Stephan Thönes,
• Anna Drozdová,
• Vladimir Křen and
• Lothar Elling

Beilstein J. Org. Chem. 2012, 8, 712–725, doi:10.3762/bjoc.8.80

• Christiane E. Kupper Ruben R. Rosencrantz Birgit Henssen Helena Pelantova Stephan Thones Anna Drozdova Vladimir Kren Lothar Elling Laboratory for Biomaterials, Institute for Biotechnology and Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Worringer Weg 1, Aachen, 52074

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

• Davide Bini,
• Francesca Cardona,
• Matilde Forcella,
• Camilla Parmeggiani,
• Paolo Parenti,
• Francesco Nicotra and
• Laura Cipolla

Beilstein J. Org. Chem. 2012, 8, 514–521, doi:10.3762/bjoc.8.58

• Davide Bini Francesca Cardona Matilde Forcella Camilla Parmeggiani Paolo Parenti Francesco Nicotra Laura Cipolla Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy Department of Chemistry “Ugo Schiff”, University of Florence, Polo

Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure

• Svenja Staudt,
• Christina A. Müller,
• Jan Marienhagen,
• Christian Böing,
• Stefan Buchholz,
• Ulrich Schwaneberg and
• Harald Gröger

Beilstein J. Org. Chem. 2012, 8, 186–191, doi:10.3762/bjoc.8.20

• Svenja Staudt Christina A. Muller Jan Marienhagen Christian Boing Stefan Buchholz Ulrich Schwaneberg Harald Groger Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestr. 42, 91054 Erlangen, Germany Department of Biotechnology, RWTH Aachen University, Worringerweg 1, 52074

• Bundesstiftung Umwelt, DBU) for generous support within the DBU-network “ChemBioTec” of the funding priority “Biotechnology” (Project AZ 13234-32).

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

• Hany M. Mohamed,
• Ashraf H. F. Abd EL-Wahab,
• Ahmed M. EL-Agrody,
• Ahmed H. Bedair,
• Fathy A. Eid,
• Mostafa M. Khafagy and
• Kamal A. Abd-EL-Rehem

Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199

• microorganisms were obtained from the Regional Center for Mycology & Biotechnology (RCMP), Al-Azhar University. The activities of these compounds were tested by using the disc-diffusion method [23] for bacteria and the paper-disk-diffusion method [24] for fungi. The area of zone inhibition was measured with

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• indispensable part of industrial biotechnology, and are used in the production of a broad range of bulk and fine chemicals [6]. When a microbial multistep biotransformation is carried out in continuous flow it might formally also be considered as a fourth-generation enzymatic process according to the above

The Eschenmoser coupling reaction under continuous-flow conditions

• Sukhdeep Singh,
• J. Michael Köhler,
• Andreas Schober and
• G. Alexander Groß

Beilstein J. Org. Chem. 2011, 7, 1164–1172, doi:10.3762/bjoc.7.135

• Sukhdeep Singh J. Michael Kohler Andreas Schober G. Alexander Gross Institute for Chemistry and Biotechnology, Technische Universität Ilmenau, Weimarerstr. 32, D-98693-Ilmenau 10.3762/bjoc.7.135 Abstract The Eschenmoser coupling is a useful carbon–carbon bond forming reaction which has been used