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Search for "antibiotic" in Full Text gives 262 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Opportunities and challenges for direct C–H functionalization of piperazines

  • Zhishi Ye,
  • Kristen E. Gettys and
  • Mingji Dai

Beilstein J. Org. Chem. 2016, 12, 702–715, doi:10.3762/bjoc.12.70

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  • used to treat HIV/AIDS [5]. Gatifloxacin is an important fluoroquinolone antibiotic [6]. Despite the high frequency appearance of piperazines in small-molecule pharmaceuticals, over 80% only contain substituents at the two nitrogen atoms and a very small fraction of them have simple carbon
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Published 13 Apr 2016

Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins

  • Guozheng Huang,
  • Simon Schramm,
  • Jörg Heilmann,
  • David Biedermann,
  • Vladimír Křen and
  • Michael Decker

Beilstein J. Org. Chem. 2016, 12, 662–669, doi:10.3762/bjoc.12.66

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  • (kernels) of H. wightiana, contains besides hydnocarpin mainly cyclopentenoic fatty acids [16], which show pronounced antibiotic activity and inhibit multiplication of mycobacteria [17]. Combination of these antibiotics together with hydnocarpin (MDR inhibitor) helped to treat such a persistent disease
  • -methoxyhydnocarpin has been described to enhance the antimicrobial activity of berberine [19]. In the light of steadily growing antibiotic resistance any potent and nontoxic MDR inhibitor is of utmost importance. Hydnocarpin has also antineoplastic activity due to sensitizing multidrug-resistant cancer cell lines
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Published 08 Apr 2016
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  • ; computational chemistry; drug design; molecular recognition; relaxed force constants; Our original publication contains an erratic number of predicted antibiotic structures in Scheme 2. With this Erratum we provide the corrected Scheme 2. Scheme 2 in the original article: Predicted new linezolid-like
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Published 31 Mar 2016

Antibiotics from predatory bacteria

  • Juliane Korp,
  • María S. Vela Gurovic and
  • Markus Nett

Beilstein J. Org. Chem. 2016, 12, 594–607, doi:10.3762/bjoc.12.58

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  • further characterized by their large genome sizes and their striking potential for the production of structurally diverse natural products with antimicrobial activities [12][30][31][32][33][34][35]. For many years, it has been speculated whether antibiotic biosynthesis is functionally linked to the
  • with a minimal inhibitory concentration (MIC) of 1 µg/mL [75]. Its mode of action was deduced after genetic characterization of myxovirescin-resistant E. coli mutants [81]. The antibiotic interferes with cell-wall biosynthesis by inhibiting a novel target, i.e., the type II signal peptidase LspA, which
  • is involved in the maturation of lipoproteins required for murein biosynthesis [81]. Myxovirescin A1 (also known as antibiotic TA) and its derivatives seem to be of particular importance for the predatory lifestyle of M. xanthus DK1622. Gene deletion experiments demonstrated that a loss of
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Published 30 Mar 2016

Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation

  • Franziska Gille and
  • Andreas Kirschning

Beilstein J. Org. Chem. 2016, 12, 564–570, doi:10.3762/bjoc.12.55

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  • moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C–N cross-coupling protocol between an acyl amide and a peptidic vinyl iodide. The presence of a neighboring arginine in the vinyl iodide posed a challenge with respect to the choice of the
  • the olefinic double bond (Scheme 6). We based the stereochemical assignment on NMR spectroscopy which included nOe experiments. Conclusion In conclusion, we report on the synthesis of dehydrovaline and dehydroisoleucine-containing oligopeptides as found in the peptide antibiotic myxovalargin using a C
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Published 22 Mar 2016
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  • : compliance constants; computational chemistry; drug design; molecular recognition; relaxed force constants; Introduction Antibiotic resistance is one of the major health problems in modern societies, causing millions of deaths per year [1][2][3]. Although Alexander Fleming recognized the importance of the
  • -resistant pneumococci, for example, led to the description of the situation today as an “Antibiotic Armageddon” [5]. In a recent WHO report it is concluded that “the problem is so serious that it threatens the achievements of modern medicine. A post-antibiotic era, in which common infections and minor
  • therefore plays a central role for the understanding of the relevant recognition processes [8][9]. Examples of antibiotic drug classes that bind the ribosomal 50S subunit are chloramphenicol, puromycin, anisomycin, streptogramina A, and macrolides [10][11]. Those compounds interact with different sites
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Published 04 Mar 2016

Mycothiol synthesis by an anomerization reaction through endocyclic cleavage

  • Shino Manabe and
  • Yukishige Ito

Beilstein J. Org. Chem. 2016, 12, 328–333, doi:10.3762/bjoc.12.35

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  • -containing lincosamide antibiotic [19]. Due to the limited availability of MSH from M. smegmatis cell culture (<1.5 mg of MSH from 1 L culture) [20], the chemical synthesis of MSH is highly desired. Bewley et al. and Lee and Rosazza independently reported the synthesis of MSH and determined the absolute
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Published 22 Feb 2016

Natural products from microbes associated with insects

  • Christine Beemelmanns,
  • Huijuan Guo,
  • Maja Rischer and
  • Michael Poulsen

Beilstein J. Org. Chem. 2016, 12, 314–327, doi:10.3762/bjoc.12.34

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  • synthetic compound libraries to counteract a declining number of new antibiotic entities in the drug development pipeline has largely failed [3], and the current poor repertoire represents a ”ticking time bomb”. Societies face, as a consequence of the rapid globalization and intensive use of antibiotics, an
  • increasing threat of multidrug-resistant pathogens, which are responsible for the growing numbers of lethal infections [4][5]. The urge to discover novel lead-like antibiotic compounds and to refill the industrial antibiotic pipeline to meet current and future societal challenges has never been greater [6
  • find more or less useful bioactivities. More rational approaches are necessary to enhance the efficacy, efficiency, and speed of drug discovery in general and antibiotic discovery in particular. In recent years, the exploration of the chemical basis of specific and well-described bacteria–host or
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Published 19 Feb 2016

A convergent, umpoled synthesis of 2-(1-amidoalkyl)pyridines

  • Tarn C. Johnson and
  • Stephen P. Marsden

Beilstein J. Org. Chem. 2016, 12, 1–4, doi:10.3762/bjoc.12.1

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  • as the antitumour antibiotic kedarcidin chromophore 1 [2] and the RNA polymerase inhibitor cyclothiazomycin B1 2 [3] (Figure 1). Additionally, the motif is commonly incorporated into synthetic pharmaceutical candidates, for example in the factor XIa inhibitor 3 [4], the orally-active renin inhibitor
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Published 04 Jan 2016

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

  • Hang Ren,
  • Haoyun An,
  • Paul J. Hatala,
  • William C. Stevens Jr,
  • Jingchao Tao and
  • Baicheng He

Beilstein J. Org. Chem. 2015, 11, 2509–2520, doi:10.3762/bjoc.11.272

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  • -D-riboside (6-β-D-MPR) is an isolated antibiotic agent that possesses potent antifungal, antiviral, and antitumor activities [44]. In order to explore the effect of fluorine on the biological activity of this pharmacophore, we synthesized 6-methylpurine-3’-deoxy-3’-fluoro-β-D-riboside (4) (Scheme 2
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Published 09 Dec 2015

Recent highlights in biosynthesis research using stable isotopes

  • Jan Rinkel and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2015, 11, 2493–2508, doi:10.3762/bjoc.11.271

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  • deduced from these labeling experiments as (2’R) via comparison of the retention times of both compounds to naturally occurring 8 on a homochiral stationary LC phase. To investigate the proposed structure of 7, which likely exhibits the antibiotic properties connected to the bacterial strain as a highly
  • function and subsequent ring closure would then lead to the proposed antibiotic 7. The other oxygen atom is lost during biosynthesis und is therefore undetectable. This example shows how well-designed labeling experiments can support biosynthetic investigations especially on highly derivatized and altered
  • gutingimycin, a guanine-adduct of 9 [27]. However, very little was known about the biosynthetic assembly of the complex antibiotic. Feeding of [1-13C]-, [2-13C]- and [1,2-13C2]acetate to S. bottropensis and analysis of the produced 9 via 13C NMR yielded the carbon origins of the polyketide core. The regular
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Published 09 Dec 2015

Bromotyrosine-derived alkaloids from the Caribbean sponge Aplysina lacunosa

  • Qun Göthel,
  • Thanchanok Sirirak and
  • Matthias Köck

Beilstein J. Org. Chem. 2015, 11, 2334–2342, doi:10.3762/bjoc.11.254

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  • activities, including antiviral [2], antibiotic [3][4][5], Na+/K+ ATPase inhibition [6][7][8], anti-HIV [9][10], antifungal [11], histidine-H3 antagonist [12], cytotoxic [13][14], and antimalarial activities [15][16][17]. During our investigation of the chemical constituents of Aplysina lacunosa (Aplysinidae
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Published 26 Nov 2015

Synthesis of D-fructose-derived spirocyclic 2-substituted-2-oxazoline ribosides

  • Madhuri Vangala and
  • Ganesh P. Shinde

Beilstein J. Org. Chem. 2015, 11, 2289–2296, doi:10.3762/bjoc.11.249

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  • compounds with a wide range of applications spanning different chemistry disciplines. 2-Oxazoline derivatives are extensively studied due to their presence in numerous bioactive natural products [1][2][3] and synthetic drugs with anticancer, antibiotic, antidiabetic, and antifungal properties (Figure 1, 1–4
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Published 24 Nov 2015

Structure and conformational analysis of spiroketals from 6-O-methyl-9(E)-hydroxyiminoerythronolide A

  • Ana Čikoš,
  • Irena Ćaleta,
  • Dinko Žiher,
  • Mark B. Vine,
  • Ivaylo J. Elenkov,
  • Marko Dukši,
  • Dubravka Gembarovski,
  • Marina Ilijaš,
  • Snježana Dragojević,
  • Ivica Malnar and
  • Sulejman Alihodžić

Beilstein J. Org. Chem. 2015, 11, 1447–1457, doi:10.3762/bjoc.11.157

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  • example, in cases of calyculin and okadaic acid it has been proposed [18][19] that the spiroketal unit acts as a β-turn mimic. Naturally occurring spiroketals exhibit a wide spectrum of biological activity: anticancer [20][21][22], antibiotic [23][24], antifungal [25], anthelmintic [26] and anti-HIV [27
  • antibiotic. This 14-membered macrolide contains a [4.4]spiroketal unit connecting 6-C–O–9-C–O–12-C. Stereochemistry at position 9-C of this spiroketal was determined by combination of NMR spectroscopy and molecular modelling [42]. The kinetics of its formation has also been extensively studied [43][44][45
  • ][46]. Most recently, in the latest revision of the reaction pathway Hassanzadeh et al. showed that this macrolide spiroketal in acid media exists in equilibrium with the 9,12-hemiacetal of erythromycin A [47]. The closely related antibiotic clarithromycin (structurally related to our starting aglycon
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Published 19 Aug 2015

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

  • Marcus Baumann and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2015, 11, 1194–1219, doi:10.3762/bjoc.11.134

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  • hydroxamic acid (5, SAHA, Figure 1) [43]. Another early application of microreactor technology was reported in 2005 detailing the assembly and subsequent decoration of the fluoroquinolinone scaffold 6 resulting in the synthesis of a library of analogues including the well-known antibiotic ciprofloxacin (6
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Published 17 Jul 2015

DBU-promoted carboxylative cyclization of o-hydroxy- and o-acetamidoacetophenone

  • Wen-Zhen Zhang,
  • Si Liu and
  • Xiao-Bing Lu

Beilstein J. Org. Chem. 2015, 11, 906–912, doi:10.3762/bjoc.11.102

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  • pharmacologically potent compounds (Figure 1) [4][5]. Warfarin, for example, is an anticoagulant widely used to prevent thrombosis [2]; Novobiocin has long been established as an aminocoumarin antibiotic [3]. Recent studies revealed that the anticoagulant Dicumarol is able to inhibit the growth of pancreatic cancer
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Published 29 May 2015

A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids

  • Johanna Trenner and
  • Evgeny V. Prusov

Beilstein J. Org. Chem. 2015, 11, 323–327, doi:10.3762/bjoc.11.37

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  • antibiotic properties, we were interested to investigate their activities in various assays but the literature survey showed that synthetic approaches to 5-hydroxylated 3-acyltetramic acids are essentially non-existent, although M. Coster reported the synthesis of 5-hydroxytetramic acid ethers by
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Published 06 Mar 2015

Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters

  • Zhengning Li,
  • Chongnian Wang and
  • Zengchang Li

Beilstein J. Org. Chem. 2015, 11, 213–218, doi:10.3762/bjoc.11.23

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  • and its analogues, sharing the similar structure of a γ-lactone with an attached β-carboxylic acid, are widely found in natural products. Related syntheses have been actively explored due to the potential antitumor and antibiotic activities of these compounds [1][2][3][4]. The synthesis methods were
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Published 06 Feb 2015

Synthesis of antibacterial 1,3-diyne-linked peptoids from an Ugi-4CR/Glaser coupling approach

  • Martin C. N. Brauer,
  • Ricardo A. W. Neves Filho,
  • Bernhard Westermann,
  • Ramona Heinke and
  • Ludger A. Wessjohann

Beilstein J. Org. Chem. 2015, 11, 25–30, doi:10.3762/bjoc.11.4

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  • orders of magnitude of concentration anyhow. Therefore no further attempt to optimize for an equal product distribution was deemed necessary. To gain insight into the antibiotic potential of the products, single compound dimers 8a–j were subjected to a preliminary evaluation against Bacillus subtilis
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Published 07 Jan 2015

(2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

  • Armin de Meijere,
  • Sergei I. Kozhushkov,
  • Dmitrii S. Yufit,
  • Christian Grosse,
  • Marcel Kaiser and
  • Vitaly A. Raev

Beilstein J. Org. Chem. 2014, 10, 2844–2857, doi:10.3762/bjoc.10.302

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  • (fluoromethylcyclopropyl)alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity. Keywords: amino acids; biosynthesis; building blocks; cyclopropanes; natural products; synthetic methods; Introduction The intermolecular signal metabolite hormaomycin (1, Figure 1) was first
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Published 03 Dec 2014

Indium-mediated allylation in carbohydrate synthesis: A short and efficient approach towards higher 2-acetamido-2-deoxy sugars

  • Christopher Albler,
  • Ralph Hollaus,
  • Hanspeter Kählig and
  • Walther Schmid

Beilstein J. Org. Chem. 2014, 10, 2230–2234, doi:10.3762/bjoc.10.231

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  • -Cope rearrangement of N-galactosyl-N-homoallylamines [18]. Aminooctoses, on the other hand, are present in the aminoglycoside antibiotic apramycin [19], in the form of an aminooctodiose derivative. However, only few syntheses of this dipyranoid aminosugar [20][21] were reported so far. Thus, we were
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Published 19 Sep 2014

De novo macrolide–glycolipid macrolactone hybrids: Synthesis, structure and antibiotic activity of carbohydrate-fused macrocycles

  • Richard T. Desmond,
  • Anniefer N. Magpusao,
  • Chris Lorenc,
  • Jeremy B. Alverson,
  • Nigel Priestley and
  • Mark W. Peczuh

Beilstein J. Org. Chem. 2014, 10, 2215–2221, doi:10.3762/bjoc.10.229

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  • . Glycosylation of an available hydroxy group on the macrocycle gave a hybrid macrolide with features common to erythromycin and sophorlipid macrolactone. Weak antibiotic activity (MICs <100 μg/mL) was observed for several of the compounds. Keywords: antibiotic; carbohydrate; exo-anomeric effect; macrolide
  • ]. Erythromycin (1, Figure 1), for example, is an archetypal macrolide due to its molecular structure as well as its antibiotic activity; it is used clinically to treat Gram positive bacterial infections. The mechanism of action of erythromycin is via inhibition of bacterial protein synthesis [3][4]. Sophorolipid
  • antibacterial activity [7][8]. Over time, antibiotic use has created a selection pressure that has led to bacterial resistance and a subsequent need for continuous development of new antibiotics. Despite cumbersome syntheses, erythromycin analogs continue to be used as front line antibiotics while the clinical
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Published 17 Sep 2014

Palladium-catalysed cyclisation of alkenols: Synthesis of oxaheterocycles as core intermediates of natural compounds

  • Miroslav Palík,
  • Jozef Kožíšek,
  • Peter Koóš and
  • Tibor Gracza

Beilstein J. Org. Chem. 2014, 10, 2077–2086, doi:10.3762/bjoc.10.216

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  • presence of BuLi and LiCl provided selectively 5-exo-trig cyclisation products with excellent 2,3-trans diastereoselectivity. Finally, we have also proposed a synthetic access to the dioxaheptane core of natural C15 acetogenins and dioxaoctane, a substructure of the macrolide-polyether antibiotic
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Published 03 Sep 2014

Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

  • Meriem Smadhi,
  • Sophie de Bentzmann,
  • Anne Imberty,
  • Marc Gingras,
  • Raoudha Abderrahim and
  • Peter G. Goekjian

Beilstein J. Org. Chem. 2014, 10, 1981–1990, doi:10.3762/bjoc.10.206

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  • good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation. Keywords: antibiotic; biofilm; glycocluster; lectin; multivalency effect; multivalent glycosystems; Introduction Pseudomonas aeruginosa (PA
  • particular due to the physical barrier created by surface-attached biofilms, thus limiting antibiotic penetration [4][5][6]. A challenging and useful task is therefore to develop novel strategies against PA colonies at this late stage of virulence. Among recent approaches, targeting biofilm formation or
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Published 25 Aug 2014

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

  • Thilo Focken and
  • Stephen Hanessian

Beilstein J. Org. Chem. 2014, 10, 1848–1877, doi:10.3762/bjoc.10.195

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  • component of polyoxins A, F, H, and K, which exhibit antibiotic properties [72]. Originally, the stereochemistry of the exocyclic double bond of polyoximic acid was incorrectly assigned as E based on a low resolution nOe experiment (Figure 3). The total synthesis of polyoximic acid (9) by Hanessian and co
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Published 13 Aug 2014
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