Tenacibactins K–M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum

• Yasuhiro Igarashi,
• Yiwei Ge,
• Tao Zhou,
• Amit Raj Sharma,
• Enjuro Harunari,
• Naoya Oku and
• Agus Trianto

Beilstein J. Org. Chem. 2022, 18, 110–119, doi:10.3762/bjoc.18.12

• repeated cadaverine–succinic acid motifs terminated by a hydroxamic acid functionality, were elucidated by NMR and negative MS/MS experiments. Compounds 1–3 were inactive against bacteria and a yeast but displayed cytotoxicity against 3Y1 rat embryonic fibroblasts and P388 murine leukemia cells at GI50 in

• related compounds such as nocardichelins [31] and MBJ-0003 [32], compounds 1–3 did not show appreciable antimicrobial activity against bacteria or a yeast (see Experimental) at 50 μg/mL but exhibited cytotoxicity against 3Y1 rat embryonic fibroblasts and P388 murine leukemia cells (Table 3). Among the

• rat embryonic fibroblasts and P388 murine leukemia cells were evaluated according to the protocols described in references [40][41]. CAS assay Compounds 1–3, along with deferoxamine mesylate as a reference, were serially half-diluted in a 96-well round-bottomed microtitre plate. To each well were

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

• Ruan Carlos B. Ribeiro,
• Patricia G. Ferreira,
• Amanda de A. Borges,
• Luana da S. M. Forezi,
• Fernando de Carvalho da Silva and
• Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 53–69, doi:10.3762/bjoc.18.5

• electrons through a redox cycle promoted by the 1,2- or 1,4-naphthoquinone system. In this cycle, transient reactive oxygen (ROS) and nitrogen (RNS) species are formed as free radicals, peroxides, superoxide anions, radical anions, or dianions. These species generated inside cells accelerate hypoxia and

• -workers synthesized other naphthoquinone derivatives 37 from β-NQSNa (18) [86]. These compounds were evaluated for their antiproliferative activities on human cancer cells, with three of them being the most active (37a–c). It has been shown that the mechanism of action passes through the production of

• synthesis of novel 4-amino-1,2-naphthoquinones 43a–c containing carbohydrates and evaluated their antitumor activity in vitro. These compounds were transformed into a series of hydrazones 44a–l with different substituted aryl groups, which were also evaluated against tumor cells. To prepare 43a–c, 18 was

Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents

• Rodolfo H. V. Nishimura,
• Thiago dos Santos,
• Valter E. Murie,
• Luciana C. Furtado,
• Leticia V. Costa-Lotufo and
• Giuliano C. Clososki

Beilstein J. Org. Chem. 2021, 17, 2968–2975, doi:10.3762/bjoc.17.206

• -, meta-, and para-substituted N-methylanilines as well as substituted anilines and furnished the corresponding 4-anilinoquinazolines in good yields. Preliminary screening of the synthesized compounds against tumor cells (HCT-116 and T98G) showed promising antiproliferative properties. Keywords: 4

• adenocarcinoma), and T98G (human glioblastoma). Initially, we evaluated all compounds at 50 µM, and we considered active the compounds that inhibited cell proliferation by over 75% for each cell line. Compounds 10b, 10c, 10g, 10k, 10l, 15a, 15b, and 15d were active against T98G cells, and compounds 10b, 15a, and

• 15b were also active against HCT-116 cells. However, none of the tested compounds was able to inhibit MCF-7 cell proliferation (Figure S1 in Supporting Information File 1). Next, we determined the IC50 of the active compounds against both HCT-116 and T98G cells; we employed doxorubicin as positive

Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes

• Shun Saito,
• Kanji Indo,
• Naoya Oku,
• Hisayuki Komaki,
• Masashi Kawasaki and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2939–2949, doi:10.3762/bjoc.17.203

• H-13 (Figure 6). Thus, an S-configuration, corresponding to an ʟ-chirality for tryptophan, was assigned. Compounds 1–6 were not cytotoxic against P388 murine leukemia cells (IC50 > 100 μM), nor antimicrobial against five bacteria, Bacillus subtilis, Staphylococcus aureus, Ralstonia solanacearum

• ), 8.01 (d, J = 8.3 Hz, 1H, NH-11), 1.73 (s, 3H, H-13); HR–ESI–TOFMS (m/z): [M + Na]+ calcd for C27H31N3NaO4, 484.2207; found, 484.2207. Cytotoxicity assay The cytotoxicity assay was carried out against P388 murine leukemia cells in the same manner as reported previously [36]. The IC50 of a reference drug

• providing R. solanacearum SUPP1541. P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002). Funding This work was supported by JSPS KAKENHI Grant Number 19K05848 to Y. I.

Total synthesis of the O-antigen repeating unit of Providencia stuartii O49 serotype through linear and one-pot assemblies

• Tanmoy Halder and
• Somnath Yadav

Beilstein J. Org. Chem. 2021, 17, 2915–2921, doi:10.3762/bjoc.17.199

• polysaccharides are one of the important constituents of the surface lipopolysaccharides (LPS) of the cell wall of Gram-negative bacteria. These antigens are responsible for several functions that include adhesion to the host cells and are also found to contribute to the evasion of the host immune responses

Photophysical, photostability, and ROS generation properties of new trifluoromethylated quinoline-phenol Schiff bases

• Inaiá O. Rocha,
• Yuri G. Kappenberg,
• Wilian C. Rosa,
• Clarissa P. Frizzo,
• Nilo Zanatta,
• Marcos A. P. Martins,
• Isadora Tisoco,
• Bernardo A. Iglesias and
• Helio G. Bonacorso

Beilstein J. Org. Chem. 2021, 17, 2799–2811, doi:10.3762/bjoc.17.191

• interesting luminescent properties [14] that have attracted great interest because of their potential applicability in the composition of organic light-emitting diodes (OLED), organic solar cells (OSC), and biomolecular markers [15][16]. Moreover, the trifluoromethyl substituent (CF3) is an interesting

• methods, which provide active ingredients to prevent or reduce the effects of oxidative stress in cells. Recently, our research group reported the synthesis of 6-amino-4-(trifluoromethyl)quinolines, which were obtained through an electrophilic aromatic substitution reaction catalyzed by sulfuric acid from

Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation

• Lukáš Ďurina,
• Anna Ďurinová,
• František Trejtnar,
• Ľuboš Janotka,
• Lucia Messingerová,
• Jana Doháňošová,
• Ján Moncol and
• Róbert Fischer

Beilstein J. Org. Chem. 2021, 17, 2781–2786, doi:10.3762/bjoc.17.188

• lines U87-MG, HepG2, JEG-3 and MOLM-13 (AML cell line) as well as immortalized proximal tubular cells HK2. We have very recently found out that even enantiomerically pure polyhydroxylated pyrrolizidine alkaloids with proven antiglycosidase activities may not exhibit antiproliferative effects against

• (±)-Codonopsinol B (1) and its N-nor-methyl analogue 2 were evaluated for their antiproliferative activity against the four cancer cell lines U87-MG, HepG2, JEG-3, MOLM-13 and against immortalized proximal tubular cells HK2 (see Supporting Information File 1, Table S1, Figures S4–S8). The IC50 values of all tested

• tubular cells HK2. (−)-Codonopsinol B (1) and its N-nor-methyl analogue 2; known inhibition activities against α-glucosidases from: (a) Bacillus stearothermophilus lyoph., (b) yeast [2]. Molecular structure of N-Cbz-protected pyrrolidine 12 confirmed by single-crystal X-ray crystallographic analysis

Synthesis of new pyrazolo[1,2,3]triazines by cyclative cleavage of pyrazolyltriazenes

• Nicolai Wippert,
• Martin Nieger,
• Claudine Herlan,
• Nicole Jung and
• Stefan Bräse

Beilstein J. Org. Chem. 2021, 17, 2773–2780, doi:10.3762/bjoc.17.187

• ranging from 0.5 µM to 50 µM (for detailed results, see Supporting Information File 1). It was found that the exemplarily chosen compounds of type 5, namely 5a, 5d–f, and 5h, did not reduce the viability of the human epithelial cervix carcinoma (HeLa) cells at every concentration tested. The derivatives

• viability of HeLa cells, their regioisomers 13a and 13d–h decreased the viability at high micromolar concentrations. A slightly increased cytotoxicity of some derivatives of compound class 12 compared to 13 was observed for 12b and 12c. The amides 9 had no influence on the viability except for derivate 9b

• ]triazines 5 and intermediates 9, 12, and 13 and their calculated IC50 values after treatment of HeLa cells with different concentrations of the respective compounds. Synthesis of 3,6-dihydro-4H-pyrazolo[3,4-d][1,2,3]triazin-4-ones 2a,b by diazotization of 3-amino-1H-pyrazole-4-carboxamides 1a or 3-amino-1H

The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet–Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids

• Marco Keller,
• Karl Sauvageot-Witzku,
• Franz Geisslinger,
• Nicole Urban,
• Michael Schaefer,
• Karin Bartel and
• Franz Bracher

Beilstein J. Org. Chem. 2021, 17, 2716–2725, doi:10.3762/bjoc.17.183

• -substituted 1-benzyl-1,2,3,4-tetrahydroisoquinolines (SG-005 and SG-094) as potent lead structures. For activity on TPC2 as well as tumor cells, these compounds were preferably bearing phenoxy and benzyloxy substituents on both aromatic rings, however, some analogues missing this “aromatic decoration

• comparison to tetrandrine and cepharanthine, we performed Ca2+ measurements in multiwell plates. Therefore, heterologously TPC2-expressing HEK293 cells were loaded with calcium indicator fluo-4/AM and Ca2+ entry was measured for 5 min after injection of various alkaloid concentrations (0.1–100 µM). None of

• the alkaloids exhibited the efficiency to activate TPC2 (data not shown). To evaluate the inhibitory potency, afterwards the same cells were stimulated with the TPC2 activators TPC2-A1-P (30 µM) and TPC2-A1-N (10 µM). Compared with the respective solvent control (DMSO), only rac-norcinnamolaurine (3b

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues

• Umesh P. Aher,
• Dhananjai Srivastava,
• Girij P. Singh and
• Jayashree B. S

Beilstein J. Org. Chem. 2021, 17, 2680–2715, doi:10.3762/bjoc.17.182

• , ʟ-nucleosides are typically endowed with lower host toxicity [11][12]. The antiviral activity and cytotoxicity in MT-4 cells showed that racemic (±)-BCH-189 (1c) possesses lower anti-HIV activity (ID50 = 0.37–1.31 µM) than AZT (ᴅ-nucleoside, ID50 = 0.0048–0.0217 µM). However, (±)-BCH-189 (1c

• ) appeared to be a more effective antiviral agent than AZT in PBM cells and U937 cells [13]. The BCH-189 core structure bears two stereocenters, and hence four stereoisomers are possible. The individual stereoisomers were also evaluated against HIV-1 activity in PBM cells and based on this study, it was

• found that out of four stereoisomers, the β-configured ʟ-(−)-enantiomer 1 (EC50 = 0.02 µM) is more potent in primary human lymphocytes than the β-configured ᴅ-(+)-enantiomer 1a (EC50 = 0.2 µM) in CEM cells [14]. Similarly, the 5-fluoro-substituted analogue of cytidine, i.e., β-configured ʟ

Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

• Ilya A. P. Jourjine,
• Lukas Zeisel,
• Jürgen Krauß and
• Franz Bracher

Beilstein J. Org. Chem. 2021, 17, 2668–2679, doi:10.3762/bjoc.17.181

• electronic and optical properties [16][17][18][19][20][21], utilized in LEDs, semiconducting polymers, and solar cells. Consequently, synthetic approaches to fluorenones have attracted large interest and numerous methodologically diverse approaches have been published in the past decades. Among these are

Synthesis of new bile acid-fused tetrazoles using the Schmidt reaction

• Dušan Đ. Škorić,
• Olivera R. Klisurić,
• Dimitar S. Jakimov,
• Marija N. Sakač and
• János J. Csanádi

Beilstein J. Org. Chem. 2021, 17, 2611–2620, doi:10.3762/bjoc.17.174

• above-mentioned potential of a nitrogen-containing steroids, and as a continuation of our research in the field of bile acids and steroidal heterocycles, in this work, we aimed to prepare a series of new bile acid tetrazoles with potential cytotoxicity towards selected tumor cells. To achieve the

• six human tumor cell lines (MCF-7 estrogen receptor positive breast adenocarcinoma, MDA-MB-231 estrogen receptor negative breast adenocarcinoma, PC-3 prostate cancer, HeLa cervix carcinoma, HT-29 colon adenocarcinoma, and A549 adenocarcinomic human alveolar basal epithelial cells). Standard MTT assay

• [52] was used with commercial nonselective antitumor agent doxorubicin (DOX) as control [53]. The results of antiproliferative in vitro analysis of all tested compounds are shown in Table 4. Among all tested compounds, ketone 3 showed the lowest IC50 value (1.06 μM) towards MDA-MB-231 cells, with

α-Ketol and α-iminol rearrangements in synthetic organic and biosynthetic reactions

• Scott Benz and
• Andrew S. Murkin

Beilstein J. Org. Chem. 2021, 17, 2570–2584, doi:10.3762/bjoc.17.172

• asperflotone and asperfloroid but also demonstrated their immunosuppressive activity against IL-6 production in induced THP-1 cells. Thus, as they noted, these two steroids may be attractive targets for total synthesis, perhaps incorporating the ring-expanding α-ketol rearrangement proposed to occur

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

• Luke O. Jones,
• Leah Williams,
• Tasmin Boam,
• Martin Kalmet,
• Chidubem Oguike and
• Fiona L. Hatton

Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171

• engineering, cell culture and microbiology, or specific chemicals to aid in chemical, environmental, and medicinal filtration, and purification applications [5][19][42][60][61]. This also aids cell immobilisation, putting cryogels forward for potential use in bioreactors [5][42]. Cells can be included within

• stem cells in cell-based therapies, detection of low levels of biomarkers in the blood (i.e., tumour cells, pathogenic microorganisms, etc.) for disease diagnosis, and general isolation of biological substances for clinical and environmental microbiology hold opportunities for cryogels [13][42][61

• adhesion. Cultivation and spreading of fibroblast NOR-10 cells were achieved within the cryogels, suggesting promise for tissue engineering applications. Building upon this work, hierarchical injectable cryogels were developed by Braschler and co-workers, based upon 3D additive manufacturing techniques [69

Strategies for the synthesis of brevipolides

• Yudhi D. Kurniawan and
• A'liyatur Rosyidah

Beilstein J. Org. Chem. 2021, 17, 2399–2416, doi:10.3762/bjoc.17.157

• [4]. These compounds demonstrated cytotoxicity against various human cancer cells. Additionally, the research group led by Pereda-Miranda later isolated more members of brevipolide (1–15) from the same plant during 2013–2017 and further confirmed the cytotoxic activity of these natural products [1

• cancer cells was conducted for brevipolides A–G (1–7) by Kinghorn and co-workers but none of the compounds showed significant activity (Table 1, entries 1–7) [4]. These seven compounds were also evaluated against HT-29 human colon carcinoma cells and only three of them were potent (Table 1, entries 1, 2

• , and 6) with the lowest ED50 value of 5.8 μM obtained for brevipolide A (1) (Table 1, entry 1). Similar cytotoxicity evaluation was performed for brevipolides G–O (7–15) against HCT-15 human colon cancer cells (Table 1, entries 7–15), and relatively high ED50 values were obtained with the lowest number

Phenolic constituents from twigs of Aleurites fordii and their biological activities

• Kyoung Jin Park,
• Won Se Suh,
• Da Hye Yoon,
• Chung Sub Kim,
• Sun Yeou Kim and
• Kang Ro Lee

Beilstein J. Org. Chem. 2021, 17, 2329–2339, doi:10.3762/bjoc.17.151

• on nitric oxide (NO) production levels in lipopolysaccharide (LPS)-stimulated murine microglial BV-2 cells to evaluate for antineuroinflammatory activities (Table 3). Compound 14 showed relative inhibitory effects on NO production with an IC50 value of 20.9 μM which was stronger than the positive

• neuroprotection activity by measuring the secretion of NGF from C6 cells into the medium (Table 4). Compounds 8 and 16 stimulated NGF release, exhibiting stimulation levels of 134.2 ± 8.1% and 134.6 ± 5.9%, respectively. Although compounds 3 and 8 have similar structures without or with a methoxy group at C-5

• as described in [37], BV2 cells were used to test the inhibitory effect of the isolated compounds on LPS-stimulated NO production [38][39]. The BV2 cells seeded on a 96-well plate (4 × 104 cells/well) were treated with and without various concentrations of the test compounds. The treated cells were

Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands

• Janina-Miriam Noy,
• Fan Chen and
• Martina Stenzel

Beilstein J. Org. Chem. 2021, 17, 2302–2314, doi:10.3762/bjoc.17.148

• cells. When TPP was conjugated to the pMPC PISA particles more cellular uptake as well as better spheroid penetration were observed, while TPP on PEG-based PISA had only little effect. It was hypothesized that TPP on the micelle surface may not be accessible enough to allow mitochondria targeting, but

• increase activity [11][12]. These nanoparticles have been decorated with targeting ligands to enhance the accumulation of the drug in cancer tissue. The activity of arsenic drugs could, however, also be enhanced by targeting mitochondria inside the cells, the target of action of arsenic drugs. To the

• mitochondria target containing nanoparticles PPM-NP4-TPP and MPM-NP2-TPP were further analysed using 3D spheroid tumour models [47]. The samples were incubated with 143B and SW982 cells and the penetration profiles of the micelles were investigated using laser scanning confocal microscopy. After 3 hours of

(Phenylamino)pyrimidine-1,2,3-triazole derivatives as analogs of imatinib: searching for novel compounds against chronic myeloid leukemia

• Luiz Claudio Ferreira Pimentel,
• Lucas Villas Boas Hoelz,
• Henayle Fernandes Canzian,
• Frederico Silva Castelo Branco,
• Andressa Paula de Oliveira,
• Vinicius Rangel Campos,
• Floriano Paes Silva Júnior,
• Rafael Ferreira Dantas,
• Jackson Antônio Lamounier Camargos Resende,
• Anna Claudia Cunha,
• Nubia Boechat and
• Mônica Macedo Bastos

Beilstein J. Org. Chem. 2021, 17, 2260–2269, doi:10.3762/bjoc.17.144

• -4 of the triazole nucleus. All compounds were evaluated for their inhibitory activities against a chronic myeloid leukemia cell line (K562) that expresses the enzyme tyrosine kinase BCR-Abl-1 and against healthy cells (WSS-1) to observe their selectivity. Three compounds showed promising results

• . Continuity and increased signaling are associated with some types of neoplasms, such as chronic myeloid leukemia (CML) [1]. A CML is a neoplasm of the bone marrow that transforms normal hematopoietic progenitor cells into malignant cells [2]. This transformation is marked by the presence of an acrocentric

• inhibition profile of substance 3 against K562 cells, we proposed, through the molecular simplification strategy, the derivatives 1a and 1b, which have hydroxyalkyl groups replacing the phenylpiperazine group. The hydroxymethyl and hydroxypropyl groups were chosen because they were not evaluated in the

Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

• Zhiwei Zhang,
• Tao Zhou,
• Taehui Yang,
• Keisuke Fukaya,
• Enjuro Harunari,
• Shun Saito,
• Katsuhisa Yamada,
• Chiaki Imada,
• Daisuke Urabe and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2194–2202, doi:10.3762/bjoc.17.141

• cytotoxicity against P388 murine leukemia cells with IC50 values of 33 and 89 μM, respectively. Keywords: Actinomadura; nomimicin; polyketide; spirotetronate; Introduction Actinomycetes are a valuable source of bioactive compounds, accounting for approximately two thirds of all known antibiotics, and more

• 2 exhibited cytotoxicity against P388 murine leukemia cells with IC50 of 33 and 89 μM, respectively. Conclusion In summary, UV-based chemical screening of bioactive compounds from marine-derived actinomycetes led to the discovery of three new polyketides, nomimicins B (1), C (2), and D (3) along

• Hikichi and Dr. Ayami Kanda at Kochi University for providing R. solanacearum SUPP1541. P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002).

Chemical syntheses and salient features of azulene-containing homo- and copolymers

• Vijayendra S. Shetti

Beilstein J. Org. Chem. 2021, 17, 2164–2185, doi:10.3762/bjoc.17.139

• photovoltaic (PV) cells. Since azulene has a fused five and seven-membered ring structure, it can be incorporated onto the polymer backbone through either of these rings or by involving both the rings. These azulene-connection patterns can influence the properties of the resulting polymers and the chemical

• synthesis of functional polymers is also an interesting proposition and such polymers can find promising applications in the organic electronics field such as organic field-effect transistors (OFET) and photovoltaic (PV) cells [15][16]. The synthesis of azulene-containing polymers can be envisaged through

• donor for organic PV cells and the blend of thin-film 69 with PC71BM showed a power conversion efficiency (PCE) of 2.04%. In 2018, Gao and co-workers [37] reported the synthesis of conjugated polymers containing 2,6-connected azulene units in the polymer backbone. The key monomer, N,N’-bis(2

Constrained thermoresponsive polymers – new insights into fundamentals and applications

• Patricia Flemming,
• Alexander S. Münch,
• Andreas Fery and
• Petra Uhlmann

Beilstein J. Org. Chem. 2021, 17, 2123–2163, doi:10.3762/bjoc.17.138

An initiator- and catalyst-free hydrogel coating process for 3D printed medical-grade poly(ε-caprolactone)

• Jochen Löblein,
• Thomas Lorson,
• Miriam Komma,
• Tobias Kielholz,
• Maike Windbergs,
• Paul D. Dalton and
• Robert Luxenhofer

Beilstein J. Org. Chem. 2021, 17, 2095–2101, doi:10.3762/bjoc.17.136

• scaffolds, which may be required for suitable interaction with cells or other materials. SIPGP does not require special equipment other than a UV lamp or special reagents. As a proof-of-concept, we demonstrated the feasibility using HEMA as monomer, but essentially any monomer polymerizable by free radical

Recent advances in the syntheses of anthracene derivatives

• Giovanni S. Baviera and
• Paulo M. Donate

Beilstein J. Org. Chem. 2021, 17, 2028–2050, doi:10.3762/bjoc.17.131

• years because of their interesting photophysical, photochemical, and biological properties. They are currently the subject of research in several areas, which investigate their use in the biological field and their application in OLEDs, OFETs, polymeric materials, solar cells, and many other organic

Progress and challenges in the synthesis of sequence controlled polysaccharides

• Giulio Fittolani,
• Theodore Tyrikos-Ergas,
• Denisa Vargová,
• Manishkumar A. Chaube and
• Martina Delbianco

Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129

• strategy in AGA has already shown promising results [182] and could fuel the production of well-defined polysaccharides based on multiple 1,2-cis-glycosidic linkages. Xylose-based polysaccharides Xylans are abundant polysaccharides mainly found in plants or in mammalian cells as proteoglycans [189][190

Asymmetric organocatalyzed synthesis of coumarin derivatives

• Natália M. Moreira,
• Lorena S. R. Martelli and
• Arlene G. Corrêa

Beilstein J. Org. Chem. 2021, 17, 1952–1980, doi:10.3762/bjoc.17.128

• acetylcholinesterase inhibitors [11][12][13], being LSPN223 the most potent compound (Figure 2). Furthermore, coumarin derivatives have been used as fluorescent probes, laser dyes, fluorescent chemosensors, light absorbers for solar cells, optical brighteners, and organic light emitting diodes (OLEDs) [14][15]. From a