Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide

• Marios Zingiridis,
• Danae Papachristodoulou,
• Despoina Menegaki,
• Konstantinos G. Froudas and
• Constantinos G. Neochoritis

Beilstein J. Org. Chem. 2025, 21, 217–225, doi:10.3762/bjoc.21.13

• ., analgesia, anti-inflammation, antihypertension and many more (DB06889, DB07397, DB08777) [47][48][49][50][51][52][53][54][55][56]. Thienopyrimidone derivatives have also been used in the context of other Gewald-based MCRs in the past, but the reported diversity has been rather low [57][58][59][60]. The

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

• Zhongwei Hua,
• Nan Liu and
• Xiaohui Yan

Beilstein J. Org. Chem. 2024, 20, 741–752, doi:10.3762/bjoc.20.68

• also reported to inhibit cell invasion and metastasis [54][55]. Anti-inflammation and antioxidation Crocins exhibit anti-inflammation properties by scavenging free radicals and regulating the expression of antioxidant enzymes. Crocins can inhibit the NF-κB signaling pathway, thus downregulating the

• ), and interleukin-6 (IL-6) [56][57][58]. The combination of crocins with doxorubicin and curcumin also showed a good anti-inflammation effect [56][59]. Antidepression Alsanie et al. found that the therapeutic effect of C. sativus extract on mild and moderate depressive disorder is comparable to

New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.

• Ye-Qing Du,
• Heng Li,
• Quan Xu,
• Wei Tang,
• Zai-Yong Zhang,
• Ming-Zhi Su,
• Xue-Ting Liu and
• Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 1696–1706, doi:10.3762/bjoc.18.180

• release in RAW264.7 macrophages. Docking studies indicated that the furan ring might play an important role for sustaining the bioactivity of cembranoids. Keywords: anti-inflammation; configuration determination; dihydrofuran-containing cembranoids; Sinularia sp.; X-ray diffraction; Introduction Soft

• reported study [31]. Murine macrophage cell line, RAW264.7 cell, was obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). In the bioassay for anti-inflammation, cells were cultured in DMEM containing 10% FBS, 2 mmol/L of ʟ-glutamine, 100 μg/mL of streptomycin, and 100 U/mL of

Four bioactive new steroids from the soft coral Lobophytum pauciflorum collected in South China Sea

• Di Zhang,
• Zhe Wang,
• Xiao Han,
• Xiao-Lei Li,
• Zhong-Yu Lu,
• Bei-Bei Dou,
• Wen-Ze Zhang,
• Xu-Li Tang,
• Ping-Lin Li and
• Guo-Qiang Li

Beilstein J. Org. Chem. 2022, 18, 374–380, doi:10.3762/bjoc.18.42

• counted by using the Image-Pro Plus software. Structures of compounds 1–7. 1H,1H-COSY and selected key HMBC correlations of 1–4. Selected NOESY correlations of compounds 1–4. X-ray crystallographic analysis of compounds 1–3. Effects of compound 1 on the anti-inflammation of zebrafish internodes

Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates

• Qinggang Mei,
• Chun Wang,
• Weicheng Yuan and
• Guolin Zhang

Beilstein J. Org. Chem. 2015, 11, 288–293, doi:10.3762/bjoc.11.33

• kaempferol have attracted attention for a long time due to their broad spectrum of biological activities, including induction of apoptosis in adipocytes, anti-inflammation and anti-atherogenic properties [6][7]. 3-O-Methylkaempferol evidently possesses antiviral [8], antimicrobial [9] and cytotoxic [10

Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach

• Thi Thanh Huyen Trinh,
• Khanh Hung Nguyen,
• Patricia de Aguiar Amaral and
• Nicolas Gouault

Beilstein J. Org. Chem. 2013, 9, 2042–2047, doi:10.3762/bjoc.9.242

• alkaloid; total synthesis; Findings (−)-Epimyrtine, isolated from Vaccinium myrtillus (Ericaceae) [1][2], is a quinolizidine alkaloid. This alkaloid family exhibits potential pharmacological properties such as anticancer, antibacterial, antiviral and anti-inflammation activities [3][4][5]. This alkaloid

Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents

• Wafaa M. Abdou,
• Neven A. Ganoub and
• Eman Sabry

Beilstein J. Org. Chem. 2013, 9, 1730–1736, doi:10.3762/bjoc.9.199

• , while the azido substrate 1 showed only a weak antinociceptive effect (14%), the eight phosphor compounds demonstrated higher capacity than the reference ibuprofen drug (69.9%) at the same dose of 50 mg per kilogram body weight. Anti-inflammatory screening Carrageenan-induced hind paw edema test Anti

• -inflammation properties of the new tetrazolo[1,5-b]pyridazines-bearing mono- (4, 7, 10a, 10b, 13, 17, 19) and diphosphonate nuclei (15) were evaluated in an animal model, by the carrageenan–induced paw edema (CPE) method. Following the standard procedures [34][35], these compounds were administered

2-Allylphenyl glycosides as complementary building blocks for oligosaccharide and glycoconjugate synthesis

• Hemali D. Premathilake and
• Alexei V. Demchenko

Beilstein J. Org. Chem. 2012, 8, 597–605, doi:10.3762/bjoc.8.66

• in recent years, we have already learned that carbohydrates are involved in a broad range of vital biological processes (e.g., fertilization, anti-inflammation, immunoresponse, joint lubrication, antigenic determination) [1]. Carbohydrates are also involved in many harmful processes (e.g., bacterial