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Search for "lipid peroxidation" in Full Text gives 9 result(s) in Beilstein Journal of Organic Chemistry.
Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies
Beilstein J. Org. Chem. 2024, 20, 3151–3173, doi:10.3762/bjoc.20.261
- biomolecules like DNA and lipids. Lipid peroxidation and membrane disruption can cause random cross-linking, resulting in cell death and the fragmentation of proteins and enzymes. Elevated concentrations of reactive oxygen species (ROS) from various molecular processes contribute to the oxidation of proteins
Synthesis, electrochemical properties, and antioxidant activity of sterically hindered catechols with 1,3,4-oxadiazole, 1,2,4-triazole, thiazole or pyridine fragments
Beilstein J. Org. Chem. 2024, 20, 2378–2391, doi:10.3762/bjoc.20.202
- antioxidant properties were determined using the reaction with synthetic radicals, the cupric reducing antioxidant capacity assay, the inhibition process of superoxide radical anion formation by xanthine oxidase, and the process of lipid peroxidation of rat liver (Wistar) homogenates in vitro. Keywords
- -thiazolyl (34.0 ± 0.10 μM). Compound 1 was the least effective in this test (81.10 ± 1.86 μM) as in the case of the methods described above. We have previously shown that catechol thioethers can act as anti- or prooxidants on lipid peroxidation processes in vitro depending on a functional group or a
- heterocycle substitute at the sulfur atom [49][50][54]. Non-enzymatic process of the rat (Wistar) liver homogenate lipid peroxidation (LP) in the presence of additives of target compounds 1–9 was studied in vitro. The concentration of the carbonyl compounds forming in the reaction of the lipid peroxidation
Allostreptopyrroles A–E, β-alkylpyrrole derivatives from an actinomycete Allostreptomyces sp. RD068384
Beilstein J. Org. Chem. 2024, 20, 1981–1987, doi:10.3762/bjoc.20.174
- substitution patterns are different (Figure 1). Natural alkylpyrroles were shown to have cytotoxicity [27], antidiabetic activity [28], anti-lipid peroxidation [12], in vivo antihypoxic activity [12], and antibacterial activity [15]. Though not impressive in cytotoxicity and tyrosinase-inhibitory evaluations
Synthesis of naturally-derived macromolecules through simplified electrochemically mediated ATRP
Beilstein J. Org. Chem. 2017, 13, 2466–2472, doi:10.3762/bjoc.13.243
- ions [27]. Quercetin inhibits xanthine oxidase [27][28][29], inhibits lipid peroxidation in vitro [27][28][30], and scavenges oxygen radicals [27][28][31][32][33]. There is a tremendous importance of this antioxidant in the prevention of a range of cardiovascular diseases [27][34][35], cancer [26][27
Use of costic acid, a natural extract from Dittrichia viscosa, for the control of Varroa destructor, a parasite of the European honey bee
Beilstein J. Org. Chem. 2017, 13, 952–959, doi:10.3762/bjoc.13.96
- essential oil were found active against Staphylococcus epidermidis, Streptococcus foecalis and Proteus vulgaris [36]. The methanol extract of the aerial parts of the plant showed antioxidant activity in a study on lipid peroxidation of rat liver microsomes [30]. n-Hexane extracts from air dried D. viscosa
Biradical vs singlet oxygen photogeneration in suprofen–cholesterol systems
Beilstein J. Org. Chem. 2016, 12, 1196–1202, doi:10.3762/bjoc.12.115
- singlet oxygen, thus being able to initiate Ch oxidation from their triplet excited states following either of the two competing mechanistic pathways. Keywords: aryl ketones; hydrogen abstraction; lipid peroxidation; photoproducts; triplet excited state; Introduction Among the constituents of cell
A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations
Beilstein J. Org. Chem. 2015, 11, 2365–2369, doi:10.3762/bjoc.11.258
- ]quinazolines were intensively investigated and promising biological activities were observed, such as anticancer, antiviral, antimicrobial, anti-inflammatory and anticonvulsant [3][4][5]. Indeed, some of them are already used as antimicrobial agents and lipid peroxidation inhibitors [6]. Consequently, the
Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view
Beilstein J. Org. Chem. 2015, 11, 249–264, doi:10.3762/bjoc.11.28
- . L., Rosaceae) and pomegranates (Punica granatum L., Lythraceae). It shows potent antioxidant effects by radical scavenging and the inhibition of lipid peroxidation [28][29]. Ellagic acid is also capable of interfering with some angiogenesis-dependent pathways. It exhibits anticarcinogenic activity
Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
Beilstein J. Org. Chem. 2014, 10, 155–162, doi:10.3762/bjoc.10.13
- autooxidation and the t-BHP-induced lipid peroxidation. Keywords: mitochondrial membrane potential; mitochondrial permeability transition; multicomponent; peptides; tetrahydro-γ-carbolines; Ugi multicomponent reaction; Introduction The design and synthesis of new efficient pharmaceutical drugs for the
- ] (Figure 1). These peptides were found to scavenge hydrogen peroxide and peroxynitrite and inhibit lipid peroxidation in vitro. By reducing mitochondrial reactive oxygen species, they inhibit MPT and cytochrome c release, thus protecting cells from oxidative cell death [11]. We expected that the
- membrane potential, mitochondrial permeability transition and lipid peroxidation. Results and Discussion The starting N-substituted tetrahydro-γ-carbolines 3a–d containing a terminal alkyne group were prepared in good yields by heating compounds 1a–d [12][13] with propargyl acrylate (2) in the presence of
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