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Search for "modular assembly" in Full Text gives 9 result(s) in Beilstein Journal of Organic Chemistry.
Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages
Beilstein J. Org. Chem. 2025, 21, 421–443, doi:10.3762/bjoc.21.30
- quickly identified the triptycenyl-based imine cages of Mastalerz [301] as a strong starting point because: (i) they offered efficient, modular assembly; (ii) all of the complexity could be confined to the privileged triptycene motifs, which would present rigid internal vectors into the cavity for
Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-endo cyclization
Beilstein J. Org. Chem. 2025, 21, 226–233, doi:10.3762/bjoc.21.14
- coupling with gold(I)-mediated 6-endo cyclization streamlines the rapid and modular assembly of the substructure of bis-tetrahydroisoquinoline (THIQ) alkaloids. The design of the key synthetic intermediate bearing a 2,3-diaminobenzofuran moiety allows both gold(I)-mediated regiocontrolled 6-endo
- hydroamination and temporary protection of nitrile and phenolic hydroxy groups. The synthetic strategy enabled the efficient synthesis of the substructure of saframycins bearing isoquinoline and THIQ units in just four steps from the modular assembly of the three components. We also found the unexpected
- THIQ alkaloids substructure 14 was efficiently synthesized in only four steps from the modular assembly of the three simple segments. A notable feature of our approach is the temporary protection of the nitrile and phenolic hydroxy groups by the 2,3-diaminobenzofuran moiety, which facilitates efficient
Chemical structure metagenomics of microbial natural products: surveying nonribosomal peptides and beyond
Beilstein J. Org. Chem. 2024, 20, 3050–3060, doi:10.3762/bjoc.20.253
- ]. Type I PKs are also constructed in a modular assembly line biosynthetic logic and may be amenable to chemical structure metagenomic approaches described herein [82]. In fact, the software suite antiSMASH can already predict the substrate specificity of individual polyketide synthase (PKS) modules, i.e
Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering
Beilstein J. Org. Chem. 2019, 15, 2889–2906, doi:10.3762/bjoc.15.283
- a result of the inherent differences between these biosynthetic machineries. In modular assembly lines, each individual domain is responsible for one defined biosynthetic transformation, while TCs rather act as chaperones [10] to guide oligoprenyl pyrophosphate precursors through a cascade of
Assembly of synthetic Aβ miniamyloids on polyol templates
Beilstein J. Org. Chem. 2015, 11, 2646–2653, doi:10.3762/bjoc.11.284
- peptides, which are linked to the template as boronic esters. A shape-persistent template is necessary which offers the correct spacing between Aβ strands to allow for their preferred cross-β-sheet contacts. The modular assembly of peptides on a template is expected to access synthetic Aβ miniamyloids with
Some aspects of radical chemistry in the assembly of complex molecular architectures
Beilstein J. Org. Chem. 2013, 9, 557–576, doi:10.3762/bjoc.9.61
- tedious by more traditional routes. The possibility of iterating the radical addition allows for a convergent and highly modular assembly of complex scaffolds. The three successive additions outlined in Scheme 8 and leading to 37 illustrate nicely this approach [25]. One xanthate, 36, and three different
Design and synthesis of quasi-diastereomeric molecules with unchanging central, regenerating axial and switchable helical chirality via cleavage and formation of Ni(II)–O and Ni(II)–N coordination bonds
Beilstein J. Org. Chem. 2012, 8, 1920–1928, doi:10.3762/bjoc.8.223
- framework of our recently described methodology for applying a new generation of nucleophilic glycine equivalents [27][28][29][30][31][32] to a general asymmetric synthesis of α-amino acids [33][34][35][36][37][38]. In this manner, modular assembly of achiral C2-symmetric pentadentate ligands 12 was carried
Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization
Beilstein J. Org. Chem. 2012, 8, 930–940, doi:10.3762/bjoc.8.105
- , Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan 10.3762/bjoc.8.105 Abstract By emulating the universal biosynthetic strategy, which employs modular assembly and
- divergent cyclizations, we have developed a four-step synthetic process to yield a collection of natural-product-inspired scaffolds. Modular assembly of building blocks onto a piperidine-based manifold 6, having a carboxylic acid group, was achieved through Ugi condensation, N-acetoacetylation and
- undertaken. Keywords: chemical diversity; divergent cyclization; indole alkaloids; modular assembly; rhodium-catalyzed cyclization–cycloaddition; skeletal and stereochemical diversity; Introduction Biologically intriguing natural products often possess cyclic scaffolds bearing dense arrays of functional
Calix[4]arene-click-cyclodextrin and supramolecular structures with watersoluble NIPAAM-copolymers bearing adamantyl units: “Rings on ring on chain”
Beilstein J. Org. Chem. 2010, 6, 784–788, doi:10.3762/bjoc.6.83
- progress in the field of supramolecular chemistry is based on click chemistry, a versatile and powerful tool that permits the modular assembly of new molecular entities [6][7]. Both CDs as well as calixarenes have already been modified by click chemistry [8][9][10][11][12][13][14]. However, the coupling of
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