Synthesis of tricarbonylated propargylamine and conversion to 2,5-disubstituted oxazole-4-carboxylates

• Kento Iwai,
• Akari Hikasa,
• Kotaro Yoshioka,
• Shinki Tani,
• Kazuto Umezu and
• Nagatoshi Nishiwaki

Beilstein J. Org. Chem. 2024, 20, 2827–2833, doi:10.3762/bjoc.20.238

• -acylamine; oxazole; propargylamine; Introduction Propargylamine is an important motif in the synthesis of heterocyclic compounds [1][2][3][4] and drug discovery [5][6] due to its multifunctionality, which includes a basic and nucleophilic amino group, an electrophilic and dipolarophilic triple bond, and an

• the N-acyl group, achieved by altering the acid amide during the reaction with DEMO [23][24][25]. Specifically, aliphatic amide 1b can be used, which reacts with lithium acetylide (3a) to yield 4e (Table 2, entry 4). Subsequently, ring closure utilizing the multifunctionality of 4 was examined (Table

Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

• Alemayehu Gashaw Woldegiorgis and
• Xufeng Lin

Beilstein J. Org. Chem. 2021, 17, 2729–2764, doi:10.3762/bjoc.17.185

• the important reports by Akiyama and Terada [31][47], chiral phosphoric acids have received much attention in the efficient construction of chiral molecules not only by using them as organocatalysts, but also by applying them as ligands in transition-metal catalysis due to their multifunctionality

Volatile emission and biosynthesis in endophytic fungi colonizing black poplar leaves

• Christin Walther,
• Pamela Baumann,
• Katrin Luck,
• Beate Rothe,
• Peter H. W. Biedermann,
• Jonathan Gershenzon,
• Tobias G. Köllner and
• Sybille B. Unsicker

Beilstein J. Org. Chem. 2021, 17, 1698–1711, doi:10.3762/bjoc.17.118

• ]. The multifunctionality of CxTPS1 and CxTPS2 was only observed when the fungal TPS was expressed heterologously in E. coli and assayed in vitro whereas the fungus itself only emitted (E)-β-caryophyllene (1) when growing on agar medium. Thus, we speculate that GPP, the substrate for monoterpene

Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor

• Xianzhi Chai,
• Hai-Hao Han,
• Yi Zang,
• Jia Li,
• Xiao-Peng He,
• Junji Zhang and
• He Tian

Beilstein J. Org. Chem. 2019, 15, 2380–2389, doi:10.3762/bjoc.15.230

• precise outputs can be obtained for targeted analytes even at low concentrations. Though promising, common “photochromophore–fluorophore”-type sensors require elaborate designs to integrate multifunctionality (e.g., photoswitching, fluorescence sensing, targetability, water solubility, etc.) into one

Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• ; hyperbranched polymer; multifunctionality; polymer nanocarrier; Introduction In recent years, many nanostructured materials (such as polymeric micelles) used as pharmaceutical nanocarriers have been applied in different fields of biomedicine for controlled release, diagnostics, imaging, treatment and

• morphologies and larger aggregates have no evident effect on the multifunctionality of MP2 and MP3 as nanocarriers, as will be confirmed in the next section. Multifunctional properties of nanocarriers In order to address the high drug loading, multiregion encapsulation and controlled release capabilities of

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• Fabrizio Chiodo,
• Marco Marradi,
• Javier Calvo,
• Eloisa Yuste and
• Soledad Penadés

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

• application of gold nanoparticles as a DDS is an expanding field due to the inert properties of the gold core, their controlled fabrication, and multifunctionality [14]. This last property allows the design of particles simultaneously containing multiple chemotherapeutics and targeting moieties. Few studies

Multivalent display of the antimicrobial peptides BP100 and BP143

• Imma Güell,
• Rafael Ferre,
• Kasper K. Sørensen,
• Esther Badosa,
• Iteng Ng-Choi,
• Emilio Montesinos,
• Eduard Bardají,
• Lidia Feliu,
• Knud J. Jensen and
• Marta Planas

Beilstein J. Org. Chem. 2012, 8, 2106–2117, doi:10.3762/bjoc.8.237

• [18][19][20][21][22]. Carbohydrates are promising candidates as templates for the display of functional groups due to their inherent multifunctionality, the relative rigidity of their structure, and the ease of regioselective chemical manipulation [23][24][25]. Jensen and co-workers reported the

Recent advances towards azobenzene-based light-driven real-time information-transmitting materials

• Jaume García-Amorós and
• Dolores Velasco

Beilstein J. Org. Chem. 2012, 8, 1003–1017, doi:10.3762/bjoc.8.113

• ligand, etc.). Moreover, in some cases, a combination of some of them is required so as to endow the final material with multifunctionality. In comparison with chemical stimulation, both electrochemical and mainly photochemical excitation can be switched back and forward easily and rapidly. On the other