Nanoinformatics: spanning scales, systems and solutions

• Iseult Lynch,
• Diego S. T. Martinez,
• Kunal Roy and
• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 423–427, doi:10.3762/bjnano.17.28

• nanomaterials, thus helping to fill the current gap in the toxicity data for zebrafish [8]. A major driver of the development of nanomaterials, nanoinformatics and ML/AI is the potential for solutions to real-world issues, whether in nanomedicine, nano-enabled agriculture, or environmental remediation

• . Improving the efficacy of targeted therapies and minimizing off-target effects are key challenges in nanomedicine. To address these, Dasgupta et al. mapped the structural fingerprints of ligands governing the cellular uptake of MeOx nanomaterials based on classification-based ML models (i.e., Bayesian

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• applications in disease diagnosis and sensing technologies. Despite the promising potential of nanomedicine, significant progress has been limited. This can be attributed to the low targeted accumulation of the nanocarriers at the desired site of action. For instance, in cancer therapy, the accumulation of

• . These properties are particularly valuable for treating inflammatory diseases and targeting tumors. Crossing the blood–brain barrier (BBB) remains a significant challenge for nanomedicine. BNPs coated with membranes from cells capable of BBB penetration, such as neutrophils or cancer cells, show

Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets

• Paulina Trzaskowska,
• Ewa Rybak,
• Maciej Trzaskowski,
• Kamil Kopeć,
• Jakub Krzemiński,
• Rafał Podgórski,
• Hatice Genc,
• Mehtap Civelek and
• Iwona Cicha

Beilstein J. Nanotechnol. 2026, 17, 365–380, doi:10.3762/bjnano.17.25

• Engineering, Warsaw University of Technology, Warynskiego 1, 00-645 Warsaw, Poland Section of Experimental Oncology and Nanomedicine, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsklinikum Erlangen, Glueckstraße 10a, 91054 Erlangen, Germany 10.3762/bjnano.17.25 Abstract Polydopamine

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• /bjnano.16.157 Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) offer promising applications in nanomedicine due to their appealing properties. Their magnetic and magnetic hyperthermia properties are considered as relevant tools for low invasive cancer therapeutic applications. In this work

• development of magnetic nanoparticles with enhanced SAR and improved biocompatibility has been a major objective in the field of nanomedicine. Among the various materials used for magnetic hyperthermia, superparamagnetic iron oxide nanoparticles (SPIONs), such as magnetite (Fe3−δO4) and maghemite (γ-Fe2O3

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• examination of unique nanostructures, nanoscale characterization, metrology to nanoelectronics, nanophotonics, nanobiotechnology, nanomedicine, nanofabrication, and nanomanufacturing [4][5]. These new developments catalyzed the initiation of numerous new experimental and theoretical areas in different

• notably less than the often-cited (and inflated) $1 trillion figure [13][14][15]. This funding has primarily supported fundamental research across materials science, chemistry, physics, and bioengineering. These efforts have led to major scientific advances, mainly in nanoelectronics, nanomedicine

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• specificity. Integration with emerging nanomedicine approaches such as theranostics, controlled drug delivery, and precision oncology could further advance the translational potential of AgSbS2 NCs. Synthesis procedure (a), XRD pattern (b), crystal geometry (c), and FTIR spectrum (d) of the synthesized NCs

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• PEG; immunogenicity; lipid nanoparticles; PEG alternatives; PEG lipids; therapeutic delivery; Review Introduction Lipid nanoparticles (LNPs) have become a promising platform in modern nanomedicine, especially for delivering genetic payloads such as mRNA and siRNA. These nanoscale particles can

• components plays a specific role in maintaining the nanoparticles’ structure and enhancing their performance [2]. The remarkable success of mRNA-based COVID-19 vaccines has highlighted LNPs as a transformative nanomedicine, driving significant interest and innovation in this field [3]. As a key ingredient in

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• Food and Drug Administration (FDA) agency approved the first nanomedicine, Doxil® (doxorubicin-loaded liposomes) for chemotherapy. Over the past 30 years, research and development in nanotechnology have expanded significantly, with more than 70 nanomedicines approved by FDA or EMA [83][84][85][86

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• disease cases [13]. Advances in nanomedicine have provided effective solutions, particularly for treating DED [1]. To address challenges in topical ocular drug delivery and to develop products that mimic tear film composition, ocular nanosystems (ONSs) with diameters ranging from 50 to 300 nm are being

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• , Istanbul, Turkey 10.3762/bjnano.16.105 Keywords: biomedical applications; drug delivery; nanocarriers; nanomaterials; nanomedicine; nanoparticles; polymeric nanoparticles; tissue regeneration; Medicine has rapidly advanced over the last few decades, and nanotechnology has played a significant role in

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• opportunities for the application of cobalt-based agents in nanomedicine. Conclusion Antimicrobial resistance continues to pose a critical threat to global health, undermining the effectiveness of conventional antibiotics and complicating the treatment of infectious diseases. In the search for more effective

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• tumor therapy. It also highlights the fascinating outcome of liposome-mediated ferroptosis in overcoming the obstacles to cancer therapy, along with the limitations and possible future directions. Keywords: cancer; ferroptosis; liposome; nanomedicine; stimuli-responsive; Review 1 Introduction Cancer

• ’ rapid growth and metabolism. Therefore, these stimuli in the TME can be employed as TME-responsive nanomedicine strategies to enhance the efficacy of cancer immunotherapy and reduce side effects through specific aggregation in tumors and regulated release of drugs [171]. In addition to internal stimuli

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• Research Center (ERFARMA), Erciyes University, 38039, Kayseri, Turkey Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan 66000, Pakistan Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, 84112, USA Department of Pharmacy, Quaid-i-Azam

• intravenous administration of T cell membrane-coated nanoparticles directed to the cancerous organ by an externally applied magnetic field, followed by immune cell membrane-mediated cancer targeting. This strategy led to accelerated accumulation of nanomedicine in the tumor with minimal off-target exposure

• delivery systems interact with different body structures as well as physiologic environments. Thus, the structures of drug carriers must be constructed in a way that allows them to elude immune recognition and overcome barriers via effective bio-interfacing. Within the scope of biomimetic nanomedicine for

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• organized the NPs into four primary categories, namely, carbon based nanomaterials (CNMs), metal based NMs, biomimetic NMs and antibody-functionalized NMs. Carbon-based nanomaterials for the detection and inhibition of AβO Recent advances in nanomedicine have spotlighted CNMs because of their remarkable

Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• of DDR either through autophagy modulation or poly (ADP-ribose) polymerase (PARP) inhibition could provide a better therapeutic response [6][7]. Recently, nanomedicine has shown immense potential/efficacy in the treatment of chemoresistant tumors by providing improved molecular targeting, better

• supported by the funding obtained from the Indo–US Joint Centre of Nanomedicine for Head & Neck Cancer/34-2012/2015-16. Conflict of Interest The authors declare no conflict of interest.

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• to enhance the photoacoustic signals and minimize the laser-induced photothermal and photochemical damages [203]. Gels with internally embedded AgCu2O nanoparticles were applied for the treatment of fungal keratitis, and the residence time of the nanomedicine and the corneal therapeutic effect were

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• delve into the intriguing potential of nanomedicine in neurology and traumatology, associated with macrophage interaction, and the exciting possibilities it holds for the future. Keywords: drug delivery; macrophages; nanomedicine; polarization; RNA-based therapies; Review 1 Introduction In the vast

• nanomedicine landscape, the design and development of nanocarriers (NCs) for precise drug delivery are a pivotal innovation. NCs address significant pharmacological challenges, such as enhancing drug solubility, ensuring specific distribution, and facilitating the crossing of biological barriers [1]. Tailoring

• characteristics [13][14]. This dynamic and complex spectrum of macrophage activity features nuanced challenges and opportunities in leveraging macrophage responses to enhance the therapeutic potential of NCs. Recent research has highlighted the dual role of macrophages in the context of nanomedicine. While their

Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster

• Joel Antúnez-García,
• Roberto Núñez-González,
• Vitalii Petranovskii,
• H’Linh Hmok,
• Armando Reyes-Serrato,
• Fabian N. Murrieta-Rico,
• Mufei Xiao and
• Jonathan Zamora

Beilstein J. Nanotechnol. 2025, 16, 44–53, doi:10.3762/bjnano.16.5

• development of nanotechnology and the emergence of composite zeolite materials have opened up unprecedented opportunities for their application in nanomedicine [47]. The unique properties of magnetic nanoparticles allow them to be used for targeted drug delivery and visualization of internal organs [48

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• approaches in unraveling the complex mechanisms of intracellular trafficking. Further in vivo validation is necessary to confirm the efficacy of SO in various therapeutic nanotherapies, potentially broadening its application in nanomedicine. This work provides a robust framework for the rational design of

• delivery and nanomedicine. Experimental Materials The lipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, CAS No. 18194-24-6), 16:0 Liss Rhod PE (rhodamine B-PE, CAS No. 384833-01-6), NBD-PE (CAS No. 384832-99-9), and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE, CAS No. 4004-05-1) were

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

• Julia E. Poletaeva,
• Anastasiya V. Tupitsyna,
• Alina E. Grigor’eva,
• Ilya S. Dovydenko and
• Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

• vacated space is quickly occupied by neighboring components of the medium, as a result of which the composition of the soft corona is constantly changing, even when a NP suspension is stirred [8][9]. As data accumulate on the role of the protein corona in the implementation of nanomedicine, researchers

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• interdisciplinary approach is to integrate advances in biotechnology, nanomaterials, biomedical robotics, and genetic engineering into the broader field of nanomedicine. On a larger scale, the application of nanotechnology in medicine enhances efficiency, accelerates processes, and improves functional performance

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• ; intranasal delivery; liposomes; nanomedicine; nanostructured lipid carriers (NLCs); polymer nanoparticles; RNA delivery; solid lipid nanoparticles (SLNs); Introduction The central nervous system (CNS) consists of the brain and the spinal cord and is considered the body’s processing and control center. While

Green synthesis of carbon dot structures from Rheum Ribes and Schottky diode fabrication

• Muhammed Taha Durmus and
• Ebru Bozkurt

Beilstein J. Nanotechnol. 2024, 15, 1369–1375, doi:10.3762/bjnano.15.110

• range of uses in the fields of electrocatalysis, bioimaging, chemical sensors, biosensors, nanomedicine, biomolecule/drug release, light-emitting diodes, and photocatalysts. They also have promising applications in areas such as lasers and optoelectronic device applications [2][3][4][5]. CDs can be

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• characteristics made TA attractive to nanomaterial synthesis and functionalization for applications in nanomedicine, sensors, electronics, and composites [25][26][27]. In these different fields, TA has been applied in green alternative methods of GO synthesis and physicochemical modifications (e.g., reduction and