Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• showed a time- and concentration-dependent internalization pattern, with high impact of the surface characteristics of the different formulations. In addition, transport studies on hCMEC/D3/SH-SY5Y co-cultures confirmed the successful transport of NLs across the BBB cells and their subsequent uptake by

• drastically affect the physicochemical, biopharmaceutical, and surface characteristics of the vesicles. For this process, the required amounts of SL, CHOL, and commercially available mPEG2000 conjugated to DSPE (PEG) were dissolved in a methanol/chloroform mixture (1:4, v/v). The organic solvents were then

• neurons (ranging from 25.17% to 27.54%). Fluorescence and confocal microscopy micrographs revealed that, once internalized, NLs were concentrated in the perinuclear cell regions. Keywords: blood–brain barrier; cell co-culture; cell uptake; internalization; nanoliposomes; stability; surface

Missing links in nanomaterials research impacting productivity and perceptions

• Santosh K. Tiwari and
• Nannan Wang

Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149

• nanomaterials becomes a tedious and expensive task, often more so than for advanced bulk materials. It is indispensable to acknowledge that even after detailed characterization, warranting that even 90% of the nanoparticles have uniform size and identical surface characteristics is difficult. This is largely

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• control over site specificity and drug release [28]. The absorption of PNs depends on their size, surface characteristics, and morphology, which may exhibit distinct features, classifying them as either nanocapsules or nanospheres. Nanocapsules consist of an oily core where the drug is encapsulated

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• the process. The removal of MPs by adsorbents primarily relies on hydrophobic interactions, electrostatic attraction and hydrogen bonding, which are influenced by their surface characteristics. Among various adsorbents, activated carbon and biochar have gained wide attention for treating water

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• Freundlich isotherm fitting and heterogeneous surface characteristics. However, the adsorption behavior can vary on many factors such as type of adsorbates, adsorbent composition, reaction conditions, and degree of functionality. In our case, the adsorption behavior of pure CNT-based dendrimer adsorbents

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• quenching, and the challenges of oxidation in nanoparticle synthesis. Cost-effective methods for modifying the surface characteristics of Si nanocrystals (Si-ncs) and BaTaOxNy perovskite particles using laser fragmentation are reported in [39] and [40], respectively. In particular, laser fragmentation in

• , effective method used for producing NPs with a narrow size distribution and tailored surface characteristics. While challenges such as oxidation and pulse limitations exist, its ability to create ultrasmall NPs and nanoclusters makes it particularly promising for applications in catalysis, material

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• structuring offers a straightforward means to manipulate the functional and surface characteristics of substrates [10][11][12][13]. The applications span a broad spectrum, encompassing colorization control, self-cleaning surfaces, regulation of cell and bacterial films, antireflective surfaces, surface

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• concentration of 60 mg·L–1 at pH 6–7, reaching equilibrium after 12 h. The surface characteristics and structural properties of PGC were determined using various material characterization techniques, including FTIR, SEM, EDX, and BET. Verification experiments under optimal conditions confirmed that the

• ) and polyvinyl alcohol (PVA); and cationized with Ca2+ and Zn2+ for the removal of TC from aquaculture effluents. Our approach involves optimizing the material’s synthesis using the response surface methodology, and a wide range of characterization methods was performed to assess the surface

• characteristics and morphology of the synthesized adsorbent. Additionally, the study examines the adsorption mechanism of TC on the material’s surface and evaluates the effects of pH value, adsorbent dosage, and matrix composition. As a biodegradable and easily recoverable material derived from natural cellulose

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• effectively recognize all oligomeric forms, complicating the development of broad-spectrum therapies. Unlike larger aggregates, which may present multiple binding sites, AβOs have fewer defined surface characteristics that can be targeted. AβOs can interconvert between different oligomeric states and may also

• nm) have been primarily distributed in kidney, spleen, and liver, while larger GO sheets (>200 nm) accumulate in the lungs [99]. For brain targeting, NPs between 100 and 300 nm have been found optimal for BBB transport, while those smaller than 15 nm show faster clearance. Surface characteristics

• , by activating macrophages and other immune cells [100]. The size and surface characteristics of NPs are critical in determining

N₂⁺-implantation-induced tailoring of structural, morphological, optical, and electrical characteristics of sputtered molybdenum thin films

• Usha Rani,
• Kafi Devi,
• Divya Gupta and
• Sanjeev Aggarwal

Beilstein J. Nanotechnol. 2025, 16, 495–509, doi:10.3762/bjnano.16.38

• conductivity of molybdenum thin films by introducing defects, modifying the crystal structure, doping the material with nitrogen ions, and potentially improving surface characteristics. Correlation of structural, optical, and electrical parameters with thickness Figure 12 depicts the mutual correlations

Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• -based propidium iodide uptake analysis The efficacy of nanomedicines mainly depends upon the effective cellular internalization and their transport to the appropriate intercellular effector site [52][53]. Studies have shown that based on its size and surface characteristics (i.e., hydrophilicity or

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• for CNS targeting. For example, size, shape, and surface characteristics of a DDS directly affect cellular transport and uptake, biodistribution, and the interaction with biological interfaces [64][65]. Regarding particle size, NPs with a size of approx. 15 nm or below were observed to penetrate the

• revealed that an increase in particle size led to a shift towards caveolae-mediated internalization, the primary pathway for particles sized around 500 nm [69]. This shows the possibility of an even more extended particle size range to be considered for N2B delivery [69]. Regarding surface characteristics

• and specific targeting. In N2B delivery, DDSs provide them stability and the ability to penetrate biological barriers through their tailorable surface characteristics. Among biopharmaceuticals, siRNAs also stand out because of their selectivity for a single gene, bringing new opportunities to provide

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• biological principles could result in vehicles capable of agile and precise movements and increased stability in turbulent conditions. Despite these promising possibilities, the shape and surface characteristics of the hymenopteran metasoma remain underexplored, and families with unique metasomal forms still

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• avidity effects. On the other hand, too many ligands could alter the original surface characteristics of usNPs, leading to stronger nonspecific interactions with plasma proteins. Targeted usNPs with weak binding to cancer cell surface receptors may not provide any additional value over non-targeted

Atomistic insights into the morphological dynamics of gold and platinum nanoparticles: MD simulations in vacuum and aqueous media

• Evangelos Voyiatzis,
• Eugenia Valsami-Jones and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 995–1009, doi:10.3762/bjnano.15.81

• for NPs is the consistency in their shape, surface characteristics, and crystallinity. Nevertheless, developing straightforward and widely applicable approaches to crystallize or melt NPs uniformly, with precise control, remains a significant challenge [25]. For instance, it has been shown that atomic

The effect of age on the attachment ability of stick insects (Phasmatodea)

• Marie Grote,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 867–883, doi:10.3762/bjnano.15.72

• to fly, they adapted strongly to their local environment [11][19][22][23]. Phasmids have evolved considerably depending on plants since pre-angiosperm times [24]. As plants display a huge range of different surface characteristics [25][26][27][28], the diversity of microstructures on phasmatodean

• investigated various functions of this system and how it changes under certain conditions, such as substrate geometry [36], the presence or absence of claws [37], different surface characteristics of substrates [33][38][39], and the combined effect with pad fluids [40]. For these animals, whose lives strongly

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• symmetrical vibration of Si–O and Si–C linkages. This absorption was due to the formation of silica particles on the GO layer during modification. Contact angle The effect of GO modification with VTES on GO surface characteristics was investigated by measuring the contact angle. Figure 6 shows images of

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• comparable size and surface characteristics but variable Young’s moduli ranging from 45 kPa to 19 MPa. In contrast to many other studies, soft nanoliposomes (NLPs) are taken up better by cells than harder particles used in this study. This is explained by the combination of membrane fusion and clathrin

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• increasing in the third month up to 155 nm. The Z-average parameter was chosen to report the nanoparticles size. The size values were consistent with the TEM image analysis. The zeta potential (ζ) was measured by Doppler anemometry and operated as a report of the formulation surface characteristics. The

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• surface characteristics and concentration of nanocatalyst, which directly impact the binding/adsorption capability of the reactant and the release/desorption of the reaction products [49]. This study aims to investigate the catalytic activity of the nanocomposite AgNPs@Lac/Alg for the degradation of two

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• significantly related to excess lethality at 120 hpf, with limited influence of descriptors representing the primary particle size or surface characteristics is interesting. The finding that the Pauling metal atom electronegativity descriptor was of greatest significance is broadly in keeping with earlier

• different oxidation states of the same metal were not considered in our dataset may also have resulted in a variable related purely to the metal atom identity being assigned elevated significance. Our finding that surface characteristics are of negligible importance, compared to core chemical composition is

• variability in biological effects [28][29][31]. It is possible that our results regarding the limited significance of surface characteristics may be skewed by the manner in which surface chemical composition was represented using descriptors and the incomplete availability of surface charge information. (See

Morphology-driven gas sensing by fabricated fractals: A review

• Vishal Kamathe and
• Rupali Nagar

Beilstein J. Nanotechnol. 2021, 12, 1187–1208, doi:10.3762/bjnano.12.88

• , the extension of fractals in all three dimensions not only adds to the total number of active adsorption sites but also enhances their density. It is well known that surface gas adsorption and desorption are the rate-determining steps and mostly depend on surface characteristics such as surface area

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• without ligands, in a healthy murine model. Even though the authors reported an organ distribution of nearly 20% per gram in the BM, most of the porous silicon particles were entrapped in the spleen, liver, and lungs, because of their size and surface characteristics. In this case, the physicochemical

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

• unique surface characteristics [228]. Therefore, for safe biological applications (i.e. in the medical and food industry), this approach would be preferred as an alternative for methods that necessarily require the use of chemical stabilizers [108][112]. In addition, the small NP size, low agglomeration

• –gel technique at 100 °C and produced particles with an average diameter of 25 nm with hexagonal cross section. In the sol–gel process, besides temperature and gel composition, the solvent plays an important role in determining the size, morphology, and surface characteristics of the synthesized AgNPs