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Search for "DNA" in Full Text gives 282 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

  • Supratik Kar and
  • Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

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  • of their unique properties. However, their size, surface area, and reactivity can cause toxicity, potentially leading to oxidative stress, inflammation, and cellular or DNA damage. In this study, a nano-quantitative structure–toxicity relationship (nano-QSTR) model was initially developed to assess
  • , it was reported that MONPs have been found in human tissues such as brain, heart, and liver [11] and that occupational exposure to metal oxide nanomaterials increased oxidative stress biomarkers, suggesting potential DNA oxidative damage and lipid peroxidation [12]. Given the limited data available
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Published 10 Sep 2024

Recent progress on field-effect transistor-based biosensors: device perspective

  • Billel Smaani,
  • Fares Nafa,
  • Mohamed Salah Benlatrech,
  • Ismahan Mahdi,
  • Hamza Akroum,
  • Mohamed walid Azizi,
  • Khaled Harrar and
  • Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

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  • to detect a wide range of biomolecules, such as proteins, DNA, and antibodies. This article presents a comprehensive review of advancements in the architectures of FET-based biosensors aiming to enhance device performance in terms of sensitivity, detection time, and selectivity. The review
  • biosensors for accurate detection of viruses [25], cancer [15], proteins [36], DNA, glucose [17], and nucleic acids has been strongly developed [37]. On the other hand, specific biomolecule classifications by microbiologists has led to the realization and development of different biosensors, significantly
  • biomolecule species. Wenga et al. [90] designed a step-gate polysilicon FET-based biosensor for the detection of DNA. An emerging step-gate polycrystalline silicon NW FET-based biosensor was fabricated to enable highly sensitive electrical biosensing for DNA hybridization detection with a low-cost and simple
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Published 06 Aug 2024

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

  • Thi Ngoc Han Pham,
  • Phuong-Thao Dang-Luong,
  • Hong-Phuc Nguyen,
  • Loc Le-Tuan,
  • Xuan Thang Cao,
  • Thanh-Danh Nguyen,
  • Vy Tran Anh and
  • Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

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  • and non-lymphoma Hodgkin’s [16][17], advanced ovarian and breast cancer [17][18], and some autoimmune illnesses [19]. Like other alkylating drugs, CHL inhibits tumor growth by cross-linking guanine or adenine bases in DNA double helix strands, preventing them from uncoiling and separating, and
  • consequently disrupting DNA replication in proliferating cancer cells. The neurotoxicity and myelotoxicity of CHL, however, limit its clinical use [20][21]. Moreover, the instability of chemotherapeutics due to the hydrolysis of the chloroethyl group significantly hampers their therapeutic impact [22
  • the cells. Folic acid plays an important role in cancer cells; it takes part in cell proliferation, methylation for gene expression, DNA replication, oxidative stress, and DNA mutation. Many studies and cancer drugs, therefore, have used folic acid as a targeting ligand for the folate receptor, which
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Published 31 Jul 2024

Electrospun nanofibers: building blocks for the repair of bone tissue

  • Tuğrul Mert Serim,
  • Gülin Amasya,
  • Tuğba Eren-Böncü,
  • Ceyda Tuba Şengel-Türk and
  • Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

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  • , antibiotics, anticancer agents, proteins, DNA, RNA, and growth factors for tissue regeneration [6][7][8]. In addition, nanofibers as drug delivery systems provide rapid or delayed and controlled release of pharmaceuticals. Apart from being implantable drug delivery systems, nanofiber scaffolds can contribute
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Published 25 Jul 2024

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

  • Nabojit Das,
  • Vikas,
  • Akash Kumar,
  • Sanjeev Soni and
  • Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

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  • -known noble metal materials whose resonance occurs in both visible and infrared range of the electromagnetic spectrum, rendering pertinence in various disciplines such as surface-enhanced Raman scattering (SERS), optical sensors, fluorescence (SPR) sensor chips, deoxyribonucleic acid (DNA) sensors
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Published 07 Jun 2024

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

  • Theo Fromme,
  • Sven Reichenberger,
  • Katharine M. Tibbetts and
  • Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

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  • as water and even aqueous solutes. Thus, this model formed the basis that enabled the derivation of yield functions for a variety of direct electron-mediated DNA damage pathways and indirect damage by •OH radicals resulting from laser and electron interactions with water [85]. In general, LSPC in
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Published 05 Jun 2024

AFM-IR investigation of thin PECVD SiOx films on a polypropylene substrate in the surface-sensitive mode

  • Hendrik Müller,
  • Hartmut Stadler,
  • Teresa de los Arcos,
  • Adrian Keller and
  • Guido Grundmeier

Beilstein J. Nanotechnol. 2024, 15, 603–611, doi:10.3762/bjnano.15.51

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  • refined and found its way into many and highly diverse fields of application, including virology, DNA nanotechnology, polymer science, and materials science [5][6][7][8][9]. The importance of AFM-IR steadily grew over the past decade and its development has been described in detail in several review
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Published 24 May 2024

Classification and application of metal-based nanoantioxidants in medicine and healthcare

  • Nguyen Nhat Nam,
  • Nguyen Khoi Song Tran,
  • Tan Tai Nguyen,
  • Nguyen Ngoc Trai,
  • Nguyen Phuong Thuy,
  • Hoang Dang Khoa Do,
  • Nhu Hoa Thi Tran and
  • Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

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  • strongly to high levels of ROS that can cause damage to DNA molecules resulting in abnormal cell proliferation. Various studies reported that oxidative damage can have a deleterious effect on cancer development through raising genetic mutations, abnormal protein functions, and tumor growth [164][165
  • ]. Antioxidants contribute to cancer inhibition and cancer treatment by several mechanisms. First, nanoantioxidants reduce cancer initiation by protecting DNA molecules from oxidative stress and stimulating DNA repair. For example, platinum nanoparticles inhibited the growth of epithelial lung cancer cells by
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Published 12 Apr 2024

Nanomedicines against Chagas disease: a critical review

  • Maria Jose Morilla,
  • Kajal Ghosal and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

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  • cells, BNZ is reduced by oxygen-sensitive nitroreductases. During its anaerobic nitro reduction, primarily in the hepatic microsomal fraction, BNZ generates reactive metabolites that bind to the host’s DNA, proteins, and lipids. The nitro reduction also occurs in fecal matter, with an intensity that
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Published 27 Mar 2024
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  • enhance the catalytic activity of Fenton/Fenton-like reactions, but can also result in cellular damage [16]. ROS can break down the basic components of the cell, including DNA, proteins, and lipids. ROS can cause double-strand breaks in DNA by converting guanine to 8-oxoguanine. This conversion can lead
  • surface. Unfortunately, this interaction can lead to DNA damage through processes such as delocalization, redox chemistry, and the generation of ROS. Our research aimed to examine how the time of exposure to metal oxide affects cell damage, regardless of other physiochemical properties of MeOx NPs. Our
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Published 12 Mar 2024

Ion beam processing of DNA origami nanostructures

  • Leo Sala,
  • Agnes Zerolová,
  • Violaine Vizcaino,
  • Alain Mery,
  • Alicja Domaracka,
  • Hermann Rothard,
  • Philippe Boduch,
  • Dominik Pinkas and
  • Jaroslav Kocišek

Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20

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  • , ENSICAEN, UNICAEN, CEA, CNRS, CIMAP, Boulevard Henri Becquerel, BP 5133, 14070, Caen cedex 5, France Electron Microscopy Center, Institute of Molecular Genetics of the CAS, Vídenská 1083, 142 20, Prague, Czech Republic 10.3762/bjnano.15.20 Abstract DNA origami nanostructures are emerging as a bottom-up
  • nanopatterning approach. Direct combination of this approach with top-down nanotechnology, such as ion beams, has not been considered because of the soft nature of the DNA material. Here we demonstrate that the shape of 2D DNA origami nanostructures deposited on Si substrates is well preserved upon irradiation
  • by ion beams, modeling ion implantation, lithography, and sputtering conditions. Structural changes in 2D DNA origami nanostructures deposited on Si are analyzed using AFM imaging. The observed effects on DNA origami include structure height decrease or increase upon fast heavy ion irradiation in
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Published 12 Feb 2024

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

  • Phuong-Thao Dang-Luong,
  • Hong-Phuc Nguyen,
  • Loc Le-Tuan,
  • Xuan-Thang Cao,
  • Vy Tran-Anh and
  • Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

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  • ][24]. Thus, using IR780 in our NPs would bring advantages for local imaging and treatment. Chemotherapy medications assist in inhibiting the development of tumors. Chemotherapeutic agents such as doxorubicin attach to chromosomes and inhibit DNA replication, while paclitaxel depolymerizes the
  • cytoskeleton and chlorambucil (CHL) inhibits DNA synthesis. These drugs can be encapsulated inside nanoparticles for administration to increase the stability of the medication in circulation and therapeutic efficacy. For example, doxorubicin can be inserted into liposomes and paclitaxel attaches to the protein
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Published 06 Feb 2024

New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water

  • Azam Bagheri Pebdeni,
  • Mohammad N. AL-Baiati and
  • Morteza Hosseini

Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9

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  • ], photocatalytic degradation and bactericidal action [21], sensors and biosensors [22][23][24][25], and as electrocatalysts [26]. Aptamers are single-stranded DNA or RNA oligonucleotides that attach to their targets with great affinity and specificity. Aptamers have high stability in a variety of environments and
  • months; storage at 4 °C is necessary. The peroxide activity of the Ag/Pt NPLs enhanced following the addition of the aptamer. Using DNA to functionalize NPLs can increase not only target recognition but also enzyme activity, which is a useful technique for developing biosensors for target detection
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Published 17 Jan 2024

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

  • Douglas Dourado,
  • Thayse Silva Medeiros,
  • Éverton do Nascimento Alencar,
  • Edijane Matos Sales and
  • Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

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  • leishmaniasis. Additionally, this molecule produces reactive oxygen species (ROS) and elevates cytosolic calcium. These occur in the exposure of phosphatidylserine to the outer plasma membrane leaflet and DNA fragmentation, causing the death of the leishmaniasis parasite [47][52]. Despite its promising
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Published 04 Jan 2024

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

  • Eloïse Equy,
  • Jordana Hirtzel,
  • Sophie Hellé,
  • Béatrice Heurtault,
  • Eric Mathieu,
  • Morgane Rabineau,
  • Vincent Ball and
  • Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

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  • % with Equation 3, using DAPI in water as the reference [33]. where, ΦDAPI is the fluorescence quantum yield of DAPI when unbound to DNA (4%) [32], and are the integrated fluorescence intensities of the light emitted by Ox-BSA/PDA NPs and DAPI, respectively, AOx-BSA/PDA NPs and ADAPI are the absorption
  • . Compared to the quantum yields of FITC, RhBITC, and DAPI bound to DNA, which are in the range of 40–90% at room temperature [31][32][34], Ox-BSA/PDA NPs reveal low emission efficiency. However, even if the quantum yield of Ox-BSA/PDA NPs is low, it is significantly higher than the quantum yield of non
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Published 22 Dec 2023

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

  • Jonathan-Gabriel Nimz,
  • Pichayut Rerkshanandana,
  • Chiraphat Kloypan,
  • Ulrich Kalus,
  • Saranya Chaiwaree,
  • Axel Pruß,
  • Radostina Georgieva,
  • Yu Xiong and
  • Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

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  • dependence of HbMP uptake on these receptors. Table 2 gives an overview of the samples of indirect phagocytosis test no. 2; the incubation time with HbMPs was 30 min. All samples were analyzed by flow cytometry. Leucocytes were identified by DNA staining with propidium iodide (PI) or diamidinophenylindole
  • (DAPI). The closely spaced emission maxima of DAPI and FITC, or PI and APC, necessitated the use of different dyes for DNA staining depending on which signal, FITC or APC, was of interest in each sample. In each run, 2000 monocytes were analyzed. The mean fluorescence intensity (MFI) of the reference
  • -labeled mouse anti-human CD14 antibody (anti-CD14-wb) and APC-labeled mouse anti-human CD163 antibody (blocking antibody) (anti-CD163-wb); also, a whole blood sample lysed and DNA-stained only was prepared for comparison (wb). In addition, a whole blood sample that had been kept at 37 °C for 120 min, as
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Published 19 Oct 2023

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

  • Elangovan Sarathkumar,
  • Rajasekharan S. Anjana and
  • Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

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  • ]. However, even with these modifications, it relied on the colorimetric principle and was not applicable for the quantitative determination of analytes. In recent years, to address these challenges, various signal amplification strategies, such as DNA amplification, nanozyme activity, surface-enhanced Raman
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Published 04 Oct 2023

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

  • Mamta Kumari,
  • Amitabha Acharya and
  • Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

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  • , drug resistance, and tumor relapse are the leading challenges in cancer diagnosis and treatment. The commonly used methods for the diagnosis of cancer involve identification of cancer-causing features in cells, such as DNA and RNA mutations, impaired expression of proteins, and changes in confirmation
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Published 04 Sep 2023

Investigations on the optical forces from three mainstream optical resonances in all-dielectric nanostructure arrays

  • Guangdong Wang and
  • Zhanghua Han

Beilstein J. Nanotechnol. 2023, 14, 674–682, doi:10.3762/bjnano.14.53

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  • strong laser beam generates a piconewton level of force, which can be used to manipulate small dielectric particles, including biological entities such as DNA, enzymes, and cells. The underlying physics of nanoparticle manipulation by optical tweezers can be interpreted as the trend of the particle to
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Published 02 Jun 2023

Plasmonic nanotechnology for photothermal applications – an evaluation

  • A. R. Indhu,
  • L. Keerthana and
  • Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

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Published 27 Mar 2023

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

  • Yao Yao,
  • Yeongun Ko,
  • Grant Grasman,
  • Jeffery E. Raymond and
  • Joerg Lahann

Beilstein J. Nanotechnol. 2023, 14, 351–361, doi:10.3762/bjnano.14.30

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  • , payload retention, and interparticle variability in the context of nucleic acid-based nanotherapeutics. In order to illustrate these issues and concerns, we analyzed the materials and methods sections of 50 papers published within the last five years on the topic of NP-mediated delivery of plasmid DNA
  • (only 6% used 3D imaging, Figure 1a3) [19]. Furthermore, the subjective interpretation of results obtained by imaging techniques cannot be neglected [17]. Based on 50 studies regarding NP-mediated delivery of plasmid DNA to cells/tissues, only a small fraction reported systematic image quantification
  • 50 nanoparticle (NP)-mediated plasmid DNA (pDNA) delivery experiments published in 2017–2022. (a) 5-year prevalence of reporting imaging, imaging quantification, and 3D imaging capture for investigating NP cellular uptake and (or) transfection. (b) 5-year prevalence of reporting flow cytometry for
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Published 17 Mar 2023

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

  • Santiago Grijalvo and
  • Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

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  • surface becomes positive at a given cationic surfactant concentration and, therefore, the nanoparticles can be complexed with DNA plasmids. This complexation leads to an increase in the hydrodynamic diameter. This increase is larger for plasmids with higher molecular weight. The obtained complexes (Figure
  • . Representative TEM images of negatively stained nanoparticles (NPs) complexed with DNA plasmids (pVAX and pVAX-HisAK70). (A) NP 1:1. (B) NP 1:1/pVAX = 5/1. (C) NP 1:1/pVAX-HisAK70 = 10/1. (D) Zoomed region from each sample (A–C) (all scale bars represent 100 nm). Figure 5 was reprinted from [61], European
  • Polymer Journal, vol. 120, by E. Soler Besumbes; C. Fornaguera; M. Monge; M. J. García-Celma; J. Carrión: C. Solans; A. Dols-Perez, “PLGA cationic nanoparticles, obtained from nanoemulsion templating, as potential DNA vaccines”, article No. 109229, Copyright (2019), with permission from Elsevier. This
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Published 13 Mar 2023

Overview of mechanism and consequences of endothelial leakiness caused by metal and polymeric nanoparticles

  • Magdalena Lasak and
  • Karol Ciepluch

Beilstein J. Nanotechnol. 2023, 14, 329–338, doi:10.3762/bjnano.14.28

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  • . observed that direct exposure of HUVECs to SiO2 NPs resulted in oxidative damage induced by ROS, generated by the action of NPs. After 24 h of NP exposure, an increase in cell necrosis and apoptosis was observed. Significant DNA damage and cell cycle arrest at the G2/M point also occurred after NP exposure
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Published 08 Mar 2023

Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes

  • Akeem Adeyemi Oladipo and
  • Faisal Suleiman Mustafa

Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26

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  • ][66]. Fluoroquinolones have a detrimental impact on the morphology and photosynthesis of plants, as well as on the ability of eukaryotic cells to synthesise DNA and replicate plastids. Streptomycin prevents Hordeum vulgare from producing chlorophyll, while ciprofloxacin, enrofloxacin, and
  • dye. Additionally, some dyes, such as xanthene and erythrosine, have been related to allergic reactions, neurotoxins, and DNA damage in both humans and animals [70]. An eco-friendly, practical, and efficient treatment method is urgently needed because of the increasing pollution and health and
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Published 03 Mar 2023

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

  • Filip Gorachinov,
  • Fatima Mraiche,
  • Diala Alhaj Moustafa,
  • Ola Hishari,
  • Yomna Ismail,
  • Jensa Joseph,
  • Maja Simonoska Crcarevska,
  • Marija Glavas Dodov,
  • Nikola Geskovski and
  • Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

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Published 22 Feb 2023
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