Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• theranostics in the future. Keywords: Au nanorods; cancer theranostics; fluorescent bioimaging; folate; polydopamine; targeted phototherapy; Introduction Multifunctional imaging and combined multimodal therapy strategies are very promising in cancer theranostics [1][2]. Possible way for such purpose is to

• efficient multimodal cancer treatments both in vitro and in vivo. An ideal nanorod coating for efficient nanocomposite formation should meet several important criteria. First, the resulting nanoparticles should be nontoxic and colloidally stable in blood serum. Second, the shell should have high loading

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• biological application and therapy of human diseases [26][27]. In this work, we demonstrated a novel GNR@CdSe/ZnS multimodal nanostructure in aqueous phase. We chose CdSe/ZnS QDs as a PL contributor due to its high degree of brightness, excellent photostability, and good spectral overlap with GNRs. We then

Size-selected Fe₃O₄–Au hybrid nanoparticles for improved magnetism-based theranostics

• Maria V. Efremova,
• Yulia A. Nalench,
• Eirini Myrovali,
• Anastasiia S. Garanina,
• Ivan S. Grebennikov,
• Polina K. Gifer,
• Maxim A. Abakumov,
• Marina Spasova,
• Makis Angelakeris,
• Alexander G. Savchenko,
• Michael Farle,
• Natalia L. Klyachko,
• Alexander G. Majouga and
• Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

• be adjusted by heterogeneous nucleation of NPs on noble metal seeds [21][22]. Additionally, such bifunctional Fe3O4–Au NPs are potentially applicable for targeted drug delivery, enhanced hyperthermia, multimodal imaging and theranostics [8][23][24][25][26][27]. In this work, we present the first size

High-throughput micro-nanostructuring by microdroplet inkjet printing

• Hendrikje R. Neumann and
• Christine Selhuber-Unkel

Beilstein J. Nanotechnol. 2018, 9, 2372–2380, doi:10.3762/bjnano.9.222

• : biofunctional surfaces; inkjet printing; microstructures; nanolithography; nanoparticles; Introduction Many applications require well-organized micro- and nanoscale patterning of metallic nanoparticles. Examples include high-performance optics [1], multimodal waveguides [2], biosensors [3] and biomaterials [4

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

• Alina M. Ermakova,
• Julia E. Morozova,
• Yana V. Shalaeva,
• Victor V. Syakaev,
• Aidar T. Gubaidullin,
• Alexandra D. Voloshina,
• Vladimir V. Zobov,
• Irek R. Nizameev,
• Olga B. Bazanova,
• Igor S. Antipin and
• Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

• micelles exhibited a slower release rate. In the first 10 h, the released amount of 3 + RhB micelles was around 40%, then the release slowed down and about 30% of the substrate was released over a period of the following 80 h. The slower release of RhB-loaded micelles is attributed to the multimodal

Multimodal noncontact atomic force microscopy and Kelvin probe force microscopy investigations of organolead tribromide perovskite single crystals

• Yann Almadori,
• David Moerman,
• Jaume Llacer Martinez,
• Philippe Leclère and
• Benjamin Grévin

Beilstein J. Nanotechnol. 2018, 9, 1695–1704, doi:10.3762/bjnano.9.161

• photocarrier lifetime is quantified by performing KPFM measurements under frequency-modulated illumination. Our multimodal approach provides a unique way to investigate the interplay between the charges and ionic species, the photocarrier-lattice coupling and the photocarrier dynamics in hybrid perovskites

• modulation of the illumination source. Thus, it has been possible to analyze both the photostriction and carrier lifetime as a function of the optical power. Our multimodal approach opens up new possibilities to investigate a wide range of photo-physical process and dynamical phenomena in organic–inorganic

Sulfur-, nitrogen- and platinum-doped titania thin films with high catalytic efficiency under visible-light illumination

• Boštjan Žener,
• Lev Matoh,
• Giorgio Carraro,
• Bojan Miljević and
• Romana Cerc Korošec

Beilstein J. Nanotechnol. 2018, 9, 1629–1640, doi:10.3762/bjnano.9.155

• distribution (≈10 nm), whereas S3 has a multimodal pore size distribution. The distributions of pores in other samples synthesized with HCl (Urea_15, Thiourea_15) and H2SO4 (S3_N0.5, S3_N0.5+1% Pt) are similar to the distributions shown in Figure 3. Band gap measurements The diffuse reflectance, R, of the

Field-controlled ultrafast magnetization dynamics in two-dimensional nanoscale ferromagnetic antidot arrays

• Anulekha De,
• Sucheta Mondal,
• Sourav Sahoo,
• Saswati Barman,
• Yoshichika Otani,
• Rajib Kumar Mitra and
• Anjan Barman

Beilstein J. Nanotechnol. 2018, 9, 1123–1134, doi:10.3762/bjnano.9.104

• observe a distinct variation in the magnetization dynamics. For all φ and a-values, multimodal SW spectra are observed corresponding to the damped nonuniform oscillations [36]. The experimental data of bias-field-angle dependence of SW spectra for S1 has been taken at H = 1.0 kOe, whereas for S2 the data

Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

Synthesis and functionalization of NaGdF₄:Yb,Er@NaGdF₄ core–shell nanoparticles for possible application as multimodal contrast agents

• Dovile Baziulyte-Paulaviciene,
• Vitalijus Karabanovas,
• Marius Stasys,
• Greta Jarockyte,
• Vilius Poderys,
• Simas Sakirzanovas and
• Ricardas Rotomskis

Beilstein J. Nanotechnol. 2017, 8, 1815–1824, doi:10.3762/bjnano.8.183

• Institute of Chemistry, Center for Physical Sciences and Technology, Sauletekio Ave. 3, Vilnius, LT-10222, Lithuania 10.3762/bjnano.8.183 Abstract Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and

• contrast probe for in vivo bioimaging. Keywords: cancer theranostics; core–shell structure; luminescence; multimodal; nanoparticles; upconverting nanoparticles; upconversion; Introduction Lanthanide-doped multimodal upconverting nanoparticles (UCNPs), which can convert near-infrared (NIR) radiation into

• amphiphilic polymer coating [18] have been developed in order to transfer nanoparticles with hydrophobic surfaces into aqueous media. Furthermore, the multimodal UCNP surface modification field still lacks reference materials and established protocols for functionalization and targeting. Some studies showed

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

• Arūnas Jagminas,
• Agnė Mikalauskaitė,
• Vitalijus Karabanovas and
• Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

• nanomedicine, biocompatible iron oxide-based NPs have attracted particular interest due to their size-dependent magnetic, optical and chemical properties that allow for the design of NPs for multimodal imaging and photothermal therapy of cancer cells [1]. Dual-imaging probes, capable to perform simultaneously

Calcium fluoride based multifunctional nanoparticles for multimodal imaging

• Marion Straßer,
• Joachim H. X. Schrauth,
• Sofia Dembski,
• Daniel Haddad,
• Bernd Ahrens,
• Stefan Schweizer,
• Bastian Christ,
• Alevtina Cubukova,
• Marco Metzger,
• Heike Walles,
• Peter M. Jakob and
• Gerhard Sextl

Beilstein J. Nanotechnol. 2017, 8, 1484–1493, doi:10.3762/bjnano.8.148

• nanoparticles; magnetic resonance imaging (MRI); multifunctional nanoparticles; multimodal imaging; photoluminescence; Introduction In recent years, medical imaging has become an important approach in the fields of diagnostics, therapy and regenerative medicine. Besides the classical technology of X-ray

• imaging modality has its advantages and disadvantages. The integration of multiple functions into one NP system yields synergies and allows for a precise and fast diagnosis of diseases. Recently, various multimodal imaging probes on the basis of different functional NPs were fabricated for more accurate

• fluorolytic sol–gel process [33]. The stability and biocompatibility of CaF2 makes it an attractive material for biomedical applications [28][29]. In addition, due to the high capacity to accept lanthanide ions, CaF2 is suitable for the preparation of CAs for multimodal imaging [24]. In this study, we report

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• in combination with DTX and MMC evoked additive to partly synergistic anti-tumor effects. CNFs and CNTs possess the ability to sensitize cancer cells to a wide range of structurally diverse chemotherapeutics and thus represent an interesting option for the development of multimodal cancer therapies

• with our previous findings, this study shows that CNFs and CNTs can enhance the cytotoxic effects of a wide range of structurally diverse chemotherapeutics. Thus, the development of multimodal therapies based on carbon nanomaterials seems very promising, as carbon nanomaterials possess great potential

Multimodal cantilevers with novel piezoelectric layer topology for sensitivity enhancement

• Steven Ian Moore,
• Michael G. Ruppert and
• Yuen Kuan Yong

Beilstein J. Nanotechnol. 2017, 8, 358–371, doi:10.3762/bjnano.8.38

• multifrequency AFM and has the potential to provide higher resolution imaging on higher order modes. Keywords: atomic force microscopy; multifrequency AFM; multimodal AFM; piezoelectric cantilever, self-sensing; Introduction The invention of the atomic force microscope (AFM) [1] provided for the observation of

Nanoanalytics for materials science

• Thilo Glatzel and
• Tom Wirtz

Beilstein J. Nanotechnol. 2016, 7, 1674–1675, doi:10.3762/bjnano.7.159

• high-sensitivity chemical information at the nanoscale are of utmost importance for future developments [1]. One of the possible approaches is based on bimodal or even multimodal nanoanalysis, which was increasingly developed during the last decade. Other important aspects that have to be considered

• and reliable understanding and accurate physical models. Furthermore, a reliable and easy way to extract a maximum of information out of the multimodal datasets, efficient data visualization strategies, and methods for analysis, mining and modeling are of utmost importance. This Thematic Series on

Generalized Hertz model for bimodal nanomechanical mapping

• Aleksander Labuda,
• Marta Kocuń,
• Waiman Meinhold,
• Deron Walters and
• Roger Proksch

Beilstein J. Nanotechnol. 2016, 7, 970–982, doi:10.3762/bjnano.7.89

• include bimodal [28][29][30][31][32][33], trimodal [34] or more generally multimodal/multifrequency [35] techniques, and have demonstrated quantitative mapping without compromising on the high speeds that define parametric imaging techniques. Currently, state-of-the-art bimodal methodologies are mostly

Correlative infrared nanospectroscopic and nanomechanical imaging of block copolymer microdomains

• Benjamin Pollard and
• Markus B. Raschke

Beilstein J. Nanotechnol. 2016, 7, 605–612, doi:10.3762/bjnano.7.53

• ][13][14]. Here, we combine IR s-SNOM and force–distance spectroscopy for a multimodal study of heterogeneous molecular thin films. Although s-SNOM is commonly already based on intermittent-contact atomic force microscopy (AFM), the enabled compatibility with numerous advanced scanning probe modalities

• force–distance spectroscopy to create a multimodal dataset of material and optical properties of nanoscale heterogeneous soft matter. Using a single AFM/s-SNOM setup and a metallized scanning probe tip, we produced images of a particular 500 × 500 nm size region of a PS-b-PMMA film via IR s-SNOM and

In situ observation of deformation processes in nanocrystalline face-centered cubic metals

• Aaron Kobler,
• Christian Brandl,
• Horst Hahn and
• Christian Kübel

Beilstein J. Nanotechnol. 2016, 7, 572–580, doi:10.3762/bjnano.7.50

• ncPda (dA = 25 nm) and ncAuPda (dA = 26 nm). Both systems have a multimodal distribution with peaks in the small angle regime (<10°), a ≈39° regime (Σ9-rotation), and a ≈60° twin regime (Σ3-rotation) (a similar distribution has been found in two other Pd–Au systems not shown here). The small angle

High-bandwidth multimode self-sensing in bimodal atomic force microscopy

• Michael G. Ruppert and
• S. O. Reza Moheimani

Beilstein J. Nanotechnol. 2016, 7, 284–295, doi:10.3762/bjnano.7.26

• to strain sensitivity. The applicability of the multimodal self-sensing principle is verified by bimodal AFM experiments to obtain qualitative phase contrast on the higher eigenmode when imaging a soft polymer blend. Modeling Piezoelectric constitutive laws By sputtering a piezoelectric layer to the

3D solid supported inter-polyelectrolyte complexes obtained by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate)

• Eduardo Guzmán,
• Armando Maestro,
• Sara Llamas,
• Jesús Álvarez-Rodríguez,
• Francisco Ortega,
• Ángel Maroto-Valiente and
• Ramón G. Rubio

Beilstein J. Nanotechnol. 2016, 7, 197–208, doi:10.3762/bjnano.7.18

• layers obtained by the layer-by-layer method. A multimodal characterization showed the absence of stratification of the films formed by the alternate deposition of poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Indeed the final organization might be regarded as three

A simple and efficient quasi 3-dimensional viscoelastic model and software for simulation of tapping-mode atomic force microscopy

• Santiago D. Solares

Beilstein J. Nanotechnol. 2015, 6, 2233–2241, doi:10.3762/bjnano.6.229

• modified to implement other controls schemes in order to aid in the interpretation of AFM experiments. Keywords: atomic force microscopy (AFM); modeling; multifrequency; multimodal; polymers; simulation; spectroscopy; standard linear solid; tapping-mode AFM; viscoelasticity; Introduction The

High sensitivity and high resolution element 3D analysis by a combined SIMS–SPM instrument

• Yves Fleming and
• Tom Wirtz

Beilstein J. Nanotechnol. 2015, 6, 1091–1099, doi:10.3762/bjnano.6.110

• of the TiCN cermet. Keywords: alloy; atomic force microscopy (AFM); correlative microscopy; differential sputtering; in situ; multimodal imaging; nano-cluster; polymer blend; secondary ion mass spectrometry (SIMS); scanning probe microscopy (SPM); SIMS artefacts; sputter-induced effects; sputter

• rate; Introduction With the progress of miniaturisation, driven by future needs in various fields in materials and life sciences, the 3D analysis of devices and material structures becomes increasingly challenging. As a consequence, the interest for performing bimodal or even multimodal nano-analysis

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

• applications for diagnosis and therapy of disease sites. Through smart and careful chemical modifications of the nanoparticle surface, these can be converted to multifunctional tiny objects which in turn can be used as vehicle for delivering multimodal imaging agents and therapeutic material to specific target

• sites in vivo. In this sense, bimodal imaging probes that simultaneously enable magnetic resonance imaging and fluorescence imaging have gained tremendous attention because disease sites can be characterized quick and precisely through synergistic multimodal imaging. But such hybrid nanocomposite

• stages of growth and, thus, plays an integral part in medical diagnosis. All the currently available diagnostic imaging methods have their intrinsic advantages and disadvantages. The combination of multimodal imaging and theranostics will lead to cutting-edge technologies in which the potential of the

Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization

• Lisa Landgraf,
• Ines Müller,
• Peter Ernst,
• Miriam Schäfer,
• Christina Rosman,
• Isabel Schick,
• Oskar Köhler,
• Hartmut Oehring,
• Vladimir V. Breus,
• Thomas Basché,
• Carsten Sönnichsen,
• Wolfgang Tremel and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2015, 6, 300–312, doi:10.3762/bjnano.6.28

• form double-sided asymmetric shapes right up to nanoflowers offers the possibility for multimodal imaging and multiple drug loading without steric hindrance [28][29][30][31]. These nanoparticles are very new in the field of nanomedicine and poorly investigated despite their interesting features

High-frequency multimodal atomic force microscopy

• Adrian P. Nievergelt,
• Jonathan D. Adams,
• Pascal D. Odermatt and
• Georg E. Fantner

Beilstein J. Nanotechnol. 2014, 5, 2459–2467, doi:10.3762/bjnano.5.255