Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• solid choice to prevent massive implant degradation. Carbon nanomaterial coatings can prevent adverse chemical reactions triggered by both the adsorption of proteins and the metabolism of cells [151][152][153]. Hassan et al. [97] extensively investigated the effect of graphene and graphitic coatings as

Entry of nanoparticles into cells and tissues: status and challenges

• Kirsten Sandvig,
• Tore Geir Iversen and
• Tore Skotland

Beilstein J. Nanotechnol. 2024, 15, 1017–1029, doi:10.3762/bjnano.15.83

• proteins, including dominant-negative mutants, may, due to their high concentration, facilitate low-affinity interactions with partner proteins that they normally would not bind to. Furthermore, we have the challenge that a given molecule can be involved in more than one pathway. For instance, cdc42 is

• . However, if binding to the cell surface and cross-linking plasma membrane lipids or proteins, they may even induce their own uptake [61][62]. For instance, cross-linking of receptors by quantum dots (QDs) with Tat proteins can induce Rac activation and macropinocytosis [61]. Similarly, cross-linking

• (PEG) chains (e.g., density and chain lengths) and how these chains affect the binding of proteins to the NPs. The protein corona most often contains proteins involved in complement activation, macrophage uptake, lipid metabolism, and blood coagulation [82][83][84][85]. A challenge regarding the

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• to detect a wide range of biomolecules, such as proteins, DNA, and antibodies. This article presents a comprehensive review of advancements in the architectures of FET-based biosensors aiming to enhance device performance in terms of sensitivity, detection time, and selectivity. The review

• beneficial [18]. Additionally, biosensors have been used to detect SARS-CoV-2, which causes COVID-19-related severe respiratory distress [19][20]. For the accurate detection of COVID-19 RNA [21][22], proteins [23][24], and virus particles [25][26], various methods have been proposed, such as CRISPR systems

• biosensors for accurate detection of viruses [25], cancer [15], proteins [36], DNA, glucose [17], and nucleic acids has been strongly developed [37]. On the other hand, specific biomolecule classifications by microbiologists has led to the realization and development of different biosensors, significantly

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• system. A zero charge or a slightly negative charge on the nanoparticles would prevent them from aggregating and interacting with blood proteins [43]. Our nanoparticles’s zeta potential in ten-time diluted PBS was −84.3 ± 2.5 mV and −77.4 ± 3 mV for F127-folate@PLGA/CHL/IR780 and F127@PLGA/CHL/IR780

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• , antibiotics, anticancer agents, proteins, DNA, RNA, and growth factors for tissue regeneration [6][7][8]. In addition, nanofibers as drug delivery systems provide rapid or delayed and controlled release of pharmaceuticals. Apart from being implantable drug delivery systems, nanofiber scaffolds can contribute

• bone [16]. The most dominant component of the organic matrix is collagen, which is synthesized by osteoblasts and performs many mechanical functions. Collagen is a protein found abundantly not only in bones but also in almost every tissue of mammals. One third of all body proteins are collagens [20

• , which is closely related to mineralization, other non-collagenous organic proteins such as osteonectin and osteopontin, as well as proteoglycans [10][12][22]. The cellular structure of bone tissue Bone, a living tissue, is constantly changing with the help of cells playing different roles. There are a

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• because of their enhanced reactivity, large surface area, and tunable properties [7][8]. ENMOs can enter the human body [9] and engage with various biomacromolecules, including sugars, lipids, proteins, and nucleic acids. These biomolecules rapidly envelop the nanoparticle surface, creating a dynamic

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• through edge effects. Edge-functionalized GQDs have oxygen-containing functional groups such as hydroxy, carboxyl, carbonyl, and epoxy groups, which can conjugate to various biological/organic/inorganic molecules such as proteins, antibodies, or metal ions [12]. The capability of electron transfer/energy

Functional fibrillar interfaces: Biological hair as inspiration across scales

• Guillermo J. Amador,
• Brett Klaassen van Oorschot,
• Caiying Liao,
• Jianing Wu and
• Da Wei

Beilstein J. Nanotechnol. 2024, 15, 664–677, doi:10.3762/bjnano.15.55

• detecting the presence and alteration of chemicals [142], which differs from the way hairs sense touch and vibration. The binding of receptor proteins on sensory cells to chemicals in the air or solution initiates a sequence of biochemical reactions, resulting in the production of electrical signals, which

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• proteins, n(cd2) = 7 cell lines (SH-SY5Y, CHO-K1, HEK293, PC-12, CHO, HEK-293T, and HuT78), and n(cd3) = 7 model organisms (Homo sapiens, Rattus norvegicus, Mus musculus, Cavia porcellus, Canis lupus familiaris, Macacafas cicularis, and Caenorhabditis elegans). The information downloaded from ChEMBL also

• two different partitions (subsets) of variables cI and cII. The partition cI defines the biological characteristics; it contains, among other things, cd0 = biological activity parameters of NDDs (e.g., IC50, Ki, potency, and time) and cd1 = type of proteins involved in the NDs. The partition cII

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• cells, BNZ is reduced by oxygen-sensitive nitroreductases. During its anaerobic nitro reduction, primarily in the hepatic microsomal fraction, BNZ generates reactive metabolites that bind to the host’s DNA, proteins, and lipids. The nitro reduction also occurs in fecal matter, with an intensity that

• proteins, and prematurely release their cargos; also, they are phagocytosed by circulating monocytes or tissue macrophages to be degraded. This gives rise to the emergence of new modes of toxicity, including hemolysis, inflammation, oxidative stress, and impaired lysosomal or mitochondrial function. In the

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• protein corona. The formation of a protein corona on the surface of NPs, which influences the interaction with cell membranes or proteins, is also associated with zeta potential and surface charge. Very limited studies have reported the influence of zeta potential, surface charge, hydrophobicity, and

• enhance the catalytic activity of Fenton/Fenton-like reactions, but can also result in cellular damage [16]. ROS can break down the basic components of the cell, including DNA, proteins, and lipids. ROS can cause double-strand breaks in DNA by converting guanine to 8-oxoguanine. This conversion can lead

• to mispairing with adenine, resulting in transversion mutations. Proteins can also be damaged when their amino acid side chains are oxidized by ROS. Exposure of lipids to ROS can result in lipid peroxidation, which can cause cell damage and generate reactive by-products that further damage the cell

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• modelling of the interaction between various surfaces, that is (100), (110), and (111), of fcc aluminum with the most abundant milk proteins and lactose. Our approach combines atomistic molecular dynamics, a coarse-grained model of protein adsorption, and kinetic Monte Carlo simulations to predict the

• protein corona composition in the deposited milk layer on aluminum surfaces. We consider a simplified model of milk, which is composed of the six most abundant milk proteins found in natural cow milk and lactose, which is the most abundant sugar found in dairy. Through our study, we ranked selected

• proteins and lactose adsorption affinities based on their corresponding interaction strength with aluminum surfaces and predicted the content of the naturally forming biomolecular corona. Our comprehensive investigation sheds light on the implications of aluminum in food processing and packaging

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• DLS and PDI increased to approx. 280 nm and 0.24, respectively. The NPs were still well dispersed in cell culture media; however, the size increase suggested the adsorption of FBS proteins onto the NPs. The SEM results (Figure 1B) showed the actual size of the nanoparticles, which had a round shape of

• -life. When NPs are administered, they come into contact with blood cells and plasma proteins, which may cause adsorption or opsonization by serum proteins [35]. However, these proteins will have a reduced probability of interacting with our negatively charged nanoparticles, as most proteins are

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• were purchased from Sigma-Aldrich. Vinyltriethoxysilanes, tert-butyl hydroperoxide (TBHPO), and urea were purchased from Tokyo Chemical Industry, Japan. Removal of proteins from natural rubber According to the method reported in [24], deproteinization of HANR was carried out using urea as a denaturing

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• at 1000 mg/L. Conversely, at a concentration of 2000 mg/L, ZnO NPs significantly reduced soluble proteins and increased IAA levels, indicating toxicity and physiological stress. Plants treated with a dose of 10,000 mg/L exhibited wilting and yellowing by day 18 and did not survive until day 45. A

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• sublethal doses can cause alterations in parasite tegument [85]. Bee venom comprises various pharmacologically active components, including melittin (constituting more than 50% of total proteins) and a mixture of enzymes, cell-lytic peptides, proteases, and bioactive amines [86]. This mixture has

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• ]. These properties can even be controlled by an external signal [17][18][19]. PDA NPs are formed upon oxidation in dopamine (DA) solutions with additives such as surfactants, polyelectrolytes, and proteins [14]. Eumelanin-like NPs with a diameter less than 20 nm have been obtained by this method. The

• structure of these albumin/PDA NPs has not been elucidated completely. It has been demonstrated that proteins are present in the NPs’ shell; they might also be present in the core (Figure 1d). Nevertheless, their potential both for fluorescent labelling of alive bacterial cells and as nanovector for

• between DA and BSA, which contains the KE diad and allows for the control of the NP formation [13]. During the synthesis, DA is added into the BSA solution, thus avoiding that the proteins come into contact with already formed PDA. Bergtold et al. proposed that the size control is exerted by the specific

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• pharmacokinetic drawbacks such as poor water solubility resulting in low bioavailability, low absorption, rapid metabolism, and elimination [6][7]. The reported solubility of free CUR in distilled water at 25 °C is 1.34 µg/mL [8]. The conjugation of CUR with proteins has been confirmed to improve its aqueous

• Na2CO3 solutions in the presence of albumin [26][27]. This approach has been shown to have high effectiveness for entrapping various biopolymers (e.g., proteins and hemoglobin) into carbonate particles before dissolving with EDTA to obtain pure biopolymer submicron particles. The CCD technique is a

• albumin proteins [30]. CUR showed strong binding affinity towards HSA, likely at the tryptophan residue, which is present in the hydrophobic cavities of HSA [23][31]. The final CUR-HSA-MPs are obtained after dissolution of the MnCO3 template with EDTA. Characterization of CUR-HSA-MPs Dynamic light

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• scavenging and consecutive increase in peripheral vascular resistance. Whether binding between cell surface proteins and Hb/HBOC can occur, and how high the corresponding affinity is, probably depends on modifications made to Hb. Intramolecular crosslinking has an impact, depending on whether the binding

• × 1015 molecules/mL. The average Hpx serum concentration of 0.6 g/L corresponds to 4.5 × 1015 molecules/mL. Thus, the dose of 60 g HBOC 201 is sufficient to bind the available Hp and Hpx, allowing subsequent doses of HBOCs to remain in circulation until these proteins are replenished. In case of infusion

• since both proteins are specific for monocytes. CD163 was tested because of its direct affinity to Hb. Also, we tested the effect of blocking CD204 (scavenger receptor A/SR-A). SR-A is a membrane protein occurring in the monocyte/macrophage lineage. Playing an important role in host defense, it exhibits

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• active targeting via the functionalization of ligands, such as antibodies or proteins, that interact with receptors overexpressed at the target site [5][6]. However, the movement of NPs is hampered by biological barriers such as endothelial, cellular, skin, and mucosal barriers, which obstruct their

• targeting capabilities [7]. Researchers focused their interest on understanding the obstructions that impede targeted drug delivery, and several advances have been made to develop NPs with enhanced ability to cross these barriers. Bio-pharmacological drugs, which include recombinant proteins, monoclonal

• NPs specifically bind to the cell surface proteins and deliver the drug cargo to tumor sites via passive or active targeting. As a result, the therapeutic ratio is improved. At the same time, the systemic toxicity is reduced and the therapeutic efficacy is increased [13]. Antibody-conjugated NPs

Biomimetics on the micro- and nanoscale – The 25th anniversary of the lotus effect

• Matthias Mail,
• Kerstin Koch,
• Thomas Speck,
• William M. Megill and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 850–856, doi:10.3762/bjnano.14.69

• biological processes and surface interactions involved in the bioselective adhesion of mammalian cells. The second topic of the review was on repellence of microbes on protein-based material surfaces, highlighting the importance of materials made of recombinant spider silk proteins. Biomaterials that

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• intrinsic toxicity of our nanoscale vehicle on T. cruzi may be linked to a modification of glycosylphosphatidylinositols (GPIs). Glycosylphosphatidylinositols are the main anchor complexes used by protozoans to bind to cell surface proteins. It covalently attaches to the C terminus of a protein connecting

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• antibacterial properties can serve as a source of silver ions. Another mechanism involves the electrostatic attraction between negatively charged microbial cells and positively charged AgNPs [25]. Because of their affinity to sulfur proteins and through electrostatic attraction, silver ions can bind to both

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

• , proteins, aptamers, and immunoglobulins) to realise an analyte-specific reaction. Because of their modification with biomolecules, some electrochemical biosensors have shown higher specificity and selectivity than unmodified electrochemical sensors; nevertheless, they have shorter lifetimes and poorer

Suspension feeding in Copepoda (Crustacea) – a numerical model of setae acting in concert

• Alexander E. Filippov,
• Wencke Krings and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 603–615, doi:10.3762/bjnano.14.50

• -resolution CLSM imaging or atomic force microscopy. As it was visualized by CLSM [55][56][57], the basal parts of some short and long setae appear to be relatively soft and seem to contain resilin or other proteins. This should influence the mobility of the rotating setae. To account for this in the