Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

• to less efficient binding with protein targets that would work as ligands for receptor-mediated transport and delivery, finally resulting in partial inhibition and reduction of cellular uptake ([24]). Taken into consideration all aforementioned, it can be summarized that cellular transport and

Capabilities of the 3D-MLSI software tool in superconducting neuron design

• Irina E. Tarasova,
• Nikita S. Shuravin,
• Liubov N. Karelina,
• Fedor A. Razorenov,
• Evgeny N. Zhardetsky,
• Aleksandr S. Ionin,
• Mikhail M. Khapaev and
• Vitaly V. Bol’ginov

Beilstein J. Nanotechnol. 2026, 17, 122–138, doi:10.3762/bjnano.17.8

• dielectric layers are planarized, as is done, for example, in the process described in [6]. One more important feature of the program is non-uniform meshing related to the Triangle meshing engine [52]. It allows for a reduction of allocated memory and solution time, and provides better accuracy as well

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• CCR cell line, the IC50 values for immunoliposomes were higher than those for liposomes. Also, for phototoxicity experiments it was found a reduction in IC50 for all groups tested. The internalization of R-PE was verified, highlighting a greater internalization in the immunoliposome within 24 h. Thus

• potential application in cancer treatment, ranging from in vitro cell programmed death induction in the liver, lung, and gastric cancer cells [12] to in vivo reduction in nodule number and liver weight in rats [13]. In addition, R-PE also has a photosensitizing role that can be explored in photodynamic

• slight reduction in vesicle size compared to previous reports can be possibly due to the presence of DSPE–PEG [34]. The incorporation of hydrophilic molecules into liposomal formulations does not necessarily result in an increase in vesicle size [42]. For instance, liposomes composed of HSPC 50 and

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• . However, since the bulk-modified samples exhibited a more compact microstructure, mechanical tests resulted in an increased compressive strength for these samples, suggesting stronger structural reinforcement, an improved heat resistance, and a reduction in open pores and surface area, contributing to

Subdigital integumentary microstructure in Cyrtodactylus (Squamata: Gekkota): do those lineages with incipiently expressed toepads exclusively exhibit adhesive setae?

• Philipp Ginal,
• Yannick Ecker,
• Timothy Higham,
• L. Lee Grismer,
• Benjamin Wipfler,
• Dennis Rödder,
• Anthony Russell and
• Jendrian Riedel

Beilstein J. Nanotechnol. 2026, 17, 38–56, doi:10.3762/bjnano.17.4

• species showing secondary reduction of setae in the seta-group (C. pharbaungensis and C. zebraicus), which show no increase or secondary reduction in these measurements. The seta-bearing intertidal species, C. seribuatensis, did not exhibit a reduction of these traits. Only the terrestrial C

• . brevidactylus Bauer, 2002 [66], the karst species C. chrysopylos Bauer, 2003 [67] (both sharing the prong microstructure type with the khasiensis group of which they are a part), and the terrestrial, spine-bearing C. jeyporensis (triedrus group) did not show a reduction or an increase (C. brevidactylus for

• evolved setae independently from all other species, is isolated in its morphospace, having the lowest value on PC1 for seta-bearing species (Figure 4B). Furthermore, one secondary reduction from setae back to spines (C. zebraicus) and prongs (C. pharbaungensis) is indicated. The PMS analysis shows that

Reduced graphene oxide paper electrode for lithium-ion cells – towards optimized thermal reduction

• Agata Pawłowska,
• Magdalena Baran,
• Stefan Marynowicz,
• Aleksandra Izabela Banasiak,
• Adrian Racki,
• Adrian Chlanda,
• Tymoteusz Ciuk,
• Marta Wolczko and
• Andrzej Budziak

Beilstein J. Nanotechnol. 2026, 17, 24–37, doi:10.3762/bjnano.17.3

• electrode material in lithium-ion cells. Mildly reduced graphene oxide paper underwent further thermal reduction steps. The structural and chemical properties of the obtained materials were determined using Raman and Fourier-transform infrared spectroscopies and elemental combustion analysis. The morphology

• . Keywords: electrode material; graphene paper; lithium-ion batteries; reduced graphene oxide; thermal reduction; Introduction Electrode materials comprising reduced graphene oxide (rGO) for energy storage in lithium-ion-based or sodium-ion-based technologies have been the subject of over 3800 publications

• with the oxygen in the ketone groups and the electrons from the external circuit, creating Li-terminated chains. From a practical point of view, it is crucial to ensure an increased number of ketone groups by optimizing the reduction process of graphene oxide. Acik et al. presented a detailed

Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy

• Aydan Çiçek,
• Markus Kratzer,
• Christian Teichert and
• Christian Mitterer

Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1

• displaced, vanishing from one scan line to the other. The corresponding 3D image in Figure 2e indicates a change in the NP’s position relative to the substrate. The reduction in height from 7 to 5 nm is interpreted as the initial stage of NP displacement, where the particle starts moving before the tip has

• partial penetration, removal, or reduction cannot be excluded. We did not detect changes in the roughness between pristine and plasma-treated surfaces (RMS < 0.2 nm at 5 × 5 µm area) that would contribute to a change in friction. Interfacial redox reactions between the copper NP and the wafer surface

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• ± 1.7, and 45.0 ± 1.2 nm exhibited Ms values of 0.012, 0.031, 0.12, and 7 A·m2·kg−1, respectively (Table 3). Similar trends have been reported in the literature, where larger particle sizes lead to higher Ms values due to the reduction of surface spin canting and the improved alignment of magnetic

Geometry-controlled engineering of the low-temperature proximity effect in normal metal–superconductor junctions

• Munisa A. Tomayeva,
• Vyacheslav D. Neverov,
• Andrey V. Krasavin,
• Alexei Vagov and
• Mihail D. Croitoru

Beilstein J. Nanotechnol. 2025, 16, 2265–2273, doi:10.3762/bjnano.16.155

• time, the coupling between these confined modes on the NM side and the continuum modes on the SC side weakens because of increasing momentum mismatch, which suppresses the transmission probability of the channels through the interface. Together, the reduction in channel number and the suppressed

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• ][101][102]. When the localized surface plasmon resonance of metal seeds is excited, hot electrons reduce Ag+ or from solution and deposit metallic Ag and Au. However, various studies in the past two decades on the plasmon-mediated reduction of Ag(I) and Au(III) have demonstrated a weak dependence of

• distribution of PVP. Ag(I) and Au(III) reduction potentials suggest their reduction is relatively not energetically demanding. (AgCl/Ag: 0.80 V vs SHE and /Au: 0.99 V vs SHE) [101]. As discussed in Section 2.1, these reactions can be triggered by warm electrons far from the hot spots. Indeed, [101] inferred

• that the sites of Au deposition ( reduction) are the locations of electrons from the nanoparticle transferred via PVP. Researchers made similar observations when electron beam lithography resist was exposed to hot electrons from AuNRs [86]. This study found hydrogen silsesquioxane underwent water

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• ), and fatigue reduction [2][36]. VB12 deficiency represents a significant global public health concern, impacting approx. 6% of the global population and 1.6% to 10% of European communities [37]. The different demographic data showed that the most vulnerable groups to VB12 deficiency comprise geriatric

Electromagnetic study of a split-ring resonator metamaterial with cold-electron bolometers

• Ekaterina A. Matrozova,
• Alexander V. Chiginev,
• Leonid S. Revin and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2025, 16, 2199–2206, doi:10.3762/bjnano.16.152

• bandwidth. The trade-off between the bandwidth expansion due to miniaturization and the reduction in absorption efficiency determined by the Airy spot size of the coupling lens is investigated. To solve this issue, a simultaneous miniaturization of the size of the entire structure with an increase in the

• transition from a single-ring antenna to a double split-ring resonator design, while keeping the number of elements constant, resulted in a significant improvement in performance. The addition of the inner ring, which increases the total capacitance of the resonant element, leads to a slight reduction of the

• are governed by the requirement to fill the Airy spot of the silicon lens. If the total array size is smaller than the Airy spot, a portion of the incident signal will not interact with the metamaterial, instead scattering into the surrounding space. Our simulations confirm this principle: A reduction

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• on the selected single particles (Figure 7, see also related scans in Supporting Information File 1, Figure S4). The particle height of 16.7 ± 1.6 nm increases by 0.3 nm under medium and by 1.6 nm under high humidity. The PEG AuNPs of 13.3 ± 1.0 nm show an apparent slight reduction by 0.3 nm, but

• organic content). Synthesis of gold nanoparticles Gold nanoparticles were synthesized by the Bio Nano Plasmonics Lab at CIC biomaGUNE according to [10]. Both PEG AuNPs and dimanno-AuNPs were obtained by reduction of AuCl4− with BH4− in the presence of the corresponding thiol ligands. For the PEG AuNPs, a

Hartree–Fock interaction in superconducting condensate fractals

• Edward G. Nikonov,
• Yajiang Chen,
• Mauro M. Doria and
• Arkady A. Shanenko

Beilstein J. Nanotechnol. 2025, 16, 2177–2182, doi:10.3762/bjnano.16.150

• the system’s quasiperiodicity, reflecting a general feature of superconducting quasicrystals. The enhancement of these oscillations leads to a reduction of the critical temperature, which can be pronounced depending on the model’s microscopic parameters. We also find that the critical exponent β of

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• been compared with rivers in temperate zones, where improved waste management systems cause a reduction in MP accumulation. According to Bhaduri et al., this disparity reflects how essential cooperating waste management policies and plans are in the Himalayas to prevent MP pollution [25]. Matta et al

• Treaty with an aim to constitute legally binding plastic reduction instruments along with MP reduction. Consequently, the European Union (EU) also deliberately limited incorporated MPs in the EU Microplastic Restriction Proposal of the REACH regulation of cosmetics, cleaning products, and agricultural

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• difference (p < 0.05) in pH compared with earlier time points. Although the reduction was modest, from pH 6.4 ± 0.1 to 5.9 ± 0.3, it is hypothesized to result from a combination of physicochemical and microbiological factors [42]. One possible explanation involves the oxidative or hydrolytic degradation of

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• infections dominated by this pathogen. However, their relatively weaker activity against E. coli and B. subtilis suggests that optimization may be necessary to broaden their spectrum through surface modification, particle size reduction, or combination with other antibacterial agents. Cytotoxicity of AgSbS2

Calibration of piezo actuators and systems by dynamic interferometry

• Knarik Khachatryan and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 2086–2091, doi:10.3762/bjnano.16.143

• thickness, respectively. According to the widely used convention, the piezo tube is poled so that a negative potential applied to the inner electrode Vz,f < 0 results in an extension ΔL > 0 that translates into a reduction of the cavity length Δd = derr = −ΔL < 0. From d31 and the geometry parameters of the

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• a notable influence on the characteristics of the resultant nanofibers. A reduction in the needle-to-collector distance from 15 (Figure 4D) to 12 cm (Figure 4B) resulted in a significant increase in the average fiber diameter, from 250 ± 74 to 439 ± 100 nm. This phenomenon is likely associated with

• an HA core compared to the monolithic PLA fibers. The prominent peaks, centered at approximately 2θ = 13°, 16°, and 19°, appeared broadened and merged when the amorphous HA core was incorporated. This reduction in crystallinity, resulting from an increase in amorphous regions within the material, may

• high hydrophobicity of this polymer. In cases where not all the hydrophilic core content is fully coated by the shell, a reduction in membrane hydrophobicity is observed due to the presence of hydrophilic nanofibers [77]. Surface hydrophilicity assays revealed that the produced nanofibers exhibit high

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• low to melt the particles, the shape transformation can be induced using photochemical processes. However, in this case, the addition of precursors, reducing, and stabilizing agents is required. The pristine NPs that are present in the solution act as seeds, while photoinduced reduction occurs at

• nanofibers has been shown to occur via anisotropic growth, using the fibrous products of the organic precursor decomposition for self-templating, which guides the following processes of reduction of silver ions at their surface. The concentration of the organic precursor further influences the shape

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• -based LNPs formulated with varying DMPE-PEG2k content from 1 to 5 mol %, changes were observed in nanoparticle diameter, polydispersity index (PDI), surface charge, and payload encapsulation efficiency (EE%). Increasing the PEG lipid content led to a reduction in the hydrodynamic diameter of LNPs, with

• . Intravenous injection at 0.3 mg·kg−1 further validated the efficacy of these functionalized pLNPs. RVG29 and AP2 pLNPs achieved nearly 70-fold increases in brain transfection, while mApoE pLNPs demonstrated significant tropism shift from liver to spleen. A liver luminescence reduction from over 90% to 25% was

• primed for a heightened response. As illustrated in Figure 5, anti-PEG antibodies can rapidly neutralize PEGylated nanoparticles, triggering the accelerated blood clearance (ABC) phenomenon [4][69]. This effect is characterized by a dramatic reduction in circulation time for subsequent doses, often

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• development and contributing to the reduction of the adult mosquito population. Ovicidal activities are also reported, which prevent eggs from hatching, interrupting the life cycle of the vector. Furthermore, essential oils exhibit repellent properties that keep mosquitoes away, reducing the incidence of

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• stiffness values of the order of 100 N/m to avoid the tip jumping to contact and sticking to the surface [21]. Such a stiffness would necessitate seven orders of magnitude improvement in detector noise to achieve an equivalent force sensitivity. Reduction of detection noise is therefore critical for

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• during the biosynthesis of metallic nanoparticles [34][35]. For instance, plants from the Lamiaceae family (e.g., Ocimum spp., Rosmarinus officinalis, and Salvia rosmarinus) are extensively documented for their abundant polyphenols such as rosmarinic acid and caffeic acid, which facilitate the reduction

• structural, optical, and chemical properties. FTIR enables the identification of functional groups involved in the reduction and stabilization of nanoparticles, typically derived from phytochemicals in plant extracts used as reducing agents [52][56]. UV–vis spectroscopy is widely employed to monitor

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• evaluated, only the zeta potential showed a significant reduction at day 30 (p < 0.05), while no significant changes were observed in the other parameters, as shown in Figure 2a,b. Similarly, the formulations maintained their stability under all centrifugation conditions and time points analyzed, as

• fully confirm the long-term stability and therapeutic reliability of the formulation. Additionally, the presence of glycerin as a co-solvent may have contributed to the reduction in interfacial tension and improved droplet uniformity, factors known to enhance long-term stability [41]. Importantly, the

• evaluate the leishmanicidal potential of these nanoemulsions. As PHYT-NE concentrations and exposure times increased, the leishmanicidal activity also improved. Importantly, this formulation did not induce a reduction in cell viability sufficient to indicate cytotoxicity to 3T3 cells, even at the highest