Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• of chemotherapy with PCX. A promising step was taken with the FDA approval of albumin nanoparticle bound PCX (Abraxane®) in 2005 for breast cancer treatment with a significantly lower dose [8]. This was considered a breakthrough in PCX formulation development as it avoided the use of solubilizers

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• mostly additive to partly synergistic induction of the cell death rate (Table 1). Discussion In addition to surgery and radiotherapy chemotherapy is the third pillar in cancer treatment. In PCa, systemic chemotherapy with DTX is mainly applied for the treatment of advanced PCa stages, whereas neoadjuvant

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

• Isabella Tavernaro,
• Christian Cavelius,
• Henrike Peuschel and
• Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

• drug carriers [3][4][5], as transfection agents [6][7], for cancer treatment by local hyperthermia [8][9], for labelling [10][11] and for bioimaging [12][13][14]. The detection of cell-associated and internalised nanoparticles and the analysis of their interactions with extracellular or subcellular

3D Nanoprinting via laser-assisted electron beam induced deposition: growth kinetics, enhanced purity, and electrical resistivity

• Brett B. Lewis,
• Robert Winkler,
• Xiahan Sang,
• Pushpa R. Pudasaini,
• Michael G. Stanford,
• Harald Plank,
• Raymond R. Unocic,
• Jason D. Fowlkes and
• Philip D. Rack

Beilstein J. Nanotechnol. 2017, 8, 801–812, doi:10.3762/bjnano.8.83

• detection [4], the study of biological systems important in determining cancer treatment options [5], and reliable, low cost, high performance magnetic hard disk drives [6]. A variety of fabrication techniques have been used to construct multi-dimensional nanostructures [7][8][9][10] with differing degrees

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• as well as DNA damage by the inhibition of topoisomerase II [1][2]. However, the second mechanism involving the increased production of ceramides inside cells has been recently postulated [3]. Application of this drug in the cancer treatment is limited because of serious side effects including drug

Simultaneous cancer control and diagnosis with magnetic nanohybrid materials

• Reza Saadat and
• Franz Renz

Beilstein J. Nanotechnol. 2016, 7, 121–125, doi:10.3762/bjnano.7.14

• detect cancer tissue with radiopharmaceuticals. By substitution of the Ga isotope with an alpha emitter the same compound could be used for cancer treatment. Furthermore the nanoparticles were connected to pH-sensitive complexes, enabling a pH-controlled assembly/disassembly and therefore the spreading

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• quantitative data (i.e., numerical values for different characterization parameters) associated with a specific class of dendrimer, poly(amidoamine) (PAMAM), which shows promise for cancer treatment. PAMAM dendrimers are three-dimensional, highly-branched, polymeric ENMs synthesized by growing shells of

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• nanocarriers for vitamin D3 delivery towards cancer treatment. Vitamin D3 vectorisation to guarantee specific action on malignant cells that avoids side effects such as hypercalcemia has been proposed. Nguyen et al. developed a formulation based on poly(vinyl neodecanoate-crosslinked-ethyleneglycol

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• compared to ZnO NP. We were able to show that the effect of ZnO NPs was improved by the formation of ZnO:Ag nanocomposites thereby improving their cell killing ability. Daylight-photodynamic therapy can provide a basis for targeted cancer treatment. However, further studies are required to evaluate the

Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• particles used for catalysis [52][63][64], drug delivery [65], bimodal bioimaging [36][66][67][68], and biomedical applications [69][70] such as cancer treatment [71] are dumbbell-like Au@Fe3O4 nanoparticles. As no ternary Au-Fe-O phase or a gold oxide is present under the experimental conditions, there is

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• near-infrared region as a photothermal agent for in vivo cancer treatment, while scrutinising the effects originating from different graphene sizes and coatings [97]. Several research groups have focused on graphene as biosensors. Dey et al. [98] developed an amperometric cholesterol biosensor; Tang

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• , electronics, chemical labeling, optics and sensors. [4][5][6][7][8]. Nanomaterials that are biocompatible have gained research interest for biomedical applications that include cancer treatment [9][10]. Consequently, one of the challenges in synthesizing nanoscale biocompatible materials is designing

Carbon dioxide hydrogenation to aromatic hydrocarbons by using an iron/iron oxide nanocatalyst

• Hongwang Wang,
• Jim Hodgson,
• Tej B. Shrestha,
• Prem S. Thapa,
• David Moore,
• Xiaorong Wu,
• Myles Ikenberry,
• Deryl L. Troyer,
• Donghai Wang,
• Keith L. Hohn and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2014, 5, 760–769, doi:10.3762/bjnano.5.88

• been developed [34][35][36][37][38][39][40][41]. The application of such materials in cancer diagnosis and cancer treatment, such as MRI and magnetic hyperthermia are intensively studied [42][43][44]. The use of iron-containing nanomaterials as catalysts for the methanol oxidation reaction [45], and

Effect of spherical Au nanoparticles on nanofriction and wear reduction in dry and liquid environments

• Dave Maharaj and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2012, 3, 759–772, doi:10.3762/bjnano.3.85

• include, but are not limited to, their use in targeted drug delivery and chemical sensors in the identification of oil, removal of contaminants and enhanced oil recovery (EOR). Au, iron oxide, polymer and silica nanoparticles have been studied in targeted drug delivery [3][4][5][6][7][8]. In cancer

• treatment, nanoparticles are either functionalized with biomolecules that recognize and attach to the cancer cells, [6][7] or in the case of iron-oxide nanoparticles, the nanoparticles are directed by an external magnetic field [9]. The cells are destroyed by drugs that coat the nanoparticles or by

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• to the tumor site is highly desirable in cancer treatment, because it is capable of minimizing collateral damage. Herein, we report the synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe3O4 magnetic nanoparticles (MNPs) and the topoisomerase I blocker SN38 bound

• the payload of tumor-homing double-stable RAW264.7 cells; (2) Release of chemotherapeutic SN38 at the cancer site by means of the self-containing Tet-On Advanced system; (3) Provide localized magnetic hyperthermia to enhance the cancer treatment, both by killing cancer cells through magnetic heating

• of hyperthermia with radiation therapy and chemotherapy can greatly improve the efficacy of cancer treatment [30][31]. Ultrasmall magnetic nanoparticles generate heat efficiently in an alternating magnetic field (AMF). Due to their superior properties, such as negligible or low toxicity