A nonenzymatic reduced graphene oxide-based nanosensor for parathion

• Sarani Sen,
• Anurag Roy,
• Ambarish Sanyal and
• Parukuttyamma Sujatha Devi

Beilstein J. Nanotechnol. 2022, 13, 730–744, doi:10.3762/bjnano.13.65

• , inhalation, or dermal penetration [3][4]. Due to its extreme toxicity, it is necessary that easy-to-use, cost-effective diagnostic kits for routine screening of pesticides in fruits and vegetables are developed. The high-throughput analytical methods such as chromatographic (gas, liquid) and spectroscopic

Fabrication and testing of polymer microneedles for transdermal drug delivery

• Vahid Ebrahiminejad,
• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2022, 13, 629–640, doi:10.3762/bjnano.13.55

• considerable potential for medical applications such as transdermal drug delivery, point-of-care diagnostics, and vaccination. These miniature microdevices should successfully pierce the skin tissues while having enough stiffness to withstand the forces imposed by penetration. Developing low-cost and simple

• safety for the current MN design demonstrated its potential for transdermal drug delivery and fluid sampling. Experimental results indicated significant penetration improvements using the prototype applicator, which produced array penetration efficiencies as high as >92%, depending on the impact velocity

• setting. Keywords: hot embossing; microneedles; penetration efficiency; thermoplastic polymers; two-photon polymerization; Introduction During the past two decades, MN devices have become a promising tool for transdermal drug delivery, vaccination, and point-of-care diagnostics [1][2]. MNs are a

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• microneedles are based on polymers such as PVA, PVP, chitosan, and poly(lactide-co-glycolide) [19]. In our study, polymer-based microneedles were optimized to achieve a formulation that can efficiently penetrate the skin. In this context, microneedles were studied regarding drug content and penetration of

• tip diameter. In a previous study, sharp tips with 5 µm tip diameter were required for smooth skin penetration, in contrast to needles with a larger tip diameter (15 µm or more), which showed sudden increase in depth after initial superficial penetration [30]. Moreover, in another study, the square

• base of the microneedles was shown to cause deeper penetration compared to hexagonal bases [31]. The shape of the microneedles in our study was faceted pyramidal due to the use of the pyramidal PDMS mold in the microneedle preparation. The faceted appearance of the CIP_MN1 and CIP_MN2 microneedles was

Design and characterization of polymeric microneedles containing extracts of Brazilian green propolis

• Camila Felix Vecchi,
• Rafaela Said dos Santos,
• Jéssica Bassi da Silva and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2022, 13, 503–516, doi:10.3762/bjnano.13.42

• into the biological substrate, it was observed that MNs with a diameter of 5 µm presented greater penetration power than MNs with larger diameters [42]. The MNs containing EE and GE displayed similar tip shapes and sizes as the MNs of this previous study, thus favoring penetration. Analysis of hardness

• force of the best formulations are displayed in Table 4. The MNs did not yield total penetration of PVC film, Parafilm M, and porcine skin; however, it was verified that the applied force was sufficient to mark the substrates. All evaluated formulations displayed penetration of the gelatin substrate

• resulted in lower mechanical strength [34]. In contrast, the presence of EE resulted in better structured MNs that were harder and had greater penetration capacity. In other studies using MNs composed of PVA, Carbopol 971P, and alginic acid, it was observed that with a force of 0.03 N or greater, most MNs

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

• Çiğdem Yücel,
• Gökçe Şeker Karatoprak,
• Sena Yalçıntaş and
• Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

• Application and Research Center, Kayseri, Turkey 10.3762/bjnano.13.41 Abstract Controlled release systems containing natural compounds have been successfully applied in cosmetics as antiaging products to enhance the penetration of active compounds through the skin. In this study, we aimed to develop novel

• these problems and enhance their effectiveness [13][14][15]. Upon application of various topical formulations, lipophilic drugs can easily penetrate into the skin, while hydrophilic drugs, such as EGCG, are limited in terms of penetration. The skin displays selective permeability for the penetration of

• many drugs. The stratum corneum in the epidermis, which is the top layer of the skin consisting of three layers, acts as an important barrier against penetration into the skin [9][16]. To overcome penetration limitations, various techniques such as penetration enhancers, phonophoresis, electroporation

Tunable superconducting neurons for networks based on radial basis functions

• Andrey E. Schegolev,
• Nikolay V. Klenov,
• Sergey V. Bakurskiy,
• Igor I. Soloviev,
• Mikhail Yu. Kupriyanov,
• Maxim V. Tereshonok and
• Anatoli S. Sidorenko

Beilstein J. Nanotechnol. 2022, 13, 444–454, doi:10.3762/bjnano.13.37

• . In this case, the spin-valve effect determines the efficiency of penetration of superconducting correlations into the current-carrying layer, which is the reason for the change in inductance. Appendix We present the derivation of Equation 2–Equation 4 in the framework of the resistively shunted

Relationship between corrosion and nanoscale friction on a metallic glass

• Haoran Ma and
• Roland Bennewitz

Beilstein J. Nanotechnol. 2022, 13, 236–244, doi:10.3762/bjnano.13.18

• be found in [21]. The lack of height contrast in Figure 3a is explained by penetration of the AFM tip into the soft outer layer surrounding the scan field. No height difference can be measured between the surrounding area, where the tip penetrates the outer layer, and the scan field, where the outer

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• biofilm inhibition and treatment [88][89][90]. The size of the nps impacts the diffusion into the extracellular polymeric substance matrix, with diameters up to 130 nm demonstrating deep penetration into biofilms. Moreover, positively charged nps exert greater biofilm penetration over anionic or uncharged

• drawback of using TiO2 as photosensitizer is the shallow penetration depth in tissues as it gets activated only by UV light; however, for deep penetration of light into tissues, the wavelength should be in the near-infrared (NIR) window (700–1100 nm) [111]. TiO2 nps can be retained in the body for more

• continuous layer of TiO2 on rare earth nanomaterials and found 50–60% cell destruction when illuminated with NIR light. The results show the penetration of the nanoconstruct into deep tissue tumors, and PEG makes them more biocompatible in conjunction with a strong therapeutic efficacy in vitro as well as in

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• imaging, on the other hand, has better sensitivity but suffers from limitations in the penetration depth in in vivo studies. However, it is quite successful in the preclinical research [43]. Hence, a combination of the two modalities provides many advantages. One of the approaches towards such structures

Nanoscale friction and wear of a polymer coated with graphene

• Robin Vacher and
• Astrid S. de Wijn

Beilstein J. Nanotechnol. 2022, 13, 63–73, doi:10.3762/bjnano.13.4

• indentation simulation with a load of 6.4 nN to determine the penetration depth after a long period of time (Figure 5). We observe only a slight increase in depth by around 1 Å between 1 and 4 ns. Thus, we consider the tip to be indented fully after 1 ns. We do note, however, that during sliding the tip sinks

• crumpled graphene sheet. The graphene layer affects the roughness and structure of the substrate. The penetration depth versus time for long indentations, and for the sliding process, for a tip with radius of 50 Å and load of 6.4 nN (4 eV/Å), on the flat graphene. The dashed line represents the time at

Sputtering onto liquids: a critical review

• Anastasiya Sergievskaya,
• Adrien Chauvin and
• Stephanos Konstantinidis

Beilstein J. Nanotechnol. 2022, 13, 10–53, doi:10.3762/bjnano.13.2

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• penetration and hemocompatibility which can be useful for biomedical applications [12][17]. Furthermore, in order to be exploited in biomedical applications, NPs need to fulfill certain criteria which include water solubility, excellent colloidal stability, biocompatibility, and high saturation magnetization

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• associated with modelling the 24 hpf endpoint might possibly reflect different systemic exposure routes and the failure of the descriptors to properly account for factors affecting dermal penetration. Whilst the experimental setup involved continuous waterborne exposure of the embryonic zebrafish to the ENMs

• dispersed in fish water medium and dermal penetration is typically observed as the main route of systemic exposure up to 120 hpf, the appearance of swallowing around 72 hpf allows for toxicity via an oral exposure route to manifest prior to 120 hpf but not at 24 hpf [31]. However, it is also possible that

• models developed here for excess lethality at 120 hpf and improved models for mortality at 24 hpf.) It is possible that our findings reflect the fact that toxicity up to 24 hpf requires dermal penetration to reach the site of biological action, since swallowing does not start until around 72 hpf [31

Nonmonotonous temperature dependence of Shapiro steps in YBCO grain boundary junctions

• Leonid S. Revin,
• Dmitriy V. Masterov,
• Alexey E. Parafin,
• Sergey A. Pavlov and
• Andrey L. Pankratov

Beilstein J. Nanotechnol. 2021, 12, 1279–1285, doi:10.3762/bjnano.12.95

• temperature. Figure 1 also shows the change in the Josephson junction characteristic length L/λJ, where is the Josephson penetration depth, which determines the size of a fluxon in the junction. Here μ0 is the vacuum permeability, Jc is the critical current density, and d = t + 2λL is the effective magnetic

• thickness with the junction barrier thickness t = 1.5 nm and the London penetration depth λL = 250–150 nm [38]. It can be seen from the figure that, for nitrogen temperatures, the Josephson junction can generally be considered as a short JJ. With the decrease in the temperature, its characteristic dimension

A new method for obtaining model-free viscoelastic material properties from atomic force microscopy experiments using discrete integral transform techniques

• Berkin Uluutku,
• Enrique A. López-Guerra and
• Santiago D. Solares

Beilstein J. Nanotechnol. 2021, 12, 1063–1077, doi:10.3762/bjnano.12.79

• sinusoidal stresses and strains. To analyze the case of an AFM tip penetrating a viscoelastic surface we need an equation relating force with sample penetration (indentation). Equation 1 and Equation 2 relate stress and strain but do not consider the geometrical aspects of our boundary value problem

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• microelectromechanical systems (MEMS) and provided a platform for microfabrication of compact miniaturized medical devices for human health screening, monitoring, and diagnostic purposes. Microneedles are microstructures that are sharp and robust enough for skin penetration, made using MEMS technology. The application

• micromoulding [5]. In addition to microneedles for skin penetration, these microstructures have also been used in other sites of the body including the delivery of bioactive drugs into the eyes [6] and the insertion of molecules into cells using nanoneedles [7][8]. The present article reviews applications

• and causing discomfort to the patient. Human skin penetration experiments have demonstrated the reduced pain associated with microneedle penetration and the effect has been quantified using the visual analogue scale (VAS), showing an approximately 90% reduction in pain for a microneedle penetrating

Progress and innovation of nanostructured sulfur cathodes and metal-free anodes for room-temperature Na–S batteries

• Marina Tabuyo-Martínez,
• Bernd Wicklein and
• Pilar Aranda

Beilstein J. Nanotechnol. 2021, 12, 995–1020, doi:10.3762/bjnano.12.75

• had important security and corrosion issues since sodium and sulfur are both liquid under the working conditions. Therefore, the applicability of HT Na–S batteries is limited to stationary deployment, and the operation temperature needs to be reduced in order to improve market penetration of Na–S

In situ transport characterization of magnetic states in Nb/Co superconductor/ferromagnet heterostructures

• Olena M. Kapran,
• Roman Morari,
• Taras Golod,
• Evgenii A. Borodianskyi,
• Vladimir Boian,
• Andrei Prepelita,
• Nikolay Klenov,
• Anatoli S. Sidorenko and
• Vladimir M. Krasnov

Beilstein J. Nanotechnol. 2021, 12, 913–923, doi:10.3762/bjnano.12.68

• -linear flux-flow Hall effect Resistivity in type-II superconductors with sizes larger than the London penetration depth, λ, is caused by motion of Abrikosov vortices, that is, it has a flux-flow (FF) nature [50][51][52][53]. Since our micrometer-size bridges are significantly larger than λ ≈ 100 nm of Nb

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• several review articles [3][7][10][11]. Endogenous or internal stimuli can be hard to control because of the heterogeneous disease environment. On the other hand, the use of exogenous or external stimuli may cause tissue damage and the depth of penetration may not be sufficient to trigger drug release

• generation are recognized as the mechanism of action of US-responsive nanomaterials. These nanomaterials can act through at least one of the mechanisms. Cargo release, drug activation, cell damage, and enhanced cargo penetration, in addition to contrast enhancement, are the clinically practical consequences

• are involved in US contrast imaging and can provide a way to improve the penetration capability of large particles, genes, and cells. They can trigger local drug release and provide better in vivo spatial control by applying mechanical forces of oscillation, expansion, and inertial cavitation from ADV

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• other forms [21]. As a biofriendly approach, the penetration of biological tissues without damage and free movement in the microbial environment can be achieved with magnetic fields, which has become a highlight of research in the field of MNRs. A magnetic microrobot (MMR) [14] is a micro-/nanoscale

A review of defect engineering, ion implantation, and nanofabrication using the helium ion microscope

• Frances I. Allen

Beilstein J. Nanotechnol. 2021, 12, 633–664, doi:10.3762/bjnano.12.52

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• binding between the virus and the host cell [109]. A viral infection begins with the adhesion or binding of the virus to the host receptors, followed by penetration, replication, and budding. The main antiviral strategies are to effectively block the binding of the virus to the host receptors (i.e, the

• prophylactic effect) and to inhibit viral replication and budding (i.e, the therapeutic effect) [75][76][110]. In vitro studies reveal that AgNPs can act as inhibitors of viral entry by blocking viral attachment and penetration into cells [109][111][112]. They also inhibit the synthesis of viral negative

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Structural and optical characteristics determined by the sputtering deposition conditions of oxide thin films

• Petronela Prepelita,
• Florin Garoi and
• Valentin Craciun

Beilstein J. Nanotechnol. 2021, 12, 354–365, doi:10.3762/bjnano.12.29

• films, as depicted in the SEM images (Figure 7a–c). The morphology of these samples was verified using the depth penetration technique of SEM, where it was evidenced that the analyzed films were compact. We could also observe an increase in granulation of the samples with an increase in thickness. The

Intracranial recording in patients with aphasia using nanomaterial-based flexible electronics: promises and challenges

• Qingchun Wang and
• Wai Ting Siok

Beilstein J. Nanotechnol. 2021, 12, 330–342, doi:10.3762/bjnano.12.27

• µm PI layers. The bifurcated flap shape was used to achieve good penetration and attachment to the cortical surface and avoid injuring blood vessels on the brain midline (Figure 5c, left). The width of the Au lines was designed to be 100 µm to reach a low impedance value and enhance the signal-to