Comparative analysis of the ultrastructure and adhesive secretion pathways of different smooth attachment pads of the stick insect Medauroidea extradentata (Phasmatodea)

• Julian Thomas,
• Stanislav N. Gorb and
• Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 612–630, doi:10.3762/bjnano.15.52

• delineate a potential pathway for adhesive secretions, originating from exocrine epidermal cells and traversing various layers before reaching the surface. Within the attachment pad, the fluid may influence the viscoelastic properties of the pad and control the attachment/detachment process. Understanding

• particles together into larger complexes for easier removal [25][26]. It can also improve attachment to surfaces with different surface chemistry by mediating between the two surfaces in contact [27][28]. The lipid-containing pad secretion protects the insect from additional water loss through the thin

• relatively large adhesive organs that bear no further surface microstructures [47][55][56] and because the droplet morphology of its tarsal secretion has been recently analysed [28][38][47][55][56]. Combining different imaging techniques, including scanning electron microscopy (SEM), confocal laser scanning

AFM-IR investigation of thin PECVD SiO_x films on a polypropylene substrate in the surface-sensitive mode

• Hendrik Müller,
• Hartmut Stadler,
• Teresa de los Arcos,
• Adrian Keller and
• Guido Grundmeier

Beilstein J. Nanotechnol. 2024, 15, 603–611, doi:10.3762/bjnano.15.51

• /bjnano.15.51 Abstract Thin silicon oxide films deposited on a polypropylene substrate by plasma-enhanced chemical vapor deposition were investigated using atomic force microscopy-based infrared (AFM-IR) nanospectroscopy in contact and surface-sensitive mode. The focus of this work is the comparison of

• the different measurement methods (i.e., contact mode and surface-sensitive mode) with respect to the chemical surface sensitivity. The use of the surface-sensitive mode in AFM-IR shows an enormous improvement for the analysis of thin films on the IR-active substrate. As a result, in this mode, the

• signal of the substrate material could be significantly reduced. Even layers that are so thin that they could hardly be measured in the contact mode can be analyzed with the surface-sensitive mode. Keywords: AFM-IR; polypropylene; surface-sensitive mode; silicon oxide; thin films; XPS; Introduction

Stiffness calibration of qPlus sensors at low temperature through thermal noise measurements

• Laurent Nony,
• Sylvain Clair,
• Daniel Uehli,
• Aitziber Herrero,
• Jean-Marc Themlin,
• Andrea Campos,
• Franck Para,
• Alessandro Pioda and
• Christian Loppacher

Beilstein J. Nanotechnol. 2024, 15, 580–602, doi:10.3762/bjnano.15.50

• ; thermal noise; ultrahigh vacuum; Introduction Since the 2000s, non-contact atomic force microscopy (nc-AFM) has established itself as a scanning probe method for the topographical, chemical, and electrical mapping of the surface of a sample down to the atomic scale [1][2][3]. When used in an ultrahigh

• -vacuum (UHV) system and at, or close to, liquid helium temperature (4–10 K, LT UHV), the method allows for the direct characterization of individual molecules with intramolecular contrast [4], opening up the field of studying on-surface reactions [5] or tip-induced chemistry [6]. The method also makes it

• possible to quantify the interatomic interaction forces that develop between the tip and the surface acquired in spectroscopic data cube modes [7][8] with both high sensitivity and high spatial resolution. Recently, the force sensitivity has been pushed forward, and forces as low as 100 fN have been

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

• Yanyan Wen,
• Ningning Song,
• Yueyou Peng,
• Weiwei Wu,
• Qixiong Lin,
• Minjie Cui,
• Rongrong Li,
• Qiufeng Yu,
• Sixue Wu,
• Yongkang Liang,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

• ). The special structure of nanoflowers improves the stability and efficiency of the surface reaction [24]. Furthermore, prior research has verified that radiofrequency (RF) hyperthermia can significantly improve the sensitivity of cancer cells to chemotherapy at approximately 42 °C [25][26][27

• and coassembled with a CUR layer on their surface. Then, CUR-Fe@MnO2 NFs were obtained by further modification with MnO2 and polyethylene glycol (PEG), which increased the stability and dispersion of the CUR-Fe@MnO2 NFs (Figure 1). MnO2 is difficult to degrade under physiological conditions in vivo

• ), and CUR-Fe@MnO2 NFs were observed via transmission electron microscopy (TEM) (Figure 2a–c). The sizes of Fe3O4 NCs, CUR-Fe NPs, and CUR-Fe@MnO2 NFs were 50.72 ± 10.16 nm, 94.00 ± 12.21 nm, and 96.27 ± 19.14 nm, respectively. The Fe3O4 NCs surface coating can be seen in Figure 1b, indicating that CUR

Directed growth of quinacridone chains on the vicinal Ag(35 1 1) surface

• Niklas Humberg,
• Lukas Grönwoldt and
• Moritz Sokolowski

Beilstein J. Nanotechnol. 2024, 15, 556–568, doi:10.3762/bjnano.15.48

• the vicinal Ag(35 1 1) surface was investigated by scanning tunneling microscopy and low-energy electron diffraction. The focus was on the influence of the steps on the QA structures and their preferential azimuthal orientations with the aim of achieving a selective orientation. After deposition at a

• sample temperature of 300 K, QA forms the same kind of molecular chains as on the nominally flat Ag(100) surface because of strong intermolecular hydrogen bonds, which we reported in a previous publication [Humberg, N.; Bretel, R.; Eslam, A.; Le Moal, E.; Sokolowski, M. J. Phys. Chem. C 2020, 124, 24861

• –24873]. The vicinal surface leads to one additional chain orientation, which is parallel to the Ag step edges. However, most chains nucleate on the Ag terraces between steps with four distinct azimuthal orientations that are identical to those on Ag(100), and which are determined by the interactions

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• = [Dd1, Dd2, Dd3] in order to define the chemical structure of the NDD compound. Specifically, we used two types of molecular descriptor for the i-th compound, namely Dd1 = logarithm of the n-octanol/water partition coefficient (LOGPi) and Dd2 = topological polar surface area (PSAi). The detailed

• of potential bioactive molecules [73]. These structural descriptors are Dd1 = logarithm of the n-octanol/water partition coefficient (LOGPi) and Dd2 = topological polar surface area (PSAi). In contrast, the cytotoxicity NP vector lists the elements as Dnk = [Dn1, Dn2, Dn3, Dn4, Dn5, Dn6, Dn7, Dn8

• (unsaturation index), Dn8 = Hycoat (hydrophilic factor), Dn9 = AMR coat (Ghose–Crippen molar refractivity), Dn10 = TPSA(NO)coat (topological polar surface area using N,O polar contributions), Dn11 = TPSA(Tot)coat (topological polar surface area using N,O,S,P polar contributions), Dn12 = ALOGPcoat (Ghose–Crippen

Electron-induced deposition using Fe(CO)₄MA and Fe(CO)₅ – effect of MA ligand and process conditions

• Hannah Boeckers,
• Atul Chaudhary,
• Petra Martinović,
• Amy V. Walker,
• Lisa McElwee-White and
• Petra Swiderek

Beilstein J. Nanotechnol. 2024, 15, 500–516, doi:10.3762/bjnano.15.45

• new precursor for focused electron beam-induced deposition (FEBID), was investigated by surface science experiments under UHV conditions. Auger electron spectroscopy was used to monitor deposit formation. The comparison between Fe(CO)4MA and Fe(CO)5 revealed the effect of the modified ligand

• surface reactions; Introduction Focused electron beam-induced deposition (FEBID) is a state-of-the-art direct-write process for the fabrication of nanoscale materials and devices with arbitrary shape and size down to the sub-10 nm regime [1][2][3]. In FEBID, precursor molecules that contain the element

• of the desired material, typically a metal, are dosed via a gas inlet system onto a surface placed in a scanning electron microscope (SEM). There, the precursor is decomposed by the tightly focused electron beam to form a solid deposit. To provide the precursor with sufficient volatility, the metal

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• preserved; however, the surface of their arms became more granulated, as shown in Figure 1b. The XRD analysis of the sample produced in the 4 h procedure shows that it consists of two phases (Figure 2a). The reflexes are indexed to a cubic zinc blende ZnS phase according to the JCPDS cards no. 772100 and no

• symmetries in the ZnS wurtzite phase in non-polarized measurements, (iii) some contribution from the surface optical SO modes, which are inherent to porous and nanostructured materials [37][38], (iv) interaction of LO phonon modes with plasmons (LOPC), and (v) effects of strain and phonon confinement [37

• , some suppositions are possible. The fact that the intensity of the low-energy PL band around 2.4 eV decreases significantly with changing the environment from air to vacuum in the sample prepared in the 8 h technological procedure may indicate the participation of surface states in the recombination

Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• consist of graphene sheets that are single-, double-, or multilayered, all smaller than 10 nm in thickness and 100 nm in width. Therefore, GQDs possess an ultralarge specific surface area thanks to nanometre-sized graphene sheets. Graphene quantum dots are fabricated via two techniques, that is, by

• GQDs is still unclear. It is possible that electron–hole recombination, quantum effects, and surface defects in the functional groups of the GQDs are involved [18]. The XRD pattern of GQDs prepared from starch without iron and cobalt salts is presented in Figure 2c. The diffraction peaks of the GQDs

• of CoFe2O4 and CF/GQDs. All isotherm curves belong to type V according to IUPAC. At a high relative pressure (above 0.8), the hysteresis sloop indicates that the materials have micro-meso structures. The surface area of CoFe2O4 is small because of heavy agglomeration (21.0 m2·g−1). However, CF/GQDs

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• warrants further investigation for the development of CNS therapeutics. Nanocrystals play an important role in pharmaceutic design and development. The properties of nanocrystals are remarkably different from their bulk material counterpart, attributed to the large surface-area-to-volume ratio which can

• ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [23]. The limitations of conventional medication delivery can be overcome by advanced drug delivery methodologies, such as transdermal drug delivery (TDD

• for enteric solid dosage coating and is used in this work for DCS enteric administration test. An amount of 5.66 g of Kollicoat MAE 30 DP was mixed with 0.34 g of propylene glycol for the enteric coating material, which was evenly brushed on the surface of the size 9 empty porcine hard gelatin

Superconducting spin valve effect in Co/Pb/Co heterostructures with insulating interlayers

• Andrey A. Kamashev,
• Nadir N. Garif’yanov,
• Aidar A. Validov,
• Vladislav Kataev,
• Alexander S. Osin,
• Yakov V. Fominov and
• Ilgiz A. Garifullin

Beilstein J. Nanotechnol. 2024, 15, 457–464, doi:10.3762/bjnano.15.41

• layer to oxygen atmosphere at 100 mbar for two hours. Next, Co1 was deposited in the main deposition chamber at a vacuum pressure of the order of 10−9 mbar on top of the CoOx layer. The I1 layer was formed on the surface of Co1 in a similar way as described above in an oxygen atmosphere of ≈10−2 mbar

• for 60 s. It was shown in [43] that significant partial oxidation of a few nanometers thin metallic Co layer can be achieved by exposing it to the ambient atmospheric environment, implying that lowering the atmospheric pressure by five orders of magnitude enables one to oxidize only the surface

• form the I2 layer by exposing the Pb surface to an oxygen atmosphere of ≈10−2 mbar for 30 s. After that, the Co2 layer was deposited similar to the Co1 layer. According to [40][42] the O2 molecules adsorbed on the surface of the superconducting Pb layer oxidize the top ferromagnetic Co2 layer during

Sidewall angle tuning in focused electron beam-induced processing

• Sangeetha Hari,
• Willem F. van Dorp,
• Johannes J. L. Mulders,
• Piet H. F. Trompenaars,
• Pieter Kruit and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 447–456, doi:10.3762/bjnano.15.40

• flat top of the line, the etch pit shown as the green curve in Figure 2a results. But when the etching occurs on the sloped sidewall, the secondary electron yield is assumed to increase by 1/cos α(x), where α(x) is the angle between the incident beam and the normal to the surface at the point of

• . Clearly, etching with the same PE dose at different positions on the slope, separated by as little as 20 nm, results in very different profiles. Although the profiles of etch 1 and etch 2 appear Gaussian as expected from the etching of a plane surface, proceeding outwards brings about the abrupt onset of

• residence time of the etching products on the surface [22]. As none of these models attempted to describe the evolution of the deposit shape subject to etching, the simple model described above will be slightly extended by including under-etching of the deposit once the etch pit has reached the substrate

Heat-induced morphological changes in silver nanowires deposited on a patterned silicon substrate

• Elyad Damerchi,
• Sven Oras,
• Edgars Butanovs,
• Allar Liivlaid,
• Mikk Antsov,
• Boris Polyakov,
• Annamarija Trausa,
• Veronika Zadin,
• Andreas Kyritsakis,
• Loïc Vidal,
• Karine Mougin,
• Siim Pikker and
• Sergei Vlassov

Beilstein J. Nanotechnol. 2024, 15, 435–446, doi:10.3762/bjnano.15.39

• ][23]. This phenomenon is closely related to the variation of surface energy with size [24]. For instance, the melting temperature can decrease by several hundred degrees for structures smaller than 10 nm [25]. In practical applications, the diameters of Ag NWs are typically significantly larger

• . However, during prolonged heat treatment (lasting minutes or more), surface atom diffusion can lead to morphological changes in NWs even at temperatures several hundred degrees below the melting point of the material [26][27]. Sintering of Ag and Au NWs at intersections can occur at temperatures as low as

• instability and energy minimization via spheroidization [28][31]. It has been demonstrated that various coatings can effectively protect metallic NWs by suppressing surface diffusion [32][33][34]. The kinetics of diffusive processes in NWs are tightly related to the surface energies of the system. Both Ag and

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• Ag NPs-DES sample is used in a surface-enhanced Raman scattering (SERS) sensor. The two analytes for SERS quantitation are nitrofurantoin (NFT) and sulfadiazine (SDZ) whose residues can be traced down to 10−8 M. The highest enhancement factors (EFs) are competitive at 6.29 × 107 and 1.69 × 107 for

• synthesis of nanomaterials for biosensor substrate construction. Keywords: Ag NPs; antibiotic residue; deep eutectic solvents; potential; SERS; Introduction Surface-enhanced Raman scattering (SERS) is a ubiquitous technology for detecting and tracing substances, applied in various kinds of sensors. The

• of plasmonic materials, which extensively respond to electromagnetic waves with proper wavelengths in terms of free electrons resonating to the incident waves [9][15]. This is the fundamental principle of surface plasmon resonance (SPR). Moreover, plasmons are easily controlled at the nanoscale

Unveiling the nature of atomic defects in graphene on a metal surface

• Karl Rothe,
• Nicolas Néel and
• Jörg Kröger

Beilstein J. Nanotechnol. 2024, 15, 416–425, doi:10.3762/bjnano.15.37

• Karl Rothe Nicolas Neel Jorg Kroger Institut für Physik, Technische Universität Ilmenau, D-98693 Ilmenau, Germany 10.3762/bjnano.15.37 Abstract Low-energy argon ion bombardment of graphene on Ir(111) induces atomic-scale defects at the surface. Using a scanning tunneling microscope, the two

• , during its epitaxial growth in surface science experiments or its fabrication for applications, defects, that is, deviations from the ideal 2D lattice, inevitably occur. Examples for defects are vacancies, interstitial atoms, grain boundaries, stacking faults or wrinkles [5][6][7][8][9][10][11][12][13

• of defects. Experimental A combined STM-AFM was operated in ultrahigh vacuum (5 × 10−9 Pa) and at low temperature (5 K). Surfaces of Ir(111) were cleaned by Ar+ ion bombardement and annealing. The epitaxial growth of graphene proceeded by exposing the heated (1300 K) Ir(111) surface to the gaseous

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Also, progress in nanotechnology enables us to easily control size, morphology, surface coating, and chemical configuration, which are highly related to the antioxidant activities. The integration of

• ]. Antioxidant nanomaterials can be synthesized from carbon-based compounds, polymeric compounds, and metal-based compounds. Metal-based nanoantioxidants exhibit strong reactivity because there are atoms with unpaired electrons on the surface. Therefore, metal-based nanoantioxidants have a significant advantage

• action, and expand their applications, especially in medicine and healthcare. For example, the question of why nanoparticles with a majority of Ce3+ on the surface have stronger antioxidant activity than those with Ce4+ has recently been answered by Dutta and co-workers [11]. Ce3+ nanoparticles have a

Insect attachment on waxy plant surfaces: the effect of pad contamination by different waxes

• Elena V. Gorb and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 385–395, doi:10.3762/bjnano.15.35

• shape and dimensions of the wax structures and examined insect adhesive organs after they have contacted waxy substrates. For comparison, we performed the experiments with the same beetle individuals on a clean glass sample just before (gl1) and immediately after (gl2) the test on a plant surface. The

• cases of the plant surfaces covered with wax projections having higher aspect ratios. The data obtained clearly indicated the impact of waxy plant surfaces on the insect ability to subsequently attach to the clean smooth surface. This effect is caused by the contamination of adhesive pads and

• [8] tests up to precise measurements of attachment forces with different experimental techniques, such as pulling [9] and centrifugal [10] setups. It has been demonstrated that not only the presence of wax projections on the plant cuticle surface, but also their size, distribution, and density

On the mechanism of piezoresistance in nanocrystalline graphite

• Sandeep Kumar,
• Simone Dehm and
• Ralph Krupke

Beilstein J. Nanotechnol. 2024, 15, 376–384, doi:10.3762/bjnano.15.34

• measured thickness of the grown film was ca. 5 nm. The NCG film was then transferred onto a 100 μm thick PET substrate. For the transfer process, first, the NCG film on SiO2/Si was coated with 200 nm thick PMMA and put into 5 M NaOH solution at 80 °C. The NCG/PMMA film floats on the surface after the

Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar⁺ ion beam: a comparative study

• Indra Sulania,
• Harpreet Sondhi,
• Tanuj Kumar,
• Sunil Ojha,
• G R Umapathy,
• Ambuj Mishra,
• Ambuj Tripathi,
• Richa Krishna,
• Devesh Kumar Avasthi and
• Yogendra Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 367–375, doi:10.3762/bjnano.15.33

• fabrication on Si and Ge by 100 keV Ar+ ion beam bombardment is discussed. The irradiation was performed in the ion fluence range of ≈3 × 1017 to 9 × 1017 ions/cm2 and at an incident angle of θ ≈ 60° with respect to the surface normal. The investigation focuses on topographical studies of pattern formation

• surface, it may lose its energy in the following ways. If the ion has enough energy to cross the repulsive potential energy barrier of target atoms at the surface, it will pass through the solid. A collision cascade is created within the target atoms during the slowing-down course. The impinging ion

• and energy of the incoming ion and on the mass of the target atom. It may be expressed as the spatial distribution of the energy transferred/deposited within the target [27][28]. Sometimes the energy distribution on the target atoms at the surface may be sufficient to overcome binding energies so as

Modulated critical currents of spin-transfer torque-induced resistance changes in NiCu/Cu multilayered nanowires

• Mengqi Fu,
• Roman Hartmann,
• Julian Braun,
• Sergej Andreev,
• Torsten Pietsch and
• Elke Scheer

Beilstein J. Nanotechnol. 2024, 15, 360–366, doi:10.3762/bjnano.15.32

• the surface area of the AAO template (or Si substrate) is isolated from the bottom electrodes and the magnetic nanowires, thereby largely improving the flexibility for the design of the top electrodes. After removing the overgrowth by a thin blade or milling in argon plasma, a thick Al film of 180 nm

• was patterned to build the top electrode by thermal evaporation at a large deposition rate (>3 Å/s) to ensure quick and continuous film formation and, thus, to efficiently avoid Al to be deposited into the pores. Therefore, only the nanowires the top of which have reached the upper surface of the AAO

• characterization, the thickness of the bottom NiCu layers is estimated to be around 22 nm and is reduced to below 10 nm towards the upper end of the nanowire. Only NiCu is deposited in the pores near the surface of the AAO template forming a long segment of NiCu on the very top of the nanowires. This varying

Controllable physicochemical properties of WO_x thin films grown under glancing angle

• Rupam Mandal,
• Aparajita Mandal,
• Alapan Dutta,
• Rengasamy Sivakumar,
• Sanjeev Kumar Srivastava and
• Tapobrata Som

Beilstein J. Nanotechnol. 2024, 15, 350–359, doi:10.3762/bjnano.15.31

• , film crystallinity and compositional variations in such films can also be adjusted as a function of the growth angle [27][28], making GLAD a promising approach to yield nanostructured (NS) films [29][30][31]. Electronic devices consisting of multilayers often require information on surface

• electrochemical property variation of the underlying films induced by structural changes. Therefore, a systematic investigation on the surface work function of the NS-WOx films as a function of thickness holds the potential for accessing its practical device application. In this article, we report on tunable

• −7 mbar). The thickness of the films was measured using a surface profilometer (Ambios, XP 200). The surface morphology of the as-deposited and the annealed films was acquired using tapping mode AFM (Asylum Research). AFM images were recorded at different places on each sample to confirm the film

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• the nanometer range (100–1000 nm), with a theoretical drug loading of 100%. They consist of pure drugs, usually in a solid amorphous state, with a minimal quantity of surface-active agents for stabilization. Nanocrystals are superior to microsuspensions at increasing the oral bioavailability of class

• -II drugs with low solubility, or low or irregular bioavailability, and promoting adhesion to the gastrointestinal wall [95]. The small size of the crystals is associated with a large surface area, which increases interactions with the dissolving medium and accelerates the dissolution rate. The latest

• profile [113][114]. The industrial quality control is much more complex than that of conventional pharmaceuticals, focused mainly on the properties of the low-molecular-weight drug constituting the active pharmaceutical ingredient [115][116][117]. Given their structural complexity and high surface area

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• regulatory classification for some of the samples tested. The electron microscopy results published here are supported by results from other complementary methods including surface area measurements. It is the intention of this publication to contribute to an ongoing discussion on size measurements of TiO2

• determination and validation. For untreated, non-porous materials, the specific surface area (SSA) serves as a useful independent method. The SSA of the pigment samples was calculated from the particle size distributions, and these values were directly compared with the measured SSA. As with all titanium

• and evaluated (see Experimental section). The EM MinFeret and EM ECD values according to measurement method M2 are given in Table 4, together with the SSA, the calculated specific surface area (c-SSA), and the CIELAB L*, a*, and b* coordinates showing the light scattering properties of each sample

Investigating structural and electronic properties of neutral zinc clusters: a G₀W₀ and G₀W₀Г₀⁽¹⁾ benchmark

• Sunila Bakhsh,
• Muhammad Khalid,
• Sameen Aslam,
• Muhammad Sohail,
• Muhammad Aamir Iqbal,
• Mujtaba Ikram and
• Kareem Morsy

Beilstein J. Nanotechnol. 2024, 15, 310–316, doi:10.3762/bjnano.15.28

• optimization (PSO), combined with density functional approximations, was used to determine the ground state structure. Thus, one can efficiently locate the global minimum in the potential energy surface. Based on the PSO algorithm, Wang et al. [13][14] developed a code called CALYPSO (“Crystal Structure

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• , nanoparticles can easily agglomerate into particles with larger diameter. Upon intake by organisms, depending on the pH value, these agglomerations disintegrate again becoming a source for toxins in the body [8]. The formation of agglomerated NPs depends upon the surface charge of the NPs, which is believed to

• stabilize and prevent agglomeration of NPs. As no experimental techniques are available to measure the surface charge directly, its value is measured through the zeta potential (ζ) in a given medium [9]. Zeta potential is the electrostatic potential at the electrical double layer surrounding the NPs in

• protein corona. The formation of a protein corona on the surface of NPs, which influences the interaction with cell membranes or proteins, is also associated with zeta potential and surface charge. Very limited studies have reported the influence of zeta potential, surface charge, hydrophobicity, and