Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• differential effect of AuNPs on the cell viabilities of the fibroblasts and the cancer cell lines. Additional studies, such as cellular uptake and in vivo studies must be conducted to unravel the mechanism involved in the internalization of AuNPs and to understand the anticancer properties of the prepared

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

• Dominic Docter,
• Christoph Bantz,
• Dana Westmeier,
• Hajo J. Galla,
• Qiangbin Wang,
• James C. Kirkpatrick,
• Peter Nielsen,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

• explanation, corona formation reduced ASP30 cellular uptake, which was however not significantly affected by ASP surface charge in our model. Collectively, our study uncovers an impact of ASP size as well as of the protein corona on cellular toxicity, which might be relevant for processes at the nano–bio

• protein corona on the cellular uptake Nanoparticle uptake is an important determinant for nanopathology [22][34][35]. To investigate the effect of the protein corona on cellular uptake mechanisms we analyzed the uptake of two fluorescently labeled ASPs with comparable physico-chemical characteristics

• carboxylation (ASP30F versus ASP30-COOH; Table 1) we did not, however, observe a significant difference in cellular uptake (Figure 7A/B). As reflected by the rather similar zeta potential after incubation of the different ASP in protein-containing medium the protein corona seems to shield the charged ASP

Antimicrobial properties of CuO nanorods and multi-armed nanoparticles against B. anthracis vegetative cells and endospores

• Pratibha Pandey,
• Merwyn S. Packiyaraj,
• Himangini Nigam,
• Gauri S. Agarwal,
• Beer Singh and
• Manoj K. Patra

Beilstein J. Nanotechnol. 2014, 5, 789–800, doi:10.3762/bjnano.5.91

• particles were spear shaped with one tapered end. Most likely the tapered spears of P5 penetrate easily into the bacterial cell on collision causing more cellular damage and cell death compared to the nanorods. The shape of the nanoparticles is known to be an important contributor in their cellular uptake

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

• Tianxun Gong,
• Douglas Goh,
• Malini Olivo and
• Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

• the encapsulated AuNRs synthesized in this study. The bright red and orange scattered spots located within the cells suggest that the AuNRs were internalized into the cells by non-specific cellular uptake since no biomolecules were attached to our gold formulations. Huang et al. performed a similar