Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• Leishmania spp. Although its mechanism of action has not yet been fully elucidated, its leishmanicidal potential may be associated with its antioxidant and anti-inflammatory properties. However, it has limitations that compromise its clinical use. Conversely, nanotechnology has been used as a tool for

• high tolerance profile, and it has shown in vitro and in vivo leishmanicidal properties against different species of Leishmania spp. [11][14]. Despite its pharmacological potential, curcumin has some physicochemical and biopharmaceutical limitations that should be highlighted, such as: (i) low aqueous

• . Thus, seeking therapeutic alternatives to those currently available, many natural or synthetic molecules have been studied and evaluated for their antileishmanial potential, among which curcumin may be featured [4]. Curcumin and its antileishmanial properties Curcumin (curc) is a polyphenol (Figure 1

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• identified works presented results in the clinical phase. Finally, based on our findings, the outlook appears favorable, as there is a significant diversity of new substances with schistosomicidal potential. However, financial efforts are required to advance these nanoformulations. Keywords: delivery system

• children, but the bitter taste of PZQ makes it difficult for them to adhere to treatment [8]. Moreover, high dosages of PZQ have been associated with side effects such as abdominal pain, nausea, and allergy [9]. In this context, nanotechnological tools are being investigated as potential solutions to

• advantages of using this type of nanoparticles as nanocarriers are their potential use for drug controlled release, the ability to protect drugs and other molecules with biological activity against the environment, improvement of their bioavailability and therapeutic index [17]. These nanocarriers are

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• structure of these albumin/PDA NPs has not been elucidated completely. It has been demonstrated that proteins are present in the NPs’ shell; they might also be present in the core (Figure 1d). Nevertheless, their potential both for fluorescent labelling of alive bacterial cells and as nanovector for

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• Iceland, Dunhagi 3, 107 Reykjavík, Iceland Inorganic and Organometallic Chemistry, Universität Erlangen-Nürnberg, 91058 Erlangen, Germany Carl Zeiss SMT GmbH, 64380 Roßdorf, Germany 10.3762/bjnano.14.98 Abstract Motivated by the potential of focused-electron-beam-induced deposition (FEBID) in the

• fabrication of functional gold nanostructures for application in plasmonic and detector technology, we conducted a comprehensive study on [Au(CH3)2Cl]2 as a potential precursor for such depositions. Fundamental electron-induced dissociation processes were studied under single collision conditions, and the

• the potential to widen the scope of applicable nanomaterials. In FEBID, a focused electron beam is directed onto the surface of a substrate in close proximity to a gas inlet, through which a precursor compound is supplied to deliver the material for the nanostructures to be built. For metallic

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• patterned nano-/microstructured PU films enhance both PC12 neurite elongation and alignment, showing the potential use of our proposed method for the micro-/nanopatterning of polymers for nerve tissue engineering. Keywords: hierarchical; nanopatterning; neurite alignment; neurite outgrowth; topography

• nerves are few and far between. Thus, further work is necessary to ascertain the potential of such structures for peripheral nerve regeneration. One of the reasons for the limited work on discrete nanostructures and hierarchical structures may be the expensive or non-versatile techniques for substrate

• and nanoholes promote neurite elongation in PC12 cells, we combined the nanostructures with microgrooves to determine their potential use in neurite guidance. Following the strategy in our previous work [16], hierarchical structures in the SU-8 master were achieved using a simple UV-LED

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• Agnes-Valencia Weiss Marc Schneider Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Campus C4 1, Saarbruecken, Germany 10.3762/bjnano.14.95 Abstract Nanoparticles have shown an enormous potential as drug delivery systems in the lab. However

• , translation to the clinics or even market approval often fails. So far, the reason for this discrepancy is manifold. Physicochemical properties such as size, surface potential, and surface chemistry are in focus of research for many years. Other equally important parameters, influencing whether a successful

• in vivo and even more to the clinics often fails and only a limited number of products make it to the market. This holds true even though Comirnaty® and Spikevax® were approved during the SARS CoV-2 pandemic using lipid nanoparticle (NPs) formulations underlining their potential [5][6][7]. By

A multi-resistance wide-range calibration sample for conductive probe atomic force microscopy measurements

• François Piquemal,
• Khaled Kaja,
• Pascal Chrétien,
• José Morán-Meza,
• Frédéric Houzé,
• Christian Ulysse and
• Abdelmounaim Harouri

Beilstein J. Nanotechnol. 2023, 14, 1141–1148, doi:10.3762/bjnano.14.94

• electrical quantities (i.e., current and resistance) at the nanoscale. In C-AFM, a micro-machined conductive probe with a sharp nanometer-sized tip acts as a top electrode brought into contact with the surface of a sample while applying a potential difference relative to a back electrode. The small currents

• flowing through the system are measured using a current amplifier, typically ranging from 100 fA to 10 µA for most commercially available microscopes [2][3]. By sweeping the potential difference while the tip is fixed in contact with the sample, current versus voltage (I–V) curves are acquired. I–V curves

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of −15

• cytotoxicity of CUR-HSA-MPs showed promising anticancer potential against human hepatocellular carcinoma (Huh-7) and human breast adenocarcinoma (MCF-7) cell lines, although this effect was less pronounced in human dermal fibroblasts (HDFB) and human cholangiocyte (MMN) cell lines. Confocal microscopy was used

• especially anticancer potential [1][2]. Several in vivo and in vitro studies in recent years have demonstrated that CUR can influence cancer cell proliferation, invasion, angiogenesis, and metastasis [3]. It has been reported that CUR exerts anticancer effects in human breast cancer cells (MCF-7) by

A bifunctional superconducting cell as flux qubit and neuron

• Dmitrii S. Pashin,
• Pavel V. Pikunov,
• Marina V. Bastrakova,
• Andrey E. Schegolev,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2023, 14, 1116–1126, doi:10.3762/bjnano.14.92

• ? This article is devoted to the search for answers to these questions. Hence, below we explore the quantum dynamics of observables in superconducting interferometers, discuss the implications for quantum computing, and the challenges that remain to be addressed. In addition, we note the potential for

• l). Here and further, we use magnetic fluxes normalised by the quantum value, Φ0. To investigate the flux-to-flux transfer characteristics of such a system, it is convenient to interpret its evolution as the movement of a particle with “mass” M = and “momentum” p = in the potential profile defined

• -adiabatic effects impose on the potential use of the proposed cell as a neuromorphic, coupling, and tuning element in quantum computing systems. At the same time, we will also gain an understanding of the possibilities for controlling the population of levels in the simplest implementation of an adiabatic

Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli

• Lany S. Araujo-Yépez,
• Juan O. Tigrero-Salas,
• Vicente A. Delgado-Rodríguez,
• Vladimir A. Aguirre-Yela and
• Josué N. Villota-Méndez

Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91

• potential botanical sources for developing new insecticides [25]. Their active components act against pest species through toxicant and repellent effects, developmental and behavioral alterations, and induction of sterility or infertility of insects [26]. Technologies such as nanoformulations or

Density functional theory study of Au-fcc/Ge and Au-hcp/Ge interfaces

• Olga Sikora,
• Małgorzata Sternik,
• Benedykt R. Jany,
• Franciszek Krok,
• Przemysław Piekarz and
• Andrzej M. Oleś

Beilstein J. Nanotechnol. 2023, 14, 1093–1105, doi:10.3762/bjnano.14.90

• . Recently, nanostructures including different polytypes of gold have been observed in various experiments and have gained interest regarding potential applications. For example, the interface regions of polytypic gold nanorods were found to be highly active in catalysis [15]. The hexagonal phases seen in

Dual-heterodyne Kelvin probe force microscopy

• Benjamin Grévin,
• Fatima Husainy,
• Dmitry Aldakov and
• Cyril Aumaître

Beilstein J. Nanotechnol. 2023, 14, 1068–1084, doi:10.3762/bjnano.14.88

• time-periodic surface electrostatic potential generated under optical (or electrical) pumping with an atomic force microscope. The modulus and phase coefficients are probed by exploiting a double heterodyne frequency mixing effect between the mechanical oscillation of the cantilever, modulated

• components of the time-periodic electrostatic potential at harmonic frequencies of the pump, and an ac bias modulation signal. Each harmonic can be selectively transferred to the second cantilever eigenmode. We show how phase coherent sideband generation and signal demodulation at the second eigenmode can be

• achieved by using two numerical lock-in amplifiers configured in cascade. Dual-heterodyne KPFM (DHe-KPFM) can be used to map any harmonic (amplitude/phase) of the time-periodic surface potential at a standard scanning speed. The Fourier spectrum (series of harmonics) can also be recorded in spectroscopic

Spatial mapping of photovoltage and light-induced displacement of on-chip coupled piezo/photodiodes by Kelvin probe force microscopy under modulated illumination

• Zeinab Eftekhari,
• Nasim Rezaei,
• Hidde Stokkel,
• Jian-Yao Zheng,
• Andrea Cerreta,
• Ilka Hermes,
• Minh Nguyen,
• Guus Rijnders and
• Rebecca Saive

Beilstein J. Nanotechnol. 2023, 14, 1059–1067, doi:10.3762/bjnano.14.87

• be used to measure contact potential difference (CPD) between the tip and the sample [18][19][20]. In particular, time-dependent KPFM [21][22][23] allows us to determine temporal changes of CPD and understand the dynamic behavior of functional devices at the nanoscale. Kelvin probe force microscopy

• from the top reached the Si p–n junction and generated electron–hole pairs, building a potential difference across the junction. The generated photovoltage was applied to the piezoelectric capacitor through the photolithographically defined contacts and induced mechanical displacement in the

• leading to a better signal-to-noise ratio. The feedback applies a DC bias (VDC) matching the potential difference between the tip and the sample, which compensates for the electrostatic force. Therefore, the sidebands disappear. The value of VDC corresponds to the contact potential difference

Experimental investigation of usage of POE lubricants with Al₂O₃, graphene or CNT nanoparticles in a refrigeration compressor

• Kayhan Dağıdır and
• Kemal Bilen

Beilstein J. Nanotechnol. 2023, 14, 1041–1058, doi:10.3762/bjnano.14.86

• prevent sedimentation as suggested in previous studies [32]. The zeta potential values of nanolubricants containing Al2O3 were also measured and given in Figure 9. Accordingly, it can be said that the stability of nanolubricant samples with Al2O3 is excellent and normal for the lowest mass fraction (ω

• balance. Zeta potential of nanolubricants containing Al2O3 at the lowest and highest mass fractions [21]. Images of the FPS2800 fluid property sensor. P–h diagram of the refrigeration system for validation tests. Measurement of a) density and b) dynamic viscosity of water for validation at 25 °C. Required

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• coprecipitation–crosslinking–dissolution (CCD) are promising as HBOCs. CCD provides particles that are malleable and show a consistent morphology and narrow size distribution, as well as a negative zeta potential [19][31][32][33]. It could be shown that neither NO scavenging nor vasoconstriction can be detected

• for potential use as oxygen transporters in vivo, the particles were characterized in different ways. Thus, comparability was achieved between different particle batches in different experiments. All experiments within this work have been performed with HbMPs from the same batch. Concentration

• determination HbMP suspension was placed in glass capillaries for hematocrit determination and then centrifuged at 15,000g for 10 min. The amount of particle sediment was determined manually, and the remaining suspension was diluted with 0.9% NaCl to a concentration of 2% HbMP. Size, zeta potential, and

A visible-light photodetector based on heterojunctions between CuO nanoparticles and ZnO nanorods

• Doan Nhat Giang,
• Nhat Minh Nguyen,
• Duc Anh Ngo,
• Thanh Trang Tran,
• Le Thai Duy,
• Cong Khanh Tran,
• Thi Thanh Van Tran,
• Phan Phuong Ha La and
• Vinh Quang Dang

Beilstein J. Nanotechnol. 2023, 14, 1018–1027, doi:10.3762/bjnano.14.84

• nanoparticles and ZnO nanorods obtained via a simple and cost-effective synthesis process has great potential for optoelectronic applications. Keywords: CuO nanoparticles; heterojunction; optoelectronics; visible-light photodetector; ZnO nanorods; Introduction Optoelectronics is a field to accelerate the

• ]) to extend the light absorption towards the visible region. Copper oxide (CuO) is a candidate because of its narrow bandgap (ca. 1.35 eV), which is suitable for visible-light detection. Hence, CuO can be a potential material for solving the problem of limited light absorption of ZnO. Conduction and

• valence bands of CuO are at a more negative potential than those of ZnO to form type-II region bonds between CuO and ZnO, avoiding recombination and accelerating the separation of photogenerated electron–hole pairs [37]. To explore and confirm the effects of combining CuO and ZnO, we developed a

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• the NIR absorption potential, nanomaterials can also be used in the field of photothermal nanosensors, which is an underexplored, yet highly potential, area of research [31]. To use nanoparticles for photothermal applications, the absorption wavelength should lie in the NIR region (650–900 nm

• possessing well-engineered characteristics in terms of size, shape, and composition are regarded as potential candidates for diverse photothermal applications, including photothermal LFAs. Photothermal materials can be categorized into four main types, depending on their chemistry and light absorption

• factor of almost 256 (Figure 7D). This observation underscores the importance of optimizing GNP size for maximizing sensitivity while mitigating potential drawbacks. This finding opens new possibilities for the highly sensitive and quantitative detection using LFAs, enhancing the applicability in various

Fragmentation of metal(II) bis(acetylacetonate) complexes induced by slow electrons

• Janina Kopyra and
• Hassan Abdoul-Carime

Beilstein J. Nanotechnol. 2023, 14, 980–987, doi:10.3762/bjnano.14.81

• attachment. The reported data may contribute to a better understanding of the physical chemistry underlying the electron–molecule interactions, which is crucial for potential applications of these molecular systems in the deposition of nanoscale structures. Keywords: dissociative electron attachment; gas

• nanocrystals [13][14]. The popularity of these compounds is related to their volatile nature, ease of preparation, and often lower air sensitivity and toxicity in comparison to organometallic compounds containing carbon–metal bonds (e.g., metallocenes). In the context of a potential use of these organometallic

• the dissociation products and the pathways for anion production will contribute to a better understanding of the fundamental chemistry of ML2 compounds. This is desirable for potential applications requiring the knowledge of decomposition of such organometallic complexes by particles (e.g., electron

Isolation of cubic Si₃P₄ in the form of nanocrystals

• Polina K. Nikiforova,
• Sergei S. Bubenov,
• Vadim B. Platonov,
• Andrey S. Kumskov,
• Nikolay N. Kononov,
• Tatyana A. Kuznetsova and
• Sergey G. Dorofeev

Beilstein J. Nanotechnol. 2023, 14, 971–979, doi:10.3762/bjnano.14.80

• number of potential benefits to both science and industry. These methods often employ new strategies for the synthesis of specific classes of substances. For example, the widely known development of perovskite synthesis through ion exchange reactions has attracted attention in scientific as well as

• . Several techniques for functionalization and colloidal solubilization of Si3P4 NPs were outlined. Optical properties of the material were studied to reveal an experimental bandgap of 1.25 eV. Potential applications of the material include the preparation of microcircuits through the introduction of P

Metal-organic framework-based nanomaterials for CO₂ storage: A review

• Ha Huu Do,
• Iqra Rabani and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 964–970, doi:10.3762/bjnano.14.79

• metal sites; pore size; Introduction One of the major issues associated with CO2 emissions is the heightened risk of climate change faced by our planet. Furthermore, there is an alarming issue of elevated levels of air pollution affecting human population [1]. One potential solution to address this

• structures that were modified with amino groups [43]. This study could provide adequate information for further experiments in CO2 storage areas. Conclusion Undoubtedly, MOFs have been widely recognized as promising nanomaterials for CO2 adsorption, offering potential mitigiation of the impact of CO2 gas on

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• knowledge of the authors, this is the first work on ML models using periodic table descriptors to successfully demonstrate the high potential of the proposed modeling approaches. Methods and Materials Dataset The dataset was collected from previously published literature [20]. A mixture of nano-TiO2 powders

Upscaling the urea method synthesis of CoAl layered double hydroxides

• Camilo Jaramillo-Hernández,
• Víctor Oestreicher,
• Martín Mizrahi and
• Gonzalo Abellán

Beilstein J. Nanotechnol. 2023, 14, 927–938, doi:10.3762/bjnano.14.76

• materials is one of the most relevant fields in materials science. Layered double hydroxides (LDHs), a versatile class of anionic clays, exhibit great potential in photocatalysis, energy storage and conversion, and environmental applications. However, its implementation in real-life devices requires the

• ]. These materials play a key role both from a fundamental point of view and regarding potential applications in electronic devices, drug delivery, and energy storage and conversion, to name a few [5][6][7][8]. Layered materials range from monoelementals (i.e., graphene, silicene, germanene, or pnictogens

• storage and conversion [19][20][21], quantum materials [22][23], and others [24]. This wide range of potential applications makes the development of reliable scaling processes crucial. Usually, LDHs are obtained by different synthesis procedures such as co-precipitation [25], hydrothermal synthesis [13

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• is an essential water-soluble vitamin for normal cellular function, growth, and cell signaling. Biotin receptors are highly overexpressed in the body; therefore, it is a potential target for a large number of diseases [65]. Avidin is a tetrameric basic glycoprotein with oligosaccharide moieties of

• potential plays an essential role in the interaction between protein and NPs as opposite charges produce strong interaction and result in high conformational changes [76]. The conjugation of antibodies on nanoparticle surfaces enhances the delivery of drug cargo specifically to disease sites. Once NPs enter

• affected by their physicochemical properties, including hydrodynamic diameter, surface potential, shape, functional groups, and hydrophobicity. The protein corona reduces the targeted delivery of NPs by disturbing or inhibiting the binding of target molecules to their receptors. Mirshafiee et al. used a

Ni, Co, Zn, and Cu metal-organic framework-based nanomaterials for electrochemical reduction of CO₂: A review

• Ha Huu Do and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 904–911, doi:10.3762/bjnano.14.74

• valuable compounds through electrochemical reduction. The electrocatalytic process for CO2 reduction reactions (CO2RR) encounters a persistent obstacle in the activation of CO2 [4]. The formation of CO2•− necessitates a high thermodynamic potential of −1.90 V vs the standard hydrogen electrode

• presented. Finally, we present the potential pathways and current problems in progressing MOF-based nanomaterials for CO2 conversion. Review Mechanism of CO2RR The process of CO2 reduction consists of three steps. First, the CO2 molecules are adsorbed on the active sites of catalysts. Second, charge

• products, as shown in Figure 1. In addition to the properties of the catalyst material, other parameters, such as potential, pH, solvent, and temperature, also determine the formation of desired products. MOFs nanomaterials for electrocatalytic reduction of CO2 Ni-based MOFs nanomaterials Two-dimensional

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• The main goal of this work was to evaluate the therapeutic potential of green superparamagnetic iron oxide nanoparticles (SPIONs) produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis. Optical and electron microscopy techniques were used to evaluate the

• ). Discussion SPIONs represent a new approach to diagnosing and treating diseases, particularly when associated with magnetic hyperthermia, an emerging form of active treatment [14][15][16][17][18]. However, despite all their potential, the synthesis processes of the SPIONs are characterized by being expensive

• and toxic to humans and the environment [6]. In this scenario, our group demonstrated the therapeutic potential of low-cost biocompatible SPIONs produced by green synthesis [9]. The present study aimed to evaluate in vitro the therapeutic potential of SPIONs produced with coconut water to treat