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Search for "degradation" in Full Text gives 481 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation
Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24
- lysosomes results in a very low LC3 content in autolysosomes due to subsequent degradation of LC3 by lysosomal enzymes [65]. Therefore, the endogenous GFP-LC3 is visualized as a diffuse cytoplasmic pool or punctate structures and could be used for the selective quantification of autophagosomes, thus
Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans
Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23
- partial degradation of the proteins [33]. In this study, FE-SEM analysis further confirmed that one of the mechanisms by which BerNPs kill S. mutans involves the disruption and damage of the bacterial membrane. Inhibition of biofilm formation Streptococcus mutans is the primary cause of dental caries [34
Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts
Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21
- studies and sustainable technologies, this study presents new insights into the complex relationship between contaminants and catalytic degradation processes. Compared to single and binary photocatalysts, modified ternary composites were found to have superior photodegradation performance under visible
- light exposure. To be specific g-C3N4-based ternary photocatalysts exhibited more than 90% degradation of tetracycline and sulfamethazine antibiotics within one hour of irradiation. This study addresses the antibiotic degradation efficiency during photocatalytic processes and suggests new approaches to
- improve the performance and scalability for wider use in real-world situations. Keywords: antibiotics; degradation pathways; heterojunctions; mechanisms; photocatalysts; semiconductor; Introduction Antibiotics are chemical substances used to treat bacterial infections in humans, animals, aquaculture
Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide
Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18
- to changes in the structure of RNA, protein chromatin structure, gene expression and replication, and synthesis and repair of DNA [30]. It has also been shown that TMZ has radiosensitizing effects [31][32], increasing the degradation of DNA strains and cell death when combined with RT, which is a
- . Therefore, it is of paramount importance to prolong the half-life of TMZ at physiological pH and to increase its accumulation in the tumor cells prior to degradation in the central circulation. Several strategies have been exploited to stabilize TMZ and overcome the disadvantages. Among them is the
- ). Carbon-based TMZ carriers with a favorable release profile have been prepared considering the importance of controlled and sustained drug release to prevent fast TMZ degradation, postsurgical sensitization on radiotherapy, less frequent drug administration, and improved risk/benefit ratio in patients
Synthesis and the impact of hydroxyapatite nanoparticles on the viability and activity of rhizobacteria
Beilstein J. Nanotechnol. 2025, 16, 216–228, doi:10.3762/bjnano.16.17
- a troubling and progressive increase in land degradation, primarily caused by the excessive use of chemical fertilizers. This issue is compounded by the growing population and the subsequent increase in food demands, leading to widespread consequences such as the loss of soil biodiversity, pollution
Recent advances in photothermal nanomaterials for ophthalmic applications
Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16
- collapse of these VNBs transform thermal energy into mechanical forces, such as jets and acoustic shock waves, enabling cellular or tissue treatment with minimal thermal damage. Currently, VNBs are being explored for applications in cancer cell eradication [51], harmful protein aggregate degradation [52
- neuropathy [125][126]. Currently, ocular drug delivery is the prevalent treatment approach; however, it faces challenges due to drug degradation and obstacles in drug diffusion, rendering the therapy less effective [127][128]. Therefore, ocular drug delivery systems capable of controlled and sustained drug
- explanations of material size, structure, dosage, and administration methods [215]. During treatment, processes such as nanoparticle aggregation, material degradation, cellular uptake/excretion, and unintended release of adsorbents require comprehensive safety analysis. In inorganic photothermal nanomaterials
A review of metal-organic frameworks and polymers in mixed matrix membranes for CO2 capture
Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14
Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity
Beilstein J. Nanotechnol. 2025, 16, 141–154, doi:10.3762/bjnano.16.13
- oxidation, extraction, and biodegradation [4]. Unfortunately, these methods exhibit inefficiencies due to the generation of secondary pollution and high operational costs. Biological and anaerobic degradation of dyes may yield carcinogenic by-products [4][5], highlighting the significant challenge in
Comparison of organic and inorganic hole transport layers in double perovskite material-based solar cell
Beilstein J. Nanotechnol. 2025, 16, 119–127, doi:10.3762/bjnano.16.11
- perfect material properties, such as uniformity in thickness, defect density, and material interfaces, which do not represent real-world conditions. Further, complicated interfacial effects between the active layer and the HTLs, such as chemical interactions, degradation, or the existence of intermediary
Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy
Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10
- following degradation in lysosomes using hydrolytic enzymes and reactive oxygen species (ROS). Additionally, macrophages present antigen fragments through major histocompatibility complex (MHC) molecules, activating adaptive immune responses [16]. 2.2 Macrophage polarization Macrophages are involved in
- stimulated the activation of T-cells and natural killer cells, resulting in significant tumor regression [72]. Small interfering RNA (siRNA) therapeutics: siRNAs are double-stranded RNA molecules that induce the degradation of specific mRNAs, effectively silencing their expression. This approach has shown
- pathway for improving mRNA-based therapies. These vaccines use LNPs designed to facilitate endosomal escape, preventing RNA degradation within lysosomes and improving intracellular delivery efficacy [80][81]. Developing targeted delivery systems, summarized in Table 2, that can fine-tune macrophage
Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258
Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8
- electronic transition, making them suitable for further applications in photocatalysis, electronics, and optoelectronics. Photocatalytic study ZnO NPs were utilized in a photocatalytic degradation test to reduce the concentration of the harmful dye methylene blue (MB). A solution containing 20 mg of ZnO NP
- MB dye progressed with time and yielded 95% degradation under 120 min. The process involved in dye degradation is exciting electrons and generating holes in the semiconductor. The produced electrons form superoxide radicals (•O2−) by reacting with O2, while holes react with water (H2O) molecules to
- produce hydroxyl radicals (•OH−). These radicals degrade the dye molecules into harmless substances; the degradation is shown in Figure 2d. TEM analysis The size of the ZnO NPs, which was determined from TEM using Image J software, varied from 7 to 98 nm, with an average size of 10 nm. The SAED pattern of
Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research
Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7
- from compounding, machining, use, weathering, degradation, or incineration of products. To achieve such a full characterisation of the materials along their complete life cycle and, at the same time, move the methods forward on their road to standardisation – all in the short time of the project
A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2
- disintegrates the nanocarrier, leading to the release of Atr (Scheme 1). This paper discusses the synthesis of the Atr nanocarrier, its physicochemical and biological properties, the encapsulation of Atr into the nanocarrier cavity, ACh hydrolysis, nanocarrier degradation, and Atr release under the ACh action
- observed (Figure 4). With further dilution, no erythrocyte effects were noted, as confirmed by bright-field microscopy (Figure 4). The nanocarrier p(Hist-CA) induced hemolysis (27.1%) and agglutination solely at the highest concentration (Figure 3 and Supporting Information File 1, Figure S4). Degradation
- of p(Hist-CA) under the influence of ACh The degradation of p(Hist-CA) was analyzed using DLS, GPC, and conductometry. After adding a tenfold excess of ACh compared to the RA fragments, the PdI of p(Hist-CA) increased to 0.6, and three peaks appeared in the distribution diagram with average
Orientation-dependent photonic bandgaps in gold-dust weevil scales and their titania bioreplicates
Beilstein J. Nanotechnol. 2025, 16, 1–10, doi:10.3762/bjnano.16.1
- step (130 °C). Raising the temperature slightly might increase the effective refractive index of titania before lattice degradation occurs. If the process could be additionally tuned by, for example, varying process times and chemical compositions (including hybrid sol/gels), a further reduction of
Mechanistic insights into endosomal escape by sodium oleate-modified liposomes
Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131
- are frequently confined within endosomes, where they risk degradation in lysosomes or expulsion back to the cell surface. This endosomal barrier critically impedes the effective release of encapsulated drugs into the cytosol, limiting their therapeutic impact [2][3]. Consequently, facilitating
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications
Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127
- relevant and challenging human diseases. This study demonstrates that mimicking cell membranes, particularly those of immune system cells, offers significant benefits by reducing the degradation of biomaterials by the host. The use of biocompatible coatings not only enhances treatment efficacy but also
Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol
Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124
- (2.8 μM) for As3+, and 245.49 ppb (4.7 μM) for Cr3+. Additionally, these nanoparticles demonstrated catalytic activity regarding the degradation of p-nitrophenol (P-NP), achieving complete degradation of 0.25 and 1 mM solutions within 5 and 10 min, respectively. This study reveals the potential of ʟ
- -car-AgNPs for both heavy metal ion detection and catalytic degradation of P-NP, indicating their suitability for environmental monitoring and remediation applications. Further optimization and research are needed to expand their environmental applications and to understand their interaction mechanisms
- biomagnification [1]. Similarly, organic pollutants such as p-nitrophenol (P-NP), from agricultural and industrial processes, are of significant concern because of their toxicity and resistance to degradation [2]. Consequently, detection and removal of these contaminants have become crucial for environmental
Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123
- lead to oxidation and degradation of enzymes and organelles in the intracellular space of cells, affecting cellular physiological processes, leading to large-scale apoptosis and, consequently, larval death. Vinoth, et al. [51] evaluated the larvicidal activity of AgNPs from S. polycystum seaweed
Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies
Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119
- ]. The digital twin serves as a powerful tool for predictive modelling, optimization, and design of materials, allowing researchers to assess performance under different conditions, predict degradation mechanisms, and optimize material properties. It also facilitates virtual experimentation, reducing the
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- polyethylene glycol (PEG), poly(lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and chitosan (CHS), provides structural integrity, controlled release properties, and protection against premature degradation [14][15]. This hybrid structure improves the encapsulation efficiency of phytochemicals/drugs
- metabolism, and degradation in the physiological fluids. This necessitates higher doses to achieve therapeutic effects, which may increase the risk of side effects and toxicity [26][27]. Chemical instability is also a critical challenge. Phytochemicals can be chemically unstable and degrade under
- physiological conditions, such as varying pH levels, temperature, and enzymatic activity. Degradation reduces the effective concentration of the phytochemical, diminishing its therapeutic potential [28][29]. Rapid metabolism and clearance further complicate phytochemical delivery. Phytochemicals are often
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113
- ][26] and protect the drug from biological or chemical degradation or deactivation, which results in increased bioavailability in the brain [18][27]. This is particularly important since many other routes of administration pose multiple barriers and lead to relevant drug degradation, which are huge
- administration also suffers from enzymatic degradation including peptidase and protease activity, making it challenging to deliver peptides and proteins [29][30]. Yet, the intranasal route still yields lower enzymatic degradation and higher bioavailability in the brain [31]. While the challenges of the
- ][62]. Drug delivery systems for N2B delivery applications DDS can deliver the encapsulated APIs to the brain using olfactory or trigeminal pathways while protecting the drug from biological and chemical degradation. Moreover, they can provide target-specific delivery via surface modifications and
Various CVD-grown ZnO nanostructures for nanodevices and interdisciplinary applications
Beilstein J. Nanotechnol. 2024, 15, 1390–1399, doi:10.3762/bjnano.15.112
- ], photocatalytic degradation [41], and water splitting for hydrogen technologies [38]. Figure 3a–d show SEM images of ZnO tetrapods. These various morphologies were grown at approx. 625–650 °C. The first one, named T1 in Figure 3a, has needle-like arms of ≈1 μm of length. The dimeter of the arms is less than 50 nm
Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol
Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106
- nanoparticle-based systems capable of efficient detection and degradation. However, conventional approaches utilizing strong capping agents like cetrimonium bromide (CTAB) on nanoparticles lead to limitations due to the rigid nature of CTAB. This restricts its utility in heavy metal detection and 4-NP
- degradation, requiring additional surface modifications using linker molecules, thereby increasing process complexity and cost. To overcome these limitations, there is a critical need for the development of an easy-to-use, dual-functional, linker-free nanosystem capable of simultaneous detection of heavy
- metals and efficient degradation of 4-NP. For enabling linker-free/ligand-free detection of heavy metal ions and catalytic degradation of 4-NP, CTAB was engineered as a versatile capping agent on gold and silver nanoparticles. Various factors, including nanoparticle characteristics such as shape, size
Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans
Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105
- , phototransformation, and degradation [8]. Furthermore, because of the presence of sites for different types of interaction mechanisms (i.e., hydrogen bonding, van der Waals interaction, and π–π stacking), its structure favors the adsorption of different molecules (i.e., biomolecules and organic pollutants) and metal
- ions [8][9][10]. The physicochemical changes and interactions undergone by GO in the environment greatly influence the biological effects of this material. Recently, Bortolozzo et al. [11] showed that GO degradation by sodium hypochlorite resulted in the mitigation of GO toxicity to Caenorhabditis
Mn-doped ZnO nanopowders prepared by sol–gel and microwave-assisted sol–gel methods and their photocatalytic properties
Beilstein J. Nanotechnol. 2024, 15, 1283–1296, doi:10.3762/bjnano.15.104
- use in photocatalysis processes (i.e., degradation of oxalic acid). In addition, the measured excitonic PL indicates the need for deeper investigation on the ability of the investigated materials to generate reactive oxygen species (ROS) under light irradiation. The photoluminescence signal of the
- fluorescent compound, namely umbelliferone, a coumarin degradation product obtained in the presence of hydroxyl radicals. Figure 11a–c clearly shows that ·OH radicals are photogenerated to a greater extent by the MW catalyst. This could be the result of specific differences in surface chemistry of the two
- photocatalyst for organic pollutant degradation but also underscore the importance of optimizing synthesis methods to enhance efficiency and reduce energy consumption. These advancements are crucial for addressing pressing environmental challenges and pave the way for more sustainable approaches to water
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