Interface-engineered Caco-2 cell culture on a collagen-coated liquid–liquid interface in a microfluidic device

• Satoru Kuriu and
• Soo Hyeon Kim

Beilstein J. Nanotechnol. 2026, 17, 760–768, doi:10.3762/bjnano.17.53

• Caco-2 cells in the device, we show that the liquid interface supports cell attachment and the formation of monolayers. Immunofluorescence observation reveals the development of tight junctions and organized actin cytoskeletons, indicating early-stage epithelial maturation. Our new microfluidic system

• substrates for epithelial cell culture and highlight their potential for the development of flexible, multiphase microfluidic models of epithelial barrier. Results and Discussion Liquid–liquid interface formation in the microfluidic device The liquid–liquid interface was formed by first filling the

Superconducting artificial neural networks and quantum circuits

• Anatolie S. Sidorenko

Beilstein J. Nanotechnol. 2026, 17, 744–747, doi:10.3762/bjnano.17.51

• - and video-based traffic violation detection systems or face recognition in crowds [2]. Hardware neural networks, in contrast, are implemented as specialised physical devices such as chips or processors [3]. The development of such systems represents a complex physical and engineering challenge

• analogues [5]. Tuneable superconducting neurons and network architectures based on these principles have already been demonstrated [6]. Despite broad scientific and engineering interest in the development of artificial neural networks and quantum circuits, many fundamental problems remain unresolved. Among

• broadband signal reception, including superconducting signal processing for wideband spectrum sensing [10], as well as the development of quantum computing architectures and basic qubit technologies [11]; (iii) on-board signal processing in satellite systems, where severe constraints on power consumption

Environmental applications of silver nanoparticles: state-of-the-art review and emerging trends

• Soni Prajapati,
• Akash Kumar and
• Ranjana Singh

Beilstein J. Nanotechnol. 2026, 17, 697–736, doi:10.3762/bjnano.17.49

• , as shown in Figure 3. 3.1 Water applications The global demand for clean and safe drinking water continues to increase due to population growth, urbanisation, and industrialisation. Clean water and sanitation are part of Sustainable Development Goal 6 (SDG6), which must be achieved by 2030

• poses a significant threat to human health and the environment, necessitating the development of efficient and sustainable air purification technologies. The primary air pollutants include particulate matter (PM), gases (CO, NO2, SO2), metals (Pb), PAHs, volatile organic compounds (VOCs), and dioxins

Molecular engineering of individual dye-based nanoparticle photostability for ultrabright two-photon fluorescence

• Eleonore Kurek,
• Sasha Cooper,
• Alexandre Clausolles,
• Karen Perronet,
• Jonathan Daniel,
• Mireille Blanchard-Desce and
• François Marquier

Beilstein J. Nanotechnol. 2026, 17, 688–696, doi:10.3762/bjnano.17.48

• significantly faster, confirming the trade-off between absorption efficiency and photostability. These results demonstrate that the photophysical behavior of dFONs can be rationally engineered at the molecular level and provide design principles for the development of optimized organic nanoparticles for

Protein-based custom-designed molecular nanotraps for biomedical applications

• Devid Maniglio,
• Alice Marinangeli and
• Alessandra Maria Bossi

Beilstein J. Nanotechnol. 2026, 17, 683–687, doi:10.3762/bjnano.17.47

• /bjnano.17.47 Abstract The development of highly selective nanoscaled platforms for molecular recognition has gained significant attention in nanomedicine. Recently, we pioneered a versatile methodology for fabricating custom-designed molecular nanotraps using naturally derived polymers, by relying on

afspm: A framework for manufacturer-agnostic automation in scanning probe microscopy

• Nicholas J. Sullivan,
• Julio J. Valdés,
• Kirk H. Bevan and
• Peter Grutter

Beilstein J. Nanotechnol. 2026, 17, 653–667, doi:10.3762/bjnano.17.45

• scripts via our IPC interface (see Figure 9a, matching the design of Figure 4f). Minor changes were made to GXSM’s Python programming interface to simplify cancelling and restarting scripts, pushed to GXSM’s main development branch. Since a pre-existing Python package for reading GXSM scans and

• made minor modifications to this tool in order to support the underlying data analysis software used by Asylum Research, an earlier version of Igor PRO. These changes were pushed to “ZeroMQ-XOP”’s main development branch. For reading Asylum Research scans and spectroscopies, the Python package

• , the Bluesky data model may serve as a useful approach for organizing experimental data and metadata for later search and retrieval. The development of automated tasks within a manufacturer-agnostic framework enables code sharing among the SPM community. This framework is a reasonable first step toward

Cellulose as a photocatalyst support material: extraction, structural features, and environmental applications

• Yee Teng Lim,
• Nur Farhana Jaafar,
• Azizul Hakim Lahuri and
• Endang Tri Wahyuni

Beilstein J. Nanotechnol. 2026, 17, 635–652, doi:10.3762/bjnano.17.44

• promising candidate for sustainable material development across various industries. This review focuses on the extraction and isolation of cellulose from different types of biomass waste, including agricultural residues, forestry byproducts, and industrial waste. Several conventional and advanced methods

• development of magnetic paper designed for anti-counterfeiting purposes [66]. Cellulose has a long history of use in the biomedical field. Today, several forms of medical-grade cellulose are widely available, including propellant cellulose, MCC, and its common derivatives such as carboxymethyl cellulose and

• solubility, improved compatibility with biological systems, and the ability to be tuned or functionalized for the development of advanced composite materials [68][69]. These forms of cellulose are particularly valuable in producing highly purified wound dressings that promote tissue regeneration, especially

Two-step laser synthesis of Ag@TiO₂ nanomaterials for the photocatalytic degradation of rhodamine B

• Marija Kovačević,
• Miloš Tošić,
• Rafaela Radičić,
• Vladimir Rajić,
• Nikša Krstulović,
• Miloš Momčilović and
• Sanja Živković

Beilstein J. Nanotechnol. 2026, 17, 622–634, doi:10.3762/bjnano.17.43

• photocatalytic degradation of RhB. Comparison of the results obtained with literature data. Funding This research was funded by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Contract number: 451-03-33/2026-03/ 200017). This work was supported by the project Centre

• for Advanced Laser Techniques (CALT), co-funded by the European Union through the European Regional Development Fund under the Competitiveness and Cohesion Operational Programme (Grant No. KK.01.1.1.05.0001).

Recent progress in enhancing built-in electric fields of perovskite solar cells via junction engineering

• Tong Xiao and
• Ke Xu

Beilstein J. Nanotechnol. 2026, 17, 602–621, doi:10.3762/bjnano.17.42

• unified framework of BEF descriptors, magnitude, penetration depth, directionality, and spatial continuity. Special emphasis is placed on the potential for synergistic integration of multiple junction architectures and on the development of mild, process-compatible fabrication routes. Ultimately

• the top of the absorber extends homojunction control from the interface into the bulk, revealing a trend toward the development of continuous gradient junctions across the film thickness (see Table 1 for representative strategies and photovoltaic performance). This study quantified the impact of the n

Towards targeted drugs and next generation of nanomedicines

• Anna Salvati,
• Silvia Giordani and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2026, 17, 598–601, doi:10.3762/bjnano.17.41

• -CoV-2 infection during the COVID-19 pandemic [5][6][7]. While the successes of these technologies are clear, extensive research is still focused on further improving nanomedicine efficacy toward the development of the next generation of nanomedicines. From a semantic point of view, one might argue

• controls available, which were decisive for the development towards clinical use. Last but not least, the field of nanosafety/nanotoxicology has set focus on the importance of counterbalancing the benefits and risks of the use of nanomaterials for potential clinical applications. Hence, while the first

• future development. Bioavailability is an important factor for pharmaceutical agents. Here nanoparticles have the great advantage that their physicochemical properties can be largely tailored. A hydrophobic drug can be made more water soluble by linking it to a hydrophilic nanoparticle. However, as with

Probing tribological evolution in atomically thin MoS₂ at different scales

• Xingzhong Zeng and
• Miao Zhang

Beilstein J. Nanotechnol. 2026, 17, 586–597, doi:10.3762/bjnano.17.40

• advance the understanding of 2D material tribology from the nanoscale to the sub-nanoscale, providing a framework for predicting and controlling friction in atomically thin materials. The load-layer thickness phase diagram for MoS2 friction behaviors offers critical guidance for the development of low

Laser–material interactions in liquids for the synthesis of nanomaterials: current status and perspectives

• Carlos Doñate Buendia,
• Bilal Gökce and
• Leonid V. Zhigilei

Beilstein J. Nanotechnol. 2026, 17, 571–575, doi:10.3762/bjnano.17.38

• development of cost-effective, high-throughput technologies. Laser processing in liquids is not merely a synthesis technique – it is an enabling platform for innovation in the development of next-generation nanomaterials, and its full potential is only beginning to be realized. Carlos Doñate Buendia, Bilal

Advances in nanotechnology applied to natural products

• Douglas Dourado,
• Fábio Rocha Formiga,
• Éverton do Nascimento Alencar and
• Franceline Reynaud

Beilstein J. Nanotechnol. 2026, 17, 555–558, doi:10.3762/bjnano.17.36

• this thematic issue, we bring together advances from original full research, letter, and review articles examining how nanostructured systems can enable the development of safer, more stable, and more effective formulations containing natural products. The collection spans lipid-based, polymeric

• experimental models [13]. In topical applications, they can promote skin permeation, and controlled release and support formulation robustness, including those intended for transdermal and ocular administration, thereby consolidating microemulsions as versatile and practical platforms for the development of

• therapeutic agents has enabled the development of multifunctional platforms, which can improve cellular uptake, enhance tumor penetration, reduce systemic side effects, and integrate therapeutic and diagnostic functions [19]. Beyond lipid-based systems, polymeric nanosystems have emerged as versatile

Electrochemical determination of ciprofloxacin using a MIL-101/reduced graphene oxide-modified electrode

• Nguyen Quang Man,
• Nguyen Ngoc Nghia,
• Nguyen Vinh Phu,
• Vo Thi Khanh Ly,
• Le Lam Son,
• Pham Khac Lieu,
• Le Thi Hong Phong,
• Nguyen Dinh Luyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2026, 17, 541–554, doi:10.3762/bjnano.17.35

• fluids, and aquatic environments [2][3]. The uncontrolled presence of ciprofloxacin not only poses risks to human health but also promotes the development of antibiotic-resistant bacteria, raising significant environmental and public health concerns [4]. Therefore, developing sensitive, selective, and

Defects and defect-mediated engineering of two-dimensional materials: challenges and open questions

• Arkady V. Krasheninnikov,
• Matthias Batzill,
• Anouar-Akacha Delenda,
• Marija Drndić,
• Chris Ewels,
• Katharina J. Franke,
• Mahdi Ghorbani-Asl,
• Alexander Holleitner,
• Ado Jorio,
• Ute Kaiser,
• Daria Kieczka,
• Hannu-Pekka Komsa,
• Jani Kotakoski,
• Manuel Längle,
• David Lamprecht,
• Yun Liu,
• Steven G. Louie,
• Janina Maultzsch,
• Thomas Michely,
• Katherine Milton,
• Anna Niggas,
• Hanako Okuno,
• Joshua A. Robinson,
• Marika Schleberger,
• Bruno Schuler,
• Alexander Shluger,
• Kazu Suenaga,
• Kristian S. Thygesen,
• Richard A. Wilhelm,
• E. Harriet Åhlgren and
• Carla Bittencourt

Beilstein J. Nanotechnol. 2026, 17, 454–488, doi:10.3762/bjnano.17.31

• been computationally prohibitively costly, but modern machine learning models have enabled such simulations for non-resonant Raman experiments. Therefore, the great challenge is the development of higher-precision measurements utilizing nano-Raman spectroscopy (see Figure 3). When nano-Raman is

• , promise to further enhance defect characterization and accelerate the development of high-performance materials for various applications. The fundamental principle of XPS lies in its ability to probe the binding energies of core electrons, which are influenced by the local electronic environment

Nanocarrier-integrated multilayer films produced by 3D printing for improved skin adhesion and curcumin photostability

• Thayse Viana de Oliveira,
• Ana Paula Farias Leão,
• Júlia Leão,
• Cesar Liberato Petzhold and
• Ruy Carlos Ruver Beck

Beilstein J. Nanotechnol. 2026, 17, 440–453, doi:10.3762/bjnano.17.30

• antioxidant compound. The development of topical films for cutaneous delivery faces several challenges, including the need for strong skin adhesion and the protection of photolabile actives from light exposure. We hypothesized that multilayered films designed for the cutaneous delivery of curcumin and

• formulations, drug combinations, and release profiles can be developed in the form of either immediate-release or extended-release options [1][2]. Several 3D printing techniques can be applied to pharmaceutical development, including material jetting, fused deposition modelling, stereolithography, selective

• the development of specialised dressings using materials such as alginate and carboxymethylcellulose as alternatives to traditional gauze [13][14]. Bioactive molecules such as curcumin have shown promise for use in the promotion of skin repair and wound healing. Curcumin is a photosensitive polyphenol

Nanoinformatics: spanning scales, systems and solutions

• Iseult Lynch,
• Diego S. T. Martinez,
• Kunal Roy and
• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 423–427, doi:10.3762/bjnano.17.28

• nanomaterials physicochemical properties, structural features, and biomolecule interactions using both physics-based and machine-learning (ML) approaches; (ii) prediction of nanomaterials toxicity including development of novel toxicity-related descriptors; (iii) solution-focussed approaches applying advanced

• nanomaterials, thus helping to fill the current gap in the toxicity data for zebrafish [8]. A major driver of the development of nanomaterials, nanoinformatics and ML/AI is the potential for solutions to real-world issues, whether in nanomedicine, nano-enabled agriculture, or environmental remediation

• approaches to establish a framework for representing materials-related information and facilitate interoperability across diverse tools. The approach highlights the role of digital twins in nanomaterials development and examines the impact of knowledge engineering in establishing data and information

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

• Valentina I. Gorbacheva,
• Alexey S. Grabovoy,
• Polina S. Marukhina,
• Anastasiia O. Syrocheva and
• Ekaterina P. Kolesova

Beilstein J. Nanotechnol. 2026, 17, 396–422, doi:10.3762/bjnano.17.27

• examines recent progress in the development of BNPs for cancer photodynamic therapy, with particular attention to their ability to target tumors, counteract hypoxia, and stimulate the immune system. We also explore their use in treating different types of cancer, the emergence of multifunctional platforms

• and active targeting mechanisms, (iii) controlled and stimuli-responsive release profiles, (iv) overcoming of tumor hypoxia, (v) efficient light conversion, and (vi) the development of multifunctional platforms by combining PDT with other therapeutic modalities [38]. Additionally, nanoparticles enable

• theranostic applications [39] by facilitating tumor visualization through various imaging techniques [40], including fluorescence imaging [41], computed tomography [42], and magnetic resonance imaging (MRI) [43]. The development of nanobiotechnology in PDT opens new horizons for creating more effective and

Eco-efficient materials for agricultural crops based on a mineral rich in MOR- and HEU-type zeolites

• Esperanza Yamile de la Nuez-Pantoja,
• Inocente Rodríguez-Iznaga,
• Gerardo Rodríguez-Fuentes,
• Vitalii Petranovskii,
• Ariel Martínez García,
• José Juan Calvino Gámez and
• Daniel Goma Jiménez

Beilstein J. Nanotechnol. 2026, 17, 381–395, doi:10.3762/bjnano.17.26

• development of plants, as evidenced in the cultivation tests. Keywords: adsorption; agroecological fertilizer; ion exchange; MOR–HEU zeolite mixture; natural zeolite; Introduction Traditional chemical fertilizers, widely used in agriculture, undergo significant nutrient losses resulting from dissolution and

• natural zeolites are a viable alternative for the development of efficient, agroecologically sustainable, and low-cost fertilizer materials for massive applications [3][4]. Natural zeolites are porous crystalline hydrated aluminosilicates. They have a three-dimensional, rigid, negatively charged structure

• losses during dissolution [6][7][8][9]; also, more than 30% of their total weight is water, which provides additional moisture during hot and dry periods. These characteristics make zeolites potentially applicable in agriculture for the development of modern fertilizers with controlled release and

Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets

• Paulina Trzaskowska,
• Ewa Rybak,
• Maciej Trzaskowski,
• Kamil Kopeć,
• Jakub Krzemiński,
• Rafał Podgórski,
• Hatice Genc,
• Mehtap Civelek and
• Iwona Cicha

Beilstein J. Nanotechnol. 2026, 17, 365–380, doi:10.3762/bjnano.17.25

• controlled nanoscale surface features in the development of next-generation bioactive coatings for medical implants and blood-contacting devices. Experimental Materials and methods Stainless steel samples Stainless steel 316L discs (14 mm in diameter, 0.8 mm in thickness) were laser-cut by STOMILEX (Poland

Ferroelectric nanodot reservoir for neuromorphic computing

• Anna Razumnaya,
• Yuri Tikhonov,
• Dmitrii Naidenko,
• Léo Boron,
• Valerii Vinokur and
• Igor Lukyanchuk

Beilstein J. Nanotechnol. 2026, 17, 352–364, doi:10.3762/bjnano.17.24

• implementations. Contactless interfaces Contactless input and output methods of data integration between the reservoir and external neuromorphic interfaces are of particular importance for the development of scalable, high-resolution, ultrafast, and non-invasive neuromorphic systems. They enable direct

Beam shaping techniques for pulsed laser ablation in liquids: Unlocking tunable control of nanoparticle synthesis in liquids

• Sergio Molina-Prados,
• Nadezhda M. Bulgakova,
• Alexander V. Bulgakov,
• Jesus Lancis,
• Gladys Mínguez Vega and
• Carlos Doñate-Buendia

Beilstein J. Nanotechnol. 2026, 17, 309–342, doi:10.3762/bjnano.17.22

Fast vortex dynamics and relaxation times in NbRe-based heterostructures

• Francesco De Chiara,
• Zahra Makhdoumi Kakhaki,
• Francesco Avitabile,
• Francesco Colangelo,
• Abhishek Kumar,
• Carmine Attanasio and
• Carla Cirillo

Beilstein J. Nanotechnol. 2026, 17, 292–302, doi:10.3762/bjnano.17.20

• optimization of superconducting quantum technologies, including superconducting detectors [10][11][12], superconducting qubits [13][14], and superconducting nano- and microstrips used in high-speed electronics [15], as well as for the development of hybrid architectures enabling magnon–fluxon interactions [16

Advancing nanolithography: a comprehensive review of materials for local anodic oxidation with AFM

• Matteo Lorenzoni

Beilstein J. Nanotechnol. 2026, 17, 275–291, doi:10.3762/bjnano.17.19

• provide a comprehensive understanding of material selection in LAO and its implications for advancing nanotechnology. Keywords: local anodic oxidation; nanofabrication; scanning probe lithography; Review 1 Introduction Advancements in nanotechnology have led to the development of numerous nanoscale

• positive and negative tone as well as self-development reactions within ultrathin molecular resist layers [56][65][66], with resolutions reaching sub-10 nm scales [67]. As demonstrated by Prof. Ivo W. Rangelov and colleagues, FEL relies on the high-intensity electric fields generated at the sharp AFM tip

• potential for advancing protein patterning, tissue engineering, biomedical implants, and biosensor development. LAO offers a promising route for fabricating superconducting quantum devices by enabling direct, nanoscale patterning of Josephson junctions without conventional lithography. Using a biased AFM

Durable antimicrobial activity of fabrics functionalized with zeolite ion-exchanged nanomaterials against Staphylococcus aureus and Escherichia coli

• Perla Sánchez-López,
• Kendra Ramirez Acosta,
• Sergio Fuentes Moyado,
• Ruben Dario Cadena-Nava and
• Elena Smolentseva

Beilstein J. Nanotechnol. 2026, 17, 262–274, doi:10.3762/bjnano.17.18

• functionalization. This method demonstrates a simple and industry-compatible approach for producing durable antimicrobial cotton fabrics. Keywords: antimicrobial activity; Escherichia coli; fabrics functionalization; ion exchange; nanomaterial; Staphylococcus aureus; zeolite; Introduction The development of