Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• for rapid adjustments to nanomaterial formulations or processing parameters in response to emerging safety or efficacy concerns. By simulating how nanomaterials behave across varying operational scenarios – incorporating factors like temperature, pH, or mechanical stress – digital twins will

Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery

• Dushko Shalabalija,
• Ljubica Mihailova,
• Nikola Geskovski,
• Andreas Zimmer,
• Otmar Geiss,
• Sabrina Gioria,
• Diletta Scaccabarozzi and
• Marija Glavas Dodov

Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

Functional surface engineering for cultural heritage protection: the role of superhydrophobic and superoleophobic coatings – a comprehensive review

• Giuseppe Cesare Lama,
• Marino Lavorgna,
• Letizia Verdolotti,
• Federica Recupido,
• Giovanna Giuliana Buonocore and
• Bharat Bhushan

Beilstein J. Nanotechnol. 2026, 17, 63–96, doi:10.3762/bjnano.17.6

• the analysis of the statue of Darius from Susa, in modern Iran [13]. The statue was found in Egypt in 1972, and was then transferred to Teheran, Iran. The paper by Shahrokh reveals how a combination of natural wear, such as erosion and structural stress, and anthropogenic damage, including the loss of

• transparency; however, several limitations can be highlighted. The resins are not always compatible with metal patina [49] and are also easily prone to yellowing due to ageing from ultraviolet (UV) radiation or thermal stress [50], while the waxes guarantee a protection from corrosion, but only in the early

• ICOM preventive conservation criteria. Substrate characteristics determine not only how the coating adheres, but also how easily it can be removed, how stable it remains under environmental stress, and whether it alters the optical appearance of the surface. These considerations are particularly

Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy

• Aydan Çiçek,
• Markus Kratzer,
• Christian Teichert and
• Christian Mitterer

Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1

• strength provides a practical framework for characterizing NP/substrate interactions. Such understanding is essential for developing reliable NP coatings, where adhesion directly influences coating stability, uniformity, and functional performance under varying environmental and mechanical stress

Internal 3D temperature mapping in biological systems using ratiometric light-sheet imaging and lipid-coated upconversion nanothermometers

• Dannareli Barron-Ortiz,
• Enric Pérez-Parets,
• Rubén D. Cadena-Nava,
• Emilio J. Gualda,
• Jacob Licea-Rodríguez,
• Juan Hernández-Cordero,
• Pablo Loza-Álvarez and
• Israel Rocha-Mendoza

Beilstein J. Nanotechnol. 2025, 16, 2306–2316, doi:10.3762/bjnano.16.159

• range was chosen because (i) it remains below the high-stress temperature threshold of C. elegans (>35 °C) [53] and (ii) it falls within the linear, high-sensitivity region of the NaYF4:Yb/Er nanoparticle thermometric response (20–100 °C) [44]. The black diamonds denote the combined mean values of both

• millisecond-scale slice acquisition inherent to LSFM make real-time thermometry in living organisms entirely feasible. This capability would enable monitoring metabolic or stress-induced temperature fluctuations at the single-organ level and evaluating thermal side effects of optogenetic, photothermal, or

• metabolism to organ-specific stress responses. Characteristic UC fluorescent emission spectra of NaYF4:Er3+/Yb3+ in the green region when irradiated with 980 nm laser light. Insets: UC process scheme (right). Schematic representation of the energy transfer between Yb3+ and Er3+ ions and the UC emission in an

Improving magnetic properties of Mn- and Zn-doped core–shell iron oxide nanoparticles by tuning their size

• Dounia Louaguef,
• Ghouti Medjahdi,
• Sébastien Diliberto,
• Klaus M. Seemann,
• Thomas Gries,
• Joelle Bizeau,
• Damien Mertz,
• Eric Gaffet and
• Halima Alem

Beilstein J. Nanotechnol. 2025, 16, 2285–2295, doi:10.3762/bjnano.16.157

• they induce oxidative stress, genotoxic effects, and inflammation [8][9]. This has raised concerns regarding their use in clinical applications, leading researchers to develop alternative, non-toxic substitutes for Co-based nanoparticles. In this context, manganese ferrite (MnFe2O4) has been identified

• high SAR values, cobalt-containing nanoparticles are not suitable for biomedical applications due to the well-known cytotoxicity of cobalt ions. Studies have shown that cobalt ions released from nanoparticles can induce oxidative stress, inflammation, and cellular damage, which limits their use in

Visualizing nanostructures in supramolecular hydrogels: a correlative study using confocal and cryogenic scanning electron microscopy

• Shaun M. Smith,
• Ferdinando Malagreca,
• Jacqueline Hicks,
• Giuseppe Mantovani,
• David B. Amabilino,
• Christopher Parmenter and
• Lluïsa Pérez-García

Beilstein J. Nanotechnol. 2025, 16, 2274–2284, doi:10.3762/bjnano.16.156

• insights into gel behaviour under mechanical stress, did not reliably capture the morphology of the hydrated gel in its native state. These results show the limitations of using low quantum yield fluorophores like ZnPc for CLSM analysis of supramolecular hydrogels. DPP-BC@Gel In general, DPP dyes are

• exist [37][38]) for the morphological analysis of soft materials, particularly where fluorophore properties or sample preparation requirements might obscure key features in a single modality. Moreover, the results stress the importance of fluorophore selection in CLSM studies of supramolecular systems

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• ]. This water-soluble micronutrient is essential for improving brain and nervous system functions, blood cell development, bone health improvement, energy and DNA production, fertility and embryo development, control of neurological symptoms (e.g., stress, depression, dementia, and visual disturbances

Microplastic pollution in Himalayan lakes: assessment, risks, and sustainable remediation strategies

• Sameeksha Rawat,
• S. M. Tauseef and
• Madhuben Sharma

Beilstein J. Nanotechnol. 2025, 16, 2144–2167, doi:10.3762/bjnano.16.148

• -altitude lakes, where particles accumulate in the gut and gill tissues and interfere with normal physiological functions [113]. The low molecular weight of MPs, and particularly nanoparticles (NPs), allows them to easily translocate into organs and tissues resulting in inflammation, oxidative stress, and

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• of the MEgel could not be determined. However, NaCMC solutions exhibit negligible surface activity and typically maintain surface tension values close to that of water [48]. Rheological analysis Rheological profiling provides key insights into the behavior of formulations under applied stress or

• . Accordingly, the microemulsions were evaluated for their shear stress and viscosity at both room temperature (25 ± 2 °C) and skin temperature (32.5 ± 2 °C). Microemulsions can exhibit diverse rheological behaviors depending on their type, structure, droplet density, and interdroplet interactions [49]. As

• . Shear stress and viscosity profiles of (A) the base microemulsion, and (B) the gelled microemulsion at 25 and 32.5 °C. Mitochondrial activity of (A) RAW 264.7 murine macrophages and (B) HUVECs after 24 h and 48 h of exposure to different concentrations of the microemulsion, assessed by the MTT assay

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• novel antimicrobial agents. Nanoparticle therapy is emerging as a prominent avenue toward that end [8]. Free radicals represent an important focus in pharmacological research. The severity of oxidative stress, defined as the imbalance between the formation of reactive oxygen/nitrogen species (ROS/RNS

• ) and the activity of the organism’s antioxidative defense systems, is associated with various pathologies such as cancer, aging, and cardiovascular diseases [9]. Some anti-pathological responses of nanoparticles are mediated through increased production of ROS and induction of oxidative stress. This

• nanoparticles [44][45]. Cell inhibition in cell lines can be attributed to intracellular accumulation of nanoparticles leading to oxidative stress-induced apoptosis and necrosis [46]. The findings of this investigation demonstrate that NCs exhibit a substantially lower inhibitory effect on healthy cell lines

Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• the purity of the NMs and remove any impurities before their use, such as CCFs [43]. Studies have shown that CCFs can induce oxidative stress and inflammation in cells, potentially leading to cellular damage and toxicity [44]. The potential toxicity of CCFs is a concern in the field of CNM research

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• mesh at the end of the spatulae were also removed to be replaced by molecular spatulae models. Table 1 lists the parameters and values used to construct the continuum part of the model. The finite element mesh response was governed by linear isotropic elasticity, with the stress–strain relationship

• given by Hooke’s law [36][37]: where σ is the Cauchy stress tensor, ε is the infinitesimal strain tensor, tr(ε) denotes the trace of the strain tensor, I is the second-order identity tensor, and λ and μ are the Lamé parameters defined as: with E being Young’s modulus and ν Poisson’s ratio. The real seta

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• stress, being easily degradable or evaporated upon exposure to air, light, heat, and humidity during processing, use, or storage [27][28]. Their volatile nature, susceptibility to oxidation, and insolubility in water limit their industrial application [29]. To overcome these limitations

Low-temperature AFM with a microwave cavity optomechanical transducer

• Ermes Scarano,
• Elisabet K. Arvidsson,
• August K. Roos,
• Erik Holmgren,
• Riccardo Borgani,
• Mats O. Tholén and
• David B. Haviland

Beilstein J. Nanotechnol. 2025, 16, 1873–1882, doi:10.3762/bjnano.16.130

• in the literature [28][29][30]. The main limitation to the internal quality factor of our microwave resonators is the highly disordered low-stress Si–N layer, which causes significant dielectric losses [31]. As discussed above, the figure of merit of a displacement detector should be evaluated with

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• the threads under wave-induced stress, thereby allowing the byssus to function as both an adhesive and a shock-absorbing tether [7]. Mussel adhesives are difficult to re-create either synthetically or recombinantly [8], the latter due largely to difficulties associated with post-translational

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• water, affecting microbial communities and bioaccumulating in food chains, as shown in the study by Yang and colleagues [110]. Carbon-based nanomaterials, like GO, have the potential to react with biological systems, causing oxidative stress in aquatic organisms by generating reactive oxygen species

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• least 30 days of storage and at least 15 days even under stress conditions, with no signs of macroscopic instability or changes in droplet size. The cytocompatibility of NEs was confirmed in 3T3 fibroblasts at the concentrations tested, indicating potential safety for in vivo trials. Notably, PHYT-NE

• was evaluated over a period of 30 days by monitoring droplet size, PdI, zeta potential, and pH values. In parallel, the samples were subjected to centrifugation at two different speeds (960 and 8600g) to simulate stress conditions. After centrifugation, droplet size, PdI, and ZP were assessed over a

• effectiveness of PHYT-NE in maintaining colloidal stability under storage and stress conditions. For pharmaceutical applications and the intended therapeutic purpose, nanoemulsions must not only be functional but also safe and selective. That is, they should effectively damage the parasite without causing

Piezoelectricity of layered double hydroxides: perspectives regarding piezocatalysis and nanogenerators

• Evgeniy S. Seliverstov,
• Evgeniya A. Tarasenko and
• Olga E. Lebedeva

Beilstein J. Nanotechnol. 2025, 16, 1812–1817, doi:10.3762/bjnano.16.124

• and external stress, leading to increased current generation and reactive oxygen species production. The authors proposed that the piezoelectric field of LDHs facilitates the separation of photo-induced electron–hole pairs and modulates band alignment, thereby synergistically enhancing the piezo

• and 29 times higher than that of individual Zn/Al-LDHs and LDHs combined with peroxydisulfate without light and stress exposure, respectively. This significant enhancement was also attributed to the stimulation of a high current by the photo-piezocatalytic effect generating electrons and holes in Zn

• higher current under mechanical stress) rather than from standardized direct measurements (e.g., d33 coefficients, calibrated PFM, polarization–voltage loops, or macroscopic electromechanical tests). This makes it difficult to determine whether the observed effects are truly piezoelectric in origin, or

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

Beyond the bilayer: multilayered hygroscopic actuation in pine cone scales

• Kim Ulrich,
• Max David Mylo,
• Tom Masselter,
• Fabian Scheckenbach,
• Sophia Fischerbauer,
• Martin Nopens,
• Silja Flenner,
• Imke Greving,
• Linnea Hesse and
• Thomas Speck

Beilstein J. Nanotechnol. 2025, 16, 1695–1710, doi:10.3762/bjnano.16.119

• FEA in Ansys (ver. 2024 R2, Ansys, Inc., Canonsburg, PA, USA). Expansion was modeled using thermal stress analysis (a combination of the steady-state thermal and static structural solvers). The thermal expansion coefficients of the three tissues involved (sclereid layer, sclerenchyma fibers, and brown

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• evolution of passive films under electrochemical stress [67][68]. Batteries The dip-and-pull method allows for surface-sensitive XPS measurements of interfaces that are typically hidden inside batteries. Whilst the cell geometry obviously differs dramatically from that of any conventional cell, the approach

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• cell cycle arrest, regulate oxidative stress, enhance metabolic reprogramming, inhibit invasion and metastasis, and modulate immunity and inflammation [129]. The developed nanoparticles underwent physicochemical characterization by SEM, UV–vis spectroscopy, and encapsulation testing, in which the

• effects, which could contribute to cancer prevention and treatment [135]. In cancer therapy, PCs show potential for inhibiting cancer cell proliferation, inducing apoptosis, modulating oxidative stress, suppressing angiogenesis, and interfering with signaling pathways involved in tumor progression [136