Search results

Search for "Friedel–Crafts" in Full Text gives 190 result(s) in Beilstein Journal of Organic Chemistry.

Ionic multiresonant thermally activated delayed fluorescence emitters for light emitting electrochemical cells

  • Merve Karaman,
  • Abhishek Kumar Gupta,
  • Subeesh Madayanad Suresh,
  • Tomas Matulaitis,
  • Lorenzo Mardegan,
  • Daniel Tordera,
  • Henk J. Bolink,
  • Sen Wu,
  • Stuart Warriner,
  • Ifor D. Samuel and
  • Eli Zysman-Colman

Beilstein J. Org. Chem. 2022, 18, 1311–1321, doi:10.3762/bjoc.18.136

Graphical Abstract
  • 23% overall yield. First, hydrolysis of 1, in situ conversion to the acyl chloride and subsequent Lewis acid-promoted FriedelCrafts acylation reaction produced compound 2 (Scheme 1), where the AlCl3 was also responsible for the demethylation. Compound 2 was then subjected to monoalkylation with 1,4
PDF
Album
Supp Info
Full Research Paper
Published 22 Sep 2022

Vicinal ketoesters – key intermediates in the total synthesis of natural products

  • Marc Paul Beller and
  • Ulrich Koert

Beilstein J. Org. Chem. 2022, 18, 1236–1248, doi:10.3762/bjoc.18.129

Graphical Abstract
  • cycloisomerization of the α-ketoester 22, which can be described as a FriedelCrafts-type reaction or an aldol reaction of an S,O-ketene acetal (Scheme 4). The required ketoester 22 was synthesized from sulfonylchromenone 20, accessible from dihydroxyacetophenone 19 and thiol 18 derived from known alcohol 17 [11][12
  • precursor for an intramolecular FriedelCrafts cyclization (Scheme 9) [24]. Therefore, phenylacetaldehyde 52 was converted to the alcohol 53, which was esterified with the α-ketoacid 54 to give ketoester 55. Grignard addition to the keto carbonyl and subsequent TBS deprotection delivered the tertiary
  • alcohol 56, which was dehydroxylated to the diastereomeric cations VIII and IX. FriedelCrafts reaction gave diastereomeric lactones 57 and 58. The major diastereomer 58 could be converted to the complex polyphenol (−)-hopeanol (59) in seven further steps. (+)-Camptothecin In the formal synthesis of the
PDF
Album
Review
Published 15 Sep 2022

Electrochemical Friedel–Crafts-type amidomethylation of arenes by a novel electrochemical oxidation system using a quasi-divided cell and trialkylammonium tetrafluoroborate

  • Hisanori Senboku,
  • Mizuki Hayama and
  • Hidetoshi Matsuno

Beilstein J. Org. Chem. 2022, 18, 1040–1046, doi:10.3762/bjoc.18.105

Graphical Abstract
  • , Hokkaido 060-8628, Japan 10.3762/bjoc.18.105 Abstract Electrochemical FriedelCrafts-type amidomethylation was successfully carried out by a novel electrochemical oxidation system using a quasi-divided cell and trialkylammonium tetrafluoroborates, such as iPr2NHEtBF4. Constant current electrolysis of
  • amidomethylated products in good to high yields. Keywords: electrochemical oxidation; FriedelCrafts type amidomethylation; N-acyliminium ion; quasi-divided cell; trialkylammonium salt; Introduction Oxidation of amides generates useful intermediates, N-acyliminium ions, which have been widely used in organic
  • synthesis [1][2][3][4]. For example, FriedelCrafts-type amidomethylation [5][6][7][8][9][10][11][12][13][14][15] proceeds efficiently by the reaction of N-acyliminium ions with electron-rich arenes to give the corresponding amidomethylated products in good yields. Since amides are important intermediates
PDF
Album
Supp Info
Letter
Published 18 Aug 2022

Introducing a new 7-ring fused diindenone-dithieno[3,2-b:2',3'-d]thiophene unit as a promising component for organic semiconductor materials

  • Valentin H. K. Fell,
  • Joseph Cameron,
  • Alexander L. Kanibolotsky,
  • Eman J. Hussien and
  • Peter J. Skabara

Beilstein J. Org. Chem. 2022, 18, 944–955, doi:10.3762/bjoc.18.94

Graphical Abstract
  • using polyphosphoric acid [16] and sulfuric acid failed [42], therefore we tried FriedelCrafts acylation. For that, 27 was hydrolysed to the corresponding diacid 28 with lithium hydroxide [15]. In a manner similar to [24], firstly, a ‘cold’ FriedelCrafts acylation in dichloromethane was attempted, in
  • the ring closure proceeded on one side of the molecule. It was assumed that this species precipitated, preventing further reaction. We thus turned to a ‘hot’ FriedelCrafts acylation, in which the reaction mixture was refluxed after the addition of oxalyl chloride, followed by removal of the volatiles
  • . Since the ring-closure with a ‘hot’ FriedelCrafts acylation [43] led to an insoluble material, we wanted to synthesise a soluble derivative by attaching 4-(2-ethylhexyl)-2-methylthiophene groups. This was done by reacting intermediate 27 with compound 32, which was prepared as shown in Scheme 3. In a
PDF
Album
Supp Info
Full Research Paper
Published 01 Aug 2022

Synthetic strategies for the preparation of γ-phostams: 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides

  • Jiaxi Xu

Beilstein J. Org. Chem. 2022, 18, 889–915, doi:10.3762/bjoc.18.90

Graphical Abstract
  • -phenylphosphinamide (92a) and chloromethyl N,N’-dimethyl-N,N’-diphenylphosphondiamide (92b) via an intramolecular FriedelCrafts alkylation. Although they tried several different amide derivatives, only phosphinamide 92a and phosphonic diamide 92b gave the corresponding 1-methyl-1,3-dihydrobenzo[d][1,2]azaphosphole 2
  • from P-(chloromethyl)amide precursors 92a and 92b through intramolecular FriedelCrafts alkylation. Synthesis of 2-allylamino-1,5-dihydro-1,2-azaphosphole 2-oxides from N,N’-diallyl-vinylphosphonodiamides. Diastereoselective synthesis of 2-allylamino-1,5-dihydro-1,2-azaphosphole 2-oxides from N,N
PDF
Album
Review
Published 22 Jul 2022

Copper-catalyzed multicomponent reactions for the efficient synthesis of diverse spirotetrahydrocarbazoles

  • Shao-Cong Zhan,
  • Ren-Jie Fang,
  • Jing Sun and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2022, 18, 796–808, doi:10.3762/bjoc.18.80

Graphical Abstract
  • . On the other hand, the tetrahydrospiro[carbazole-3,5'-pyrimidine] 4 can be converted to aromatized spiro[carbazole-3,5'-pyrimidine] 3 through the oxidation of DDQ. In the absence of the effective dienophile, the normal FriedelCrafts alkylation of 2-methylindole with aromatic aldehyde gives the well
PDF
Album
Supp Info
Full Research Paper
Published 07 Jul 2022

Synthesis of odorants in flow and their applications in perfumery

  • Merlin Kleoff,
  • Paul Kiler and
  • Philipp Heretsch

Beilstein J. Org. Chem. 2022, 18, 754–768, doi:10.3762/bjoc.18.76

Graphical Abstract
  • SAC-13, alkylation of m-cresol with isopropanol proceeds via a FriedelCrafts-type mechanism in much lower selectivity. In contrast, the authors proposed that employing γ-Al2O3 as Lewis acid catalyst, reaction of 39 and isopropanol leads to isopropyl ether 40. This intermediate undergoes a Fries-type
PDF
Album
Review
Published 27 Jun 2022

Heteroleptic metallosupramolecular aggregates/complexation for supramolecular catalysis

  • Prodip Howlader and
  • Michael Schmittel

Beilstein J. Org. Chem. 2022, 18, 597–630, doi:10.3762/bjoc.18.62

Graphical Abstract
  • catalysts that allow ON/OFF reaction control in photoredox catalysis [120], phosphate diester transesterification [121], FriedelCrafts reaction, ring opening of epoxides, oligomerization [116], and acyl-transfer reactions [122][123]. While there are further examples by Mirkin [124][125][126], Schmittel
PDF
Album
Review
Published 27 May 2022

Menadione: a platform and a target to valuable compounds synthesis

  • Acácio S. de Souza,
  • Ruan Carlos B. Ribeiro,
  • Dora C. S. Costa,
  • Fernanda P. Pauli,
  • David R. Pinho,
  • Matheus G. de Moraes,
  • Fernando de C. da Silva,
  • Luana da S. M. Forezi and
  • Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43

Graphical Abstract
PDF
Album
Review
Published 11 Apr 2022

Regioselectivity of the SEAr-based cyclizations and SEAr-terminated annulations of 3,5-unsubstituted, 4-substituted indoles

  • Jonali Das and
  • Sajal Kumar Das

Beilstein J. Org. Chem. 2022, 18, 293–302, doi:10.3762/bjoc.18.33

Graphical Abstract
  • [Pd(C3H5)Cl]2 and ligand L1 (Scheme 2) [11]. The reaction, that could also be considered as FriedelCrafts type, intramolecular allylic alkylation, delivered nine-membered ring bearing 3,4-fused indoles 2 in moderate to good yields. In the asymmetric version of the reaction catalyzed by [Ir(cod)Cl]2
  • in their studies on the intramolecular FriedelCrafts (FC) acylation of 4-substituted indoles [20]. Specifically, N-Ns/Ts-indolyl Meldrum's acid derivatives 28a–f delivered 4,5-fused indoles 29a–f under BF3·OEt2 or Yb(OTf)3 catalysis (Scheme 10A). It should be noted that the authors could not extend
  • preference for cyclization onto the C5 position is more dominating than the higher nucleophilicity of the C3 position, making the CAr–C bond formation completely regioselective at the C5 position. Subsequently in 2017, Li and co-workers also applied the intramolecular FriedelCrafts acylation strategy to get
PDF
Album
Commentary
Published 08 Mar 2022

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

  • Ruan Carlos B. Ribeiro,
  • Patricia G. Ferreira,
  • Amanda de A. Borges,
  • Luana da S. M. Forezi,
  • Fernando de Carvalho da Silva and
  • Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 53–69, doi:10.3762/bjoc.18.5

Graphical Abstract
  • transformations. Organometallics are the most commonly used catalysts to promote C–C bond formation. In addition, other so-called classical reactions are also widely used, such as FriedelCrafts alkylation and acylation, Wittig and Horner–Emmons reactions, carbonyl addition/substitution, α-alkylation, aldol
PDF
Album
Review
Published 05 Jan 2022

Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

  • Ilya A. P. Jourjine,
  • Lukas Zeisel,
  • Jürgen Krauß and
  • Franz Bracher

Beilstein J. Org. Chem. 2021, 17, 2668–2679, doi:10.3762/bjoc.17.181

Graphical Abstract
  • activated derivatives (intramolecular FriedelCrafts acylation) [29][30][31] found wide application here. In a different approach, a total synthesis of dengibsin (1a) was accomplished by Wang and Snieckus in 15 steps by means of a directed remote metalation [32], using a benzamide residue as the directing
PDF
Album
Supp Info
Correction
Full Research Paper
Published 02 Nov 2021

Synthesis of new substituted 7,12-dihydro-6,12-methanodibenzo[c,f]azocine-5-carboxylic acids containing a tetracyclic tetrahydroisoquinoline core structure

  • Agnieszka Grajewska,
  • Maria Chrzanowska and
  • Wiktoria Adamska

Beilstein J. Org. Chem. 2021, 17, 2511–2519, doi:10.3762/bjoc.17.168

Graphical Abstract
  • the intramolecular FriedelCrafts double cyclization reaction and N,N-dibenzylaminoacetaldehyde dialkyl acetals [12][14][15][16] in the Pomeranz–Fritsch-type double cyclization reaction. There is also one example of employing p-quinol acetates as substrates for the synthesis of these compounds [17
  • ]. Recently, a methodology for the synthesis of dihydromethanodibenzoazocines based on a combination of FriedelCrafts and Pictet–Spengler reactions was proposed by Moshkin et al. [18]. We have developed a convenient method for the preparation of C-1-substituted tetrahydroisoquinoline derivatives by using the
PDF
Album
Supp Info
Full Research Paper
Published 07 Oct 2021

Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4-c]carbazoles via domino Diels–Alder reaction

  • Ren-Jie Fang,
  • Chen Yan,
  • Jing Sun,
  • Ying Han and
  • Chao-Guo Yan

Beilstein J. Org. Chem. 2021, 17, 2425–2432, doi:10.3762/bjoc.17.159

Graphical Abstract
  • scope of this domino Diels–Alder reaction, another kind of 3-vinylindoles was employed in the one-pot reaction. First, the 3-(indol-3-yl)-1,3-diphenylpropan-1-ones prepared through FriedelCrafts alkylation of indole with chalcones, were oxidized by DDQ in acetonitrile to generate in situ the expected
PDF
Album
Supp Info
Full Research Paper
Published 16 Sep 2021

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions

  • Andrey I. Puzanov,
  • Dmitry S. Ryabukhin,
  • Anna S. Zalivatskaya,
  • Dmitriy N. Zakusilo,
  • Darya S. Mikson,
  • Irina A. Boyarskaya and
  • Aleksander V. Vasilyev

Beilstein J. Org. Chem. 2021, 17, 2417–2424, doi:10.3762/bjoc.17.158

Graphical Abstract
  • bond of these oxadiazoles quantitatively resulted in E/Z-vinyl triflates. The reactions of the cationic intermediates have been studied by DFT calculations and the reaction mechanisms are discussed. Keywords: acetylene-oxadiazoles; FriedelCrafts reaction; hydroarylation; superelectrophilic activation
PDF
Album
Supp Info
Full Research Paper
Published 15 Sep 2021

Advances in mercury(II)-salt-mediated cyclization reactions of unsaturated bonds

  • Sumana Mandal,
  • Raju D. Chaudhari and
  • Goutam Biswas

Beilstein J. Org. Chem. 2021, 17, 2348–2376, doi:10.3762/bjoc.17.153

Graphical Abstract
  • derivative 127. The plausible mechanism for the formation of compound 127 proceeded consecutively with π-complex formation, FriedelCrafts type addition, deprotonation, and finally protonation of alcohol for the elimination of water to get the final product [92]. A Hg(OTf)2-mediated cyclization was utilized
  • exemplifying benzyl derivative 160 [106]. The reported methodology was an example of the Hg(OTf)2·(TMU)3 complex promoting a moderate and efficient procedure for arylalkyne cyclization to directly afford dihydronapthalene derivatives (Scheme 47). Later, FriedelCrafts type reaction of alkynylfuran 162 and 164
PDF
Album
Review
Published 09 Sep 2021

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

  • Li Liu,
  • Yue Li,
  • Tiao Huang,
  • Dulin Kong and
  • Mingshu Wu

Beilstein J. Org. Chem. 2021, 17, 2321–2328, doi:10.3762/bjoc.17.150

Graphical Abstract
  • recently as precursors in FriedelCrafts reactions of arenes [30][31] and cross-coupling reactions of arylboronic reagents [32]. However, the direct SN1 reaction of such isatin-derived 3-phosphate-substituted oxindoles by halide ions as nucleophiles has not been developed yet and remains an unsolved
PDF
Album
Supp Info
Full Research Paper
Published 07 Sep 2021

Transition-metal-free intramolecular Friedel–Crafts reaction by alkene activation: A method for the synthesis of some novel xanthene derivatives

  • Tülay Yıldız,
  • İrem Baştaş and
  • Hatice Başpınar Küçük

Beilstein J. Org. Chem. 2021, 17, 2203–2208, doi:10.3762/bjoc.17.142

Graphical Abstract
  • significance were synthesized by developing a new synthesis method. In order to obtain xanthene derivatives, the original alkene compounds to be used as the starting materials were synthesized in four steps using appropriate reactions. A cyclization reaction by intramolecular FriedelCrafts alkylation was
  • carried out in order to synthesize the desired xanthene derivatives using the alkenes as starting compounds. The intramolecular FriedelCrafts reaction was catalyzed by trifluoroacetic acid (TFA) and provided some novel substituted 9-methyl-9-arylxanthenes with good yields at room temperature within 6–24
  • hours. As a result, an alkene compound was used for activation with TFA in the synthesis of xanthene through intramolecular FriedelCrafts alkylation for the first time. Keywords: alkene activation; intramolecular FriedelCrafts alkylation; trifluoroacetic acid; xanthene; Introduction The interest in
PDF
Album
Supp Info
Full Research Paper
Published 30 Aug 2021

Facile and innovative catalytic protocol for intramolecular Friedel–Crafts cyclization of Morita–Baylis–Hillman adducts: Synergistic combination of chiral (salen)chromium(III)/BF3·OEt2 catalysis

  • Karthikeyan Soundararajan,
  • Helen Ratna Monica Jeyarajan,
  • Raju Subimol Kamarajapurathu and
  • Karthik Krishna Kumar Ayyanoth

Beilstein J. Org. Chem. 2021, 17, 2186–2193, doi:10.3762/bjoc.17.140

Graphical Abstract
  • .17.140 Abstract The chiral (salen)Cr(III)/BF3·OEt2 catalytic combination was found to be an effective catalyst for intramolecular FriedelCrafts cyclization of electron-deficient Morita–Baylis–Hillman adducts. In presence of mild reaction conditions the chiral (salen)Cr(III)/BF3·OEt2 complex affords 2
  • -substituted-1H-indenes from unique substrates of Morita–Baylis–Hillman adducts via an easy operating practical procedure. Keywords: boron trifluoride etherate; chiral (salen)chromium(III); intramolecular FriedelCrafts cyclization; Morita–Baylis–Hillman adducts; substituted-1H-indenes; Introduction
  • Reactions associated with carbon–carbon bond formations are explored for their synthetic utility in extending the carbon framework in organic molecules [1][2][3]. Among the known C–C bond forming methodologies the FriedelCrafts reaction is the most utilized methodology. As a result of its broad scope of
PDF
Album
Supp Info
Letter
Published 26 Aug 2021

Catalyzed and uncatalyzed procedures for the syntheses of isomeric covalent multi-indolyl hetero non-metallides: an account

  • Ranadeep Talukdar

Beilstein J. Org. Chem. 2021, 17, 2102–2122, doi:10.3762/bjoc.17.137

Graphical Abstract
  • )silane 38 that involved n-BuLi as the base [58]. The strategy was later adopted by Ohshita in 2004 (40a, Scheme 6) [59]. Between 2016 and 2018, some acid-catalyzed syntheses of bis(indol-3-yl)silanes appeared [60][61][62][63]. Chen and co-workers demonstrated a Brønsted acid-catalyzed FriedelCrafts
  • the similar mechanisms. First, the Brønsted or Lewis acid coordinates with silane 51 leading to a solvent-stabilized electron-deficient silane complex 57, where N-protected indole attacks in a FriedelCrafts fashion to give the 3-silylindoles 60 along with molecular hydrogen (Scheme 7b and Scheme 7d
  • FriedelCrafts fashion (Scheme 10a) gave 82 with moderate to good product yields, respectively [69][70]. A similar work by Janosik involved strongly basic conditions at low temperature with bis(phenylsulfonyl)sulfide (83) as the sulfur donor (Scheme 10b) [73][74]. Disulfides are also important reagents
PDF
Album
Review
Published 19 Aug 2021

Recent advances in the syntheses of anthracene derivatives

  • Giovanni S. Baviera and
  • Paulo M. Donate

Beilstein J. Org. Chem. 2021, 17, 2028–2050, doi:10.3762/bjoc.17.131

Graphical Abstract
  • years (2008–2020) and focuses on direct and indirect methods to construct anthracene and anthraquinone frameworks. Keywords: anthracenes; anthraquinones; FriedelCrafts cyclization; intramolecular cyclization; metal-catalyzed; Introduction Anthracene is an important aromatic hydrocarbon consisting of
  • has been reported over the years. The most familiar methods to obtain substituted anthracenes include FriedelCrafts reactions [17], Elbs reaction [18], aromatic cyclodehydration [19][20], Bradsher-type reactions from diarylmethanes [21][22][23], and, more recently, metal-catalyzed reactions with
  • efficiently cyclized [42]. FriedelCrafts alkylation of arenes with aromatic aldehydes The Lewis acid-catalyzed FriedelCrafts alkylation of electron-rich arenes with aromatic aldehydes has proven an efficient and often direct method to prepare anthracene derivatives. Kodomari and co-workers disclosed a
PDF
Album
Review
Published 10 Aug 2021

Cascade intramolecular Prins/Friedel–Crafts cyclization for the synthesis of 4-aryltetralin-2-ols and 5-aryltetrahydro-5H-benzo[7]annulen-7-ols

  • Jie Zheng,
  • Shuyu Meng and
  • Quanrui Wang

Beilstein J. Org. Chem. 2021, 17, 1481–1489, doi:10.3762/bjoc.17.104

Graphical Abstract
  • affording intermediary benzyl carbenium ions, which are then trapped by a variety of electron-rich aromatics via FriedelCrafts alkylation. This cascade Prins/FriedelCrafts cyclization protocol paves an expedient path to medicinally useful 4-aryltetralin-2-ol and 5-aryltetrahydro-5H-benzo[7]annulen-7-ol
  • derivatives. Keywords: 4-aryltetralin-2-ol; 5-aryl-benzo[7]annulen-7-ol; cascade reaction; Prins/FriedelCrafts; Introduction 2,4-Disubstituted tetralins (Figure 1, 1), especially 2-functionalized tetralins are privileged building blocks for medicinal chemistry applications which are known to exhibit a wide
  • to 2,4-disubstituted tetralin compounds and thus facilitate their biological investigations. The cascade Prins/FriedelCrafts reaction to form multiple chemical bonds in one operation has emerged as an atom-economic and straightforward strategy for the construction of oxygen-containing heterocycles
PDF
Album
Supp Info
Full Research Paper
Published 22 Jun 2021

Iodine-catalyzed electrophilic substitution of indoles: Synthesis of (un)symmetrical diindolylmethanes with a quaternary carbon center

  • Thanigaimalai Pillaiyar,
  • Masoud Sedaghati,
  • Andhika B. Mahardhika,
  • Lukas L. Wendt and
  • Christa E. Müller

Beilstein J. Org. Chem. 2021, 17, 1464–1475, doi:10.3762/bjoc.17.102

Graphical Abstract
  • undergoes a C3-selective FriedelCrafts reaction with 2a to deliver intermediate D, and the catalyst I2 is regenerated by the reaction of HOI and I− (see C to D in box highlighted by dashed line). The intermediate D is stabilized by aromatization yielding product 3a and H2O. Conclusion The described novel
  • and efficient synthetic protocol provides a convenient access to a wide range of unsymmetrical trifluoromethylated 3,3'-diindolylmethanes via I2-catalyzed FriedelCrafts alkylation reaction of trifluoromethylated (indol-3-yl)-1-phenylethan-1-ols with substituted indoles. The method was also extended
PDF
Album
Supp Info
Full Research Paper
Published 18 Jun 2021

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

  • Guido Gambacorta,
  • James S. Sharley and
  • Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

Graphical Abstract
PDF
Album
Review
Published 18 May 2021

Prins cyclization-mediated stereoselective synthesis of tetrahydropyrans and dihydropyrans: an inspection of twenty years

  • Asha Budakoti,
  • Pradip Kumar Mondal,
  • Prachi Verma and
  • Jagadish Khamrai

Beilstein J. Org. Chem. 2021, 17, 932–963, doi:10.3762/bjoc.17.77

Graphical Abstract
  • subsequent trapping of the carbocation with the bromide ion led to all-cis-2,4,6-trisubstituted tetrahydropyran 297 (Scheme 69). Lalli and van de Weghe reported a chiral BINOL-derived bisphosphoric acid- and CuCl-catalyzed enantioselective tandem Prins–FriedelCrafts cyclization between homoallylic alcohol
  • ion, which was followed by a completely diastereoselective FriedelCrafts reaction (Scheme 70). List and co-workers devised a strategy employing highly acidic confined iminoimidodiphosphate (iIDP) Brønsted acids 308 that catalyzed asymmetric Prins cyclizations of both aliphatic and aromatic aldehydes
PDF
Album
Review
Published 29 Apr 2021
Other Beilstein-Institut Open Science Activities